-
1
-
-
0037733975
-
The importance of glutathione in human disease
-
DOI 10.1016/S0753-3322(03)00043-X
-
Townsend DM, Tew KD, Tapiero H. The importance of glutathione in human disease. Biomed Pharmacother 57: 145-155, 2003. (Pubitemid 36740460)
-
(2003)
Biomedicine and Pharmacotherapy
, vol.57
, Issue.3
, pp. 145-155
-
-
Townsend, D.M.1
Tew, K.D.2
Tapiero, H.3
-
2
-
-
0034942192
-
Glutathione-nutritional and pharmacological viewpoints: Part II
-
Valencia E, Marin A, Hardy G. Glutathione-nutritional and pharmacological viewpoints: Part II. Nutrition 17: 485-486, 2001.
-
(2001)
Nutrition
, vol.17
, pp. 485-486
-
-
Valencia, E.1
Marin, A.2
Hardy, G.3
-
3
-
-
33750622197
-
Subcellular compartmentalization of glutathione: Correlations with parameters of oxidative stress related to genotoxicity
-
DOI 10.1093/mutage/gel043
-
Green RM, Graham M, O'Donovan M R, Chipman JK, Hodges NJ. Subcellular compartmentalization of glutathione: correlations with parameters of oxidative stress related to genotoxicity. Mutagenesis 21: 383-390, 2006. (Pubitemid 44691127)
-
(2006)
Mutagenesis
, vol.21
, Issue.6
, pp. 383-390
-
-
Green, R.M.1
Graham, M.2
O'Donovan, M.R.3
Chipman, J.K.4
Hodges, N.J.5
-
4
-
-
0033230043
-
Glutathione and its role in cellular functions
-
DOI 10.1016/S0891-5849(99)00177-X, PII S089158499900177X
-
Sies H. Glutathione and its role in cellular functions. Free Rad Biol Med 27: 916-921, 1999. (Pubitemid 29507465)
-
(1999)
Free Radical Biology and Medicine
, vol.27
, Issue.9-10
, pp. 916-921
-
-
Sies, H.1
-
5
-
-
37549023835
-
The central role of glutathione in the pathophysiology of human diseases
-
Franco R, Schoneveld OJ, Pappa A, Panayiotidis MI. The central role of glutathione in the pathophysiology of human diseases. Arch Physiol Biochem 113: 234-258, 2007.
-
(2007)
Arch Physiol Biochem
, vol.113
, pp. 234-258
-
-
Franco, R.1
Schoneveld, O.J.2
Pappa, A.3
Panayiotidis, M.I.4
-
6
-
-
3042802690
-
Glutathione: An overview of biosynthesis and modulation
-
DOI 10.1016/S0009-2797(97)00146-4, PII S0009279797001464
-
Anderson ME. Glutathione: an overview of biosynthesis and modulation. Chem Biol Interact 111-112: 1-14, 1998. (Pubitemid 28271929)
-
(1998)
Chemico-Biological Interactions
, vol.111-112
, pp. 1-14
-
-
Anderson, M.E.1
-
7
-
-
25144482448
-
Novel mechanisms of natural antioxidant compounds in biological systems: Involvement of glutathione and glutathione-related enzymes
-
DOI 10.1016/j.jnutbio.2005.05.013, PII S095528630500152X
-
Masella R, Di Benedetto R, Vari R, Filesi C, Giovannini C. Novel mechanisms of natural antioxidant compounds in biological systems: Involvement of glutathione and glutathione related enzymes. J Nutr Biochem 16: 577-586, 2005. (Pubitemid 41338369)
-
(2005)
Journal of Nutritional Biochemistry
, vol.16
, Issue.10
, pp. 577-586
-
-
Masella, R.1
Di, B.R.2
Vari, R.3
Filesi, C.4
Giovannini, C.5
-
8
-
-
77952959747
-
Kinetic mechanism and molecular properties of glutathione reductase
-
Tandogǎ;n B, Ulusu NN. Kinetic mechanism and molecular properties of glutathione reductase. FABAD J Pharm Sci 31: 230-237, 2006.
-
(2006)
FABAD J Pharm Sci
, vol.31
, pp. 230-237
-
-
Tandogǎ1
n, B.2
Ulusu, N.N.3
-
9
-
-
0029562117
-
Formation of protein-glutathione mixed disulfides in the developing rat conceptus following diamide treatment in vitro
-
DOI 10.1002/tera.1420520405
-
Hiranruengchok R, Harris C. Formation of protein-glutathione mixed disulfides in the developing rat conceptus following diamide treatment in vitro. Teratology 52: 196-204, 1995. (Pubitemid 26027208)
-
(1995)
Teratology
, vol.52
, Issue.4
, pp. 196-204
-
-
Hiranruengchok, R.1
Harris, C.2
-
10
-
-
0036709889
-
Glutathione catabolism as a signaling mechanism
-
DOI 10.1016/S0006-2952(02)01173-5, PII S0006295202011735
-
Paolicchi A, Dominici S, Pieri L, Maellaro E, Pompella A. Glutathione catabolism as a signaling mechanism. Biochem Pharmacol 64: 1027-1035, 2002. (Pubitemid 35232278)
-
(2002)
Biochemical Pharmacology
, vol.64
, Issue.5-6
, pp. 1027-1035
-
-
Paolicchi, A.1
Dominici, S.2
Pieri, L.3
Maellaro, E.4
Pompella, A.5
-
11
-
-
33744994567
-
Glutathione in cancer biology and therapy
-
DOI 10.1080/10408360500523878, PII N17547068357
-
Estrela JM, Ortega A, Obrador E. Glutathione in cancer biology and therapy. Crit Rev Clin Lab Sci 43: 143-181, 2006. (Pubitemid 43860449)
-
(2006)
Critical Reviews in Clinical Laboratory Sciences
, vol.43
, Issue.2
, pp. 143-181
-
-
Estrela, J.M.1
Ortega, A.2
Obrador, E.3
-
12
-
-
33947515598
-
+-coupled glutathione transport
-
DOI 10.1139/Y06-067
-
Gukasyan HJ, Lee VH, Simityan H, Kim KJ, Kannan R. Thermodynamic stoichiometry of Na+-coupled glutathione transport. Can J Physiol Pharmacol 84: 1223-1227, 2006. (Pubitemid 46465935)
-
(2006)
Canadian Journal of Physiology and Pharmacology
, vol.84
, Issue.11
, pp. 1223-1227
-
-
Gukasyan, H.J.1
Lee, V.H.L.2
Simityan, H.3
Kim, K.-J.4
Kannan, R.5
-
13
-
-
0034955787
-
Novel roles for glutathione in gene expression, cell death, and membrane transport of organic solutes
-
DOI 10.1016/S0168-8278(01)00037-X, PII S016882780100037X
-
Hammond CL, Lee TK, Ballatori N. Novel roles for glutathione in gene expression, cell death, and membrane transport of organic solutes. J Hepatol 34: 946-954, 2001. (Pubitemid 32595199)
-
(2001)
Journal of Hepatology
, vol.34
, Issue.6
, pp. 946-954
-
-
Hammond, C.L.1
Lee, T.K.2
Ballatori, N.3
-
14
-
-
17444419342
-
Molecular mechanisms of reduced glutathione transport: Role of the MRP/CFTR/ABCC and OATP/SLC21A families of membrane proteins
-
DOI 10.1016/j.taap.2004.09.008, Membrane Transporters in Toxicology
-
Ballatori N, Hammond CL, Cunningham JB, Krance SM, Marchan R. Molecular mechanisms of reduced glutathione transport: role of the MRP/CFTR/ABCC and OATP/SLC21A families of membrane proteins. Toxicol Appl Pharmacol 204: 238-255, 2005. (Pubitemid 40545229)
-
(2005)
Toxicology and Applied Pharmacology
, vol.204
, Issue.3
, pp. 238-255
-
-
Ballatori, N.1
Hammond, C.L.2
Cunningham, J.B.3
Krance, S.M.4
Marchan, R.5
-
15
-
-
33751161012
-
A study of glutathione status in the blood and tissues of patients with breast cancer
-
Yeh CC, Hou MF, Wu SH, Tsai SM, Lin SK, Hou LA, Ma H, Tsai LY. A study of glutathione status in the blood and tissues of patients with breast cancer. Cell Biochem Funct 24: 555-559, 2006.
