Free radicals and related reactive species as mediators of tissue injury and disease: Implications for Health

Critical Reviews in Toxicology

Volumn 45, Issue 9, 2015, Pages 765-798

  Kehrer, James P ^a   Klotz, Lars Oliver ^b  

^a UNIVERSITY OF ALBERTA   (Canada)

^b FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

Antioxidants; autoxidation; cell signaling; free radicals; mitochondria; oxidative stress; reactive oxygen species; redox cycling

Indexed keywords

ANTIOXIDANT; CARBOHYDRATE; FREE RADICAL; NANOPARTICLE; OXIDOREDUCTASE; OXYGEN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TRANSITION ELEMENT; REACTIVE NITROGEN SPECIES;

ARTICLE; AUTOOXIDATION; BIOLOGICAL ACTIVITY; CARDIOVASCULAR DISEASE; CHEMISTRY; CHEMOPROPHYLAXIS; DIABETES MELLITUS; DNA OXIDATION; ELECTRON TRANSPORT; HUMAN; IMMUNE SYSTEM; INTRACELLULAR SIGNALING; LIPID OXIDATION; MALIGNANT NEOPLASTIC DISEASE; METABOLIC SYNDROME X; MICROSOME; MITOCHONDRION; NONHUMAN; OXYGEN TOXICITY; PHOTOTOXICITY; PROTEIN OXIDATION; RADICAL REACTION; RHEUMATOID ARTHRITIS; RNA OXIDATION; TISSUE INJURY; ANIMAL; DISEASES; HEALTH;

ANIMALS; DISEASE; FREE RADICALS; HEALTH; HUMANS; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN SPECIES;

EID: 84949322613     PISSN: 10408444     EISSN: 15476898     Source Type: Journal    
DOI: 10.3109/10408444.2015.1074159     Document Type: Article

References (271)

1. Adhami VM, Bailey HH, Mukhtar H. Cancer chemoprevention is not a failure. Carcinogenesis 2014; 35: 2154-2155.
2. Ale-Agha N, Albrecht C, Klotz LO. Loss of gap junctional intercellular communication in rat lung epithelial cells exposed to quartz particles. Biochem Biophys Res Commun 2009; 390: 44-47.
3. Ale-Agha N, Albrecht C, Klotz LO. Loss of gap junctional intercellular communication in rat lung epithelial cells exposed to carbon or silica-based nanoparticles. Biol Chem 2010; 391: 1333-1339.
4. Allen RG, Tresini M. Oxidative stress and gene regulation. Free Radic Biol Med 2000; 28: 463-499.
5. Ames BN, Cathcart R, Schwiers E, Hochstein P. Uric acid provides an antioxidant defense in humans against oxidant-and radical-caused aging and cancer: a hypothesis. Proc Natl Acad Sci USA 1981; 78: 6858-6862.
6. Andreoli SP. Mechanisms of endothelial cell ATP depletion after oxidant injury. Pediatr Res 1989; 25: 97-101.
7. Ariki M, Shamoo AE. Oxidation of reactive sulfhydryl groups of sarcoplasmic reticulum ATPase. Biochim Biophys Acta 1983; 734: 83-90.
8. Aviram M. Modified forms of low density lipoprotein and atherosclerosis. Atherosclerosis 1993; 98: 1-9.
9. Aykin-Burns N, Ahmad IM, Zhu Y, Oberley LW, Spitz DR. Increased levels of superoxide and H 2O 2 mediate the differential susceptibility of cancer cells versus normal cells to glucose deprivation. Biochem J 2009; 418: 29-37.
10. Babior BM, Kipnes RS, Carnutte JT. Biological defense mechanisms. The production by leukocytes of superoxide, a potential bactericidal agent. J Clin Invest 1973; 52: 741-744.
11. Babior BM. Phagocytes and oxidative stress. Am J Med 2000; 109: 33-44.
12. Baraibar MA, Liu L, Ahmed EK, Friguet B. Protein oxidative damage at the crossroads of cellular senescence, aging, and age-related diseases. Oxid Med Cell Longev 2012; 2012: 919832.
13. Barcellos-Hoff MH, Nguyen DH. Radiation carcinogenesis in context: how do irradiated tissues become tumors Health Phys 2009; 97: 446-457.
14. Barthel A, Klotz LO. Phosphoinositide 3-kinase signaling in the cellular response to oxidative stress. Biol Chem 2005; 386: 207-216.
15. Bauer AK, Dwyer-Nield LD, Hankin JA, Murphy RC, Malkinson AM. The lung tumor promoter, butylated hydroxytoluene (BHT), causes chronic inflammation in promotion-sensitive BALB/cByJ mice but not in promotion-resistant CXB4 mice. Toxicology 2001; 169: 1-15.
16. Benigni R, Bossa C, Tcheremenskaia O. Nongenotoxic carcinogenicity of chemicals: mechanisms of action and early recognition through a new set of structural alerts. Chem Rev 2013; 113: 2940-2957.
17. Bentinger M, Brismar K, Dallner G. The antioxidant role of coenzyme Q. Mitochondrion 2007; 7 (supplement): S41-S50.
18. Begleiter A. Clinical applications of quinone-containing alkylating agents. Front Biosci 2000; 5: e153-e171.
19. Bielski BH, Cabelli DE. Highlights of current research involving superoxide and perhydroxyl radicals in aqueous solutions. Int J Radiat Biol 1991; 59: 291-319.
20. Bogdan C. Nitric oxide and the immune response. Nat Immunol 2001; 2: 907-916.
21. Bolton JL, Trush MA, Penning TM, Dryhurst G, Monks TJ. Role of quinones in toxicology. Chem Res Toxicol 2000; 13: 135-160.
22. Bosio GN, Breitenbach T, Parisi J, Relgosa M, Blalkie FH, Pedersen BW, Silva EFF, et al. Antioxidant β-carotene does not quench singlet oxygen in mammalian cells. J Am Chem Soc 2013; 135: 272-279.
23. Boveris A, Chance B. The mitochondria1 generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen. Biochem J 1973; 134: 707-716.
24. Boveris A, Oshino N, Chance B. The cellular production of hydrogen peroxide. Biochem J 1972; 128: 617-630.
25. Breton-Romero R, Lamas S. Hydrogen peroxide signaling in vascular endothelial cells. Redox Biol 2014; 2: 529-534.
26. Brigelius-Flohe R, Flohe L. Basic principles and emerging concepts in the redox control of transcription factors. Antioxid Redox Signal 2011; 15: 2335-2381.
27. Brigelius-Flohe R, Maiorino M. Glutathione peroxidases. Biochim Biophys Acta 2013; 1830: 3289-3303.
28. Briviba K, Klotz LO, Sies H. Toxic and signaling effects of photochemically or chemically generated singlet oxygen in biological systems. Biol Chem 1997; 378: 1259-1265.
