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Volumn 314, Issue , 2016, Pages 47-63

Rosuvastatin enhances anti-inflammatory and inhibits pro-inflammatory functions in cultured microglial cells

Author keywords

Anti inflammation; Gene expression; Lipopolysaccharide; Phagocytosis; Pro inflammation; Rosuvastatin

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 1BETA; ROSUVASTATIN; TUMOR NECROSIS FACTOR ALPHA; ANTIINFLAMMATORY AGENT; AUTACOID; CYTOKINE; LIPOPOLYSACCHARIDE;

EID: 84949567296     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2015.11.053     Document Type: Article
Times cited : (49)

References (91)
  • 2
    • 34250796207 scopus 로고    scopus 로고
    • Actin-binding proteins coronin-1a and IBA-1 are effective microglial markers for immunohistochemistry
    • Ahmed Z., Shaw G., Sharma V.P., Yang C., McGowan E., Dickson D.W. Actin-binding proteins coronin-1a and IBA-1 are effective microglial markers for immunohistochemistry. J Histochem Cytochem 2007, 55:687-700.
    • (2007) J Histochem Cytochem , vol.55 , pp. 687-700
    • Ahmed, Z.1    Shaw, G.2    Sharma, V.P.3    Yang, C.4    McGowan, E.5    Dickson, D.W.6
  • 3
    • 33847008267 scopus 로고    scopus 로고
    • Comparison of the effects of high doses of rosuvastatin versus atorvastatin on the subpopulations of high-density lipoproteins
    • Asztalos B.F., Le Maulf F., Dallal G.E., Stein E., Jones P.H., Horvath K.V., McTaggart F., Schaefer E.J. Comparison of the effects of high doses of rosuvastatin versus atorvastatin on the subpopulations of high-density lipoproteins. Am J Cardiol 2007, 99:681-685.
    • (2007) Am J Cardiol , vol.99 , pp. 681-685
    • Asztalos, B.F.1    Le Maulf, F.2    Dallal, G.E.3    Stein, E.4    Jones, P.H.5    Horvath, K.V.6    McTaggart, F.7    Schaefer, E.J.8
  • 4
    • 29144478789 scopus 로고    scopus 로고
    • Dynamic monitoring of cell adhesion and spreading on microelectronic sensor arrays
    • Atienza J.M., Zhu J., Wang X., Xu X., Abassi Y. Dynamic monitoring of cell adhesion and spreading on microelectronic sensor arrays. J Biomol Screen 2005, 10:795.
    • (2005) J Biomol Screen , vol.10 , pp. 795
    • Atienza, J.M.1    Zhu, J.2    Wang, X.3    Xu, X.4    Abassi, Y.5
  • 6
    • 0029671454 scopus 로고    scopus 로고
    • Cholesterol modulates alpha-secretase cleavage of amyloid precursor protein
    • Bodovitz S., Klein W.L. Cholesterol modulates alpha-secretase cleavage of amyloid precursor protein. J Biol Chem 1996, 271:4436-4440.
    • (1996) J Biol Chem , vol.271 , pp. 4436-4440
    • Bodovitz, S.1    Klein, W.L.2
  • 7
    • 33645456200 scopus 로고    scopus 로고
    • Up-regulated expression of the CXCR2 ligand KC/GRO-alpha in atherosclerotic lesions plays a central role in macrophage accumulation and lesion progression
    • Boisvert W.A., Rose D.M., Johnson K.A., Fuentes M.E., Lira S.A., Curtiss L.K., Terkeltaub R.A. Up-regulated expression of the CXCR2 ligand KC/GRO-alpha in atherosclerotic lesions plays a central role in macrophage accumulation and lesion progression. Am J Pathol 2006, 168:1385-1395.
    • (2006) Am J Pathol , vol.168 , pp. 1385-1395
    • Boisvert, W.A.1    Rose, D.M.2    Johnson, K.A.3    Fuentes, M.E.4    Lira, S.A.5    Curtiss, L.K.6    Terkeltaub, R.A.7
  • 8
    • 79961118496 scopus 로고    scopus 로고
    • Regulation of HMG-CoA reductase in mammals and yeast
    • Burg J.S., Espenshade P.J. Regulation of HMG-CoA reductase in mammals and yeast. Progr Lipid Res 2011, 50:403-410.
