-
1
-
-
79952284127
-
Hallmarks of cancer: The next generation
-
Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 144(5), 646-674 (2011).
-
(2011)
Cell
, vol.144
, Issue.5
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
2
-
-
79953151458
-
Cancer immunoediting: Integrating immunity's roles in cancer suppression and promotion
-
Schreiber RD, Old LJ, Smyth MJ. Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion. Science 331(6024), 1565-1570 (2011).
-
(2011)
Science
, vol.331
, Issue.6024
, pp. 1565-1570
-
-
Schreiber, R.D.1
Old, L.J.2
Smyth, M.J.3
-
3
-
-
84960949820
-
Cancer: A biological approach III. Viruses associated with neoplastic conditions. IV. Practical applications
-
Burnet M. Cancer: a biological approach. III. Viruses associated with neoplastic conditions. IV. Practical applications. Br. Med. J. 1(5023), 841-847 (1957).
-
(1957)
Br. Med. J
, vol.1
, Issue.5023
, pp. 841-847
-
-
Burnet, M.1
-
4
-
-
22144465860
-
A critical function for type i interferons in cancer immunoediting
-
Dunn GP, Bruce AT, Sheehan KC et al. A critical function for type I interferons in cancer immunoediting. Nat. Immunol. 6(7), 722-729 (2005).
-
(2005)
Nat. Immunol
, vol.6
, Issue.7
, pp. 722-729
-
-
Dunn, G.P.1
Bruce, A.T.2
Sheehan, K.C.3
-
5
-
-
33749319703
-
Type, density, and location of immune cells within human colorectal tumors predict clinical outcome
-
Galon J, Costes A, Sanchez-Cabo F et al. Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science 313(5795), 1960-1964 (2006).
-
(2006)
Science
, vol.313
, Issue.5795
, pp. 1960-1964
-
-
Galon, J.1
Costes, A.2
Sanchez-Cabo, F.3
-
6
-
-
29144514645
-
Effector memory T cells, early metastasis, and survival in colorectal cancer
-
Pages F, Berger A, Camus M et al. Effector memory T cells, early metastasis, and survival in colorectal cancer. N. Engl. J. Med. 353(25), 2654-2666 (2005).
-
(2005)
N. Engl. J. Med
, vol.353
, Issue.25
, pp. 2654-2666
-
-
Pages, F.1
Berger, A.2
Camus, M.3
-
7
-
-
84898948823
-
Emerging immunologic biomarkers: Setting the (TNM-immune) stage
-
Taube JM. Emerging immunologic biomarkers: setting the (TNM-immune) stage. Clin. Cancer Res. 20(8), 2023-2025 (2014).
-
(2014)
Clin. Cancer Res
, vol.20
, Issue.8
, pp. 2023-2025
-
-
Taube, J.M.1
-
8
-
-
44349150012
-
Inhibitory B7-family molecules in the tumour microenvironment
-
Zou W, Chen L. Inhibitory B7-family molecules in the tumour microenvironment. Nat. Rev. Immunol. 8(6), 467-477 (2008).
-
(2008)
Nat. Rev. Immunol
, vol.8
, Issue.6
, pp. 467-477
-
-
Zou, W.1
Chen, L.2
-
9
-
-
0025322552
-
T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1
-
Linsley PS, Clark EA, Ledbetter JA. T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1. Proc. Natl Acad. Sci. USA 87(13), 5031-5035 (1990).
-
(1990)
Proc. Natl Acad. Sci. USA
, vol.87
, Issue.13
, pp. 5031-5035
-
-
Linsley, P.S.1
Clark, E.A.2
Ledbetter, J.A.3
-
10
-
-
0029120245
-
CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation
-
Krummel MF, Allison JP. CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J. Exp. Med. 182(2), 459-465 (1995).
-
(1995)
J. Exp. Med
, vol.182
, Issue.2
, pp. 459-465
-
-
Krummel, M.F.1
Allison, J.P.2
-
11
-
-
0028484545
-
CTLA-4 can function as a negative regulator of T cell activation
-
Walunas TL, Lenschow DJ, Bakker CY et al. CTLA-4 can function as a negative regulator of T cell activation. Immunity 1(5), 405-413 (1994).
-
(1994)
Immunity
, vol.1
, Issue.5
, pp. 405-413
-
-
Walunas, T.L.1
Lenschow, D.J.2
Bakker, C.Y.3
-
12
-
-
34848831575
-
The B7 family and cancer therapy: Costimulation and coinhibition
-
Zang X, Allison JP. The B7 family and cancer therapy: costimulation and coinhibition. Clin. Cancer Res. 13(18 Pt 1), 5271-5279 (2007).
-
(2007)
Clin. Cancer Res
, vol.13
, Issue.18
, pp. 5271-5279
-
-
Zang, X.1
Allison, J.P.2
-
13
-
-
0029947568
-
Enhancement of antitumor immunity by CTLA-4 blockade
-
Leach DR, Krummel MF, Allison JP. Enhancement of antitumor immunity by CTLA-4 blockade. Science 271(5256), 1734-1736 (1996).
-
(1996)
Science
, vol.271
, Issue.5256
, pp. 1734-1736
-
-
Leach, D.R.1
Krummel, M.F.2
Allison, J.P.3
-
14
-
-
0033517152
-
Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colony-stimulating factor (GMCSF)-producing vaccines induces rejection of subcutaneous and metastatic tumors accompanied by autoimmune depigmentation
-
Van Elsas A, Hurwitz AA, Allison JP. Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colony-stimulating factor (GMCSF)-producing vaccines induces rejection of subcutaneous and metastatic tumors accompanied by autoimmune depigmentation. J. Exp. Med. 190(3), 355-366 (1999).
-
(1999)
J. Exp. Med
, vol.190
, Issue.3
, pp. 355-366
-
-
Van Elsas, A.1
Hurwitz, A.A.2
Allison, J.P.3
-
15
-
-
0033592924
-
Elimination of residual metastatic prostate cancer after surgery and adjunctive cytotoxic T lymphocyte-associated antigen 4 (CTLA-4 ) blockade immunotherapy
-
Kwon ED, Foster BA, Hurwitz AA et al. Elimination of residual metastatic prostate cancer after surgery and adjunctive cytotoxic T lymphocyte-associated antigen 4 (CTLA-4 ) blockade immunotherapy. Proc. Natl Acad. Sci. USA 96(26), 15074-15079 (1999).
-
(1999)
Proc. Natl Acad. Sci. USA
, vol.96
, Issue.26
, pp. 15074-15079
-
-
Kwon, E.D.1
Foster, B.A.2
Hurwitz, A.A.3
-
16
-
-
77954801079
-
Improved survival with ipilimumab in patients with metastatic melanoma
-
Hodi FS, O'day SJ, Mcdermott DF et al. Improved survival with ipilimumab in patients with metastatic melanoma. N. Engl. J. Med. 363(8), 711-723 (2010).
-
(2010)
N. Engl. J. Med
, vol.363
, Issue.8
, pp. 711-723
-
-
Hodi, F.S.1
O'Day, S.J.2
McDermott, D.F.3
-
17
-
-
0026700235
-
Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death
-
Ishida Y, Agata Y, Shibahara K, Honjo T. Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. EMBO J. 11(11), 3887-3895 (1992).