29. Bruunsgaard H, Poulsen HE, Pedersen BK, Nyyssonen K, Kaikkonen J, Salonen JT. Long-term combine supplementations with a-tocopherol and vitamin C have no detectable anti-inflammatory effects in health men. J Nutr 2003; 133: 1170-1173.
30. Buchczyk DP, Klotz L-O, Lang K, Fritsch C, Sies H. High efficiency of 5-aminolevulinate-photodynamic treatment using UVA irradiation. Carcinogenesis 2001; 22: 879-883.
31. Buettner GR. The pecking order of free radicals and antioxidants: lipid peroxidation, alpha-tocopherol, and ascorbate. Arch Biochem Biophys 1993; 300: 535-543.
32. Burhans WC, Heintz NH. The cell cycle is a redox cycle: linking phase-specific targets to cell fate. Free Radic Biol Med 2009; 47: 1282-1293.
33. Bürkle A, Virág L. Poly(ADP-ribose): PARadigms and PARadoxes. Mol Aspects Med 2013; 34: 1046-1065.
34. Bursch W, Oberhammer F, Schulte-Hermann R. Cell death by apoptosis and its protective role against disease. Trends Pharmacol Sci 1992; 13: 245-251.
35. Buxton GV, Greenstock CL, Helman WP, Ross WP. Critical review of rate constants for reactions of hydrated electrons, hydrogen atoms and hydroxyl radicals in aqueous solution. J Phys Chem Ref Data 1988; 17: 513-886.
36. Cadet J, Mouret S, Ravanat JL, Douki T. Photoinduced damage to cellular DNA: direct and photosensitized reactions. Photochem Photobiol 2012; 88: 1048-1065.
37. Calcerrada P, Peluffo G, Radi R. Nitric oxide-derived oxidants with a focus on peroxynitrite: molecular targets, cellular responses and therapeutic implications. Curr Pharma Des 2011; 17: 3905-3932.
38. Canter PH, Wider B, Ernst E. The antioxidant vitamins A, C, E and selenium in the treatment of arthritis: a systematic review of randomized clinical trials. Rheumatology 2007; 46: 1223-1233.
39. Carillon J, Rouanet J-M, Cristol J-P, Brion R. Superoxide dismutase administration, a potential therapy against oxidative stress related diseases: several routes of supplementation and proposal of an original mechanism of action. Pharm Res 2013; 30: 2718-2728.
40. Carlsson LM, Jonsson J, Edlund T, Marklund SL. Mice lacking extracellular superoxide dismutase are more sensitive to hyperoxia. Proc Natl Acad Sci USA 1995; 92: 6264-6268.
41. Cathcart MK, Morel DW, Chisolm GM. Monocytes and neutrophils oxidize low density lipoprotein making it cytotoxic. J Leukoc Biol 1985; 38: 341-350.
42. Chadwick KH, Leenhouts HP. Radiation induced cancer arises from a somatic mutation. J Radiol Prot 2011; 31: 41-48.
43. Chan AT, Arber N, Burn J, Chia WK, Elwood P, Hull MA, Logan RF, et al. Aspirin in the chemoprevention of colorectal neoplasia: an overview. Cancer Prev Res 2011; 5: 164-178.
44. Chapple SJ, Cheng X, Mann GE. Effects of 4-hydroxynonenal on vascular endothelial and smooth muscle cell redox signaling and function in health and disease. Redox Biol 2013; 1: 319-331.
45. Christen V, Camenzind M, Fent K. Silica nanoparticles induce endoplasmic reticulum stress response, oxidative stress and activate the mitogen-activated protein kinase (MAPK) signaling pathway. Toxicol Rep 2014; 1: 1143-1151.
46. Circu ML, Aw TY. Reactive oxygen species, cellular redox systems, and apoptosis. Free Radic Biol Med 2010; 48: 749-762.
47. Cooke MS, Evans MD, Dizdaroglu M, Lunec J. Oxidative DNA damage: mechanisms, mutation, and disease. FASEB J 2003; 17: 1195-1214.
48. Cortassa S, ORourke B, Aon MA. Redox-optimized ROS balance and the relationship between mitochondrial respiration and ROS. Biochim Biophys Acta 2014; 1837: 287-295.
49. Coudray C, Boucher F, Pucheu S, de Leiris J, Favier A. Xanthine oxidase activity and lipid peroxide content following different types of ischemia in the isolated rat heart. Agents Actions 1994; 41: 144-150.
50. Covas G, Marinho HS, Cyrne L, Antunes F. Activation of Nrf2 by H 2O 2: de novo synthesis versus nuclear translocation. Methods Enzymol 2013; 528: 157-171.
51. Datta S, Kundu S, Shosh P, De S, Shosh A, Chatterjee M. Correlation of oxidant status with oxidative tissue damage in patients with rheumatoid arthritis. Clin Rheumatol 2014; 33: 1557-1564.
52. Davies KJA. Degradation of oxidized proteins by the 20S proteasome. Biochimie 2001; 83: 301-310.
53. Davies MJ. The oxidative environment and protein damage. Biochim Biophys Acta 2005; 1703: 93-109.
54. Dean RT, Fu S, Stocker R, Davies MJ. Biochemistry and pathology of radical-mediated protein oxidation. Biochem J 1997; 324: 1-18.
55. Demple B, Levin JD. Repair systems for radical-damaged DNA, In: Sies H., editor. Oxidative stress: oxidants and antioxidants. New York: Academic Press; 1991. pp 119-154.
56. Dhar SK, St. Clair DK. Manganese superoxide dismutase regulation and cancer. Free Radic Biol Med 2012; 52: 2209-2222.
57. Drazic A, Winter J. The physiological role of reversible methionine oxidation. Biochim Biophys Acta 2014; 1844: 1367-1382.
58. Dröge W. Free radicals in the physiological control of cell function. Physiol Rev 2002; 82: 47-95.
59. Dröge W, Schulze-Osthoff K, Mihm S, Galter D, Schenk H, Eck H-P, Roth S, Gmünder H. Functions of glutathione and glutathione disulfide in immunology and immunopathology. FASEB J 1994; 8: 1131-1138.
60. Dunlop RA, Brunk UT, Rodgers KJ. Oxidized proteins: mechanisms of removal and consequences of accumulation. Cell Mol Biol 2009; 61: 522-527.
61. El-Benna J, Dang P M-C, Perianin A. Towards specific NADPH oxidase inhibition by small synthetic peptides. Cell Mol Life Sci 2012; 69: 2307-2314.
62. Epe B. Role of endogenous oxidative DNA damage in carcinogenesis: what can we learn from repair-deficient mice Biol Chem 2002; 383: 467-475.
