HMG-CoA reductase inhibitors decrease CD11b expression and CD11b- dependent adhesion of monocytes to endothelium and reduce increased adhesiveness of monocytes isolated from patients with hypercholesterolemia

Journal of the American College of Cardiology

Volumn 30, Issue 5, 1997, Pages 1212-1217

  Weber, Christian ^a   Erl, Wolfgang ^a   Weber, Kim S C ^b   Weber, Peter C ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD11B ANTIGEN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MEVINOLIN; SIMVASTATIN;

ANTIGEN EXPRESSION; ARTICLE; CONTROLLED STUDY; ENDOTHELIUM; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HYPERCHOLESTEROLEMIA; LEUKOCYTE ADHERENCE; MONOCYTE; PRIORITY JOURNAL;

EID: 0030838319     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0735-1097(97)00324-0     Document Type: Article

References (26)

1. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease the Scandinavian Simvastatin Survival Study (4S) . Lancet. 344:1994;1383-1389.
2. Shepherd J, Cobbe SM, Ford I, et al. Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. N Engl J Med. 333:1995;1301-1307.
3. Jukema JW, Bruschke AVG, van Boven AJ, et al. Effects of lipid lowering by pravastatin on progression and regression of coronary artery disease in symptomatic men with normal to moderately elevated serum cholesterol levels. The regression growth evaluation statin study (REGRESS). Circulation. 91:1995;2528-2540.
4. Yeagle PL. Lipid regulation of cell membrane structure and function. FASEB J. 3:1989;1833-1842.
5. Goldstein JL, Brown MS. Regulation of the mevalonate pathway. Nature. 343:1990;425-430.
6. Glomset JA, Gelb MH, Farnsworth CC. Prenyl proteins in eukaryotic cells a new type of membrane anchor . Trends Biochem Sci. 15:1990;139-142.
7. 2+-influx of retinoic acid differentiated U937 and HL-60 cells. Cell Signal. 7:1994;735-742.
8. Giroux LM, Davignon J, Naruszewicz M. Simvastatin inhibits the oxidation of low-density lipoproteins by activated human monocyte-derived macrophages. Biochim Biophys Acta. 1165:1993;335-338.
9. Hrboticky N, Tang L, Zimmer B, Weber PC. Lovastatin increases arachidonic acid levels and stimulates thromboxane synthesis in human liver and monocytic cell lines. J Clin Invest. 93:1994;195-203.
10. Weber C, Erl W, Weber PC. Lovastatin induces differentiation of Mono Mac 6 cells. Cell Biochem Funct. 13:1995;273-277.
11. Ross R. The pathogenesis of atherosclerosis a perspective for the 1990s . Nature. 362:1993;801-809.
12. Springer TA. Traffic signals for lymphocyte recirculation and leukocyte emigration the multistep paradigm . Cell. 76:1994;301-314.
13. Meerschaert J, Furie MB. The adhesion molecules used by monocytes for migration across endothelium include CD11a/CD18, CD11b/CD18, and VLA-4 on monocytes and ICAM-1, VCAM-1, and other ligands on endothelium. J Immunol. 154:1995;4099-4112.
14. Weber C, Erl W, Weber PC. Enhancement of monocyte adhesion to endothelial cells by oxidatively modified low density lipoprotein is mediated by activation of CD11b. Biochem Biophys Res Commun. 206:1995;621-628.
15. Jongkind JF, Verkerk A, Hoogerbrugge N. Monocytes from patients with combined hypercholesterolemia-hypertriglyceridemia and isolated hypercholesterolemia show increased adhesion to endothelial cells in vitro II: influence of intrinsic and extrinsic monocyte binding . Metabolism. 44:1995;374-378.
16. Weber C, Erl W, Weber K, Weber PC. Increased adhesiveness of isolated monocytes to endothelium is prevented by vitamin C intake in smokers. Circulation. 93:1996;1488-1492.
17. Erl W, Weber C, Wardemann C, Weber PC. Adhesion properties of Mono Mac 6, a monocytic cell line with characteristics of mature human monocytes. Atherosclerosis. 113:1995;99-107.
18. Weber C, Erl W, Pietsch A, Ströbel M, Ziegler-Heitbrock HWL, Weber PC. Antioxidants inhibit monocyte adhesion by suppressing nuclear factor-kB mobilization and induction of vascular cell adhesion molecule-1 in endothelial cells stimulated to generate radicals. Arterioscler Thromb. 14:1994;1665-1673.
19. Buyon JP, Abramson SB, Philips MR, et al. Dissociation between increased surface expression of Gp165/95 and homotypic neutrophil aggregation. J Immunol. 140:1988;3156-3160.
20. Vedder NB, Harlan JM. Increased surface expression of CD11b/CD18 (Mac-1) is not required for stimulated neutrophil adherence to cultured endothelium. J Clin Invest. 81:1988;676-682.
21. Galis ZS, Sukhova GK, Kranzhofer R, Clark S, Libby P. Macrophage foam cells from experimental atheroma constitutively produce matrix-degrading proteinases. Proc Natl Acad Sci U S A. 92:1995;402-406.
22. Diamond MS, Springer TA. A subpopulation of Mac-1 (CD11b/CD18) molecules mediates neutrophil adhesion to ICAM-1 and fibrinogen. J Cell Biol. 120:1993;545-556.
23. Bargatze RF, Butcher EC. Rapid G protein-regulated activation event involved in lymphocyte binding to high endothelial venules. J Exp Med. 178:1993;367-372.
24. Laudanna C, Campbell JJ, Butcher EC. Role of rho in chemoattractant-activated leukocyte adhesion through integrins. Science. 271:1996;981-983.
25. Zhang Z, Vuori K, Wang H-G, Reed JC, Ruoslahti E. Integrin activation by R-ras. Cell. 85:1996;61-69.
26. Stragliotto E, Camera M, Postiglione A, Sirtori M, DiMinno G, Tremoli E. Functionally abnormal monocytes in hypercholesterolemia. Arterioscler Thromb. 13:1993;944-950.