Discovery of Nanomolar Dengue and West Nile Virus Protease Inhibitors Containing a 4-Benzyloxyphenylglycine Residue

Journal of Medicinal Chemistry

Volumn 58, Issue 23, 2015, Pages 9354-9370

  Behnam, Mira A M ^a   Graf, Dominik ^a   Bartenschlager, Ralf ^a   Zlotos, Darius P ^b   Klein, Christian D ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b German University in Cairo   (Egypt)

Author keywords

[No Author keywords available]

Indexed keywords

4 BENZYLOXYPHENYLGLYCINE; COPPER COMPLEX; ETHER DERIVATIVE; NONSTRUCTURAL PROTEIN 2B; NONSTRUCTURAL PROTEIN 3; PROTEINASE; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG; 4-HYDROXYPHENYLGLYCINE; ANTIVIRUS AGENT; BENZOIC ACID DERIVATIVE; GLYCINE; PEPTIDE; PEPTIDE HYDROLASE;

AMINO TERMINAL SEQUENCE; ANTIVIRAL ACTIVITY; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CONCENTRATION RESPONSE; DENGUE VIRUS; DENGUE VIRUS 2; DRUG CYTOTOXICITY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; EC50; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; MOLECULAR DOCKING; NONHUMAN; STRUCTURE ACTIVITY RELATION; VIRUS REPLICATION; WEST NILE VIRUS; AMINO ACID SEQUENCE; ANALOGS AND DERIVATIVES; ANIMAL; CELL LINE; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; LIVER MICROSOME; MALE; METABOLISM; SPRAGUE DAWLEY RAT; VIROLOGY; WEST NILE FEVER;

AMINO ACID SEQUENCE; ANIMALS; ANTIVIRAL AGENTS; BENZOATES; CELL LINE; GLYCINE; HUMANS; MALE; MICROSOMES, LIVER; MOLECULAR DOCKING SIMULATION; PEPTIDE HYDROLASES; PEPTIDES; PROTEASE INHIBITORS; RATS, SPRAGUE-DAWLEY; WEST NILE FEVER; WEST NILE VIRUS;

EID: 84949907949     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.5b01441     Document Type: Article

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