63. Esterbauer H, Jurgens G, Quehenberger O, Koller E. Autoxidation of human low density lipoprotein: loss of polyunsaturated fatty acids and vitamin E and generation of aldehydes. J Lipid Res 1987; 28: 495-509.
64. Fenoglio I, Ponti J, Alloa E, Ghiazza M, Corazzari I, Capamaccio R, Rembges D, et al. Singlet oxygen plays a key role in the toxicity and DNA damage caused by nanomeric TiO 2 in human keratinocytes. Nanoscale 2013; 5: 6567-6576.
65. Finkel T. Oxidant signals and oxidative stress. Curr Opin Cell Biol 2003; 15: 247-254.
66. Fleischhacker AS, Kiley P. Iron-containing transcription factors and their roles as sensors. Curr Opin Chem Biol 2011; 15: 335-341.
67. Floyd RA. Role of oxygen free radicals in carcinogenesis and brain ischemia. FASEB J 1990; 4: 2587-2597.
68. Foote CS. Definition of type I and type II photosensitized oxidation. Photochem Photobiol 1991; 54: 659.
69. Forman HJ, Ursini F, Maiorino M. An overview of mechanisms of redox signaling. J Mol Cell Cardiol 2014; 73: 2-9.
70. Forman HJ, Maiorino M, Ursini F. Signaling functions of reactive oxygen species. Biochemistry 2010; 49: 835-842.
71. Frank L, Bucher JR, Roberts RJ. Oxygen toxicity in neonatal and adult animals. J Appl Physiol 1978; 45: 699-704.
72. Frank L, Summerville J, Massaro D. Protection from oxygen toxicity with endotoxin: role of the endogenous antioxidant enzymes of the lung. J Clin Invest 1980; 65: 1104-1110.
73. Fridovich I. Superoxide radical: an endogenous toxicant. Annu Rev Pharmacol Toxicol 1983; 23: 239-257.
74. Fujii J, Taniguchi N. Phorbol ester induces manganese-superoxide dismutase in tumor necrosis factor-resistant cells. J Biol Chem 1991; 266: 23142-23146.
75. Fujiki H, Sueoka E, Suganuma M. Tumor promoters: from chemicals to inflammatory proteins. J Cancer Res Clin Oncol 2013; 139: 1603-1614.
76. Galano A, Tan DX, Reiter RJ. Melatonin as a natural ally against oxidative stress: a physicochemical examination. J Pineal Res 2011; 51: 1-16.
77. Glantzounis GK, Tsimoyiannis EC, Kappas AM, Galaris DA. Uric acid and oxidative stress. Curr Pharma Des 2005; 11: 4145-4151.
78. Go Y-M, Jones DP. Redox control systems in the nucleus: mechanisms and functions. Antiox Redox Signal 2010; 13: 489-509.
79. Golbidi S, Alireza ES, Laher I. Antioxidants in the treatment of diabetes. Curr Diabetes Rev 2011; 7: 106-125.
80. Goldstein JL, Ho YK, Basu SK, Brown MS. Binding site on macrophages that mediates the uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition. Proc Natl Acad Sci USA 1979; 76: 333-337.
81. Goyal T, Mitra S, Khaidokov M, Wang X, Singla S, Ding Z, Liu S, Mehta JL. Current concepts of the role of oxidized LDL receptors in atherosclerosis. Curr Atheroscler Rep 2012; 14: 150-159.
82. Grune T, Klotz LO, Gieche J, Rudeck M, Sies H. Protein oxidation and proteolysis by the nonradical oxidants singlet oxygen or peroxynitrite. Free Radic Biol Med 2001; 30: 1243-1253.
83. Hamann I, Klotz LO. Arsenite-induced stress signaling: modulation of the phosphoinositide 3'-kinase/Akt/FoxO signaling cascade. Redox Biol 2013; 1: 104-109.
84. Hamann I, Petroll K, Grimm L, Hartwig A, Klotz LO. Insulin-like modulation of Akt/FoxO signaling by copper ions is independent of insulin receptor. Arch Biochem Biophys 2014a; 558: 42-50.
85. Hamann I, Petroll K, Hou X, Anwar-Mohamed A, El-Kadi AO, Klotz LO. Acute and long-term effects of arsenite in HepG2 cells: modulation of insulin signaling. Biometals 2014b; 27: 317-332.
86. Hanschmann E-M, Godoy JR, Berndt C, Hudemann C, Lillig CH. Thioredoxins, glutaredoxins, and peroxiredoxins-molecular mechanisms and health significance: from cofactors to antioxidants in redox signaling. Antioxid Redox Signal 2013; 19: 1539-1605.
87. Hardeland R. Melatonins antioxidant properties: molecular mechanisms. In: Srinivasan V, Brzezinski A, Oter, S, Shillcutt SD., editors. Melatonin and melatonergic drugs in clinical practice [Chapter 2]. India: Springer; 2014. pp 17-26.
88. Harman AW, Maxwell MJ. An evaluation of the role of calcium in cell injury. Annu Rev Pharmacol Toxicol 1995; 35: 129-144.
89. Harman D. Free radicals in aging. Mol Cell Biochem 1988; 84: 155-161.
90. Heinecke JW, Baker L, Rosen L, Chait A. Superoxide-mediated modification of low density lipoprotein by arterial smooth muscle cells. J Clin Invest 1986; 77: 757-761.
91. Henderson MC, Krueger SK, Stevens JF, Williams DE. Human flavin-containing monooxygenase form 2 S-oxygenation: sulfenic acid formation from thioureas and oxidation of glutathione. Chem Res Toxicol 2004; 17: 633-640.
92. Henrickson T, Mahoney EM, Steinberg D. Enhanced macrophage degradation of low density lipoprotein previously incubated with cultured endothelial cells: recognition by the receptor for acetylated low density lipoprotein. Proc Natl Acad Sci USA 1981; 78: 6499-6503.
93. Henzler T, Steudle E. Transport and metabolic degradation of hydrogen peroxide in Chara coralline: model calculations and measurements with the pressure probe suggest transport of H 2O 2 across water channels. J Exp Bot 2000; 51: 2053-2066.
94. Hessler JR, Morel DW, Lewis LJ, Chisolm GM. Lipoprotein oxidation and lipoprotein-induced cytotoxicity. Arteriosclerosis 1983; 3: 215-222.
95. Höhn A, Jung T, Grune T. Pathophysiological importance of aggregated damaged proteins. Free Radic Biol Med 2014; 71: 70-89.
96. Höhn A, König J, Grune T. Protein oxidation in aging and the removal of oxidized proteins. J Proteomics 2013; 92: 132-159.
97. Howell KW, Meng X, Fullerton DA, Jin C, Reece B, Cleveland Jr. JC,. Toll-like receptor 4 mediates oxidized LDL-induced macrophage differentiation to foam cells. J Surg Res 2011; 171: e27-e31.