    • (2011) Progr Lipid Res , vol.50 , pp. 403-410
    • Burg, J.S.1    Espenshade, P.J.2
  • 9
    • 0037246247 scopus 로고    scopus 로고
    • On the role of Hsp27 in regulating apoptosis
    • Concannon C.G., Gorman A.M., Samali A. On the role of Hsp27 in regulating apoptosis. Apoptosis 2003, 8:61-70.
    • (2003) Apoptosis , vol.8 , pp. 61-70
    • Concannon, C.G.1    Gorman, A.M.2    Samali, A.3
  • 10
    • 12144261198 scopus 로고    scopus 로고
    • 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors attenuate β-amyloid-induced microglial inflammatory responses
    • Cordle A., Landreth G. 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors attenuate β-amyloid-induced microglial inflammatory responses. J Neurosci 2005, 25:299-307.
    • (2005) J Neurosci , vol.25 , pp. 299-307
    • Cordle, A.1    Landreth, G.2
  • 11
    • 0036139706 scopus 로고    scopus 로고
    • Rosuvastatin: a highly efficacious statin for the treatment of dyslipidaemia
    • Davidson M.H. Rosuvastatin: a highly efficacious statin for the treatment of dyslipidaemia. Exp Opin Invest Drugs 2002, 11:125-141.
    • (2002) Exp Opin Invest Drugs , vol.11 , pp. 125-141
    • Davidson, M.H.1
  • 12
    • 56349166514 scopus 로고    scopus 로고
    • Mechanisms of microglia accumulation in Alzheimer's disease: therapeutic implications
    • El Khoury J., Luster A.D. Mechanisms of microglia accumulation in Alzheimer's disease: therapeutic implications. Trends Pharmacol Sci 2008, 29:626-632.
    • (2008) Trends Pharmacol Sci , vol.29 , pp. 626-632
    • El Khoury, J.1    Luster, A.D.2
  • 13
    • 34147115541 scopus 로고    scopus 로고
    • Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease
    • El Khoury J., Toft M., Hickman S.E., Means T.K., Terada K., Geula C., Luster A.D. Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease. Nat Med 2007, 13:432-438.
    • (2007) Nat Med , vol.13 , pp. 432-438
    • El Khoury, J.1    Toft, M.2    Hickman, S.E.3    Means, T.K.4    Terada, K.5    Geula, C.6    Luster, A.D.7
  • 14
    • 84876703460 scopus 로고    scopus 로고
    • ATP-dependent transport of statins by human and rat MRP2/Mrp2
    • Ellis L.C., Hawksworth G.M., Weaver R.J. ATP-dependent transport of statins by human and rat MRP2/Mrp2. Toxicol Appl Pharmacol 2013, 269:187-194.
    • (2013) Toxicol Appl Pharmacol , vol.269 , pp. 187-194
    • Ellis, L.C.1    Hawksworth, G.M.2    Weaver, R.J.3
  • 15
    • 34249865347 scopus 로고    scopus 로고
    • Temporal expression and cellular origin of CC chemokine receptors CCR1, CCR2 and CCR5 in the central nervous system: insight into mechanism of MOG-induced EAE
    • Eltayeb S., Berg A.L., Lassmann H., Wallström E., Nilsson M., Olsson T., Ericsson-Dahlstrand A., Sunnemark D. Temporal expression and cellular origin of CC chemokine receptors CCR1, CCR2 and CCR5 in the central nervous system: insight into mechanism of MOG-induced EAE. J Neuroinflamm 2007, 4:14.
    • (2007) J Neuroinflamm , vol.4 , pp. 14
    • Eltayeb, S.1    Berg, A.L.2    Lassmann, H.3    Wallström, E.4    Nilsson, M.5    Olsson, T.6    Ericsson-Dahlstrand, A.7    Sunnemark, D.8
  • 17
    • 78149468901 scopus 로고    scopus 로고
    • Rosuvastatin reduces microglia in the brain of wild type and ApoE knockout mice on a high cholesterol diet; implications for prevention of stroke and AD
    • Famer D., Wahlund L.O., Crisby M. Rosuvastatin reduces microglia in the brain of wild type and ApoE knockout mice on a high cholesterol diet; implications for prevention of stroke and AD. Biochem Biophys Res Commun 2010, 402:367-372.