-
(2006)
Cell Biochem Funct
, vol.24
, pp. 555-559
-
-
Yeh, C.C.1
Hou, M.F.2
Wu, S.H.3
Tsai, S.M.4
Lin, S.K.5
Hou, L.A.6
Ma, H.7
Tsai, L.Y.8
-
16
-
-
0025914759
-
Technetium-99md, 1-hexamethylpropyleneamine oxime (HMPAO) uptake and glutathione content in brain tumors
-
Suess E, Malessa S, Ungersböck K, Kitz P, Podreka I, Heimberger K, Hornykiewicz O, Deecke L. Technetium-99md, 1-hexamethylpropyleneamine oxime (HMPAO) uptake and glutathione content in brain tumors. J Nucl Med 32: 1675-1681, 1991.
-
(1991)
J Nucl Med
, vol.32
, pp. 1675-1681
-
-
Suess, E.1
Malessa, S.2
Ungersböck, K.3
Kitz, P.4
Podreka, I.5
Heimberger, K.6
Hornykiewicz, O.7
Deecke, L.8
-
17
-
-
33644748361
-
Low colonic glutathione detoxification capacity in patients at risk for colon cancer
-
DOI 10.1111/j.1365-2362.2006.01618.x
-
Grubben MJ, van den Braak CC, Nagengast FM, Peters WH. Low colonic glutathione detoxification capacity in patients at risk for colon cancer. Eur J Clin Invest 36: 188-192, 2006. (Pubitemid 43341270)
-
(2006)
European Journal of Clinical Investigation
, vol.36
, Issue.3
, pp. 188-192
-
-
Grubben, M.J.A.L.1
Van Den, B.C.C.M.2
Nagengast, F.M.3
Peters, W.H.M.4
-
18
-
-
33847651267
-
Oxidisedand total non-protein bound glutathione and related thiols in gallbladder bile of patients with various gastrointestinal disorders
-
Peters WH, van Schaik A, Peters JH, van Goor H. Oxidisedand total non-protein bound glutathione and related thiols in gallbladder bile of patients with various gastrointestinal disorders. BMC Gastroenterol 7: 7, 2007.
-
(2007)
BMC Gastroenterol
, vol.7
, pp. 7
-
-
Peters, W.H.1
Van Schaik, A.2
Peters, J.H.3
Van Goor, H.4
-
19
-
-
76249105613
-
Oxidative stress in non-small cell lung cancer patients after chemotherapy: Association with treatment response
-
Gupta A, Srivastava S, Prasad R, Natu SM, Mittal B, Negi MP, Srivastava AN. Oxidative stress in non-small cell lung cancer patients after chemotherapy: association with treatment response. Respirology 15: 349-356, 2010.
-
(2010)
Respirology
, vol.15
, pp. 349-356
-
-
Gupta, A.1
Srivastava, S.2
Prasad, R.3
Natu, S.M.4
Mittal, B.5
Negi, M.P.6
Srivastava, A.N.7
-
20
-
-
34547474616
-
Salivary glutathione and uric acid levels in patients with head and neck squamous cell carcinoma
-
DOI 10.1002/hed.20579
-
Almadori G, Bussu F, Galli J, Limongelli A, Persichilli S, Zappacosta B, Minucci A, Paludetti G, Giardina B. Salivary glutathione and uric acid levels in patients with head and neck squamous cell carcinoma. Head Neck 29: 648-654, 2007. (Pubitemid 47168235)
-
(2007)
Head and Neck
, vol.29
, Issue.7
, pp. 648-654
-
-
Almadori, G.1
Bussu, F.2
Galli, J.3
Limongelli, A.4
Persichilli, S.5
Zappacosta, B.6
Minucci, A.7
Paludetti, G.8
Giardina, B.9
-
21
-
-
0035863889
-
Raised blast glutathione levels are associated with an increased risk of relapse in childhood acute lymphocytic leukemia
-
DOI 10.1182/blood.V97.2.393
-
Kearns PR, Pieters R, Rottier MM, Pearson AD, Hall AG. Raised blast glutathione levels are associated with an increased risk of relapse in childhood acute lymphocytic leukemia. Blood 97: 393-398, 2001. (Pubitemid 32060323)
-
(2001)
Blood
, vol.97
, Issue.2
, pp. 393-398
-
-
Kearns, P.R.1
Pieters, R.2
Rottier, M.M.A.3
Pearson, A.D.J.4
Hall, A.G.5
-
22
-
-
0036175650
-
-
Kawai H, Kiura K, Tabata M, Yoshino T, Takata I, Hiraki A, Chikamori K, Ueoka H, Tanimoto M, Harada M. Characterization of non-small-cell lung cancer cell lines established before and after chemotherapy 305-314, 2002.
-
(2002)
Characterization of Non-small-cell Lung Cancer Cell Lines Established before and after Chemotherapy
, pp. 305-314
-
-
Kawai, H.1
Kiura, K.2
Tabata, M.3
Yoshino, T.4
Takata, I.5
Hiraki, A.6
Chikamori, K.7
Ueoka, H.8
Tanimoto, M.9
Harada, M.10
-
23
-
-
33646093239
-
Correlations between the activities of 19 anti-tumor agents and the intracellular glutathione concentrations in a panel of 14 human cancer cell lines: Comparisons with the National Cancer Institute data
-
Bracht K, Boubakari, Grünert R, Bednarski PJ. Correlations between the activities of 19 anti-tumor agents and the intracellular glutathione concentrations in a panel of 14 human cancer cell lines: comparisons with the National Cancer Institute data. Anticancer Drugs 17: 41-51, 2006.
-
(2006)
Anticancer Drugs
, vol.17
, pp. 41-51
-
-
Bracht, K.1
Boubakari2
Grünert, R.3
Bednarski, P.J.4
-
24
-
-
0026655577
-
Cellular glutathione (GSH) and glutathione S-transferase (GST) activity in human ovarian tumor biopsies following exposure to alkylating agents
-
Britten RA, Green JA, Warenius HM. Cellular glutathione (GSH) and glutathione S-transferase (GST) activity in human ovarian tumor biopsies following exposure to alkylating agents. Int J Radiat Oncol Biol Phys 24: 527-531, 1992.
-
(1992)
Int J Radiat Oncol Biol Phys
, vol.24
, pp. 527-531
-
-
Britten, R.A.1
Green, J.A.2
Warenius, H.M.3
-
25
-
-
0036144680
-
Noninvasive imaging of tumor redox status and its modification by tissue glutathione levels
-
Kuppusamy P, Li H, Ilangovan G, Cardounel AJ, Zweier JL, Yamada K, Krishna MC, Mitchell JB. Noninvasive imaging of tumor redox status and its modification by tissue glutathione levels. Cancer Res 62: 307-312, 2002. (Pubitemid 34074020)
-
(2002)
Cancer Research
, vol.62
, Issue.1
, pp. 307-312
-
-
Kuppusamy, P.1
Li, H.2
Ilangovan, G.3
Cardounel, A.J.4
Zweier, J.L.5
Yamada, K.6
Krishna, M.C.7
Mitchell, J.B.8
-
26
-
-
0642374221
-
The role of glutathione-S-transferase in anti-cancer drug resistance
-
Townsend DM, Tew KD. The role of glutathione-S-transferase in anti-cancer drug resistance. Oncogene 22: 7369-7375, 2003.
-
(2003)
Oncogene
, vol.22
, pp. 7369-7375
-
-
Townsend, D.M.1
Tew, K.D.2
-
27
-
-
55049084123
-
Glutathione transferase: New model for glutathione activation
-
Dourado DF, Fernandes PA, Mannervik B, Ramos MJ. Glutathione transferase: new model for glutathione activation. Chemistry 14: 9591-9598, 2008.
-
(2008)
Chemistry
, vol.14
, pp. 9591-9598
-
-
Dourado, D.F.1
Fernandes, P.A.2
Mannervik, B.3
Ramos, M.J.4
-
28
-
-
0031021397
-
Structure, catalytic mechanism, and evolution of the glutathione transferases
-
DOI 10.1021/tx960072x
-
Armstrong RN. Structure, catalytic mechanism, and evolution of the glutathione transferases. Chem Res Toxicol 10: 2-18, 1997. (Pubitemid 27044902)
-
(1997)
Chemical Research in Toxicology
, vol.10
, Issue.1
, pp. 2-18
-
-
Armstrong, R.N.1
-
29
-
-
75149126749
-
Analysis of endogenous glutathione-adducts and their metabolites
-
Blair IA. Analysis of endogenous glutathione-adducts and their metabolites. Biomed Chromatogr 24: 29-38, 2010.