98. Huang CC, Aronstam RS, Chen DR, Huang YW. Oxidative stress, calcium homeostasis, and altered gene expression in human lung epithelial cells exposed to ZnO nanoparticles. Toxicol In Vitro 2009; 24: 45-55.
99. Jacob C, Giles GI, Giles NM, Sies H. Sulfur and selenium: the role of oxidation state in protein structure and function. Angew Chem Int Ed Engl 2003; 42: 4742-4758.
100. Jakoby WB, Ziegler DM. The enzymes of detoxication. J Biol Chem 1990; 265: 20715-20718.
101. James AM, Smith RAJ, Murphy MP. Antioxidant and prooxidant properties of mitochondrial coenzyme Q. Arch Biochem Biophys 2004; 423: 47-56.
102. Janero DR. Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury. Free Radic Biol Med 1990; 9: 515-540.
103. Ji L, Liu R, Zhang XD, Chen HL, Bai H, Wang X, Zhao HL, et al. N-acetylcysteine attenuates phosgene-induced acute lung injury via up-regulation of Nrf2 expression. Inhal Toxicol 2010; 22: 535-542.
104. Jialal I, Devaraj S, Adams-Huet B, Chen X, Kaur H. Increased cellular and circulating biomarkers of oxidative stress in nascent metabolic syndrome. J Clin Endocr Metab 2012; 97: E1844-E1850.
105. Jialal I, Fuller CJ. Effect of vitamin E, vitamin C and beta-carotene on LDL oxidation and atherosclerosis. Can J Cardiol 1995; Suppl G: 97G-103G.
106. Jomova K, Valko M. Advances in metal-induced oxidative stress and human disease. Toxicology 2011; 283: 65-87.
107. Jones DP. Radical-free biology of oxidative stress. Am J Physiol Cell Physiol 2008; 295: C849-C868.
108. Jung T, Grune T. The proteasome and its role in the degradation of oxidized proteins. IUBMB Life 2008; 60: 743-752.
109. Kalleet RH, Matthay MA. Hyperoxic acute lung injury. Respir Care 2013; 58: 123-141.
110. Kamp DW, Shacter E, Weitzman SA. Chronic inflammation and cancer: the role of mitochondria. Oncology (Williston Park) 2011; 25: 400-410.
111. Kansanen E, Kuosmanen SM, Leinonen H, Levonen AL. The Keap1-Nrf2 pathway: mechanisms of activation and dysregulation in cancer. Redox Biol 2013; 1: 45-49.
112. Kappus H, Sies H. Toxic drug effects associated with oxygen metabolism: redox cycling and lipid peroxidation. Experientia 1981; 37: 1233-1241.
113. Karunakaren U, Park K-G. A systematic review of oxidative stress and safety of antioxidants in diabetes: focus on islets and their defense. Diabetes Metab J 2013; 37: 106-112.
114. Katsuyama M, Matsuno K, Yabe-Nishimura C. Physiological roles of NOX/NADPH oxidase, the superoxide-generating enzyme. J Clin Biochem Nutr 2012; 50: 9-22.
115. Kehrer JP. The Haber-Weiss reaction and mechanisms of toxicity. Toxicology 2000; 149: 43-50.
116. Kehrer JP. Free radicals as mediators of tissue injury and disease. Crit Rev Toxicol 1993; 23: 21-48.
117. Kehrer JP. Reductive stress. In: Fink G. editor. Encyclopedia of stress. Vol.3, 2nd ed. Oxford: Academic Press; 2007. pp 331-335.
118. Kensler TW, Taffe BG. Free radicals in tumor promotion. Adv Free Radic Biol Med 1986; 2: 347-387.
119. Kermanizadeh A, Chauche C, Brown DM, Loft S, Møller P. The role of intracellular redox imbalance in nanomaterial induced cellular damage and genotoxicity: a review. Environ Mol Mutagen 2015; 56: 111-124.
120. Klaus V, Hartmann T, Gambini J, Graf P, Stahl W, Hartwig A, Klotz LO. 1,4-Naphthoquinones as inducers of oxidative damage and stress signaling in HaCaT human keratinocytes. Arch Biochem Biophys 2010; 496: 93-100.
121. Klein EA, Thompson IM, Tangen CM, Crowley JJ, Lucia MS, Goodman PJ, Minasian LM, et al. Vitamin E and the risk of prostate cancer: the selenium and vitamin E cancer prevention trial (SELECT). JAMA 2011; 306: 1549-1556.
122. Klotz LO, Kröncke KD, Sies H. Singlet oxygen-induced signaling effects in mammalian cells. Photochem Photobiol Sci 2003; 2: 88-94.
123. Klotz LO, Sánchez-Ramos C, Prieto-Arroyo I, Urbánek P, Steinbrenner H, Monsalve M. Redox regulation of FoxO transcription factors. Redox Biol 2015; 6: 51-72.
124. Klotz LO. Oxidant-induced signaling: effects of peroxynitrite and singlet oxygen. Biol Chem 2002; 383: 443-456.
125. Klungland A, Höss M, Gunz D, Constantinou A, Clarkson SG, Doetsch PW, Bolton PH, et al. Base excision repair of oxidative DNA damage activated by XPG protein. Mol Cell 1999; 3: 33-42.
126. Knight JA. Free radicals, antioxidants, and the immune system [Review]. Ann Clin Lab Sci 2000; 30: 145-158.
127. Kops GJ, Dansen TB, Polderman PE, Saarloos I, Wirtz KW, Coffer PJ, Huang TT, et al. Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress. Nature 2002; 419: 316-321.
128. Kovacic P, Somanathan R. Nervous about developments in electron transfer-reactive oxygen species-oxidative stress mechanisms of neurotoxicity In: Laher I., editor. Systems biology of free radicals and antioxidants. Heidelberg: Springer-Verlag; 2014, pp 1925-1944.
129. Krueger SK, Williams DE. Mammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and role in drug metabolism. Pharmacol Ther 2005; 106: 357-387.
130. Kuhns DB, Alvord WG, Heller T, Feld JJ, Pike KM, Marciano BE, Uzel G, et al. Residual NADPH oxidase and survival in chronic granulomatous disease. N Engl J Med 2010; 363: 2600-2610.
131. Kundu TK, Velayutham M, Zweier JL. Aldehyde oxidase functions as a superoxide generating NADH oxidase: an important redox regulated pathway of cellular oxygen radical formation. Biochemistry 2012; 51: 2930-2939.
132. Lebovitz RM, Zhang H, Vogel H, Cartwright J Jr, Dionne L, Lu N, Huang S, Matzuk MM. Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice. Proc Natl Acad Sci USA 1996; 93: 9782-9787.
133. Levonen A-L, Hill BG, Kansanen E, Zhang J, Darley-Usmar VM. Redox regulation of antioxidants, autophagy, and the response to stress: implications for electrophile therapeutics. Free Radic Biol Med 2014; 71: 196-207.