-
(1992)
EMBO J
, vol.11
, Issue.11
, pp. 3887-3895
-
-
Ishida, Y.1
Agata, Y.2
Shibahara, K.3
Honjo, T.4
-
18
-
-
0030005099
-
Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes
-
Agata Y, Kawasaki A, Nishimura H et al. Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes. Int. Immunol. 8(5), 765-772 (1996).
-
(1996)
Int. Immunol
, vol.8
, Issue.5
, pp. 765-772
-
-
Agata, Y.1
Kawasaki, A.2
Nishimura, H.3
-
19
-
-
77950525439
-
Programmed death-1-induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection
-
Said EA, Dupuy FP, Trautmann L et al. Programmed death-1-induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection. Nat. Med. 16(4), 452-459 (2010).
-
(2010)
Nat. Med
, vol.16
, Issue.4
, pp. 452-459
-
-
Said, E.A.1
Dupuy, F.P.2
Trautmann, L.3
-
20
-
-
0031685190
-
Immunological studies on PD-1 deficient mice: Implication of PD-1 as a negative regulator for B cell responses
-
Nishimura H, Minato N, Nakano T, Honjo T. Immunological studies on PD-1 deficient mice: implication of PD-1 as a negative regulator for B cell responses. Int. Immunol. 10(10), 1563-1572 (1998).
-
(1998)
Int. Immunol
, vol.10
, Issue.10
, pp. 1563-1572
-
-
Nishimura, H.1
Minato, N.2
Nakano, T.3
Honjo, T.4
-
21
-
-
32544459770
-
Restoring function in exhausted CD8 T cells during chronic viral infection
-
Barber DL, Wherry EJ, Masopust D et al. Restoring function in exhausted CD8 T cells during chronic viral infection. Nature 439(7077), 682-687 (2006).
-
(2006)
Nature
, vol.439
, Issue.7077
, pp. 682-687
-
-
Barber, D.L.1
Wherry, E.J.2
Masopust, D.3
-
22
-
-
81555226044
-
The PD-1/PD-L1 (B7-H1) pathway in chronic infection-induced cytotoxic T lymphocyte exhaustion
-
Hofmeyer KA, Jeon H, Zang X. The PD-1/PD-L1 (B7-H1) pathway in chronic infection-induced cytotoxic T lymphocyte exhaustion. J. Biomed. Biotechnol. 2011, 451694 (2011).
-
(2011)
J. Biomed. Biotechnol.
, vol.2011
, pp. 451694
-
-
Hofmeyer, K.A.1
Jeon, H.2
Zang, X.3
-
23
-
-
77953747963
-
The PD-1 pathway in tolerance and autoimmunity
-
Francisco LM, Sage PT, Sharpe AH. The PD-1 pathway in tolerance and autoimmunity. Immunol. Rev. 236, 219-242 (2010).
-
(2010)
Immunol. Rev
, vol.236
, pp. 219-242
-
-
Francisco, L.M.1
Sage, P.T.2
Sharpe, A.H.3
-
24
-
-
85045863267
-
A randomized controlled comparison of pembrolizumab and chemotherapy in patients with ipilimumab-refractory melanoma
-
Dummer R, Daud A, Puzanov I et al. A randomized controlled comparison of pembrolizumab and chemotherapy in patients with ipilimumab-refractory melanoma. J. Transl. Med. 13, 2062 (2015).
-
(2015)
J. Transl. Med
, vol.13
, pp. 2062
-
-
Dummer, R.1
Daud, A.2
Puzanov, I.3
-
25
-
-
84908354848
-
Anti-programmeddeath-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: A randomised dose-comparison cohort of a Phase 1 trial
-
Robert C, Ribas A, Wolchok JD et al. Anti-programmeddeath-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: a randomised dose-comparison cohort of a Phase 1 trial. Lancet 384(9948), 1109-1117 (2014).
-
(2014)
Lancet
, vol.384
, Issue.9948
, pp. 1109-1117
-
-
Robert, C.1
Ribas, A.2
Wolchok, J.D.3
-
26
-
-
77954899030
-
Phase i study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: Safety, clinical activity, pharmacodynamics, and immunologic correlates
-
Brahmer JR, Drake CG, Wollner I et al. Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates. J. Clin. Oncol. 28(19), 3167-3175 (2010).
-
(2010)
J. Clin. Oncol
, vol.28
, Issue.19
, pp. 3167-3175
-
-
Brahmer, J.R.1
Drake, C.G.2
Wollner, I.3
-
27
-
-
84862859820
-
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
-
Topalian SL, Hodi FS, Brahmer JR et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N. Engl. J. Med. 366(26), 2443-2454 (2012).
-
(2012)
N. Engl. J. Med
, vol.366
, Issue.26
, pp. 2443-2454
-
-
Topalian, S.L.1
Hodi, F.S.2
Brahmer, J.R.3
-
28
-
-
84879777241
-
Nivolumab plus ipilimumab in advanced melanoma
-
Wolchok JD, Kluger H, Callahan MK et al. Nivolumab plus ipilimumab in advanced melanoma. N. Engl. J. Med. 369(2), 122-133 (2013).
-
(2013)
N. Engl. J. Med
, vol.369
, Issue.2
, pp. 122-133
-
-
Wolchok, J.D.1
Kluger, H.2
Callahan, M.K.3
-
29
-
-
84925221855
-
PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma
-
Ansell SM, Lesokhin AM, Borrello I et al. PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma. N. Engl. J. Med. 372(4), 311-319 (2015).
-
(2015)
N. Engl. J. Med
, vol.372
, Issue.4
, pp. 311-319
-
-
Ansell, S.M.1
Lesokhin, A.M.2
Borrello, I.3
-
30
-
-
84948173672
-
Preliminary results of a phase i study of nivolumab (BMS-936558) in patients with relapsed or refractory lymphoid malignancies
-
Presented at: 56th ASH Annual Meeting and Exposition. CA, USA, 6-9 December 2014. 31 Weber JS, D'angelo SP, Minor D et al. Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, Phase 3 trial
-
Lesokhin AM, Ansell SM, Armand P et al. preliminary results of a phase i study of nivolumab (BMS-936558) in patients with relapsed or refractory lymphoid malignancies. Presented at: 56th ASH Annual Meeting and Exposition. CA, USA, 6-9 December 2014. 31 Weber JS, D'angelo SP, Minor D et al. Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, Phase 3 trial. Lancet Oncol. 16(4), 375-384 (2015).
-
(2015)
Lancet Oncol
, vol.16
, Issue.4
, pp. 375-384
-
-
Lesokhin, A.M.1
Ansell, S.M.2
Armand, P.3
-
31
-
-
85045862023
-
Nivolumab improved survival vs dacarbazine in patients with untreated advanced melanoma
-
Long GV, Atkinson V, Ascierto PA et al. Nivolumab improved survival vs dacarbazine in patients with untreated advanced melanoma. J. Transl. Med. 13, 2063 (2015).
-
(2015)
J. Transl. Med
, vol.13
, pp. 2063
-
-
Long, G.V.1
Atkinson, V.2
Ascierto, P.A.3
-
32
-
-
84936791837
-
Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer
-
Brahmer J, Reckamp KL, Baas P et al. Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer. N. Engl. J. Med. 373(2), 123-135 (2015).