    • (2010) Biochem Biophys Res Commun , vol.402 , pp. 367-372
    • Famer, D.1    Wahlund, L.O.2    Crisby, M.3
  • 18
    • 33646841989 scopus 로고    scopus 로고
    • Beta-amyloid stimulates murine postnatal and adult microglia cultures in a unique manner
    • Floden A.M., Combs C.K. Beta-amyloid stimulates murine postnatal and adult microglia cultures in a unique manner. J Neurosci 2006, 26:4644-4648.
    • (2006) J Neurosci , vol.26 , pp. 4644-4648
    • Floden, A.M.1    Combs, C.K.2
  • 19
    • 0030459070 scopus 로고    scopus 로고
    • Effects of GM-CSF and ordinary supplements on the ramification of microglia in culture: a morphometrical study
    • Fujita H., Tanaka J., Toin R., Tateishi N., SuzugI Y., Matsuda S., Sakanaka M., Maedap N. Effects of GM-CSF and ordinary supplements on the ramification of microglia in culture: a morphometrical study. Glia 1996, 18:269-281.
    • (1996) Glia , vol.18 , pp. 269-281
    • Fujita, H.1    Tanaka, J.2    Toin, R.3    Tateishi, N.4    SuzugI, Y.5    Matsuda, S.6    Sakanaka, M.7    Maedap, N.8
  • 21
    • 84866519738 scopus 로고    scopus 로고
    • The molecular mechanism of the anticancer effect of atorvastatin: DNA microarray and bioinformatic analyses
    • Gao Y., Lu X.C., Yang H.Y., Liu X.F., Cao J., Fan L. The molecular mechanism of the anticancer effect of atorvastatin: DNA microarray and bioinformatic analyses. Int J Mol Med 2012, 30:765-774.
    • (2012) Int J Mol Med , vol.30 , pp. 765-774
    • Gao, Y.1    Lu, X.C.2    Yang, H.Y.3    Liu, X.F.4    Cao, J.5    Fan, L.6
  • 22
    • 34548563114 scopus 로고    scopus 로고
    • Activated microglia in primary MS lesions: defenders or aggressors?
    • Gay F. Activated microglia in primary MS lesions: defenders or aggressors?. Int MS J MS Forum 2007, 14:78-83.
    • (2007) Int MS J MS Forum , vol.14 , pp. 78-83
    • Gay, F.1
  • 23
    • 0029076362 scopus 로고
    • Microglia: intrinsic immunoeffector cell of the brain
    • Gehrmann J., Matsumo Y., Kreutzberg G. Microglia: intrinsic immunoeffector cell of the brain. Brain Res Rev 1995, 20:269-287.
    • (1995) Brain Res Rev , vol.20 , pp. 269-287
    • Gehrmann, J.1    Matsumo, Y.2    Kreutzberg, G.3
  • 24
    • 84874882726 scopus 로고    scopus 로고
    • Sustained interleukin-1β overexpression exacerbates tau pathology despite reduced amyloid burden in an Alzheimer's mouse model
    • Ghosh S., Wu M.D., Shaftel S.S., Kyrkanides S., LaFerla F.M., Olschowka J.A., O'Banion M.K. Sustained interleukin-1β overexpression exacerbates tau pathology despite reduced amyloid burden in an Alzheimer's mouse model. J Neurosci 2013, 33:5053-5064.
    • (2013) J Neurosci , vol.33 , pp. 5053-5064
    • Ghosh, S.1    Wu, M.D.2    Shaftel, S.S.3    Kyrkanides, S.4    LaFerla, F.M.5    Olschowka, J.A.6    O'Banion, M.K.7
  • 25
    • 84869234156 scopus 로고    scopus 로고
    • Inflammatory regulation of ATP binding cassette efflux transporter expression and function in microglia
    • Gibson C.J., Hossain M.M., Richardson J.R., Aleksunes L.M. Inflammatory regulation of ATP binding cassette efflux transporter expression and function in microglia. J Pharmacol Exp Ther 2012, 343:650-660.