134. Lewinski N, Colvin V, Drezek R. Cytotoxicity of nanoparticles. Small 2008; 4: 26-49.
135. Leyendecker M, Korsten P, Reinehr R, Speckmann B, Schmoll D, Scherbaum WA, Bornstein SR, et al. Ceruloplasmin expression in rat liver cells is attenuated by insulin: role of FoxO transcription factors. Horm Metab Res 2011; 43: 268-274.
136. Li N, Sioutas C, Cho A, Schmitz D, Misra C, Sempf J, Wang M, et al. Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage. Environ Health Perspect 2003; 111: 455-460.
137. Li Y, Huang T-T, Carlson EJ, Melov S, Ursell PC, Olson JL, Noble LJ, et al. Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase. Nat Genet 1995; 11: 376-381.
138. Li Y, Jaiswal AK. Regulation of human NAD(P)H:quinone oxidoreductase gene. Role of AP1 binding site contained within human antioxidant response element. J Biol Chem 1992; 267: 15097-15104.
139. Libby P, Ridker PM, Hansson GK. Progress and challenges in translating the biology of atherosclerosis. Nature 2011; 473: 317-325.
140. Lillig CH, Berndt C, Holmgren A. Glutaredoxin systems. Biochim Biophys Acta 2008; 1780: 1304-1317.
141. Liochev SI. Reactive oxygen species and the free radical theory of aging. Free Radic Biol Med 2013; 60: 1-4.
142. Lord CJ, Ashworth A. The DNA damage response and cancer therapy. Nature 2012; 481: 287-294.
143. Lost S, Poulsen HE. Cancer risk and oxidative DNA damage in man. J Mol Med 1996; 74: 297-312.
144. Lu J, Holmgren A. The thioredoxin antioxidant system. Free Radic Biol Med 2014; 66: 75-87.
145. Luo X, Kraus WL. On PAR with PARP: cellular stress signaling through poly(ADP-ribose) and PARP-1. Genes Dev 2012; 26: 417-432.
146. Ma Q. Role of Nrf2 in oxidative stress and toxicity. Annu Rev Pharmacol Toxicol 2013; 53: 401-426.
147. Manke A, Wang L, Rojanasakul Y. Mechanisms of nanoparticle-induced oxidative stress and toxicity. BioMed Res Int 2013; 2013: 942916.
148. Marinho HS, Real C, Cyrne L, Soares H, Antunes F. Hydrogen peroxide sensing, signaling and regulation of transcription factors. Redox Biol 2014; 2: 535-562.
149. Marks F, Fürstenberger G. Tumor promotion in skin: are active oxygen species involved In: Sies H., editor. Oxidative stress. New York: Academic Press; 1985. pp 437-475.
150. Matsui M, Oshima M, Oshima H, Takaku K, Maruyama T, Yodoi J, Taketa, MM. Early embryonic lethality caused by targeted disruption of the mouse thioredoxin gene. Dev Biol 1996; 178: 179-185.
151. May JM, de Haen C. Insulin-stimulated intracellular hydrogen peroxide production in rat epididymal fat cells. J Biol Chem 1979; 254: 2214-2220.
152. McInnes IB, Schett G. The pathogenesis of rheumatoid arthritis. N Engl J Med 2011; 365: 2205-2219.
153. Meyer A, Buhl R, Magnussen H. The effect of oral N-acetylcysteine on lung glutathione levels in idiopathic pulmonary fibrosis. Eur Respir J 1994; 7: 431-436.
154. Milne GL, Yin H, Hardy KD, Davies SS, Roberts II LJ., Isoprostane generation and function. Chem Rev 2011; 111: 5973-5996.
155. Mishin V, Gray JP, Heck DE, Laskin DL, Laskin JD. Application of the Amplex Red/horseradish peroxidase assay to measure hydrogen peroxide generation by recombinant microsomal enzymes. Free Radic Biol Med 2010; 48: 1485-1491.
156. Mitchell JR, Jollow DJ, Potter WZ, Gillette JR, Brodie BB. Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione. J Pharmacol Exp Ther 1973; 187: 211-217.
157. Miyamoto S, Martinez GR, Medeiros MHG, Di Mascio P. Singlet molecular oxygen generated by biological hydroperoxides. J Photochem Photobiol B Biol 2014; 139: 24-33.
158. Mobasheri A, Biesalski HK, Shakibaei M, Henrotin Y. Antioxidants and osteoarthritis. In: Laher I., editor. Systems biology of free radicals and antioxidants. Berlin/Heidelberg: Springer-Verlag; 2014. pp 2997-3026.
159. Moncada S, Higgs A. The L-arginine-nitric oxide pathway. N Engl J Med 1993; 329: 2002-2012.
160. Muftuoglu M, Mori MP, de Souza-Pinto NC. Formation and repair of oxidative damage in the mitochondrial DNA. Mitochondrion 2014; 17: 164-181.
161. Myung S-K, Ju W, Cho B, Oh S-W, Park SM, Koo B-K, Park B-J. Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials. BMJ 2013; 346: f10.
162. Napolitano A, Manini P, dIschia M. Oxidation chemistry of catecholamines and neuronal degeneration: an update. Curr Med Chem 2011; 18: 1832-1845.
163. Nishino TJ. The conversion of xanthine dehydrogenase to xanthine oxidase and the role of the enzyme in reperfusion injury. J Biochem 1994; 116: 1-6.
164. Nishiyama T, Izawa T, Usami M, Ohnuma T, Ogura K, Hiratsuka A. Cooperation of NAD(P)H:quinone oxidoreductase 1 and UDP-glucuronosyltransferases reduces menadione cytotoxicity in HEK293 cells. Biochem Biophys Res Commun 2010; 394: 459-463.
165. Nohl H, Kozlov AV, Gille L, Staniek K. Cell respiration and formation of reactive oxygen species: facts and artefacts. Biochem Soc Trans 2003; 31: 1308-1311.
166. Nonn L, Williams RR, Erickson RP, Powis G. The absence of mitochondrial thioredoxin 2 causes massive apoptosis, exencephaly, and early embryonic lethality in homozygous mice. Mol Cell Biol 2003; 23: 916-922.
167. Nunomura A, Tomaoki T, Motohashi N, Nakamura M, McKeel Jr DW, Tabaton M, Lee H-g, et al. The earliest stage of cognitive impairment in transition from normal aging to Alzheimer disease is marked by prominent RNA oxidation in vulnerable neurons. J Neropathol Exp Neurol 2012; 71: 233-241.
168. OBrien PJ. Peroxidases. Chem Biol Interact 2000; 129: 113-139.
169. Omenn GS. Chemoprevention and lung cancers: lessons from CARET, the beta-carotene and retinol efficacy trial, and prospects for the future. Eur J Cancer Preven 2007; 16: 184-191.
