Soluble CCL5 derived from bone marrow-derived mesenchymal stem cells and activated by amyloid β ameliorates Alzheimer's disease in mice by recruiting bone marrow-induced microglia immune responses

Stem Cells

Volumn 30, Issue 7, 2012, Pages 1544-1555

  Lee, Jong Kil ^a,b   Schuchman, Edward H ^c   Jin, Hee Kyung ^a   Bae, Jae Sung ^a,b  

^a Kyungpook National University   (South Korea)

^b Kyungpook National University School of Medicine   (South Korea)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Alternatively activated microglia; Alzheimer's disease model; Bone marrow derived mesenchymal stem cells; CCL5; Recruitment

Indexed keywords

AMYLOID BETA PROTEIN; CD45 ANTIGEN; COLONY STIMULATING FACTOR 1; CXCL1 CHEMOKINE; GREEN FLUORESCENT PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 4; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MACROPHAGE INFLAMMATORY PROTEIN 2; MEMBRANE METALLOENDOPEPTIDASE; RANTES; TUMOR NECROSIS FACTOR ALPHA;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR DISORDER; BONE MARROW CELL; CELL ACTIVATION; CELL MIGRATION; CELL STIMULATION; CELLULAR IMMUNITY; CHIMERA; CONTROLLED STUDY; CYTOKINE RELEASE; IN VITRO STUDY; MEMORY DISORDER; MESENCHYMAL STEM CELL; MICROGLIA; MOUSE; NONHUMAN; PROTEIN EXPRESSION;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; BONE MARROW CELLS; CELL MOVEMENT; CHEMOKINE CCL5; DISEASE MODELS, ANIMAL; FEMALE; MALE; MESENCHYMAL STEM CELLS; MICE; MICE, TRANSGENIC; MICROGLIA;

MUS;

EID: 84862842013     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.1125     Document Type: Article

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