    • (2012) J Pharmacol Exp Ther , vol.343 , pp. 650-660
    • Gibson, C.J.1    Hossain, M.M.2    Richardson, J.R.3    Aleksunes, L.M.4
  • 27
    • 0032942060 scopus 로고    scopus 로고
    • Microglia as mediators of inflammatory and degenerative diseases
    • Gonzalez-Scarano F., Baltuch G. Microglia as mediators of inflammatory and degenerative diseases. Annu Rev Neurosci 1999, 22:219-240.
    • (1999) Annu Rev Neurosci , vol.22 , pp. 219-240
    • Gonzalez-Scarano, F.1    Baltuch, G.2
  • 28
    • 78149322599 scopus 로고    scopus 로고
    • Changing face of microglia
    • Graeber M.B. Changing face of microglia. Science 2010, 330:783-788.
    • (2010) Science , vol.330 , pp. 783-788
    • Graeber, M.B.1
  • 29
    • 84866705875 scopus 로고    scopus 로고
    • Modelling neuroinflammation in vitro: a tool to test the potential neuroprotective effect of anti-inflammatory agents
    • Gresa-Arribas N., Vieitez C., Dentesano G., Serratosa J., Saura J., Sola C. Modelling neuroinflammation in vitro: a tool to test the potential neuroprotective effect of anti-inflammatory agents. Plos One 2012, 7:9.
    • (2012) Plos One , vol.7 , pp. 9
    • Gresa-Arribas, N.1    Vieitez, C.2    Dentesano, G.3    Serratosa, J.4    Saura, J.5    Sola, C.6
  • 30
    • 84949562563 scopus 로고    scopus 로고
    • Increased astrocyte expression of IL-6 or CCL2 in transgenic mice alters levels of hippocampal and cerebellar proteins
    • Gruol D.L., Vo K., Bray J.G. Increased astrocyte expression of IL-6 or CCL2 in transgenic mice alters levels of hippocampal and cerebellar proteins. Front Cell Neurosci 2014, 8:234.
    • (2014) Front Cell Neurosci , vol.8 , pp. 234
    • Gruol, D.L.1    Vo, K.2    Bray, J.G.3
  • 31
    • 0031881755 scopus 로고    scopus 로고
    • Hydrophilicity/lipophilicity: relevance for the pharmacology and clinical effects of HMG-CoA reductase inhibitors
    • Hamelin B.A., Turgeon J. Hydrophilicity/lipophilicity: relevance for the pharmacology and clinical effects of HMG-CoA reductase inhibitors. Trends Pharmacol Sci 1998, 19:26-37.
    • (1998) Trends Pharmacol Sci , vol.19 , pp. 26-37
    • Hamelin, B.A.1    Turgeon, J.2
  • 32
    • 0036849018 scopus 로고    scopus 로고
    • Microglia as a source and target of cytokines
    • Hanisch U.K. Microglia as a source and target of cytokines. Glia 2002, 40:140-155.
    • (2002) Glia , vol.40 , pp. 140-155
    • Hanisch, U.K.1
  • 33
    • 84899147486 scopus 로고    scopus 로고
    • The amelioration of phagocytic ability in microglial cells by curcumin through the inhibition of EMF-induced pro-inflammatory responses
    • He G.L., Liu Y., Li M., Chen C.H., Gao P., Yu Z.P., Yang X.S. The amelioration of phagocytic ability in microglial cells by curcumin through the inhibition of EMF-induced pro-inflammatory responses. J Neuroinflamm 2014, 11:49.
    • (2014) J Neuroinflamm , vol.11 , pp. 49
    • He, G.L.1    Liu, Y.2    Li, M.3    Chen, C.H.4    Gao, P.5    Yu, Z.P.6    Yang, X.S.7
  • 35
    • 84897954222 scopus 로고    scopus 로고
    • TREM2 and the neuroimmunology of Alzheimer's disease
    • Hickman S.E., El Khoury J. TREM2 and the neuroimmunology of Alzheimer's disease. Biochem Pharmacol 2014, 88:495-498.
    • (2014) Biochem Pharmacol , vol.88 , pp. 495-498
    • Hickman, S.E.1    El Khoury, J.2
  • 38
    • 0032032592 scopus 로고    scopus 로고
    • Comparative dose efficacy study of atorvastatin versus simvastatin, pravastatin, lovastatin, and fluvastatin in patients with hypercholesterolemia (the CURVES study)
    • Jones P., Kafonek S., Laurora I., Hunninghake D. Comparative dose efficacy study of atorvastatin versus simvastatin, pravastatin, lovastatin, and fluvastatin in patients with hypercholesterolemia (the CURVES study). Am J Cardiol 1998, 81:582-587.