170. Orrenius S, Gogvadze V, Zhivotovsky B. Mitochondrial oxidative stress: implications for cell death. Annu Rev Pharmacol Toxicol 2007; 47: 143-183.
171. Orrenius S, Nicotera P, Zhivotovsky B. Cell death mechanisms and their implications in toxicology. Toxicol Sci 2011; 119: 3-19.
172. Oshino N, Chance B, Sies H, Bücher T. The role of H 2O 2 generation in perfused rat liver and the reaction of catalase compound I and hydrogen donors. Arch Biochem Biophys 1973; 154: 117-131.
173. Ott C, Jacobs K, Haucke E, Navarrete-Santos A, Grune T, Simm A. Role of advanced glycation end products in cellular signaling. Redox Biol 2014; 2: 411-429.
174. Pacher P, Beckman JS, Liaudet L. Nitric oxide and peroxynitrite in health and disease. Phys Rev 2006; 87: 315-424.
175. Paraidathathu T, Kehrer JP. Production of reactive oxygen by mitochondria from normoxic and hypoxic rat heart tissue. Free Radic Biol Med 1992; 13: 289-297.
176. Perchellet JP, Perchellet EM, Orten DK, Sehneider BA. Inhibition of the effects of 12-0-tetradecanoylphorbol1-3-acetate on mouse epidermal glutathione peroxidase and ornithine decarboxylase activities by glutathione level-raising agents and selenium-containing compounds. Cancer Lett 1985; 26: 283-293.
177. Petrone WF, English DK, Wong K, McCord JM. Free radicals and inflammation: superoxide-dependent activation of a neutrophil chemotactic factor in plasma. Proc Natl Acad Sci USA 1980; 77: 1159-1163.
178. Pitas RE, Boyles J, Mahley RW, Bissell DM. Uptake of chemically modified low density lipoproteins in vivo is mediated by specific endothelial cells. J Cell Biol 1985; 100: 103-117.
179. Poillet-Perez L, Despouy G, Delage-Mourroux R, Boyer-Guittaut M. Interplay between ROS and autophagy in cancer cells, from tumor initiation to cancer therapy. Redox Biol 2015; 4: 184-192.
180. Poirier MC. Chemical-induced DNA damage and human cancer risk. Nature Rev Cancer 2004; 4: 630-637.
181. Potter J. The failure of cancer chemoprevention. Carcinogenesis 2014; 35: 974-982.
182. Poulsen HE, Specht E, Broedbaek K, Henriksen T, Ellervik C, Mandrup-Poulsen T, Tonnesen M, et al. RNA modifications by oxidation: a novel disease mechanism Free Radic Biol Med 2012; 52: 1353-1361.
183. Pryor WA, Houk KN, Foote CS, Fukuto KM, Ignarro LJ, Squadrito GL, Davies KJ. Free radical biology and medicine: its a gas, man! Am J Physiol Regul Integr Comp Physiol 2006; 291: R491-R511.
184. Puntarulo S, Cederbaum AI. Production of reactive oxygen species by microsomes enriched in specific human cytochrome P450 enzymes. Free Radic Biol Med 1998; 24: 1324-1330.
185. Radi R, Peluffo G, Alvarez MN, Naviliat M, Cayota A. Unraveling peroxynitrite formation in biological systems. Free Radic Biol Med 2001; 30: 463-488.
186. Radi R. Peroxynitrite, a stealthy biological oxidant. J Biol Chem 2013; 288: 26464-26472.
187. Rains JL, Jain SK. Oxidative stress, insulin signaling, and diabetes. Free Radic Biol Med 2011; 50: 567-575.
188. Ray PD, Huang B-W, Tsuji Y. Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling. Cell Signal 2012; 24: 981-990.
189. Reaume AG, Elliott JL, Hoffman EK, Kowall NW, Ferrante RJ, Siwek DF, Wilcox HM, et al. Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury. Nat Genet 1996; 13: 43-47.
190. Regulus P, Duroux B, Bayle PA, Favier A, Cadet J, Ravanat JL. Oxidation of the sugar moiety of DNA by ionizing radiation or bleomycin could induce the formation of a cluster DNA lesion. Proc Natl Acad Sci USA 2007; 104: 14032-14037.
191. Reuter S, Gupta SC, Chaturvedi MM, Aggarwal BB. Oxidative stress, inflammation, and cancer: how are they linked Free Radic Biol Med 2010; 49: 1603-1616.
192. Rhee SG, Woo HA, Kil IS, Bae SH. Peroxiredoxin functions as a peroxidase and a regulator and sensor of local peroxides. J Biol Chem 2012; 287: 4403-4410.
193. Roberts RA, Smith RA, Safe S, Szabo C, Tjalkens RB, Robertson FM. Toxicological and pathophysiological roles of reactive oxygen and nitrogen species. Toxicology 2010; 276: 85-94.
194. Roberts SA, Price VF, Jollow DJ. Acetaminophen structure-toxicity studies: in vivo covalent binding of a nonhepatotoxic analog, 3-hydroxyacetanilide. Toxicol Appl Pharmacol 1990; 105: 195-208.
195. Robertson G, Urda EM, Breider MA, Raylene M, Gauthier D. Evaluation of hepatic toxicity of seven-day repeated-dose glutathione-depleting regimens in rats. Toxicol Mech Methods 1998; 8: 233-244.
196. Rochette L, Zeller M, Cottin Y, Vergely C. Diabetes, oxidative stress and therapeutic strategies. Biochim Biophys Acta 2014; 1840: 2709-2729.
197. Ross D. Glutathione, free radicals and chemotherapeutic agents. Mechanisms of free radical inducted toxicity and glutathione dependent protection. Pharmacol Ther 1988; 37: 231-249.
198. Ryter SW, Kim HP, Hoetzel A, Park JW, Nakahira K, Wang X, Choi AMK. Mechanisms of cell death in oxidative stress. Antiox Redox Signal 2007; 9: 49-89.
199. Sanders DC, Chaturvedi AK, Hordinsky JR. Melatonin: aeromedical, toxicopharmacological, and analytical aspects. J Anal Toxicol 1999; 23: 159-167.
200. Sayin VI, Ibrahim MX, Larsson E, Milsson JA, Lindahl P, Bergo MO. Antioxidants accelerate lung cancer progression in mice. Sci Transl Med 2014; 6: 221ra15.
201. Scharffetter-Kochanek K, Wlaschek M, Brenneisen P, Schauen M, Blaudschun R, Wenk J. UV-induced reactive oxygen species in photocarcinogenesis and photoaging. Biol Chem 1997; 378: 1247-1257.
202. Schöneich C, Sharov VS. Mass spectrometry of protein modifications by reactive oxygen and nitrogen species. Free Rad Biol Med 2006; 41: 1507-1520.