-
(2010)
Biomed Chromatogr
, vol.24
, pp. 29-38
-
-
Blair, I.A.1
-
30
-
-
34548067158
-
Genetic polymorphism and function of glutathione S-transferases in tumor drug resistance
-
DOI 10.1016/j.coph.2007.06.009, PII S1471489207001099, Cancer/Immunomodulation
-
Lo HW, Ali-Osman F. Genetic polymorphism and function of glutathione S-transferases in tumor drug resistance. Curr Opin Pharmacol 7: 367-374, 2007. (Pubitemid 47289267)
-
(2007)
Current Opinion in Pharmacology
, vol.7
, Issue.4
, pp. 367-374
-
-
Lo, H.-W.1
Ali-Osman, F.2
-
31
-
-
33645804599
-
Role of the glutathione metabolic pathway in lung cancer treatment and prognosis: A review
-
DOI 10.1200/JCO.2005.02.7110
-
Yang P, Ebbert JO, Sun Z, Weinshilboum RM. Role of the glutathione metabolic pathway in lung cancer treatment and prognosis: a review. J Clin Oncol 24: 1761-1769, 2006. (Pubitemid 46622148)
-
(2006)
Journal of Clinical Oncology
, vol.24
, Issue.11
, pp. 1761-1769
-
-
Yang, P.1
Ebbert, J.O.2
Sun, Z.3
Weinshilboum, R.M.4
-
32
-
-
59849129012
-
Protein S-glutathionylation: A regulatory device from bacteria to humans
-
Dalle-Donne I, Rossi R, Colombo G, Giustarini D, Milzani A. Protein S-glutathionylation: a regulatory device from bacteria to humans. Trends Biochem Sci 34: 85-96, 2009.
-
(2009)
Trends Biochem Sci
, vol.34
, pp. 85-96
-
-
Dalle-Donne, I.1
Rossi, R.2
Colombo, G.3
Giustarini, D.4
Milzani, A.5
-
33
-
-
34547666858
-
S-glutathionylation in protein redox regulation
-
DOI 10.1016/j.freeradbiomed.2007.06.014, PII S0891584907004224
-
Dalle-Donne I, Rossi R, Giustarini D, Colombo R, Milzani A. S-glutathionylation in protein redox regulation. Free Rad Biol Med 43: 883-898, 2007. (Pubitemid 47223636)
-
(2007)
Free Radical Biology and Medicine
, vol.43
, Issue.6
, pp. 883-898
-
-
Dalle-Donne, I.1
Rossi, R.2
Giustarini, D.3
Colombo, R.4
Milzani, A.5
-
34
-
-
51349088530
-
Molecular mechanisms and clinical implications of reversible protein S-glutathionylation
-
Mieyal JJ, Gallogly MM, Qanungo S, Sabens EA, Shelton MD. Molecular mechanisms and clinical implications of reversible protein S-glutathionylation. Antioxid Redox Signal 10: 1941-1988, 2008.
-
(2008)
Antioxid Redox Signal
, vol.10
, pp. 1941-1988
-
-
Mieyal, J.J.1
Gallogly, M.M.2
Qanungo, S.3
Sabens, E.A.4
Shelton, M.D.5
-
35
-
-
33751522909
-
The redox regulation of thiol dependent signaling pathways in cancer
-
DOI 10.2174/138161206779010549
-
Giles GI. The redox regulation of thiol dependent signaling pathways in cancer (2006). Curr Pharm Des; 12: 4427-43. (Pubitemid 44835155)
-
(2006)
Current Pharmaceutical Design
, vol.12
, Issue.34
, pp. 4427-4443
-
-
Giles, G.I.1
-
36
-
-
33646853458
-
Direct oxidative modifications of signalling proteins in mammalian cells and their effects on apoptosis
-
DOI 10.1179/135100005X70224
-
England K, Cotter TG. Direct oxidative modifications of signalling proteins in mammalian cells and their effects on apoptosis. Redox Rep 10: 237-245, 2005. (Pubitemid 44111130)
-
(2005)
Redox Report
, vol.10
, Issue.5
, pp. 237-245
-
-
England, K.1
Cotter, T.G.2
-
37
-
-
31044455445
-
Redox modifications of protein-thiols: Emerging roles in cell signaling
-
DOI 10.1016/j.bcp.2005.10.044, PII S0006295205007173
-
Biswas S, Chida AS, Rahman I. Redox modifications of proteinthiols: emerging roles in cell signaling. Biochem Pharmacol 71: 551-564, 2006. (Pubitemid 43121989)
-
(2006)
Biochemical Pharmacology
, vol.71
, Issue.5
, pp. 551-564
-
-
Biswas, S.1
Chida, A.S.2
Rahman, I.3
-
38
-
-
33745559710
-
The role of nitric oxide in tumour progression
-
DOI 10.1038/nrc1910, PII N1910
-
Fukumura D, Kashiwagi S, Jain RK. The role of nitric oxide in tumour progression. Nat Rev Cancer 6: 521-534, 2006. (Pubitemid 43980541)
-
(2006)
Nature Reviews Cancer
, vol.6
, Issue.7
, pp. 521-534
-
-
Fukumura, D.1
Kashiwagi, S.2
Jain, R.K.3
-
39
-
-
34547110841
-
Glutathione is recruited into the nucleus in early phases of cell proliferation
-
DOI 10.1074/jbc.M609582200
-
Markovic J, Borrás C, Ortega A, Sastre J, Viña J, Pallardó, FV. Glutathione is recruited into the nucleus in early phases of cell proliferation. J Biol Chem 282: 20416-20424, 2007. (Pubitemid 47099986)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.28
, pp. 20416-20424
-
-
Markovic, J.1
Borras, C.2
Ortega, A.3
Sastre, J.4
Vina, J.5
Pallardo, F.V.6
-
40
-
-
33750622197
-
Subcellular compartmentalization of glutathione: Correlations with parameters of oxidative stress related to genotoxicity
-
DOI 10.1093/mutage/gel043
-
Green RM, Graham M, O'Donovan MR, Chipman JK, Hodges NJ. Subcellular compartmentalization of glutathione: correlations with parameters of oxidative stress related to genotoxicity. Mutagenesis 21: 383-390, 2006. (Pubitemid 44691127)
-
(2006)
Mutagenesis
, vol.21
, Issue.6
, pp. 383-390
-
-
Green, R.M.1
Graham, M.2
O'Donovan, M.R.3
Chipman, J.K.4
Hodges, N.J.5
-
41
-
-
0034668215
-
Regulation of nuclear factor-κB, activator protein-1, and glutathione levels by tumor necrosis factor-α and dexamethasone in alveolar epithelial cells
-
Rahman I. Regulation of nuclear factor-κB, activator protein-1, and glutathione levels by tumor necrosis factor-α and dexamethasone in alveolar epithelial cells. Biochem Pharmacol 60: 1041-1049, 2000.
-
(2000)
Biochem Pharmacol
, vol.60
, pp. 1041-1049
-
-
Rahman, I.1
-
42
-
-
0030907275
-
Intranuclear distribution, function and fate of glutathione and glutathione-S-conjugate in living rat hepatocytes studied by fluorescence microscopy
-
DOI 10.1002/(SICI)1097-0029(19970215)36:4<243::AID-JEMT3>3.0.CO;2-N
-
Bellomo G, Palladini, G, Vairetti M. Intranuclear distribution, function and fate of glutathione and glutathione-S-conjugate in living rat hepatocytes studied by fluorescence microscopy. Microsc Res Tech 36: 243-252, 1997. (Pubitemid 27188146)
-
(1997)
Microscopy Research and Technique
, vol.36
, Issue.4
, pp. 243-252
-
-
Bellomo, G.1
Palladini, G.2
Vairetti, M.3
-
43
-
-
65049087578
-
Role of nuclear glutathione as a key regulator of cell proliferation
-
Pallardó, FV, Markovic J, García JL, Viña J. Role of nuclear glutathione as a key regulator of cell proliferation. Mol Aspects Med 30: 77-85, 2009.
-
(2009)
Mol Aspects Med
, vol.30
, pp. 77-85
-
-
Pallardó, F.V.1
Markovic, J.2
García, J.L.3
Viña, J.4
-
44
-
-
77951634950
-
Pyridine nucleotide cycling and control of intracellular redox state in relation to poly(ADP-ribose) polymerase activity and nuclear localisation of glutathione during exponential growth of Arabidopsis cells in culture
-
Pellny TK, Locato V, Vivancos PD, Markovic J, De Gara L, Pallardó FV, Foyer CH. Pyridine nucleotide cycling and control of intracellular redox state in relation to poly(ADP-ribose) polymerase activity and nuclear localisation of glutathione during exponential growth of Arabidopsis cells in culture. Mol Plant 2: 442-456, 2009.