-
(2015)
N. Engl. J. Med
, vol.373
, Issue.2
, pp. 123-135
-
-
Brahmer, J.1
Reckamp, K.L.2
Baas, P.3
-
33
-
-
84925529257
-
Human cancer immunotherapy with antibodies to the PD-1 and PD-L1 pathway
-
Ohaegbulam KC, Assal A, Lazar-Molnar E, Yao Y, Zang X. Human cancer immunotherapy with antibodies to the PD-1 and PD-L1 pathway. Trends Mol. Med. 21(1), 24-33 (2015).
-
(2015)
Trends Mol. Med
, vol.21
, Issue.1
, pp. 24-33
-
-
Ohaegbulam, K.C.1
Assal, A.2
Lazar-Molnar, E.3
Yao, Y.4
Zang, X.5
-
34
-
-
84948155687
-
Phase I, open-label study of MEDI0680, an anti-programmed cell death-1 (PD-1) antibody, in combination with MEDI4736, an anti-programmed cell death ligand-1 (PD-L1) antibody, in patients with advanced malignancies
-
Presented at IL, USA, 29 May-2 June
-
Hamid O, Chow LQM, Tavakkoli F et al. Phase I, open-label study of MEDI0680, an anti-programmed cell death-1 (PD-1) antibody, in combination with MEDI4736, an anti-programmed cell death ligand-1 (PD-L1) antibody, in patients with advanced malignancies. Presented at: 51st Annual Meeting of American Society of Clinical Oncology. IL, USA, 29 May-2 June 2015.
-
(2015)
51st Annual Meeting of American Society of Clinical Oncology
-
-
Hamid, O.1
Chow, L.Q.M.2
Tavakkoli, F.3
-
35
-
-
84948158374
-
A Phase I, multicenter, open-label, first-in-human study to evaluate MEDI0680, an anti-programmed cell death-1 antibody, in patients with advanced malignancies
-
Presented at IL, USA, 29 May-02 June
-
Infante JR, Goel S, Tavakkoli F et al. A Phase I, multicenter, open-label, first-in-human study to evaluate MEDI0680, an anti-programmed cell death-1 antibody, in patients with advanced malignancies. Presented at: 51st Annual Meeting of American Society of Clinical Oncology. IL, USA, 29 May-02 June 2015.
-
(2015)
51st Annual Meeting of American Society of Clinical Oncology
-
-
Infante, J.R.1
Goel, S.2
Tavakkoli, F.3
-
36
-
-
0032736029
-
B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion
-
Dong H, Zhu G, Tamada K, Chen L. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nat. Med. 5(12), 1365-1369 (1999).
-
(1999)
Nat. Med.
, vol.5
, Issue.12
, pp. 1365-1369
-
-
Dong, H.1
Zhu, G.2
Tamada, K.3
Chen, L.4
-
37
-
-
0034596948
-
Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
-
Freeman GJ, Long AJ, Iwai Y et al. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J. Exp. Med. 192(7), 1027-1034 (2000).
-
(2000)
J. Exp. Med
, vol.192
, Issue.7
, pp. 1027-1034
-
-
Freeman, G.J.1
Long, A.J.2
Iwai, Y.3
-
38
-
-
34347371572
-
Interaction between B7-H1 and PD-1 determines initiation and reversal of T-cell anergy
-
Tsushima F, Yao S, Shin T et al. Interaction between B7-H1 and PD-1 determines initiation and reversal of T-cell anergy. Blood 110(1), 180-185 (2007).
-
(2007)
Blood
, vol.110
, Issue.1
, pp. 180-185
-
-
Tsushima, F.1
Yao, S.2
Shin, T.3
-
39
-
-
43549115533
-
B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells
-
Azuma T, Yao S, Zhu G, Flies AS, Flies SJ, Chen L. B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells. Blood 111(7), 3635-3643 (2008).
-
(2008)
Blood
, vol.111
, Issue.7
, pp. 3635-3643
-
-
Azuma, T.1
Yao, S.2
Zhu, G.3
Flies, A.S.4
Flies, S.J.5
Chen, L.6
-
40
-
-
34447646310
-
Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses
-
Butte MJ, Keir ME, Phamduy TB, Sharpe AH, Freeman GJ. Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses. Immunity 27(1), 111-122 (2007).
-
(2007)
Immunity
, vol.27
, Issue.1
, pp. 111-122
-
-
Butte, M.J.1
Keir, M.E.2
Phamduy, T.B.3
Sharpe, A.H.4
Freeman, G.J.5
-
41
-
-
77956496386
-
B7-H1/CD80 interaction is required for the induction and maintenance of peripheral T-cell tolerance
-
Park JJ, Omiya R, Matsumura Y et al. B7-H1/CD80 interaction is required for the induction and maintenance of peripheral T-cell tolerance. Blood 116(8), 1291-1298 (2010).
-
(2010)
Blood
, vol.116
, Issue.8
, pp. 1291-1298
-
-
Park, J.J.1
Omiya, R.2
Matsumura, Y.3
-
42
-
-
5844264920
-
PD-L2 is a second ligand for PD-1 and inhibits T cell activation
-
Latchman Y, Wood CR, Chernova T et al. PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat. Immunol. 2(3), 261-268 (2001).
-
(2001)
Nat. Immunol
, vol.2
, Issue.3
, pp. 261-268
-
-
Latchman, Y.1
Wood, C.R.2
Chernova, T.3
-
43
-
-
0035794314
-
B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells
-
Tseng SY, Otsuji M, Gorski K et al. B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells. J. Exp. Med. 193(7), 839-846 (2001).
-
(2001)
J. Exp. Med
, vol.193
, Issue.7
, pp. 839-846
-
-
Tseng, S.Y.1
Otsuji, M.2
Gorski, K.3
-
44
-
-
0037111483
-
Expression of programmed death 1 ligands by murine T cells and APC
-
Yamazaki T, Akiba H, Iwai H et al. Expression of programmed death 1 ligands by murine T cells and APC. J. Immunol. 169(10), 5538-5545 (2002).
-
(2002)
J. Immunol
, vol.169
, Issue.10
, pp. 5538-5545
-
-
Yamazaki, T.1
Akiba, H.2
Iwai, H.3
-
45
-
-
84899758346
-
RGMb is a novel binding partner for PD-L2 and its engagement with PD-L2 promotes respiratory tolerance
-
Xiao Y, Yu S, Zhu B et al. RGMb is a novel binding partner for PD-L2 and its engagement with PD-L2 promotes respiratory tolerance. J. Exp. Med. 211(5), 943-959 (2014).
-
(2014)
J. Exp. Med
, vol.211
, Issue.5
, pp. 943-959
-
-
Xiao, Y.1
Yu, S.2
Zhu, B.3
-
46
-
-
84862903106
-
Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
-
Brahmer JR, Tykodi SS, Chow LQ et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N. Engl. J. Med. 366(26), 2455-2465 (2012).
-
(2012)
N. Engl. J. Med
, vol.366
, Issue.26
, pp. 2455-2465
-
-
Brahmer, J.R.1
Tykodi, S.S.2
Chow, L.Q.3
-
47
-
-
79952713568
-
6th Annual European Antibody Congress 2010: 29 November-1 December 2010
-
Beck A, Wurch T, Reichert JM. 6th Annual European Antibody Congress 2010: 29 November-1 December 2010, Geneva, Switzerland. mAbs 3(2), 111-132 (2011).