203. Sciuto AM, Strickland PT, Kennedy TP, Gurtner GH. Protective effects of N-acetylcysteine treatment after phosgene exposure in rabbits. Am J Respir Crit Care Med 1995; 151: 768-772.
204. Schulz E, Wenzel P, Münzel T, Daiber A. Mitochondrial redox signaling: interaction of mitochondrial reactive oxygen species with other sources of oxidative stress. Antioxid Redox Signal 2014; 20: 308-324.
205. Serhan CN, Petasis NA. Resolvins and protectins in inflammation resolution. Chem Rev 2011; 111: 5922-5943.
206. Sevanian A, Kim EJ. Phospholipase A2 dependent release of fatty acids from peroxidized membranes. Free Radic Biol Med 1987; 1: 263-271.
207. Shi H, Magaye R, Castranova V, Zhao J. Titanium dioxide nanoparticles: a review of current toxicological data. Part Fibre Toxicol 2013; 10: 15.
208. Shlafer M, Myers CL, Adkins S. Mitochondrial hydrogen peroxide generation and activities of glutathione peroxidase and superoxide dismutase following global ischemia. J Mol Cell Cardiol 1987; 19: 1195-1206.
209. Siddens LK, Krueger SK, Henderson MC, Williams DE. Mammalian flavin-containing monooxygenase (FMO) as a source of hydrogen peroxide. Biochem Pharmacol 2014; 89: 141-147.
210. Sies H, Jones DP. Oxidative stress. In: Fink G., editor. Encyclopedia of stress. Vol.3, 2nd ed. Oxford: Academic Press; 2007. pp 45-48.
211. Sies H. Oxidative stress: introductory remarks. In: Sies H., editor. Oxidative stress. New York: Academic Press; 1985. pp 1-8.
212. Sies H. Biochemistry of oxidative stress. Angew Chem Int Ed Engl 1986; 25: 1058-1071.
213. Sies H. Role of metabolic H 2O 2 generation. Redox signaling and oxidative stress. J Biol Chem 2014; 289: 8735-8741.
214. Sies H. Oxidative stress: a concept in redox biology and medicine. Redox Biol 2015; 4: 180-183.
215. Singh S, Khan AR, Gupta AK. Role of glutathione in cancer pathophysiology and therapeutic interventions. J Exp Ther Oncol 2012; 9: 303-316.
216. Slaga TJ, Fischer SM, Nelson K, Gleason GL. Studies on the mechanism of skin tumor promotion: evidence for several stages in promotion Proc Natl Acad Sci USA 1980; 77: 3659-3663.
217. Slaga TJ. Inhibition of skin tumor initiation, promotion, and progression by antioxidants and related compounds. Crit Rev Food Sci Nutr 1995; 35: 51-57.
218. Smith CV. Correlations and apparent contradictions in assessment of oxidant stress status in vivo. Free Radic Biol Med 1991; 10: 217-224.
219. Smith, CV, Hughes H, Mitchell JR. Free radicals in vivo. Covalent binding to lipids. Mol Pharmacol 1984; 26: 112-116.
220. Sobotta MC, Liou W, Stöcker S, Talwar D, Oehler M, Ruppert T, Scharf AN, Dick TP. Peroxiredoxin-2 and STAT3 form a redox relay for H 2O 2 signaling. Nat Chem Biol 2015; 11: 644-670.
221. Solanki V, Rana RS, Slaga TJ. Diminution of mouse epidermal superoxide dismutase and catalase activities by tumor promoters. Carcinogenesis 1981; 2: 1141-1146.
222. Son SM. Reactive oxygen and nitrogen species in pathogenesis of vascular complications of diabetes. Diabetes Med 2012; 36: 190-198.
223. Speckmann B, Walter PL, Alili L, Reinehr R, Sies H, Klotz LO, Steinbrenner H. Selenoprotein P expression is controlled through interaction of the coactivator PGC-1alpha with FoxO1a and hepatocyte nuclear factor 4 alpha transcription factors. Hepatology 2008; 48: 1998-2006.
224. Spickett DM, Pitt AR. Protein oxidation: role in signalling and detection by mass spectrometry. Amino Acids 2012; 42: 5-21.
225. St-Pierre J, Buckingham JA, Roebuck SJ, Brand MD. Topology of superoxide production from different sites in the mitochondrial electron transport chain. J Biol Chem 2002; 277: 44784-44790.
226. Stahl W, Sies H. Bioactivity and protective effects of natural carotenoids. Biochim Biophys Acta 2005; 1740: 101-107.
227. Stamp LK, Khalilova I, Tarr JM, Senthilmohan R, Turner R, Haigh RC, Winyard PG, Kettle AJ. Myeloperoxidase and oxidative stress in rheumatoid arthritis. Rheumatology 2012; 51: 1796-1803.
228. Steinbrecher UP, Zhang H, Lougheed M. Role of oxidatively modified LDL in atherosclerosis. Free Radic Biol Med 1990; 9: 155-168.
229. Stirpe F, Della Corte E. The regulation of rat liver xanthine oxidase. Conversion in vitro of the enzyme activity from dehydrogenase (type D) to oxidase (type O). J Biol Chem 1969; 244: 3855-3863.
230. Stocker R, Keaney Jr. JF. Role of oxidative modifications in atherosclerosis. Physiol Rev 2004; 84: 1381-1478.
231. Stocker R. Turning catabolism into usefulness: a jaundiced view. Clin Chem 2011; 57: 1612-1613.
232. Sugamura K, Keaney Jr. JF,. Reactive oxygen species in cardiovascular disease. Free Radic Biol Med 2011; 51: 978-992.
233. Sun W, Kalen AL, Smith BJ, Cullen JJ, Oberley LW. Enhancing the antitumor activity of adriamycin and ionizing radiation. Cancer Res 2009; 69: 4294-4300.
234. Sun WG, Weydert CJ, Zhang Y, Yu L, Liu J, Spitz DR, Cullen JJ, Oberley LW. Superoxide enhances the antitumor combination of AdMnSOD Plus BCNU in breast cancer. Cancers (Basel) 2010; 2: 68-87.
235. Sun Y. Free radicals, antioxidant enzymes, and carcinogenesis. Free Radic Biol Med 1990; 8: 583-599.
236. Svilar D, Goellner EM, Almeida KH, Sobol RW. Base excision repair and lesion-dependent subpathways for repair of oxidative DNA damage. Antiox Redox Signal 2011; 14: 2491-2507.
237. Szabo C, Ischiropoulos H, Radi R. Peroxynitrite: biochemistry, pathophysiology and development of therapeutics. Nat Rev Drug Discov 2007; 6: 662-680.
238. Tahan G, Aytac E, Aytekin H, Gunduz F, Dogusoy G, Aydin S, Tahan V, Uzun H. Vitamin E has a dual effect of anti-inflammatory and antioxidant activities in acetic acid-induced ulcerative colitis in rats. Can J Surg 2011; 54: 333-338.
