Peptide inhibitors of West Nile NS3 protease: SAR study of tetrapeptide aldehyde inhibitors

Journal of Medicinal Chemistry

Volumn 49, Issue 22, 2006, Pages 6585-6590

  Knox, John E ^a   Ma, Ngai Ling ^a   Yin, Zheng ^a   Patel, Sejal J ^a   Wang, Wei Ling ^a   Chan, Wai Ling ^a   Rao, K R Ranga ^a   Wang, Gang ^a   Ngew, Xinyi ^a   Patel, Viral ^a   Beer, David ^a   Lim, Siew Pheng ^a   Vasudevan, Subhash G ^a   Keller, Thomas H ^a  

^a Novartis Institute for Tropical Diseases   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE DERIVATIVE; ANTIVIRUS AGENT; BENZOYLNORLEUCYLLYSYLARGINYLARGININE; NONSTRUCTURAL PROTEIN 2B; NONSTRUCTURAL PROTEIN 3; PROTEINASE INHIBITOR; TETRAPEPTIDE; TETRAPEPTIDE ALDEHYDE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; CRYSTAL STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME SUBSTRATE; FLAVIVIRUS; HYDROGEN BOND; IC 50; MOLECULAR DYNAMICS; MOLECULAR MODEL; NONHUMAN; PEPTIDE ANALYSIS; PROTEIN DOMAIN; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; VIRUS INHIBITION; WEST NILE FLAVIVIRUS;

ALDEHYDES; MODELS, MOLECULAR; MOLECULAR CONFORMATION; OLIGOPEPTIDES; PROTEASE INHIBITORS; SERINE ENDOPEPTIDASES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; WEST NILE VIRUS;

EID: 33750451238     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0607606     Document Type: Article

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