-
(2009)
Mol Plant
, vol.2
, pp. 442-456
-
-
Pellny, T.K.1
Locato, V.2
Vivancos, P.D.3
Markovic, J.4
De Gara, L.5
Pallardó, F.V.6
Foyer, C.H.7
-
45
-
-
0031712812
-
Oxidative damage of mitochondrial and nuclear DNA induced by ionizing radiation in human hepatoblastoma cells
-
DOI 10.1016/S0360-3016(98)00185-0, PII S0360301698001850
-
Morales A, Miranda M, Sánchez-Reyes A, Biete A, Fernández-Checa JC. Oxidative damage of mitochondrial and nuclear DNA induced by ionizing radiation in human hepatoblastoma cells. Int J Radiat Oncol Biol Phys 42: 191-203, 1998. (Pubitemid 28435613)
-
(1998)
International Journal of Radiation Oncology Biology Physics
, vol.42
, Issue.1
, pp. 191-203
-
-
Morales, A.1
Miranda, M.2
Sanchez-Reyes, A.3
Biete, A.4
Fernandez-Checa, J.C.5
-
46
-
-
33750011601
-
Mitochondrial glutathione transport: Physiological, pathological and toxicological implications
-
DOI 10.1016/j.cbi.2006.03.001, PII S0009279706000536
-
Lash LH. Mitochondrial glutathione transport: Physiological, pathological and toxicological implications. Chem-Biol Interact 163: 54-67, 2006. (Pubitemid 44572210)
-
(2006)
Chemico-Biological Interactions
, vol.163
, Issue.1-2
, pp. 54-67
-
-
Lash, L.H.1
-
47
-
-
35348916616
-
Molecular biology of glutathione peroxidase 4: From genomic structure to developmental expression and neural function
-
DOI 10.1515/BC.2007.126
-
Savaskan NE, Ufer C, Kühn H, Borchert A. Molecular biology of glutathione peroxidase 4: from genomic structure to development expression and neural function. J Biol Chem 388: 1007-1017, 2007. (Pubitemid 47584303)
-
(2007)
Biological Chemistry
, vol.388
, Issue.10
, pp. 1007-1017
-
-
Savaskan, N.E.1
Ufer, C.2
Kuhn, H.3
Borchert, A.4
-
48
-
-
0032855506
-
Mitochondrial phospholipid hydroperoxide glutathione peroxidase suppresses apoptosis mediated by a mitochondrial death pathway
-
Nomura K, Imai H, Koumura T, Arai M, Nakagawa Y. Mitochondrial phospholipid hydroperoxide glutathione peroxidase suppresses apoptosis mediated by a mitochondrial death pathway. J Biol Chem 274: 29294-29302, 1999.
-
(1999)
J Biol Chem
, vol.274
, pp. 29294-29302
-
-
Nomura, K.1
Imai, H.2
Koumura, T.3
Arai, M.4
Nakagawa, Y.5
-
49
-
-
38649108515
-
Transient and sustained oxidative stress differentially activate the JNK1/2 pathway and apoptotic phenotype in H9c2 cells
-
Pechtelidou A, Beis I, Gaitanaki C. Transient and sustained oxidative stress differentially activate the JNK1/2 pathway and apoptotic phenotype in H9c2 cells. Mol Cell Biochem 309: 177-189, 2008.
-
(2008)
Mol Cell Biochem
, vol.309
, pp. 177-189
-
-
Pechtelidou, A.1
Beis, I.2
Gaitanaki, C.3
-
50
-
-
0030789576
-
Nitric oxide and superoxide induced p53 and Bax accumulation during mesangial cell apoptosis
-
Sandau K, Pfeilschifter J, Brüne B. Nitric oxide and superoxide induced p53 and Bax accumulation during mesangial cell apoptosis. Kidney Int 52: 378-386, 1997. (Pubitemid 27359580)
-
(1997)
Kidney International
, vol.52
, Issue.2
, pp. 378-386
-
-
Sandau, K.1
Pfeilschifter, J.2
Brune, B.3
-
51
-
-
1642463525
-
Reactive oxygen species amplify protein kinase C signaling in high glucose-induced fibronectin expression by human peritoneal mesothelial cells
-
DOI 10.1111/j.1523-1755.2004.00491.x
-
Lee HB, Yu MR, Song JS, Ha H. Reactive oxygen species amplify protein kinase C signaling in high glucose-induced fibronectin expression by human peritoneal mesothelial cells. Kidney Int 65: 1170-1179, 2004. (Pubitemid 38406955)
-
(2004)
Kidney International
, vol.65
, Issue.4
, pp. 1170-1179
-
-
Lee, H.B.1
Yu, M.R.2
Song, J.S.3
Ha, H.4
-
52
-
-
25444491515
-
Gene expression profiling reveals a signaling role of glutathione in redox regulation
-
DOI 10.1073/pnas.0504398102
-
Fratelli M, Goodwin LO, Ørom UA, Lombardi S, Tonelli R, Mengozzi M, Ghezzi P. Gene expression profiling reveals a signaling role of glutathione in redox regulation. Proc Natl Acad Sci USA 102: 13998-14003, 2005. (Pubitemid 41377692)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.39
, pp. 13998-14003
-
-
Fratelli, M.1
Goodwin, L.O.2
Orom, U.A.3
Lombardi, S.4
Tonelli, R.5
Mengozzi, M.6
Ghezzi, P.7
-
53
-
-
34548762437
-
Glutathione depletion activates mitogen-activated protein kinase (MAPK) pathways that display organ-specific responses and brain protection in mice
-
DOI 10.1016/j.freeradbiomed.2007.06.028, PII S0891584907004625
-
Limón-Pacheco JH, Hernández NA, Fanjul-Moles ML, Gonsebatt ME. Glutathione depletion activates mitogenactivated protein kinase (MAPK) pathways that display organspecific responses and brain protection in mice. Free Rad Biol Med 43: 1335-1347, 2007. (Pubitemid 47432899)
-
(2007)
Free Radical Biology and Medicine
, vol.43
, Issue.9
, pp. 1335-1347
-
-
Limon-Pacheco, J.H.1
Hernandez, N.A.2
Fanjul-Moles, M.L.3
Gonsebatt, M.E.4
-
54
-
-
33750522657
-
2-terminal kinase (JNK) decrease glutathione content and sensitize human promonocytic leukemia cells to arsenic trioxide-induced apoptosis
-
DOI 10.1002/jcp.20806
-
Ramos AM, Fernandez C, Amrán D, Esteban D, de Blas E, Palacios MA, Aller P. Pharmacologic inhibitors of extracellular signal-regulated kinase (ERKs) and c-Jun NH(2)-terminal kinase (JNK) decrease glutathione content and sensitize human promonocytic leukemia cells to arsenic trioxide-induced apoptosis. J Cell Physiol 209: 1006-1015, 2006. (Pubitemid 44665723)
-
(2006)
Journal of Cellular Physiology
, vol.209
, Issue.3
, pp. 1006-1015
-
-
Ramos, A.M.1
Fernandez, C.2
Amran, D.3
Esteban, D.4
De Blas, E.5
Palacios, M.A.6
Aller, P.7
-
55
-
-
42649140547
-
Inhibition of the EGF receptor blocks autocrine growth and increases the cytotoxic effects of doxorubicin in rat hepatoma cells: Role of reactive oxygen species production and glutathione depletion
-
Ortiz C, Caja L, Sancho P, Bertran E, Fabregat I. Inhibition of the EGF receptor blocks autocrine growth and increases the cytotoxic effects of doxorubicin in rat hepatoma cells: role of reactive oxygen species production and glutathione depletion. Biochem Pharmacol 75: 1935-1945, 2008.