239. Tanswell KA, Freeman BA. Liposome-entrapped antioxidant enzymes prevent lethal O 2 toxicity in the newborn rat. J Appl Physiol 1987; 63: 347-352.
240. Truong TH, Carroll KS. Redox regulation of protein kinases. Crit Rev Biochem Mol Biol 2013; 48: 332-356.
241. Tsan M-F. Superoxide dismutase and pulmonary oxygen toxicity. Exp Biol Med 1997; 214: 107-113.
242. Unfried K, Albrecht C, Klotz LO, von Mikecz A, Grether-Beck S, Schins RPF. Cellular responses to nanoparticles: target structures and mechanisms. Nanotoxicology 2007; 1: 52-71.
243. Van Kuijk FJGM, Sevanian A, Handelman GJ, Dratz EA. A new role for phospholipase A2: protection of membranes from lipid peroxidation damage. Trends Biochem Sci 1987; 12: 31-34.
244. Vandeplassche G, Hermans C, Thone F, Borgers M. Mitochondrial hydrogen peroxide generation by NADH-oxidase activity following regional myocardial ischemia in the dog. J Mol Cell Cardiol 1989; 21: 383-392.
245. Vasiliou V, Ross D, Nebert DW. Update of the NAD(P)H:quinone oxidoreductase (NQO) gene family. Hum Genomics 2006; 2: 329-335.
246. Venugopal R, Jaiswal AK. Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase1 gene. Proc Natl Acad Sci USA 1996; 93: 14960-14965.
247. Vieceli Dalla Sega F, Zambonin L, Fiorentini D, Rizzo B, Caliceti C, Landi L, Hrelia S, Prata C. Specific aquaporins facilitate Nox-produced hydrogen peroxide transport through plasma membrane in leukaemia cells. Biochim Biophys Acta 2014; 1843: 806-814.
248. von Montfort C, Fernau NS, Beier JI, Sies H, Klotz LO. Extracellular generation of hydrogen peroxide is responsible for activation of EGF receptor by ultraviolet A radiation. Free Radic Biol Med 2006; 41: 1478-1487.
249. Walter PL, Kampkötter A, Eckers A, Barthel A, Schmoll D, Sies H, Klotz LO. Modulation of FoxO signaling in human hepatoma cells by exposure to copper or zinc ions. Arch Biochem Biophys 2006; 454: 107-113.
250. Walter PL, Steinbrenner H, Barthel A, Klotz LO. Stimulation of selenoprotein P promoter activity in hepatoma cells by FoxO1a transcription factor. Biochem Biophys Res Commun 2008; 365: 316-321.
251. Watson WH, Yang X, Choi YE, Jones DP, Kehrer JP. Thioredoxin and its role in toxicology. Toxicol Sci 2004; 78: 3-14.
252. Weber LW, Boll M, Stampfl A. Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model. Crit Rev Toxicol 2003; 33: 105-136.
253. Weitzman SA, Weitberg AB, Clark EP, Stossel TP. Phagocytes as carcinogens: malignant transformation produced by human neutrophils. Science 1985; 227: 1231-1233.
254. Weldor D, Poulsen TD, Mikkelsen KV, Ogilby PR. Singlet sigma: the "other" singlet oxygen in solution. Photochem Photobiol 1999; 70: 369-379.
255. Werns SW, Grum CM, Ventura A, Hahn RA, Ho PK, Towner RD, Fantone JC, et al. Xanthine oxidase inhibition does not limit canine infarct size. Circulation 1991; 83: 995-1005.
256. White CW, Avraham KB, Shanley PF, Groner Y. Transgenic mice with expression of elevated levels of copper-zinc superoxide dismutase in the lungs are resistant to pulmonary oxygen toxicity. J Clin Invest 1991; 87: 2162-2168.
257. White CW, Jackson JH, Abuchowski A, Kazo GM, Mimmack RF, Berger EM, Freeman BA, et al. Polyethylene glycol-attached antioxidant enzymes decrease pulmonary oxygen toxicity in rats. J Appl Physiol 1989; 66: 584-590.
258. Winczura A, Zdżalik D, Tudek B. Damage of DNA and proteins by major lipid peroxidation products in genome stability. Free Radic Res 2012; 46: 442-459.
259. Winterbourn CC, Hampton MB. Thiol chemistry and specificity in redox signaling. Free Radic Biol Med 2008; 45: 549-561.
260. Winterbourn CC. Are free radicals involved in thiol-based redox signaling Free Radic Biol Med 2015; 80: 164-170.
261. Witschi H. Responses of the lung to toxic injury. Environ Health Perspect 1990; 85: 5-13.
262. Wondrak GT, Jacobson MK, Jacobson EL. Endogenous UVA-photosensitizers: mediators of skin photodamage and novel targets for skin photoprotection. Photochem Photobiol Sci 2006; 5: 215-237.
263. Wruck CJ, Fragoulis A, Gurzynski A, Brandenburg L-O, Kan YW, Chan K, Hassenpflug J., et al. Role of oxidative stress in rheumatoid arthritis: insights from the Nrf2-knockout mouse. Ann Rheum Dis 2011; 70: 844-850.
264. Xia T, Kovochich M, Brant J, Hotze M, Sempf J, Oberley T, Sioutas C, et al. Comparison of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigm. Nano Lett 2006; 6: 1794-1807.
265. Yang C-Y, Wang J, Krutchinsky AM, Chait BT, Morrisett JD, Smith CV. Selective oxidation in vitro by myeloperoxidase of the N-terminal amine in apolipoprotein B-100. J Lipid Res 2001; 42: 1891-1896.
266. Yu BP. Cellular defenses against damage from reactive oxygen species. Physiol Rev 1994; 74: 139-162.
267. Zhivotovsky B, Kaminskyy VO. Free radicals in cross talk between autophagy and apoptosis. Antioxid Redox Signal 2014; 21: 86-102.
268. Zhong H, Yin H. Role of lipid peroxidation derived 4-hydroxynonenal (4-HNE) in cancer: focusing on mitochondria. Redox Biol 2015; 4: 193-199.
269. Zhou S, Chan E, Duan W, Huang M, Chen YZ. Drug bioactivation covalent binding to target proteins and toxicity relevance. Drug Metab Rev 2005; 37: 41-213.
270. Ziech D, Franco R, Pappa A, Panayiotidis MI. Reactive oxygen species (ROS)-induced genetic and epigenetic alterations in human carcinogenesis. Mut Res Fundam Mol Mech Mutagen 2011; 711: 167-173.
271. Zimmerman R, Cerutti P. Active oxygen acts as a promoter of transformation in mouse embryo C3H/IOT1/2/C18 fibroblasts. Proc Natl Acad Sci USA 1984; 81: 2085-2087.