-
(2011)
Geneva, Switzerland. MAbs
, vol.3
, Issue.2
, pp. 111-132
-
-
Beck, A.1
Wurch, T.2
Reichert, J.M.3
-
48
-
-
84922634440
-
A Phase 1 study to evaluate the safety and tolerability of MEDI4736, an anti-PD-L1 antibody, in combination with tremelimumab in patients with advanced solid tumors
-
Presented at IL, USA, 30 May-03 June
-
Callahan MK, Ott PA, Odunsi K et al. A Phase 1 study to evaluate the safety and tolerability of MEDI4736, an anti-PD-L1 antibody, in combination with tremelimumab in patients with advanced solid tumors. Presented at: 50th Annual Meeting of American Society of Clinical Oncology. IL, USA, 30 May-03 June 2014.
-
(2014)
50th Annual Meeting of American Society of Clinical Oncology
-
-
Callahan, M.K.1
Ott, P.A.2
Odunsi, K.3
-
49
-
-
84905698694
-
Inhibition of PD-L1 by MPDL3280A and clinical activity in pts with metastatic urothelial bladder cancer (UBC)
-
Presented at IL, USA, 30 May-03 June
-
Powles T, Vogelzang NJ, Fine GD et al. Inhibition of PD-L1 by MPDL3280A and clinical activity in pts with metastatic urothelial bladder cancer (UBC). Presented at: 50th Annual Meeting of American Society of Clinical Oncology. IL, USA, 30 May-03 June 2014.
-
(2014)
50th Annual Meeting of American Society of Clinical Oncology
-
-
Powles, T.1
Vogelzang, N.J.2
Fine, G.D.3
-
50
-
-
84912134974
-
Phase i open-label, multiple ascending dose trial of MSB0010718C, an anti-PD-L1 monoclonal antibody, in advanced solid malignancies
-
Presented at IL, USA, 30 May-03 June
-
Heery CR, O'sullivan Coyne GH, Madan RA et al. Phase I open-label, multiple ascending dose trial of MSB0010718C, an anti-PD-L1 monoclonal antibody, in advanced solid malignancies. Presented at: 50th Annual Meeting of American Society of Clinical Oncology. IL, USA, 30 May-03 June 2014.
-
(2014)
50th Annual Meeting of American Society of Clinical Oncology
-
-
Heery, C.R.1
O'Sullivan Coyne, G.H.2
Madan, R.A.3
-
51
-
-
84948177530
-
Antibody dependent cellular cytotoxicity activity of a novel anti-PD-L1 antibody, avelumab (MSB0010718C), on human tumor cells
-
Presented at IL, USA, 29 May-2 June
-
Tsang K-Y, Boyerinas B, Jochems C et al. Antibody dependent cellular cytotoxicity activity of a novel anti-PD-L1 antibody, avelumab (MSB0010718C), on human tumor cells. Presented at: 51st Annual Meeting of American Society of Clinical Oncology. IL, USA, 29 May-2 June 2015.
-
(2015)
51st Annual Meeting of American Society of Clinical Oncology
-
-
Tsang, K.-Y.1
Boyerinas, B.2
Jochems, C.3
-
52
-
-
0042337394
-
B7x: A widely expressed B7 family member that inhibits T cell activation
-
Zang X, Loke P, Kim J, Murphy K, Waitz R, Allison JP. B7x: a widely expressed B7 family member that inhibits T cell activation. Proc. Natl Acad. Sci. USA 100(18), 10388-10392 (2003).
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, Issue.18
, pp. 10388-10392
-
-
Zang, X.1
Loke, P.2
Kim, J.3
Murphy, K.4
Waitz, R.5
Allison, J.P.6
-
53
-
-
0038094524
-
B7-H4, a molecule of the B7 family, negatively regulates T cell immunity
-
Sica GL, Choi IH, Zhu G et al. B7-H4, a molecule of the B7 family, negatively regulates T cell immunity. Immunity 18(6), 849-861 (2003).
-
(2003)
Immunity
, vol.18
, Issue.6
, pp. 849-861
-
-
Sica, G.L.1
Choi, I.H.2
Zhu, G.3
-
54
-
-
0038433329
-
B7S1, a novel B7 family member that negatively regulates T cell activation
-
Prasad DV, Richards S, Mai XM, Dong C. B7S1, a novel B7 family member that negatively regulates T cell activation. Immunity 18(6), 863-873 (2003).
-
(2003)
Immunity
, vol.18
, Issue.6
, pp. 863-873
-
-
Prasad, D.V.1
Richards, S.2
Mai, X.M.3
Dong, C.4
-
55
-
-
84866166646
-
Tissue-expressed B7x affects the immune response to and outcome of lethal pulmonary infection
-
Hofmeyer KA, Scandiuzzi L, Ghosh K, Pirofski LA, Zang X. Tissue-expressed B7x affects the immune response to and outcome of lethal pulmonary infection. J. Immunol. 189(6), 3054-3063 (2012).
-
(2012)
J. Immunol
, vol.189
, Issue.6
, pp. 3054-3063
-
-
Hofmeyer, K.A.1
Scandiuzzi, L.2
Ghosh, K.3
Pirofski, L.A.4
Zang, X.5
-
56
-
-
84867321651
-
B7x in the periphery abrogates pancreas-specific damage mediated by self-reactive CD8 T cells
-
Lee JS, Scandiuzzi L, Ray A et al. B7x in the periphery abrogates pancreas-specific damage mediated by self-reactive CD8 T cells. J. Immunol. 189(8), 4165-4174 (2012).
-
(2012)
J. Immunol
, vol.189
, Issue.8
, pp. 4165-4174
-
-
Lee, J.S.1
Scandiuzzi, L.2
Ray, A.3
-
57
-
-
79961147546
-
Tissue-specific expression of B7x protects from CD4 T cell-mediated autoimmunity
-
Wei J, Loke P, Zang X, Allison JP. Tissue-specific expression of B7x protects from CD4 T cell-mediated autoimmunity. J. Exp. Med. 208(8), 1683-1694 (2011).
-
(2011)
J. Exp. Med
, vol.208
, Issue.8
, pp. 1683-1694
-
-
Wei, J.1
Loke, P.2
Zang, X.3
Allison, J.P.4
-
58
-
-
84886944592
-
B7x and myeloid-derived suppressor cells in the tumor microenvironment: A tale of two cities
-
Jeon H, Ohaegbulam KC, Abadi YM, Zang X. B7x and myeloid-derived suppressor cells in the tumor microenvironment: a tale of two cities. Oncoimmunology 2(7), e24744 (2013).