    • (1998) Am J Cardiol , vol.81 , pp. 582-587
    • Jones, P.1    Kafonek, S.2    Laurora, I.3    Hunninghake, D.4
  • 40
    • 52949104006 scopus 로고    scopus 로고
    • Involvement of multiple transporters in the hepatobiliary transport of rosuvastatin
    • Kitamura S., Maeda K., Wang Y., Sugiyama Y. Involvement of multiple transporters in the hepatobiliary transport of rosuvastatin. Drug Metab Dispos 2008, 36:2014-2023.
    • (2008) Drug Metab Dispos , vol.36 , pp. 2014-2023
    • Kitamura, S.1    Maeda, K.2    Wang, Y.3    Sugiyama, Y.4
  • 41
    • 0030222037 scopus 로고    scopus 로고
    • Microglia: a sensor for pathological events in the CNS
    • Kreutzberg G.W. Microglia: a sensor for pathological events in the CNS. Trends Neurosci 1996, 19:312-318.
    • (1996) Trends Neurosci , vol.19 , pp. 312-318
    • Kreutzberg, G.W.1
  • 42
    • 84908028367 scopus 로고    scopus 로고
    • TNF and increased intracellular iron alter macrophage polarization to a detrimental M1 phenotype in the injured spinal cord
    • Kroner A., Greenhalgh A.D., Zarruk J.G., Passos Dos Santos R., Gaestel M., David S. TNF and increased intracellular iron alter macrophage polarization to a detrimental M1 phenotype in the injured spinal cord. Neuron 2014, 83:1098-1116.
    • (2014) Neuron , vol.83 , pp. 1098-1116
    • Kroner, A.1    Greenhalgh, A.D.2    Zarruk, J.G.3    Passos Dos Santos, R.4    Gaestel, M.5    David, S.6
  • 43
    • 84864089648 scopus 로고    scopus 로고
    • Atorvastatin and pitavastatin reduce senile plaques and inflammatory responses in a mouse model of Alzheimer's disease
    • Kurata T., Miyazaki K., Kozuki M., Morimoto N., Ohta Y., Ikeda Y., Abe K. Atorvastatin and pitavastatin reduce senile plaques and inflammatory responses in a mouse model of Alzheimer's disease. Neurol Res 2012, 34:601-610.
    • (2012) Neurol Res , vol.34 , pp. 601-610
    • Kurata, T.1    Miyazaki, K.2    Kozuki, M.3    Morimoto, N.4    Ohta, Y.5    Ikeda, Y.6    Abe, K.7
  • 44
    • 84862842013 scopus 로고    scopus 로고
    • Soluble CCL5 derived from bone marrow-derived mesenchymal stem cells and activated by amyloid β ameliorates Alzheimer's disease in mice by recruiting bone marrow-induced microglia immune responses
    • Lee J.K., Schuchman E.H., Jin H.K., Bae J.S. Soluble CCL5 derived from bone marrow-derived mesenchymal stem cells and activated by amyloid β ameliorates Alzheimer's disease in mice by recruiting bone marrow-induced microglia immune responses. Stem cells 2012, 30:1544-1555.
    • (2012) Stem cells , vol.30 , pp. 1544-1555
    • Lee, J.K.1    Schuchman, E.H.2    Jin, H.K.3    Bae, J.S.4
  • 47
    • 70350346842 scopus 로고    scopus 로고
    • The influence of microglia on the pathogenesis of Parkinson's disease
    • Long-Smith C.M., Sullivan A.M., Nolan Y.M. The influence of microglia on the pathogenesis of Parkinson's disease. Progr Neurobiol 2009, 89:277-287.
    • (2009) Progr Neurobiol , vol.89 , pp. 277-287
    • Long-Smith, C.M.1    Sullivan, A.M.2    Nolan, Y.M.3
  • 49
    • 84938418325 scopus 로고    scopus 로고
    • What happens to microglial TREM2 in Alzheimer's disease: immunoregulatory turned into immunopathogenic?