-
(2008)
Biochem Pharmacol
, vol.75
, pp. 1935-1945
-
-
Ortiz, C.1
Caja, L.2
Sancho, P.3
Bertran, E.4
Fabregat, I.5
-
56
-
-
18544374589
-
Pharmacologic inhibitors of PI3K/Akt potentiate the apoptotic action of the antileukemic drug arsenic trioxide via glutathione depletion and increased peroxide accumulation in myeloid leukemia cells
-
DOI 10.1182/blood-2004-07-2802
-
Ramos AM, Fernández C, Amrán D, Sancho P, de Blas E, Aller P. Pharmacologic inhibitors of PI3K/Akt potentiate the apoptotic action of the antileukemic drug arsenic trioxide via glutathione depletion and increased peroxide accumulation in myeloid leukemia cells. Blood 105: 4013-4020, 2005. (Pubitemid 40656150)
-
(2005)
Blood
, vol.105
, Issue.10
, pp. 4013-4020
-
-
Ramos, A.M.1
Fernandez, C.2
Amran, D.3
Sancho, P.4
De Blas, E.5
Aller, P.6
-
57
-
-
17344362169
-
Free radicals and apoptosis: Relationships with glutathione, thioredoxin and the bcl family of proteins
-
Kern JC, Kehrer JP. Free radicals and apoptosis: relationships with glutathione, thioredoxin, and the BCL family of proteins. Front Biosci 10: 1727-1738, 2005. (Pubitemid 40532954)
-
(2005)
Frontiers in Bioscience
, vol.10
, Issue.2
, pp. 1727-1738
-
-
Kern, J.C.1
Kehrer, J.P.2
-
58
-
-
33749540617
-
SLCO/OATP-like transport of glutathione in FasL-induced apoptosis: Glutathione efflux is coupled to an organic anion exchange and is necessary for the progression of the execution phase of apoptosis
-
DOI 10.1074/jbc.M602500200
-
Franco R, Cidlowski JA. SLCO/OATP-like transport of glutathione in FasL-induced apoptosis: glutathione efflux is coupled to an organic anion exchange and is necessary for the progression of the execution phase of apoptosis. J Biol Chem 281: 29542-29557, 2006. (Pubitemid 44536962)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.40
, pp. 29542-29557
-
-
Franco, R.1
Cidlowski, J.A.2
-
59
-
-
34347230130
-
Glutathione export during apoptosis requires functional multidrug resistance-associated proteins
-
DOI 10.1074/jbc.M611019200
-
Hammond CL, Marchan R, Krance SM, Ballatori N. Glutathione export during apoptosis requires functional multidrug resistance-associated proteins. J Biol Chem 282: 14337-14347, 2007. (Pubitemid 47100459)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.19
, pp. 14337-14347
-
-
Hammond, C.L.1
Marchan, R.2
Krance, S.M.3
Ballatori, N.4
-
60
-
-
4344625883
-
A critical role of glutathione in determining apoptosis sensitivity and resistance in leukemia cells
-
DOI 10.1038/sj.cdd.4401431
-
Friesen C, Kiess Y, Debatin KM. A critical role of glutathione in determining apoptosis sensitivity and resistance in leukemia cells. Cell Death Differ 11 Suppl 1: S73-85, 2004. (Pubitemid 39136800)
-
(2004)
Cell Death and Differentiation
, vol.11
, Issue.SUPPL. 1
-
-
Friesen, C.1
Kiess, Y.2
Debatin, K.-M.3
-
61
-
-
34047275734
-
High hepatic glutathione stores alleviate Fas-induced apoptosis in mice
-
DOI 10.1016/j.jhep.2006.11.015, PII S0168827806006350
-
Cazanave S, Berson A, Haouzi D, Vadrot N, Fau D, Grodet A, Lettéron P, Feldmann G, El-Benna J, Fromenty B, Robin MA, Péssayre D. High hepatic glutathione stores alleviate Fas-induced apoptosis in mice. J Hepatol 46: 858-868, 2007. (Pubitemid 46546601)
-
(2007)
Journal of Hepatology
, vol.46
, Issue.5
, pp. 858-868
-
-
Cazanave, S.1
Berson, A.2
Haouzi, D.3
Vadrot, N.4
Fau, D.5
Grodet, A.6
Letteron, P.7
Feldmann, G.8
El-Benna, J.9
Fromenty, B.10
Robin, M.-A.11
Pessayre, D.12
-
62
-
-
0036673665
-
Glutathione depletion enforces the mitochondrial permeability transition and causes cell death in Bcl-2 overexpressing HL60 cells
-
Armstrong JS, Jones DP. Glutathione depletion enforces the mitochondrial permeability transition and causes cell death in Bcl-2 overexpressing HL60 cells. FASEB J 16: 1263-1265, 2002.
-
(2002)
FASEB J
, vol.16
, pp. 1263-1265
-
-
Armstrong, J.S.1
Jones, D.P.2
-
63
-
-
31644445195
-
Survival and cell death in cells constitutively unable to synthesize glutathione
-
DOI 10.1016/j.mrfmmm.2005.08.004, PII S0027510705003982
-
Valverde M, Rojas E, Kala SV, Kala G, Lieberman MW. Survival and cell death in cells constitutively unable to synthesize glutathione. Mutat Res 594: 172-180, 2006. (Pubitemid 43170997)
-
(2006)
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
, vol.594
, Issue.1-2
, pp. 172-180
-
-
Valverde, M.1
Rojas, E.2
Kala, S.V.3
Kala, G.4
Lieberman, M.W.5
-
64
-
-
2942744672
-
Fas-mediated apoptosome formation is dependent on reactive oxygen species derived from mitochondrial permeability transition in Jurkat cells
-
Sato T, Machida T, Takahashi S, Iyama S, Sato Y, Kuribayashi K, Takada K, Oku T, Kawano Y, Okamoto T, Takimoto R, Matsunaga T, Takayama T, Takahashi M, Kato J, Niitsu Y. Fas-mediated apoptosome formation is dependent on reactive oxygen species derived from mitochondrial permeability transition in Jurkat cells. J Immunol 173: 285-296, 2004. (Pubitemid 38797353)
-
(2004)
Journal of Immunology
, vol.173
, Issue.1
, pp. 285-296
-
-
Sato, T.1
Machida, T.2
Takahashi, S.3
Iyama, S.4
Sato, Y.5
Kuribayashi, K.6
Takada, K.7
Oku, T.8
Kawano, Y.9
Okamoto, T.10
Takimoto, R.11
Matsunaga, T.12
Takayama, T.13
Takahashi, M.14
Kato, J.15
Niitsu, Y.16
-
65
-
-
24644490717
-
Oxidative Bax dimerization promotes its translocation to mitochondria independently of apoptosis
-
DOI 10.1096/fj.04-3329fje
-
D'Alessio M, De Nicola M, Coppola S, Gualandi G, Pugliese L, Cerella C, Cristofanon S, Civitareale P, Ciriolo MR, Bergamaschi A, Magrini A, Ghibelli L. Oxidative Bax dimerization promotes its translocation to mitochondria independently of apoptosis. FASEB J 19: 1504-1506, 2005. (Pubitemid 41279012)
-
(2005)
FASEB Journal
, vol.19
, Issue.11
, pp. 1504-1506
-
-
D'Alessio, M.1
De Nicola, M.2
Coppola, S.3
Gualandi, G.4
Pugliese, L.5
Cerella, C.6
Cristofanon, S.7
Civitareale, P.8
Ciriolo, M.R.9
Bergamaschi, A.10
Magrini, A.11
Ghibelli, L.12
-
66
-
-
0033953170
-
GSH extrusion and the mitochondrial pathway of apoptotic signalling
-
Coppola S, Ghibelli L. GSH extrusion and and the mitochondrial pathway of apoptotic signalling. Biochem Soc Trans 28: 56-61, 2000. (Pubitemid 30103213)
-
(2000)
Biochemical Society Transactions
, vol.28
, Issue.2
, pp. 56-61
-
-
Coppola, S.1
Ghibelli, L.2
-
67
-
-
1342305480
-
Cytochrome c, Glutathione, and the Possible Role of Redox Potentials in Apoptosis
-
DOI 10.1196/annals.1299.081
-
Hancock JT, Desikan R, Neill SJ. Cytochrome c, glutathione, and the possible role of redox potentials in apoptosis. Ann N Y Acad Sci 1010: 446-448, 2003. (Pubitemid 38265023)
-
(2003)
Annals of the New York Academy of Sciences
, vol.1010
, pp. 446-448
-
-
Hancock, J.T.1
Desikan, R.2
Neill, S.J.3
-
68
-
-
17144397637
-
Role of intracellular glutathione in cell sensitivity to the apoptosis induced by tumor necrosis factor α-related apoptosis-lnducing ligand/anticancer drug combinations
-
DOI 10.1158/1078-0432.CCR-04-1764
-
Meurette O, Lefeuvre-Orfila L, Rebillard A, Lagadic-Gossmann D, Dimanche-Boitrel MT. Role of intracellular glutathione in cell sensitivity to the apoptosis induced by tumor necrosis factor-α related apoptosis-inducing ligand/anticancer drug combinations. Clin Cancer Res 11: 3075-3083, 2005. (Pubitemid 40525214)
-
(2005)
Clinical Cancer Research
, vol.11
, Issue.8
, pp. 3075-3083
-
-
Meurette, O.1
