C-terminal residue optimization and fragment merging: Discovery of a potent peptide-hybrid inhibitor of dengue protease

ACS Medicinal Chemistry Letters

Volumn 5, Issue 9, 2014, Pages 1037-1042

  Behnam, Mira A M ^a   Nitsche, Christoph ^a   Vechi, Sérgio M ^a,b   Klein, Christian D ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b FEDERAL UNIVERSITY OF ALAGOAS   (Brazil)

Author keywords

Dengue virus; fragment merging; peptide; protease inhibitor

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; AMINO ACID DERIVATIVE; NORLEUCINE; PEPTIDE; PEPTIDE DERIVATIVE; PHENYLGLYCINE; PIPECOLIC ACID; PROTEINASE; PROTEINASE INHIBITOR;

AMINO ACID SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DENGUE VIRUS; DRUG BINDING; DRUG DESIGN; DRUG INHIBITION; DRUG POTENCY; HYBRID; IC50; NONHUMAN; PROCESS OPTIMIZATION;

EID: 84907569335     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml500245v     Document Type: Article

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