-
(2013)
Oncoimmunology
, vol.2
, Issue.7
, pp. e24744
-
-
Jeon, H.1
Ohaegbulam, K.C.2
Abadi, Y.M.3
Zang, X.4
-
59
-
-
37649013179
-
B7-H3 and B7x are highly expressed in human prostate cancer and associated with disease spread and poor outcome
-
Zang X, Thompson RH, Al-Ahmadie HA et al. B7-H3 and B7x are highly expressed in human prostate cancer and associated with disease spread and poor outcome. Proc. Natl Acad. Sci. USA 104(49), 19458-19463 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, Issue.49
, pp. 19458-19463
-
-
Zang, X.1
Thompson, R.H.2
Al-Ahmadie, H.A.3
-
60
-
-
33745886516
-
B7-H4 expression in renal cell carcinoma and tumor vasculature: Associations with cancer progression and survival
-
Krambeck AE, Thompson RH, Dong H et al. B7-H4 expression in renal cell carcinoma and tumor vasculature: associations with cancer progression and survival. Proc. Natl Acad. Sci. USA 103(27), 10391-10396 (2006).
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, Issue.27
, pp. 10391-10396
-
-
Krambeck, A.E.1
Thompson, R.H.2
Dong, H.3
-
61
-
-
77958067744
-
Tumor expression of B7-H4 predicts poor survival of patients suffering from gastric cancer
-
Jiang J, Zhu Y, Wu C et al. Tumor expression of B7-H4 predicts poor survival of patients suffering from gastric cancer. Cancer Immunol. Immunother. 59(11), 1707-1714 (2010).
-
(2010)
Cancer Immunol. Immunother
, vol.59
, Issue.11
, pp. 1707-1714
-
-
Jiang, J.1
Zhu, Y.2
Wu, C.3
-
62
-
-
33745605153
-
B7-H3 and B7-H4 expression in non-small-cell lung cancer
-
Sun Y, Wang Y, Zhao J et al. B7-H3 and B7-H4 expression in non-small-cell lung cancer. Lung Cancer 53(2), 143-151 (2006).
-
(2006)
Lung Cancer
, vol.53
, Issue.2
, pp. 143-151
-
-
Sun, Y.1
Wang, Y.2
Zhao, J.3
-
63
-
-
34250183451
-
B7-H4 (DDO110) is overexpressed in high risk uterine endometrioid adenocarcinomas and inversely correlated with tumor T-cell infiltration
-
Miyatake T, Tringler B, Liu W et al. B7-H4 (DDO110) is overexpressed in high risk uterine endometrioid adenocarcinomas and inversely correlated with tumor T-cell infiltration. Gynecol Oncol. 106(1), 119-127 (2007).
-
(2007)
Gynecol Oncol
, vol.106
, Issue.1
, pp. 119-127
-
-
Miyatake, T.1
Tringler, B.2
Liu, W.3
-
64
-
-
84919775114
-
Structure and cancer immunotherapy of the B7 family member B7x
-
Jeon H, Vigdorovich V, Garrett-Thomson SC et al. Structure and cancer immunotherapy of the B7 family member B7x. Cell Rep. 9(3), 1089-1098 (2014).
-
(2014)
Cell Rep
, vol.9
, Issue.3
, pp. 1089-1098
-
-
Jeon, H.1
Vigdorovich, V.2
Garrett-Thomson, S.C.3
-
65
-
-
84878990597
-
HHLA2 is a member of the B7 family and inhibits human CD4 and CD8 T-cell function
-
Zhao R, Chinai JM, Buhl S et al. HHLA2 is a member of the B7 family and inhibits human CD4 and CD8 T-cell function. Proc. Natl Acad. Sci. USA 110(24), 9879-9884 (2013).
-
(2013)
Proc. Natl Acad. Sci. USA
, vol.110
, Issue.24
, pp. 9879-9884
-
-
Zhao, R.1
Chinai, J.M.2
Buhl, S.3
-
66
-
-
84879668353
-
B7-H5 costimulates human T cells via CD28H
-
Zhu Y, Yao S, Iliopoulou BP et al. B7-H5 costimulates human T cells via CD28H. Nat. Commun. 4, 2043 (2013).
-
(2013)
Nat. Commun
, vol.4
, pp. 2043
-
-
Zhu, Y.1
Yao, S.2
Iliopoulou, B.P.3
-
67
-
-
84938317531
-
Expression, clinical significance, and receptor identification of the newest B7 family member HHLA2 protein
-
Janakiram M, Chinai JM, Fineberg S et al. Expression, clinical significance, and receptor identification of the newest B7 family member HHLA2 protein. Clin. Cancer Res. 21(10), 2359-2366 (2015).
-
(2015)
Clin. Cancer Res
, vol.21
, Issue.10
, pp. 2359-2366
-
-
Janakiram, M.1
Chinai, J.M.2
Fineberg, S.3
-
68
-
-
5844252552
-
B7-H3: A costimulatory molecule for T cell activation and IFN-gamma production
-
Chapoval AI, Ni J, Lau JS et al. B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production. Nat. Immunol. 2(3), 269-274 (2001).
-
(2001)
Nat. Immunol.
, vol.2
, Issue.3
, pp. 269-274
-
-
Chapoval, A.I.1
Ni, J.2
Lau, J.S.3
-
69
-
-
0041381300
-
The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses
-
Suh WK, Gajewska BU, Okada H et al. The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses. Nat. Immunol. 4(9), 899-906 (2003).
-
(2003)
Nat. Immunol
, vol.4
, Issue.9
, pp. 899-906
-
-
Suh, W.K.1
Gajewska, B.U.2
Okada, H.3
-
70
-
-
78650151049
-
B7-H3 ligand expression by primary breast cancer and associated with regional nodal metastasis
-
Arigami T, Narita N, Mizuno R et al. B7-H3 ligand expression by primary breast cancer and associated with regional nodal metastasis. Ann. Surg. 252(6), 1044-1051 (2010).
-
(2010)
Ann. Surg
, vol.252
, Issue.6
, pp. 1044-1051
-
-
Arigami, T.1
Narita, N.2
Mizuno, R.3
-
72
-
-
84979860701
-
B7-H3 expression in donor T cells and host cells negatively regulates acute graft-versus-host disease lethality
-
Veenstra RG, Flynn R, Kreymborg K et al. B7-H3 expression in donor T cells and host cells negatively regulates acute graft-versus-host disease lethality. Blood 125(21), 3335-3346 (2015).
-
(2015)
Blood
, vol.125
, Issue.21
, pp. 3335-3346
-
-
Veenstra, R.G.1
Flynn, R.2
Kreymborg, K.3
-
73
-
-
84892544676
-
Association of T-cell co-regulatory protein expression with clinical outcomes following radical cystectomy for urothelial carcinoma of the bladder
-
Xylinas E, Robinson BD, Kluth LA et al. Association of T-cell co-regulatory protein expression with clinical outcomes following radical cystectomy for urothelial carcinoma of the bladder. Eur. J. Surg. Oncol. 40(1), 121-127 (2014).
-
(2014)
Eur. J. Surg. Oncol
, vol.40
, Issue.1
, pp. 121-127
-
-
Xylinas, E.1
Robinson, B.D.2
Kluth, L.A.3
-
74
-
-
77955172320
-
Tumor associated endothelial expression of B7-H3 predicts survival in ovarian carcinomas
-
Zang X, Sullivan PS, Soslow RA et al. Tumor associated endothelial expression of B7-H3 predicts survival in ovarian carcinomas. Mod. Pathol. 23(8), 1104-1112 (2010).
