Eotaxin-2 generation is differentially regulated by lipopolysaccharide and IL-4 in monocytes and macrophages

Journal of Immunology

Volumn 168, Issue 4, 2002, Pages 1911-1918

  Watanabe, Kimiko ^a   Jose, Peter J ^a   Rankin, Sara M ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CHEMOKINE; EOTAXIN; EOTAXIN 2; INTERLEUKIN 13; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; MACROPHAGE DERIVED CHEMOKINE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ZYMOSAN;

ALLERGY; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; DNA LIBRARY; ENZYME LINKED IMMUNOSORBENT ASSAY; EOSINOPHIL; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IMMUNITY; INFLAMMATION; MACROPHAGE; MONOCYTE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TH2 CELL;

EID: 0037083509     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.168.4.1911     Document Type: Article

References (64)

1. Eotaxin and eosinophil recruitment implications for human disease
2. Cloning of the human eosinophil chemoattractant, eotaxin: Expression, receptor binding and functional properties suggest a mechanism for the selective recruitment of eosinophils
3. Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3
4. Molecular and functional characterization of two novel human C-C chemokines as inhibitors of two distinct classes of myeloid progenitors
5. Eotaxin-2, a novel CC chemokine that is selective for the chemokine receptor CCR3, and acts like eotaxin on human eosinophil and basophil leukocytes
6. Cloning and functional characterization of a novel human CC chemokine that binds to the CCR3 receptor and activates human eosinophils
7. Molecular cloning of a novel human CC chemokine (Eotaxin-3) that is a functional ligand of CC chemokine receptor 3
8. Cloning, expression and characterization of the human eosinophil eotaxin receptor
9. Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinopbils
10. Eotaxin: A potent eosinophil chemoattractant cytokine detected in a guinea-pig model of allergic airways inflammation
11. Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia
12. A novel human CC chemokine, eotaxin-3, which is expressed in IL-4-stimulated vascular endothelial cells, exhibits potent activity toward eosinophils
13. High expression of the chemokine receptor CCR3 in human blood basophils: Role in activation by eotaxin, MCP-4, and other chemokines
14. Expression of the chemokine receptor CCR3 on human mast cells
15. Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells
16. Chemokines and asthma: Redundancy of function or a coordinated effort?
17. Eotaxin is specifically cleaved by hookworm metalloproteases preventing its action in vitro and in vivo
18. Non-redundant functional groups of chemokines operate in a coordinate manner during the inflammatory response in the lung
19. C-C chemokines in allergen-induced late-phase cutaneous responses in atopic subjects: Association of eotaxin with early 6-h eosinophils, and of eotaxin-2 and monocyte chemoattractant protein-4 with the later 24-h tissue eosinophilia, and relationship to basophils and other C-C chemokines (monocyte chemoattractant protein-3 and RANTES)
20. Eotaxin-3 but not eotaxin gene expression is upregulated in asthmatics 24 hours after allergen challenge
21. The chemokine, eotaxin, activates guinea pig eosinophils in vitro, and causes their accumulation into the lung in vivo
22. Murine eotaxin: An eosinophil chemoattractant inducible in endothelial cells and in interleukin 4-induced tumor suppression
23. Cloning of rat eotaxin:ozone inhalation increases mRNA and protein expression in lungs of Brown Norway rats
24. Targeted disruption of the chemokine eotaxin partially reduces antigen-induced tissue eosinophilia
25. The coordinated action of CC chemokines in the lung orchestrates allergic inflammation and airways hyperresponsiveness
26. Murine eotaxin-2: A constitutive eosinophil chemokine induced by allergen challenge and IL-4 overexpression
27. Eosinophil chemotactic chemokines (eotaxin, eotaxin-2, RANTES, monocyte chemoattractant protein-3, and monocyte chemoattractant protein-4), and C-C chemokine receptor 3 expression in bronchial biopsies from atopic and nonatopic (intrinsic) asthmatics