    • Lue L.F., Schmitz C., Walker D.G. What happens to microglial TREM2 in Alzheimer's disease: immunoregulatory turned into immunopathogenic?. Neuroscience 2015, 302:138-150.
    • (2015) Neuroscience , vol.302 , pp. 138-150
    • Lue, L.F.1    Schmitz, C.2    Walker, D.G.3
  • 51
    • 84879554454 scopus 로고    scopus 로고
    • The changing phenotype of microglia from homeostasis to disease
    • Luo X.G., Chen S.D. The changing phenotype of microglia from homeostasis to disease. Translat Neurodegener 2012, 1:9.
    • (2012) Translat Neurodegener , vol.1 , pp. 9
    • Luo, X.G.1    Chen, S.D.2
  • 53
    • 75149118999 scopus 로고    scopus 로고
    • Neuroinflammation in Alzheimer's disease and mild cognitive impairment: a field in its infancy
    • McGeer E.G., McGeer P.L. Neuroinflammation in Alzheimer's disease and mild cognitive impairment: a field in its infancy. J Alzheimers Dis 2010, 19:355-361.
    • (2010) J Alzheimers Dis , vol.19 , pp. 355-361
    • McGeer, E.G.1    McGeer, P.L.2
  • 55
    • 0035825928 scopus 로고    scopus 로고
    • Preclinical and clinical pharmacology of Rosuvastatin, a new 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor
    • McTaggart F., Buckett L., Davidson R., Holdgate G., McCormick A., Schneck D., Smith G., Warwick M. Preclinical and clinical pharmacology of Rosuvastatin, a new 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor. Am J Cardiol 2001, 87(5A):28B-32B.
    • (2001) Am J Cardiol , vol.87 , Issue.5 A , pp. 28B-32B
    • McTaggart, F.1    Buckett, L.2    Davidson, R.3    Holdgate, G.4    McCormick, A.5    Schneck, D.6    Smith, G.7    Warwick, M.8
  • 56
    • 33748745943 scopus 로고    scopus 로고
    • Suppressive effect of simvastatin on interferon-beta-induced expression of CC chemokine ligand 5 in microglia
    • Nakamichi K., Saiki M., Kitani H., Kuboyama Y., Morimoto K., Takayama-Ito M., Kurane I. Suppressive effect of simvastatin on interferon-beta-induced expression of CC chemokine ligand 5 in microglia. Neurosci Lett 2006, 407:205-210.
    • (2006) Neurosci Lett , vol.407 , pp. 205-210
    • Nakamichi, K.1    Saiki, M.2    Kitani, H.3    Kuboyama, Y.4    Morimoto, K.5    Takayama-Ito, M.6    Kurane, I.7
  • 57
    • 0036690599 scopus 로고    scopus 로고
    • Regulating factors for microglial activation
    • Nakamura Y. Regulating factors for microglial activation. Biol Pharm Bull 2002, 25:945-953.
    • (2002) Biol Pharm Bull , vol.25 , pp. 945-953
    • Nakamura, Y.1
  • 58
    • 0032703254 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced microglial activation in culture: temporal profiles of morphological change and release of cytokines and nitric oxide
    • Nakamura Y., Si Q.S., Kataoka K. Lipopolysaccharide-induced microglial activation in culture: temporal profiles of morphological change and release of cytokines and nitric oxide. Neurosci Res 1999, 35:95-100.
    • (1999) Neurosci Res , vol.35 , pp. 95-100
    • Nakamura, Y.1    Si, Q.S.2    Kataoka, K.3
  • 59
    • 77955661661 scopus 로고    scopus 로고
    • Protective effects of microglia in multiple sclerosis
    • Napoli I., Neumann H. Protective effects of microglia in multiple sclerosis. Exp Neurol 2010, 225:24-28.
    • (2010) Exp Neurol , vol.225 , pp. 24-28
    • Napoli, I.1    Neumann, H.2
  • 60
    • 79955008182 scopus 로고    scopus 로고
    • Inhibition of microglial phagocytosis is sufficient to prevent inflammatory neuronal death
    • Neher J.J., Neniskyte U., Zhao J.W., Bal-Price A., Tolkovsky A.M., Brown G.C. Inhibition of microglial phagocytosis is sufficient to prevent inflammatory neuronal death. J Immunol 2011, 186:4973-4983.