-
(2010)
Mod. Pathol
, vol.23
, Issue.8
, pp. 1104-1112
-
-
Zang, X.1
Sullivan, P.S.2
Soslow, R.A.3
-
75
-
-
79952717517
-
VISTA, a novel mouse Ig superfamily ligand that negatively regulates T cell responses
-
Wang L, Rubinstein R, Lines JL et al. VISTA, a novel mouse Ig superfamily ligand that negatively regulates T cell responses. J. Exp. Med. 208(3), 577-592 (2011).
-
(2011)
J. Exp. Med
, vol.208
, Issue.3
, pp. 577-592
-
-
Wang, L.1
Rubinstein, R.2
Lines, J.L.3
-
76
-
-
84897445677
-
VISTA is an immune checkpoint molecule for human T cells
-
Lines JL, Pantazi E, Mak J et al. VISTA is an immune checkpoint molecule for human T cells. Cancer Res. 74(7), 1924-1932 (2014).
-
(2014)
Cancer Res
, vol.74
, Issue.7
, pp. 1924-1932
-
-
Lines, J.L.1
Pantazi, E.2
Mak, J.3
-
77
-
-
84897429090
-
VISTA Regulates the development of protective antitumor immunity
-
Le Mercier I, Chen W, Lines JL et al. VISTA Regulates the development of protective antitumor immunity. Cancer Res. 74(7), 1933-1944 (2014).
-
(2014)
Cancer Res
, vol.74
, Issue.7
, pp. 1933-1944
-
-
Le Mercier, I.1
Chen, W.2
Lines, J.L.3
-
78
-
-
79951822440
-
Role of CD27/CD70 pathway of activation in immunity and tolerance
-
Denoeud J, Moser M. Role of CD27/CD70 pathway of activation in immunity and tolerance. J. Leukoc. Biol. 89(2), 195-203 (2011).
-
(2011)
J. Leukoc. Biol
, vol.89
, Issue.2
, pp. 195-203
-
-
Denoeud, J.1
Moser, M.2
-
79
-
-
34249722182
-
Eradication of lymphoma by CD8 T cells following anti-CD40 monoclonal antibody therapy is critically dependent on CD27 costimulation
-
French RR, Taraban VY, Crowther GR et al. Eradication of lymphoma by CD8 T cells following anti-CD40 monoclonal antibody therapy is critically dependent on CD27 costimulation. Blood 109(11), 4810-4815 (2007).
-
(2007)
Blood
, vol.109
, Issue.11
, pp. 4810-4815
-
-
French, R.R.1
Taraban, V.Y.2
Crowther, G.R.3
-
80
-
-
84863918915
-
Development of a human monoclonal antibody for potential therapy of CD27-expressing lymphoma and leukemia
-
Vitale LA, He LZ, Thomas LJ et al. Development of a human monoclonal antibody for potential therapy of CD27-expressing lymphoma and leukemia. Clin. Cancer Res. 18(14), 3812-3821 (2012).
-
(2012)
Clin. Cancer Res
, vol.18
, Issue.14
, pp. 3812-3821
-
-
Vitale, L.A.1
He, L.Z.2
Thomas, L.J.3
-
81
-
-
84930944503
-
A Phase i study of an agonist anti-CD27 human antibody (CDX-1127) patients with advanced hematologic malignancies or solid tumors
-
Ansell S, Northfelt D, Flinn I et al. A Phase I study of an agonist anti-CD27 human antibody (CDX-1127) in patients with advanced hematologic malignancies or solid tumors. J. Immunother. Cancer 1(Suppl. 1), P259-P259 (2013).
-
(2013)
J. Immunother. Cancer
, vol.1
, pp. P259-P259
-
-
Ansell, S.1
Northfelt, D.2
Flinn, I.3
-
82
-
-
65349112520
-
The significance of OX40 and OX40L to T-cell biology and immune disease
-
Croft M, So T, Duan W, Soroosh P. The significance of OX40 and OX40L to T-cell biology and immune disease. Immunol. Rev. 229(1), 173-191 (2009).
-
(2009)
Immunol. Rev
, vol.229
, Issue.1
, pp. 173-191
-
-
Croft, M.1
So, T.2
Duan, W.3
Soroosh, P.4
-
83
-
-
84923537886
-
OX40 Agonists and combination immunotherapy: Putting the pedal to the metal
-
Linch SN, Mcnamara MJ, Redmond WL. OX40 Agonists and combination immunotherapy: putting the pedal to the metal. Front Oncol. 5, 34 (2015).
-
(2015)
Front Oncol
, vol.5
, pp. 34
-
-
Linch, S.N.1
Mcnamara, M.J.2
Redmond, W.L.3
-
84
-
-
42249097689
-
OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection
-
Piconese S, Valzasina B, Colombo MP. OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection. J. Exp. Med. 205(4), 825-839 (2008).
-
(2008)
J. Exp. Med
, vol.205
, Issue.4
, pp. 825-839
-
-
Piconese, S.1
Valzasina, B.2
Colombo, M.P.3
-
85
-
-
84891275907
-
OX40 is a potent immune-stimulating target in late-stage cancer patients
-
National Institues of Health
-
National Institues of Health. www.clinicaltrials.gov 87 Curti BD, Kovacsovics-Bankowski M, Morris N et al. OX40 is a potent immune-stimulating target in late-stage cancer patients. Cancer Res. 73(24), 7189-7198 (2013).
-
(2013)
Cancer Res
, vol.73
, Issue.24
, pp. 7189-7198
-
-
Kovacsovics-Bankowski, M.1
Morris, N.2
-
86
-
-
65349149089
-
Molecular mechanism and function of CD40/CD40L engagement in the immune system
-
Elgueta R, Benson MJ, De Vries VC, Wasiuk A, Guo Y, Noelle RJ. Molecular mechanism and function of CD40/CD40L engagement in the immune system. Immunol. Rev. 229(1), 152-172 (2009).
-
(2009)
Immunol. Rev
, vol.229
, Issue.1
, pp. 152-172
-
-
Elgueta, R.1
Benson, M.J.2
De Vries, V.C.3
Wasiuk, A.4
Guo, Y.5
Noelle, R.J.6
-
87
-
-
84863890977
-
Design of CD40 agonists and their use in growing B cells for cancer immunotherapy
-
Kornbluth RS, Stempniak M, Stone GW. Design of CD40 agonists and their use in growing B cells for cancer immunotherapy. Int. Rev. Immunol. 31(4), 279-288 (2012).
-
(2012)
Int. Rev. Immunol.
, vol.31
, Issue.4
, pp. 279-288
-
-
Kornbluth, R.S.1
Stempniak, M.2
Stone, G.W.3
-
88
-
-
0031977605
-
The role of CD40/CD154 interactions in the priming, differentiation, and effector function of helper and cytotoxic T cells
-
Mackey MF, Barth RJ Jr, Noelle RJ. The role of CD40/CD154 interactions in the priming, differentiation, and effector function of helper and cytotoxic T cells. J. Leukoc. Biol. 63(4), 418-428 (1998).
-
(1998)
J. Leukoc. Biol
, vol.63
, Issue.4
, pp. 418-428
-
-
Mackey, M.F.1
Barth, Jr.R.J.2
Noelle, R.J.3
-
89
-
-
0035397985
-
Phase i study of recombinant human CD40 ligand in cancer patients
-
Vonderheide RH, Dutcher JP, Anderson JE et al. Phase I study of recombinant human CD40 ligand in cancer patients. J. Clin. Oncol. 19(13), 3280-3287 (2001).