28. Kinetics of eotaxin generation and its relationship to eosinophil accumulation in allergic airways disease: Analysis in a guinea pig model in vivo
29. Enhanced expression of eotaxin and CCR3 mRNA and protein in atopic asthma: Association with airway hyperresponsiveness and predominant co-localization of eotaxin mRNA to bronchial epithelial and endothelial cells
30. Elemental signals regulating eosinophil accumulation in the lung
31. IL-4 induces eotaxin: A possible mechanism of selective eosinophil recruitment in helminth infection and atopy
32. Chemokine production by the BEAS-2B human bronchial epithelial cells: Differential regulation of eotaxin, IL-8, and RANTES by TH2- and TH1-derived cytokines
33. Regulation of human eotaxin generation by Th1-Th2-derived cytokines
34. Elevated concentrations of eotaxin and interleukin-5 in human neurocysticercosis
35. Differential regulation of eosinophil chemokine signaling via CCR3 and non-CCR3 pathways
36. Human dermal fibroblasts express eotaxin: Molecular cloning, mRNA expression, and identification of eotaxin sequence variants
37. Delayed production of biologically active O-glycosylated forms of human eotaxin by tumor necrosis factor-α-stimulated dermal fibroblasts
38. Regulation of neutrophil interleukin 8 gene expression and protein secretion by LPS, TNF-α, and IL-1β
39. Human macrophage-derived chemokine (MDC), a novel chemoattractant for monocytes, monocyte-derived dendritic cells, and natural killer cells
40. Expression of macrophage-derived chemokine (MDC) mRNA in macrophages is enhanced by interleukin-1β, tumor necrosis factor-α, and lipopolysaccharide
41. Divergent effects of interleukin-4 and interferon-γ on macrophage-derived chemokine production: An amplification circuit of polarized T helper 2 responses
42. STCP-1 (MDC) CC chemokine acts specifically on chronically activated Th2 lymphocytes and is produced by monocytes on stimulation with Th2 cytokines IL-4 and IL-13
43. Comprehensive gene expression profile of LPS-stimulated human monocytes by SAGE
44. Increased serum levels of eotaxin in patients with inflammatory bowel disease
45. Molecular basis of host-pathogen interaction in septic shock
46. The molecular pathogenesis of endotoxic shock and organ failure
47. Purification and amino acid sequencing of NAF, a novel neutrophil-activating factor produced by monocytes
48. Secretion of monocyte chemoattractant protein-1 (MCP-1) by human mononuclear phagocytes
49. Gene expression of macrophage inflammatory protein-1α from human blood monocytes and alveolar macrophages is inhibited by interleukin-4
50. Pharmacological modulation of lipopolysaccharide-induced pleural eosinophilia in the rat: A role for a newly generated protein
51. IL-5 accounts for the mouse pleural eosinophil accumulation triggered by antigen but not by LPS
52. Surface phenotype analysis of human monocyte to macrophage maturation
53. Cytokine-induced macrophage differentiation: A tale of 2 genes
54. Serial analysis of gene expression in human monocytes and macrophages
55. Chemokines and chemokine receptors during activation and deactivation of monocytes and dendritic cells and in amplification of Th1 versus Th2 responses
56. Differential responses of human monocytes and macrophages to IL-4 and IL-13
57. IL-4 reciprocally regulates IL-1 and IL-1 receptor antagonist expression in human monocytes
58. IL-4 inhibits the expression of IL-8 from stimulated human monocytes
59. Interleukin-13 inhibits macrophage inflammatory protein-1α production from human alveolar macrophages and monocytes
60. Th 2 cytokines differently regulate monocyte chemoattractant protein-1 production by human peripheral blood monocytes and alveolar macrophages
61. Interleukin-4 regulation of human monocyte and macrophage interleukin-10 and interleukin-12 production: Role of a functional interleukin-2 receptor γ-chain
62. Interleukin-4 suppression of monocyte tumour necrosis factor-α production: Dependence on protein synthesis but not on cyclic AMP production
63. Mouse monocyte-derived chemokine is involved in airway hyperreactivity and lung inflammation
64. A key role for CC chemokine receptor 4 in lipopolysaccharide-induced endotoxic shock