    • (2011) J Immunol , vol.186 , pp. 4973-4983
    • Neher, J.J.1    Neniskyte, U.2    Zhao, J.W.3    Bal-Price, A.4    Tolkovsky, A.M.5    Brown, G.C.6
  • 63
    • 1042301226 scopus 로고    scopus 로고
    • Microglia/macrophage-specific protein Iba1 binds to fimbrin and enhances its actin-bundling activity
    • Ohsawa K., Imai Y., Sasaki Y., Kohsaka S. Microglia/macrophage-specific protein Iba1 binds to fimbrin and enhances its actin-bundling activity. J Neurochem 2004, 88:844-856.
    • (2004) J Neurochem , vol.88 , pp. 844-856
    • Ohsawa, K.1    Imai, Y.2    Sasaki, Y.3    Kohsaka, S.4
  • 64
    • 58249109355 scopus 로고    scopus 로고
    • Neuroprotection and remyelination after autoimmune demyelination in mice that inducibly overexpress CXCL1
    • Omari K.M., Lutz S.E., Santambrogio L., Lira S.A., Raine C.S. Neuroprotection and remyelination after autoimmune demyelination in mice that inducibly overexpress CXCL1. Am J Pathol 2009, 174:164-176.
    • (2009) Am J Pathol , vol.174 , pp. 164-176
    • Omari, K.M.1    Lutz, S.E.2    Santambrogio, L.3    Lira, S.A.4    Raine, C.S.5
  • 67
    • 84902759627 scopus 로고    scopus 로고
    • Human APOE4 increases microglia reactivity at Aβ plaques in a mouse model of Aβ deposition
    • Rodriguez G.A., Tai L.M., LaDu M.J., Rebeck G.W. Human APOE4 increases microglia reactivity at Aβ plaques in a mouse model of Aβ deposition. J Neuroinflammation 2014, 11:111.
    • (2014) J Neuroinflammation , vol.11 , pp. 111
    • Rodriguez, G.A.1    Tai, L.M.2    LaDu, M.J.3    Rebeck, G.W.4
  • 68
    • 0033849381 scopus 로고    scopus 로고
    • Leukocyte recruitment during onset of experimental allergic encephalomyelitis is CCR1 dependent
    • Rottman J.B., Slavin A.J., Silva R., Weiner H.L., Gerard C.G., Hancock W.W. Leukocyte recruitment during onset of experimental allergic encephalomyelitis is CCR1 dependent. Eur J Immunol 2000, 30:2372-2377.
    • (2000) Eur J Immunol , vol.30 , pp. 2372-2377
    • Rottman, J.B.1    Slavin, A.J.2    Silva, R.3    Weiner, H.L.4    Gerard, C.G.5    Hancock, W.W.6
  • 70
    • 13444251203 scopus 로고    scopus 로고
    • Chemical, pharmacokinetic and pharmacodynamic properties of statins: an update
    • Schachter M. Chemical, pharmacokinetic and pharmacodynamic properties of statins: an update. Fundam Clin Pharmacol 2005, 19:117-125.
    • (2005) Fundam Clin Pharmacol , vol.19 , pp. 117-125
    • Schachter, M.1
  • 71
    • 2642536741 scopus 로고    scopus 로고
    • Inflammation, immunity, and HMG-CoA reductase Inhibitors: statins as antiinflammatory agents
    • Schönbeck U., Libby P. Inflammation, immunity, and HMG-CoA reductase Inhibitors: statins as antiinflammatory agents. Circulation 2004, 109(S1):II18-II26.
    • (2004) Circulation , vol.109 , pp. II18-II26
    • Schönbeck, U.1    Libby, P.2
  • 77
    • 0036847816 scopus 로고    scopus 로고
    • Microglia as neuroprotective immunocompetent cells of the CNS
    • Streit W.J. Microglia as neuroprotective immunocompetent cells of the CNS. Glia 2002, 40:133-139.