-
(2001)
J. Clin. Oncol
, vol.19
, Issue.13
, pp. 3280-3287
-
-
Vonderheide, R.H.1
Dutcher, J.P.2
Anderson, J.E.3
-
90
-
-
84903272348
-
A Phase II study of dacetuzumab (SGN-40) in patients with relapsed diffuse large B-cell lymphoma (DLBCL) and correlative analyses of patient-specific factors
-
De Vos S, Forero-Torres A, Ansell SM et al. A Phase II study of dacetuzumab (SGN-40) in patients with relapsed diffuse large B-cell lymphoma (DLBCL) and correlative analyses of patient-specific factors. J. Hematol. Oncol. 7, 44 (2014).
-
(2014)
J. Hematol. Oncol
, vol.7
, pp. 44
-
-
De Vos, S.1
Forero-Torres, A.2
Ansell, S.M.3
-
91
-
-
84866314973
-
A Phase 1 study of lucatumumab, a fully human anti-CD40 antagonist monoclonal antibody administered intravenously to patients with relapsed or refractory multiple myeloma
-
Bensinger W, Maziarz RT, Jagannath S et al. A Phase 1 study of lucatumumab, a fully human anti-CD40 antagonist monoclonal antibody administered intravenously to patients with relapsed or refractory multiple myeloma. Br. J. Haematol. 159(1), 58-66 (2012).
-
(2012)
Br. J. Haematol
, vol.159
, Issue.1
, pp. 58-66
-
-
Bensinger, W.1
Maziarz, R.T.2
Jagannath, S.3
-
92
-
-
84862739640
-
Immunotherapy of cancer with 4-1BB
-
Vinay DS, Kwon BS. Immunotherapy of cancer with 4-1BB. Mol. Cancer Ther. 11(5), 1062-1070 (2012).
-
(2012)
Mol. Cancer Ther
, vol.11
, Issue.5
, pp. 1062-1070
-
-
Vinay, D.S.1
Kwon, B.S.2
-
93
-
-
17644389199
-
TNF/TNFR family members in costimulation of T cell responses
-
Watts TH. TNF/TNFR family members in costimulation of T cell responses. Annu. Rev. Immunol. 23, 23-68 (2005).
-
(2005)
Annu. Rev. Immunol
, vol.23
, pp. 23-68
-
-
Watts, T.H.1
-
94
-
-
84873372202
-
Advances in targeting cell surface signalling molecules for immune modulation
-
Yao S, Zhu Y, Chen L. Advances in targeting cell surface signalling molecules for immune modulation. Nat. Rev. Drug Discov. 12(2), 130-146 (2013).
-
(2013)
Nat. Rev. Drug Discov
, vol.12
, Issue.2
, pp. 130-146
-
-
Yao, S.1
Zhu, Y.2
Chen, L.3
-
95
-
-
0030845586
-
4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses
-
Shuford WW, Klussman K, Tritchler DD et al. 4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses. J. Exp. Med. 186(1), 47-55 (1997).
-
(1997)
J. Exp. Med
, vol.186
, Issue.1
, pp. 47-55
-
-
Shuford, W.W.1
Klussman, K.2
Tritchler, D.D.3
-
96
-
-
77950403194
-
CD137 agonist antibody prevents cancer recurrence: Contribution of CD137 on both hematopoietic and nonhematopoietic cells
-
Narazaki H, Zhu Y, Luo L, Zhu G, Chen L. CD137 agonist antibody prevents cancer recurrence: contribution of CD137 on both hematopoietic and nonhematopoietic cells. Blood 115(10), 1941-1948 (2010).
-
(2010)
Blood
, vol.115
, Issue.10
, pp. 1941-1948
-
-
Narazaki, H.1
Zhu, Y.2
Luo, L.3
Zhu, G.4
Chen, L.5
-
97
-
-
0031007143
-
Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors
-
Melero I, Shuford WW, Newby SA et al. Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors. Nat. Med. 3(6), 682-685 (1997).
-
(1997)
Nat. Med
, vol.3
, Issue.6
, pp. 682-685
-
-
Melero, I.1
Shuford, W.W.2
Newby, S.A.3
-
98
-
-
79551524395
-
Agonist anti-CD137 mAb act on tumor endothelial cells to enhance recruitment of activated T lymphocytes
-
Palazon A, Teijeira A, Martinez-Forero I et al. Agonist anti-CD137 mAb act on tumor endothelial cells to enhance recruitment of activated T lymphocytes. Cancer Res. 71(3), 801-811 (2011).
-
(2011)
Cancer Res
, vol.71
, Issue.3
, pp. 801-811
-
-
Palazon, A.1
Teijeira, A.2
Martinez-Forero, I.3
-
99
-
-
84899112560
-
Trial Watch: Immunostimulatory monoclonal antibodies in cancer therapy
-
Aranda F, Vacchelli E, Eggermont A et al. Trial Watch: immunostimulatory monoclonal antibodies in cancer therapy. Oncoimmunology 3(1), e27297 (2014).
-
(2014)
Oncoimmunology
, vol.3
, Issue.1
, pp. e27297
-
-
Aranda, F.1
Vacchelli, E.2
Eggermont, A.3
-
100
-
-
84884822262
-
Immunotherapy of melanoma with the immune costimulatory monoclonal antibodies targeting CD137
-
Li SY, Liu Y. Immunotherapy of melanoma with the immune costimulatory monoclonal antibodies targeting CD137. Clin. Pharmacol. 5(Suppl. 1), 47-53 (2013).
-
(2013)
Clin. Pharmacol
, vol.5
, pp. 47-53
-
-
Li, S.Y.1
Liu, Y.2
-
101
-
-
78449237499
-
Clinical experiences with anti-CD137 and anti-PD1 therapeutic antibodies
-
Ascierto PA, Simeone E, Sznol M, Fu YX, Melero I. Clinical experiences with anti-CD137 and anti-PD1 therapeutic antibodies. Semin. Oncol. 37(5), 508-516 (2010).
-
(2010)
Semin. Oncol
, vol.37
, Issue.5
, pp. 508-516
-
-
Ascierto, P.A.1
Simeone, E.2
Sznol, M.3
Fu, Y.X.4
Melero, I.5
-
102
-
-
55949113750
-
Phase i study of BMS-663513, a fully human anti-CD137 agonist monoclonal antibody, in patients (pts) with advanced cancer (CA)
-
Presented at IL, USA, 30 May-02 June
-
Sznol M, Hodi FS, Margolin K et al. Phase I study of BMS-663513, a fully human anti-CD137 agonist monoclonal antibody, in patients (pts) with advanced cancer (CA). Presented at: 44th Annual Meeting of American Society of Clinical Oncology. IL, USA, 30 May-02 June 2008.
-
(2008)
44th Annual Meeting of American Society of Clinical Oncology
-
-
Sznol, M.1
Hodi, F.S.2
Margolin, K.3
-
104
-
-
84948181110
-
Targeting CD137 to enhance the antitumor efficacy of cetuximab by stimulation of innate and adaptive immunity
-
Presented at IL, USA, 31 May-4 June
-
Kohrt HE, Houot R, Weiskopf K et al. Targeting CD137 to enhance the antitumor efficacy of cetuximab by stimulation of innate and adaptive immunity. Presented at: 49th Annual Meeting of American Society of Clinical Oncology. IL, USA, 31 May-4 June 2013.