Lefeuvre-Orfila, L.2
Rebillard, A.3
Lagadic-Gossmann, D.4
Dimanche-Boitrel, M.-T.5
-
69
-
-
0037085261
-
Glutathione dependence of caspase-8 activation at the death-inducing signaling complex
-
DOI 10.1074/jbc.M110766200
-
Hentze H, Schmitz I, Latta M, Krueger A, Krammer PH, Wendel A. Glutathione dependence of caspase-8 activation at the death-inducing signaling complex. J Biol Chem 277: 5588-5595, 2002. (Pubitemid 34968612)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.7
, pp. 5588-5595
-
-
Hentze, H.1
Schmitz, I.2
Latta, M.3
Krueger, A.4
Krammer, P.H.5
Wendel, A.6
-
70
-
-
35748976238
-
Glutathione binding to the Bcl-2 homology-3 domain groove: A molecular basis for BCL-2 antioxidant function at mitochondria
-
DOI 10.1074/jbc.M702853200
-
Zimmermann AK, Loucks FA, Schroeder EK, Bouchard RJ, Tyler KL, Linseman DA. Glutathione binding to the Bcl-2 homology-3 domain groove: a molecular basis for Bcl-2 antioxidant function at mitochondria. J Biol Chem 282: 29296-29304, 2007. (Pubitemid 350043369)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.40
, pp. 29296-29304
-
-
Zimmermann, A.K.1
Loucks, F.A.2
Schroeder, E.K.3
Bouchard, R.J.4
Tyler, K.L.5
Linseman, D.A.6
-
71
-
-
0032539871
-
Bcl-2 expression causes redistribution of glutathione to the nucleus
-
DOI 10.1073/pnas.95.6.2956
-
Voehringer DW, McConkey DJ, McDonnell TJ, Brisbay S, Meyn RE. Bcl-2 expression causes redistribution of glutathione to the nucleus. Proc Natl Acad Sci USA 95: 2956-2960, 1998. (Pubitemid 28135836)
-
(1998)
Proceedings of the National Academy of Sciences of the United States of America
, vol.95
, Issue.6
, pp. 2956-2960
-
-
Voehringer, D.W.1
Mcconkey, D.J.2
Mcdonnell, T.J.3
Brisbay, S.4
Meyn, R.E.5
-
72
-
-
0033230015
-
BCL-2 and glutathione: alterations in cellular redox state that regulate apoptosis sensitivity
-
DOI 10.1016/S0891-5849(99)00174-4, PII S0891584999001744
-
Voehringer DW. Bcl-2 and glutathione: alterations in cellular redox state that regulate apoptosis sensitivity. Free Rad Biol Med 27: 945-950, 1999. (Pubitemid 29507468)
-
(1999)
Free Radical Biology and Medicine
, vol.27
, Issue.9-10
, pp. 945-950
-
-
Voehringer, D.W.1
-
73
-
-
0642345209
-
Potentiation of cellular antioxidant capacity by Bcl-2: Implications for its antiapoptotic function
-
DOI 10.1016/S0006-2952(03)00487-8, PII S0006295203004878
-
Jang J-H, Surh Y-J. Potentiation of cellular antioxidant capacity of Bcl-2: implications for its antiapoptotic function. Biochem Pharmacol 66: 1371-1379, 2003. (Pubitemid 38373323)
-
(2003)
Biochemical Pharmacology
, vol.66
, Issue.8
, pp. 1371-1379
-
-
Jang, J.-H.1
Surh, Y.-J.2
-
74
-
-
14844286405
-
Acceleration of glutathione efflux and inhibition of gamma- glutamyltranspeptidase sensitize metastatic B16 melanoma cells to endothelium-induced cytotoxicity
-
DOI 10.1074/jbc.M408531200
-
Benlloch M, Ortega A, Ferrer P, Segarra R, Obrador E, Asensi M, Carretero J, Estrela JM. Acceleration of glutathione efflux and inhibition of gamma-glutamyltranspeptidase sensitize metastatic B16 melanoma cells to endothelium-induced cytotoxicity. J Biol Chem 280: 6950-6959, 2005. (Pubitemid 40341251)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.8
, pp. 6950-6959
-
-
Benlloch, M.1
Ortega, A.2
Ferrer, P.3
Segarra, R.4
Obrador, E.5
Asensi, M.6
Carretero, J.7
Estrela, J.M.8
-
75
-
-
0016651663
-
Effect of glutathione depletion on tissue deposition of methylmercury in rats
-
Richardson RJ, Murphy SD. Effect of glutathione depletion on tissue deposition of methylmercury in rats. Toxicol App Pharmacol 31: 505-519, 1975.
-
(1975)
Toxicol App Pharmacol
, vol.31
, pp. 505-519
-
-
Richardson, R.J.1
Murphy, S.D.2
-
76
-
-
0034666730
-
Induction of oxidative stress and apoptosis in myeloma cells by the aziridine-containing agent imexon
-
DOI 10.1016/S0006-2952(00)00380-4, PII S0006295200003804
-
Dvorakova K, Payne CM, Tome ME, Briehl MM, McClure T, Dorr RT. Induction of oxidative stress and apoptosis in myeloma cells by the aziridine-containing agent imexon. Biochem Pharmacol 60: 749-758, 2000. (Pubitemid 30621659)
-
(2000)
Biochemical Pharmacology
, vol.60
, Issue.6
, pp. 749-758
-
-
Dvorakova, K.1
Payne, C.M.2
Tome, M.E.3
Briehl, M.M.4
McClure, T.5
Dorr, R.T.6
-
77
-
-
77956056306
-
A phase I trial of imexon, a pro-oxidant, in combination with docetaxel for the treatment of patients with advanced breast, non-small cell lung and prostate cancer
-
Moulder S, Dhillon, Ng C, Hong D, Wheler J, Naing A, Tse S, LePagtia A, Dorr RT, Hersh EM, Boytim ML, Kurzrock R. A phase I trial of imexon, a pro-oxidant, in combination with docetaxel for the treatment of patients with advanced breast, non-small cell lung and prostate cancer. Invest New Drugs 28: 634-640, 2010.
-
(2010)
Invest New Drugs
, vol.28
, pp. 634-640
-
-
Moulder, S.1
Dhillon2
Ng, C.3
Hong, D.4
Wheler, J.5
Naing, A.6
Tse, S.7
LePagtia, A.8
Dorr, R.T.9
Hersh, E.M.10
Boytim, M.L.11
Kurzrock, R.12
-
78
-
-
77953073888
-
A phase I study of imexon plus gemcitabine as first-line therapy for advanced pancreatic cancer
-
Cohen SJ, Zalupski MM, Modiano MR, Conkling P, Patt YZ, Davis P, Dorr RT, Boytim ML, Hersh EM. A phase I study of imexon plus gemcitabine as first-line therapy for advanced pancreatic cancer. Cancer Chemother Pharmacol 66: 287-294, 2009.
-
(2009)
Cancer Chemother Pharmacol
, vol.66
, pp. 287-294
-
-
Cohen, S.J.1
Zalupski, M.M.2
Modiano, M.R.3
Conkling, P.4
Patt, Y.Z.5
Davis, P.6
Dorr, R.T.7
Boytim, M.L.8
Hersh, E.M.9
-
79
-
-
84860620790
-
A phase II randomized double blind multicenter trial of gemcitabine (Gem) plus imexon (IMX) versus Gem plus placebo (P) in patients with chemotherapy-naïve pancreatic adenocarcinoma (PC)
-
abstract 4076
-
Cohen SJ, Zalupski MM, Conkling P. A phase II randomized double blind multicenter trial of gemcitabine (Gem) plus imexon (IMX) versus Gem plus placebo (P) in patients with chemotherapy-naïve pancreatic adenocarcinoma (PC). J Clin Oncol 28 (15s): abstract 4076, 2010.
-
(2010)
J Clin Oncol
, vol.28
, Issue.15 S
-
-
Cohen, S.J.1
Zalupski, M.M.2
Conkling, P.3
-
80
-
-
0034780745
-
Hammerhead ribozyme against gamma-glutamylcysteine synthetase sensitizes human colonic cancer cells to cisplatin by down-regulating both the glutathione synthesis and the expression of multidrug resistance proteins
-
DOI 10.1038/sj.cgt.7700371
-
Iida T, Kijima H, Urata Y, Goto S, ihara Y, Oka M, Kohno S, Scanlon KJ, Kondo T. Hammerhead ribozyme against gammaglutamylcysteine synthetase sensitizes human colonic cancer cells to cisplatin by down-regulating both the glutathione synthesis and the expression of multidrug resistance proteins. Cancer Gene Ther 8: 803-814, 2001. (Pubitemid 32983137)
-
(2001)
Cancer Gene Therapy
, vol.8
, Issue.10
, pp. 803-814
-
-
Iida, T.1
Kijima, H.2
Urata, Y.3
Goto, S.4
Ihara, Y.5
Oka, M.6
Kohno, S.7
Scanlon, K.J.8
Kondo, T.9
-
81
-
-
0029052835
-
Evidence for altered regulation of γ-glutamylcysteine synthetase gene expression among cisplatinsensitive and cisplatin-resistant human ovarian cancer cell lines
-
Yao KS, Godwin AK, Johnson SW, Ozols RF, O'Dwyer PJ, Hamilton TC. Evidence for altered regulation of γ-glutamylcysteine synthetase gene expression among cisplatinsensitive and cisplatin-resistant human ovarian cancer cell lines. Cancer Res 55: 4367-4374, 1995.