    • (2002) Glia , vol.40 , pp. 133-139
    • Streit, W.J.1
  • 78
    • 14844363449 scopus 로고    scopus 로고
    • Mannose-binding lectin-deficient mice display defective apoptotic cell clearance but no autoimmune phenotype
    • Erratum in: J Immunol 175:3447
    • Stuart L.M., Takahashi K., Shi L., Savill J., Ezekowitz R.A. Mannose-binding lectin-deficient mice display defective apoptotic cell clearance but no autoimmune phenotype. J Immunol 2005, 174:3220-3226. Erratum in: J Immunol 175:3447.
    • (2005) J Immunol , vol.174 , pp. 3220-3226
    • Stuart, L.M.1    Takahashi, K.2    Shi, L.3    Savill, J.4    Ezekowitz, R.A.5
  • 79
    • 84877074745 scopus 로고    scopus 로고
    • Development of the microglial phenotype in culture
    • Szabo M., Gulya K. Development of the microglial phenotype in culture. Neuroscience 2013, 241:280-295.
    • (2013) Neuroscience , vol.241 , pp. 280-295
    • Szabo, M.1    Gulya, K.2
  • 82
    • 33746473678 scopus 로고    scopus 로고
    • Simvastatin modulates chemokine and chemokine receptor expression by geranylgeranyl isoprenoid pathway in human endothelial cells and macrophages
    • Veillard N.R., Braunersreuther V., Arnaud C., Burger F., Pelli G., Steffens S., Mach F. Simvastatin modulates chemokine and chemokine receptor expression by geranylgeranyl isoprenoid pathway in human endothelial cells and macrophages. Atherosclerosis 2006, 188:51-58.
    • (2006) Atherosclerosis , vol.188 , pp. 51-58
    • Veillard, N.R.1    Braunersreuther, V.2    Arnaud, C.3    Burger, F.4    Pelli, G.5    Steffens, S.6    Mach, F.7
  • 83
    • 0037083509 scopus 로고    scopus 로고
    • Eotaxin-2 generation is differentially regulated by lipopolysaccharide and IL-4 in monocytes and macrophages
    • Watanabe K., Jose P.J., Rankin S.M. Eotaxin-2 generation is differentially regulated by lipopolysaccharide and IL-4 in monocytes and macrophages. J Immunol 2002, 168:1911-1918.
    • (2002) J Immunol , vol.168 , pp. 1911-1918
    • Watanabe, K.1    Jose, P.J.2    Rankin, S.M.3
  • 84
    • 0030838319 scopus 로고    scopus 로고
    • HMG-CoA reductase inhibitors decrease CD11b expression and CD11b-dependent adhesion of monocytes to endothelium and reduce increased adhesiveness of monocytes isolated from patients with hypercholesterolemia
    • Weber C., Erl W., Weber K.S., Weber P.C. HMG-CoA reductase inhibitors decrease CD11b expression and CD11b-dependent adhesion of monocytes to endothelium and reduce increased adhesiveness of monocytes isolated from patients with hypercholesterolemia. J Am Coll Cardiol 1997, 30:1212-1217.
    • (1997) J Am Coll Cardiol , vol.30 , pp. 1212-1217
    • Weber, C.1    Erl, W.2    Weber, K.S.3    Weber, P.C.4
  • 86
    • 24744441296 scopus 로고    scopus 로고
    • Mannose-binding lectin: biology and clinical implications
    • Worthley D.L., Bardy P.G., Mullighan C.G. Mannose-binding lectin: biology and clinical implications. Intern Med J 2005, 35:548-555.
    • (2005) Intern Med J , vol.35 , pp. 548-555
    • Worthley, D.L.1    Bardy, P.G.2    Mullighan, C.G.3
  • 88
    • 84862806753 scopus 로고    scopus 로고
    • Glyceraldehyde-3-phosphate dehydrogenase: a universal internal control for Western blots in prokaryotic and eukaryotic cells
    • Wu Y., Wu M., He G., Zhang X., Li W., Gao Y., Li Z., Wang Z., Zhang C. Glyceraldehyde-3-phosphate dehydrogenase: a universal internal control for Western blots in prokaryotic and eukaryotic cells. Anal Biochem 2012, 423:15-22.
    • (2012) Anal Biochem , vol.423 , pp. 15-22
    • Wu, Y.1    Wu, M.2    He, G.3    Zhang, X.4    Li, W.5    Gao, Y.6    Li, Z.7    Wang, Z.8    Zhang, C.9


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