Mediator - A universal complex in transcriptional regulation

Molecular Microbiology

Volumn 41, Issue 1, 2001, Pages 1-8

  Gustafsson, Claes M ^a   Samuelsson, Tore ^b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

DATA BASE; EUKARYOTE; GENE EXPRESSION REGULATION; GENETIC ANALYSIS; MEDIATOR; METAZOON; NONHUMAN; NUCLEOSOME; PRIORITY JOURNAL; PROMOTER REGION; SACCHAROMYCES CEREVISIAE; SHORT SURVEY; TRANSCRIPTION REGULATION;

FUNGAL PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; RNA POLYMERASE II; SACCHAROMYCES CEREVISIAE; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS;

EID: 0034943363     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.2001.02481.x     Document Type: Short Survey

References (39)

1. Conserved structures of mediator and RNA polymerase II holoenzyme
2. Drosophila homologs of transcriptional mediator complex subunits are required for adult cell and segment identity specification
3. Messenger RNA synthesis in mammalian cells is catalyzed by the phosphorylated form of RNA polymerase II
4. Genetics of transcriptional regulation in yeast: Connections to the RNA polymerase II CTD
5. A mammalian SRB protein associated with an RNA polymerase II holoenzyme
6. Structural organization of yeast and mammalian mediator complexes
7. Relationship of CDK-activating kinase and RNA polymerase II CTD kinase TFIIH/TFIIK
8. A mediator required for activation of RNA polymerase II transcription in vitro
9. Negative effect of the transcriptional activator GAL4
10. A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation
11. Identification of new mediator subunits in the RNA polymerase II holoenzyme from Saccharomyces cerevisiae
12. Activator-specific requirement of yeast mediator proteins for RNA polymerase II transcriptional activation
13. Temporal regulation of RNA polymerase II by Srb10 and Kin28 cyclin-dependent kinases
14. Dissecting the regulatory circuitry of a eukaryotic genome
15. Involvement of the TRAP220 component of the TRAP/SMCC coactivator complex in embryonic development and thyroid hormone action
16. A novel mediator between activator proteins and the RNA polymerase II transcription apparatus
17. A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II
18. Transcriptional activation independent of TFIIH kinase and the RNA polymerase II mediator in vivo
19. Requirement for a functional interaction between mediator components Med6 and Srb4 in RNA polymerase II transcription
20. A transcriptional mediator protein that is required for activation of many RNA polymerase II promoters and is conserved from yeast to humans
21. A kinase-cyclin pair in the RNA polymerase II holoenzyme
22. Yeast nuclear extract contains two major forms of RNA polymerase II mediator complexes
23. Mediator-nucleosome interaction
24. Transcriptional regulation through Mediator-like coactivators in yeast and metazoan cells
25. Activated transcription independent of the RNA polymerase II holoenzyme in budding yeast
26. RNA polymerase II holoenzymes and subcomplexes
27. The Med proteins of yeast and their function through the RNA polymerase II carboxy-terminal domain
28. Mediator protein mutations that selectively abolish activated transcription
29. Mediator of transcriptional regulation
30. Chromatin, TAFs, and a novel multiprotein coactivator are required for synergistic activation by Sp1 and SREBP-1a in vitro
31. Intragenic and extragenic suppressors of mutations in the heptapeptide repeat domain of Saccharomyces cerevisiae RNA polymerase II
32. In vivo requirement of activator-specific binding targets of mediator
33. RNA polymerase II C-terminal repeat influences response to transcriptional enhancer signals
34. Purification and characterization of RNA polymerase II holoenzyme from Schizosaccharomyces pombe
35. NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription
36. Evidence for a mediator cycle at the initiation of transcription
37. A multisubunit complex associated with the RNA polymerase II CTD and TATA-binding protein in yeast
38. Ubiquitous expression and embryonic requirement for RNA polymerase II coactivator subunit Srb7 in mice
39. A transcription reinitiation intermediate that is stabilized by activator