-
(1995)
Cancer Res
, vol.55
, pp. 4367-4374
-
-
Yao, K.S.1
Godwin, A.K.2
Johnson, S.W.3
Ozols, R.F.4
O'Dwyer, P.J.5
Hamilton, T.C.6
-
82
-
-
0020444895
-
Mechanism of action, metabolism, and toxicity of buthionine sulfoximine and its higher homologs, potent inhibitors of glutathione synthesis
-
Griffith OW. Mechanism of Action, Metabolism, and Toxicity of Buthionine Sulfoximine and its higher homologs, potent inhibitors of glutathione synthesis. J Biol Chem 257: 13704-13712, 1982. (Pubitemid 13187133)
-
(1982)
Journal of Biological Chemistry
, vol.257
, Issue.22
, pp. 13704-13712
-
-
Griffith, O.W.1
-
83
-
-
0022537052
-
Selective modulation of glutathione levels in human normal versus tumor cells and subsequent differential responses to chemotherapy drugs
-
Russo A, DeGraff W, Friedman N, Mitchell JB. Selective modulation of glutathione levels in human normal versus tumor cells and subsequent differential response to chemotherapy drugs. Cancer Res 46: 2845-2848, 1986. (Pubitemid 16074292)
-
(1986)
Cancer Research
, vol.46
, Issue.6
, pp. 2845-2848
-
-
Russo, A.1
DeGraff, W.2
Friedman, N.3
Mitchell, J.B.4
-
84
-
-
70449107252
-
Redox-directed cancer therapeutics: Molecular mechanisms and opportunities
-
Wondrak GT. Redox-directed cancer therapeutics: molecular mechanisms and opportunities. Antioxid Redox Signal 11: 3013-3069, 2009.
-
(2009)
Antioxid Redox Signal
, vol.11
, pp. 3013-3069
-
-
Wondrak, G.T.1
-
85
-
-
0036671651
-
Synergistic cytotoxicity of buthionine sulfoximine (BSO) and intensive melphalan (L-PAM) for neuroblastoma cell lines established at relapse after myeloablative therapy
-
DOI 10.1038/sj.bmt.1703605
-
Anderson CP, Reynolds CP. Synergistic cytotoxicity of buthionine sulfoximine (BSO) and intensive melphalan (L-PAM) for neuroblastoma cell lines established at relapse after myeloablative therapy. Bone Marrow Transplant 30: 135-140, 2002. (Pubitemid 34993851)
-
(2002)
Bone Marrow Transplantation
, vol.30
, Issue.3
, pp. 135-140
-
-
Anderson, C.P.1
Reynolds, C.P.2
-
86
-
-
0028157817
-
Phase I clinical trial of intravenous L-buthionine sulfoximine and melphalan: An attempt at modulation of glutathione
-
Bailey HH, Mulcahy RT, Tutsch KD, Arzoomanian RZ, Alberti D, Tombes MB, Wilding G, Pomplun M, Spriggs DR. Phase I clinical trial of intravenous L-buthionine sulfoximine and melphalan: an attempt at modulation of glutathione. J Clin Oncol 12: 194-205, 1994. (Pubitemid 24020640)
-
(1994)
Journal of Clinical Oncology
, vol.12
, Issue.1
, pp. 194-205
-
-
Bailey, H.H.1
Mulcahy, R.T.2
Tutsch, K.D.3
Arzoomanian, R.Z.4
Alberti, D.5
Tombes, M.B.6
Wilding, G.7
Pomplun, M.8
Spriggs, D.R.9
-
87
-
-
0030658870
-
Phase I study of continuous-infusion L-S,R-buthionine sulfoximine with intravenous melphalan
-
Bailey HH, Ripple G, Tutsch KD, Arzoomanian RZ, Alberti D, Feierabend C, Mahvi D, Schink J, Pomplun M, Mulcahy RT, Wilding G. Phase I study of continuous-infusion L-S,Rbuthionine sulfoximine with intravenous melphalan. J Natl Cancer Inst 89: 1789-1796, 1997. (Pubitemid 27516233)
-
(1997)
Journal of the National Cancer Institute
, vol.89
, Issue.23
, pp. 1789-1796
-
-
Bailey, H.H.1
Ripple, G.2
Tutsch, K.D.3
Arzoomanian, R.Z.4
Alberti, D.5
Feierabend, C.6
Mahvi, D.7
Schink, J.8
Pomplun, M.9
Mulcahy, R.T.10
Wilding, G.11
-
91
-
-
23244453323
-
TLK-199 (Telik)
-
Hamilton D, Batist G. TLK-199 (Telik). IDrugs 8: 662-669, 2005.
-
(2005)
IDrugs
, vol.8
, pp. 662-669
-
-
Hamilton, D.1
Batist, G.2
-
92
-
-
0032731289
-
Glutathione peptidomimetic drug modulator of multidrug resistance-associated protein
-
O'Brien ML, Vulevic B, Freer S, Boyd J, Shen H, Tew KD. Glutathione peptidomimetic drug modulator of multidrug resistance-associated protein. J Pharmacol Exp Ther 291: 1348-1355, 1999.
-
(1999)
J Pharmacol Exp Ther
, vol.291
, pp. 1348-1355
-
-
O'Brien, M.L.1
Vulevic, B.2
Freer, S.3
Boyd, J.4
Shen, H.5
Tew, K.D.6
-
93
-
-
67651167047
-
Phase 1-2a multicenter dose-escalation study of ezatiostat hydrochloride liposomes for injection (Telintra, TLK199), a novel glutathione analog prodrug in patients with myelodysplastic syndrome
-
Raza A, Galili N, Callander N, Ochoa L, Piro L, Emanuel P, Williams S, Burris H 3rd, Faderl S, Estrov Z, Curtin P, Larson RA, Keck JG, Jones M, Meng L, Brown GL. Phase 1-2a multicenter dose-escalation study of ezatiostat hydrochloride liposomes for injection (Telintra, TLK199), a novel glutathione analog prodrug in patients with myelodysplastic syndrome. J Hematol Oncol 2: 20, 2009.
-
(2009)
J Hematol Oncol
, vol.2
, pp. 20
-
-
Raza, A.1
Galili, N.2
Callander, N.3
Ochoa, L.4
Piro, L.5
Emanuel, P.6
Williams, S.7
Burris III, H.8
Faderl, S.9
Estrov, Z.10
Curtin, P.11
Larson, R.A.12
Keck, J.G.13
Jones, M.14
Meng, L.15
Brown, G.L.16
-
94
-
-
23644446179
-
TLK-286: A novel glutathione S-transferase-activated prodrug
-
DOI 10.1517/13543784.14.8.1047
-
Tew KD. TLK-286: a novel glutathione S-transferase-activated prodrug. Expert Opin Invest Drugs 14: 1047-1054, 2005. (Pubitemid 41131655)
-
(2005)
Expert Opinion on Investigational Drugs
, vol.14
, Issue.8
, pp. 1047-1054
-
-
Tew, K.D.1
-
95
-
-
16544388297
-
TLK-286
-
Verschraegen CF, Smith HO, Lee FC, Cathcart C, Norenberg JP. TLK-286. IDrugs 7: 771-781, 2004.
-
(2004)
IDrugs
, vol.7
, pp. 771-781
-
-
Verschraegen, C.F.1
Smith, H.O.2
Lee, F.C.3
Cathcart, C.4
Norenberg, J.P.5
-
96
-
-
17544385571
-
Tumor efficacy and bone marrow-sparing properties of TER286, a cytotoxin activated by glutathione S-transferase
-
Morgan AS, Sanderson PE, Borch RF, Tew KD, Niitsu Y, Takayama T, Von Hoff DD, Izbicka E, Mangold G, Paul C, Broberg U, Mannervik B, Henner WD, Kauvar LM. Tumor efficacy and bone marrow-sparing properties of TER286, a cytotoxin activated by glutathione S-transferase. Cancer Res 58: 2568-2575, 1998. (Pubitemid 28275427)
-
(1998)
Cancer Research
, vol.58
, Issue.12
, pp. 2568-2575
-
-
Morgan, A.S.1
Sanderson, P.E.2
Borch, R.F.3
Tew, K.D.4
Niitsu, Y.5
Takayama, T.6
Von Hoff, D.D.7
Izbicka, E.8
Mangold, G.9
Paul, C.10
Broberg, U.11
Mannervik, B.12
David, H.W.13
Kauvar, L.M.14
-
97
-
-
2542517093
-
Phase 1 study of TLK286 (telcyta) administered weekly in advanced malignancies
-
DOI 10.1158/1078-0432.CCR-03-0687
-
Rosen LS, Laxa B, Boulos L, Wiggins L, Keck JG, Jameson AJ, Parra R, Patel K, Brown GL. Phase 1 study of TLK286 (Telcyta) administered weekly in advanced malignancies. Clin Cancer Res 10: 3689-3698, 2004. (Pubitemid 38697602)
-
(2004)
Clinical Cancer Research
, vol.10
, Issue.11
, pp. 3689-3698
-
-
Rosen, L.S.1
Laxa, B.2
Boulos, L.3
Wiggins, L.4
Keck, J.G.5
Jameson, A.J.6
Parra, R.7
Patel, K.8
Brown, G.L.9
-
98
-
-
22544443334
-
Multi-institutional phase 2 study of TLK286 (TELCYTA, a glutathione S-transferase P1-1 activated glutathione analog prodrug) in patients with platinum and paclitaxel refractory or resistant ovarian cancer
-
DOI 10.1111/j.1525-1438.2005.00114.x
-
Kavanagh JJ, Gershenson DM, Choi H, Lewis L, Patel K, Brown GL, Garcia A, Spriggs DR. Multi-institutional phase 2 study of TLK286 (TELCYTA, a glutathione S-transferase P1-1 activated glutathione analog prodrug) in patients with platinum and paclitaxel refractory or resistant ovarian cancer. Int J Gynecol Cancer 15: 593-600, 2005. (Pubitemid 41022895)
-
(2005)
International Journal of Gynecological Cancer
, vol.15
, Issue.4
, pp. 593-600
-
-
Kavanagh, J.J.1
Gershenson, D.M.2
Choi, H.3
Lewis, L.4
Patel, K.5
Brown, G.L.6
Garcia, A.7
Spriggs, D.R.8
-
99
-
-
48249115538
-
NOV-002, a mimetic of glutathione disulfide
-
Townsend DM, Pazoles CJ, Tew KD. NOV-002, a mimetic of glutathione disulfide. Expert Opin Invest Drugs 17: 1075-1083, 2008.
-
(2008)
Expert Opin Invest Drugs
, vol.17
, pp. 1075-1083
-
-
Townsend, D.M.1
Pazoles, C.J.2
Tew, K.D.3
-
101
-
-
79961174087
-
NOV-002 suppresses tumor cell growth by modulating redox-sensitive cell signaling
-
Abstract C301
-
Townsend DM, Bowers R, Pazoles CJ, et al. NOV-002 suppresses tumor cell growth by modulating redox-sensitive cell signaling (2009). Mol Cancer Ther 8 (12 Suppl. 1): Abstract C301.
-
(2009)
Mol Cancer Ther
, vol.8
, Issue.12 SUPPL. 1
-
-
Townsend, D.M.1
Bowers, R.2
Pazoles, C.J.3
-
102
-
-
67649399006
-
NOV-002, a chemoprotectant/immunomodulator, added to first-line carboplatin/paclitaxel in advanced non-small cell lung cancer (NSCLC): A randomized phase 1/2, open-label, controlled study
-
[abstract 17021]
-
Pazoles CJ, Gerstein H. NOV-002, a chemoprotectant/immunomodulator, added to first-line carboplatin/paclitaxel in advanced non-small cell lung cancer (NSCLC): a randomized phase 1/2, open-label, controlled study [abstract 17021]. J Clin Oncol 24 18S Pt 1 (Jun 20 Suppl.): 668s, 2006.
-
(2006)
J Clin Oncol
, vol.24
, Issue.18 S PART 1 JUN 20 SUPPL.
-
-
Pazoles, C.J.1
Gerstein, H.2
-
103
-
-
84860646794
-
Phase 2 study of neoadjuvant treatment with cellular redox modulator NOV-002 in combination with doxorubicin and cyclophosphamide followed by docetaxel (AC T) in patients with stage II-III HER-2(-) breast cancer
-
[abstract P1-11-05]
-
Montero AJ, Diaz-Montero CM, Slingerland J, et al. Phase 2 study of neoadjuvant treatment with cellular redox modulator NOV-002 in combination with doxorubicin and cyclophosphamide followed by docetaxel (AC T) in patients with stage II-III HER-2(-) breast cancer [abstract P1-11-05]. 33rd Annual Breast Cancer Symposium; 2010 Dec 8-12; San Antonio (TX) USA.
-
33rd Annual Breast Cancer Symposium; 2010 Dec 8-12; San Antonio (TX) USA
-
-
Montero, A.J.1
Diaz-Montero, C.M.2
Slingerland, J.3
-
104
-
-
79961199877
-
NOV-002 plus carboplatin in platinum-resistant ovarian cancer
-
[abstract no. 5593] May 20
-
Krasner CN, Seiden MV, Penson RT et al. NOV-002 plus carboplatin in platinum-resistant ovarian cancer [abstract no. 5593]. J Clin Oncol 26 (May 20 Suppl.): 315s, 2008.
-
(2008)
J Clin Oncol
, vol.26
, Issue.SUPPL.
-
-
Krasner, C.N.1
Seiden, M.V.2
Penson, R.T.3
-
105
-
-
79951688311
-
Targeting malignancies with disulfiram (antabuse): Multidrug resistance, angiogenesis, and proteasome
-
Cvek B. Targeting malignancies with disulfiram (antabuse): multidrug resistance, angiogenesis, and proteasome. Curr Cancer Drug Targets 11: 332-337, 2011.
-
(2011)
Curr Cancer Drug Targets
, vol.11
, pp. 332-337
-
-
Cvek, B.1
-
106
-
-
11144224746
-
Disulfiram facilitates intracellular Cu uptake and induces apoptosis in human melanoma cells
-
DOI 10.1021/jm049568z
-
Cen D, Brayton D, Shahandeh B, Meyskens FL Jr, Farmer PJ. Disulfiram facilitates intracellular Cu uptake and induces apoptosis in human melanoma cells. J Med Chem 47: 6914-6920, 2004. (Pubitemid 40053779)
-
(2004)
Journal of Medicinal Chemistry
, vol.47
, Issue.27
, pp. 6914-6920
-
-
Cen, D.1
Brayton, D.2
Shahandeh, B.3
Meyskens Jr., F.L.4
Farmer, P.J.5
-
107
-
-
84860616155
-
-
University of California. [ClinicalTrials.gov identifier: NCT00256230]. US National Institutes of Health (USA). Available from
-
University of California. Disulfiram in metastatic melanoma [ClinicalTrials.gov identifier: NCT00256230]. US National Institutes of Health (USA). Available from URL: http://www.clinicaltrials.gov.
-
Disulfiram in Metastatic Melanoma
-
-
-
110
-
-
7444234246
-
Ethacrynic-acid-induced glutathione depletion and oxidative stress in normal and Mrp2-deficient rat liver
-
DOI 10.1016/j.freeradbiomed.2004.08.020, PII S0891584904006811
-
Ji B, Ito K, Sekine S, Tajima A, Horie T. Ethacrynic-acid-induced glutathione depletion and oxidative stress in normal and Mrp2-deficient rat liver. Free Rad Biol Med 37: 1718-1729, 2004. (Pubitemid 39441056)
-
(2004)
Free Radical Biology and Medicine
, vol.37
, Issue.11
, pp. 1718-1729
-
-
Ji, B.1
Ito, K.2
Sekine, S.3
Tajima, A.4
Horie, T.5
-
111
-
-
33745736603
-
Multidrug resistance: Retrospect and prospects in anti-cancer drug treatment
-
Perez-Tomas R. Multidrug resistance: retrospect and prospects in anti-cancer drug treatment. Curr Med Chem 13: 1859-1876, 2006.
-
(2006)
Curr Med Chem
, vol.13
, pp. 1859-1876
-
-
Perez-Tomas, R.1
-
112
-
-
0017865443
-
Inactivation of glutathione reductase by 2-chloroethyl nitrosourea-derivatised isocyanates
-
Barbson JR, Reed DJ. Inactivation of glutathione reductase by 2-chloroethyl nitrosourea-derivatised isocyanates. Biochem Biophys Res Comm 83: 745-762, 1978.
-
(1978)
Biochem Biophys Res Comm
, vol.83
, pp. 745-762
-
-
Barbson, J.R.1
Reed, D.J.2
|