-
(2013)
49th Annual Meeting of American Society of Clinical Oncology
-
-
Kohrt, H.E.1
Houot, R.2
Weiskopf, K.3
-
106
-
-
0030962132
-
A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis
-
Nocentini G, Giunchi L, Ronchetti S et al. A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis. Proc. Natl Acad. Sci. USA 94(12), 6216-6221 (1997).
-
(1997)
Proc. Natl Acad. Sci. USA
, vol.94
, Issue.12
, pp. 6216-6221
-
-
Nocentini, G.1
Giunchi, L.2
Ronchetti, S.3
-
109
-
-
84893683548
-
Combined PD-1 blockade and GITR triggering induce a potent antitumor immunity in murine cancer models and synergizes with chemotherapeutic drugs
-
Lu L, Xu X, Zhang B, Zhang R, Ji H, Wang X. Combined PD-1 blockade and GITR triggering induce a potent antitumor immunity in murine cancer models and synergizes with chemotherapeutic drugs. J. Transl. Med. 12, 36 (2014).
-
(2014)
J. Transl. Med
, vol.12
, pp. 36
-
-
Lu, L.1
Xu, X.2
Zhang, B.3
Zhang, R.4
Ji, H.5
Wang, X.6
-
110
-
-
82255181369
-
Enhancement of anti-tumor immunity through local modulation of CTLA-4 and GITR by dendritic cells
-
Pruitt SK, Boczkowski D, De Rosa N et al. Enhancement of anti-tumor immunity through local modulation of CTLA-4 and GITR by dendritic cells. Eur. J. Immunol. 41(12), 3553-3563 (2011).
-
(2011)
Eur. J. Immunol
, vol.41
, Issue.12
, pp. 3553-3563
-
-
Pruitt, S.K.1
Boczkowski, D.2
De Rosa, N.3
-
111
-
-
79960918412
-
Emerging Tim-3 functions in antimicrobial and tumor immunity
-
Sakuishi K, Jayaraman P, Behar SM, Anderson AC, Kuchroo VK. Emerging Tim-3 functions in antimicrobial and tumor immunity. Trends Immunol. 32(8), 345-349 (2011).
-
(2011)
Trends Immunol
, vol.32
, Issue.8
, pp. 345-349
-
-
Sakuishi, K.1
Jayaraman, P.2
Behar, S.M.3
Anderson, A.C.4
Kuchroo, V.K.5
-
112
-
-
33947190606
-
T cell immunoglobulin mucin-3 crystal structure reveals a galectin-9-independent ligand-binding surface
-
Cao E, Zang X, Ramagopal UA et al. T cell immunoglobulin mucin-3 crystal structure reveals a galectin-9-independent ligand-binding surface. Immunity 26(3), 311-321 (2007).
-
(2007)
Immunity
, vol.26
, Issue.3
, pp. 311-321
-
-
Cao, E.1
Zang, X.2
Ramagopal, U.A.3
-
113
-
-
36048963838
-
LAG-3 regulates CD8+ T cell accumulation and effector function in murine self-and tumor-tolerance systems
-
Grosso JF, Kelleher CC, Harris TJ et al. LAG-3 regulates CD8+ T cell accumulation and effector function in murine self-and tumor-tolerance systems. J. Clin. Invest. 117(11), 3383-3392 (2007).
-
(2007)
J. Clin. Invest
, vol.117
, Issue.11
, pp. 3383-3392
-
-
Grosso, J.F.1
Kelleher, C.C.2
Harris, T.J.3
-
114
-
-
19544374904
-
The negative regulatory function of the lymphocyte-activation gene-3 co-receptor (CD223) on human T cells
-
Macon-Lemaitre L, Triebel F. The negative regulatory function of the lymphocyte-activation gene-3 co-receptor (CD223) on human T cells. Immunology 115(2), 170-178 (2005).
-
(2005)
Immunology
, vol.115
, Issue.2
, pp. 170-178
-
-
Macon-Lemaitre, L.1
Triebel, F.2
-
115
-
-
5644263642
-
Role of LAG-3 in regulatory T cells
-
Huang CT, Workman CJ, Flies D et al. Role of LAG-3 in regulatory T cells. Immunity 21(4), 503-513 (2004).
-
(2004)
Immunity
, vol.21
, Issue.4
, pp. 503-513
-
-
Huang, C.T.1
Workman, C.J.2
Flies, D.3
-
116
-
-
84880682724
-
Novel antibodies targeting immune regulatory checkpoints for cancer therapy
-
Lee CS, Cragg M, Glennie M, Johnson P. Novel antibodies targeting immune regulatory checkpoints for cancer therapy. Br. J. Clin. Pharmacol. 76(2), 233-247 (2013).
-
(2013)
Br. J. Clin. Pharmacol
, vol.76
, Issue.2
, pp. 233-247
-
-
Lee, C.S.1
Cragg, M.2
Glennie, M.3
Johnson, P.4
-
117
-
-
84863115998
-
Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape
-
Woo SR, Turnis ME, Goldberg MV et al. Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape. Cancer Res. 72(4), 917-927 (2012).
-
(2012)
Cancer Res
, vol.72
, Issue.4
, pp. 917-927
-
-
Woo, S.R.1
Turnis, M.E.2
Goldberg, M.V.3
-
118
-
-
35748957791
-
A soluble form of lymphocyte activation gene-3 (IMP321) induces activation of a large range of human effector cytotoxic cells
-
Brignone C, Grygar C, Marcu M, Schakel K, Triebel F. A soluble form of lymphocyte activation gene-3 (IMP321) induces activation of a large range of human effector cytotoxic cells. J. Immunol. 179(6), 4202-4211 (2007).
-
(2007)
J. Immunol
, vol.179
, Issue.6
, pp. 4202-4211
-
-
Brignone, C.1
Grygar, C.2
Marcu, M.3
Schakel, K.4
Triebel, F.5
-
119
-
-
70349669259
-
A Phase i pharmacokinetic and biological correlative study of IMP321, a novel MHC class II agonist, in patients with advanced renal cell carcinoma
-
Brignone C, Escudier B, Grygar C, Marcu M, Triebel F. A Phase I pharmacokinetic and biological correlative study of IMP321, a novel MHC class II agonist, in patients with advanced renal cell carcinoma. Clin. Cancer Res. 15(19), 6225-6231 (2009).
-
(2009)
Clin. Cancer Res
, vol.15
, Issue.19
, pp. 6225-6231
-
-
Brignone, C.1
Escudier, B.2
Grygar, C.3
Marcu, M.4
Triebel, F.5
-
120
-
-
77955487541
-
First-line chemoimmunotherapy in metastatic breast carcinoma: Combination of paclitaxel and IMP321 (LAG-3Ig) enhances immune responses and antitumor activity
-
Brignone C, Gutierrez M, Mefti F et al. First-line chemoimmunotherapy in metastatic breast carcinoma: combination of paclitaxel and IMP321 (LAG-3Ig) enhances immune responses and antitumor activity. J. Transl. Med. 8, 71 (2010).
-
(2010)
J. Transl. Med
, vol.8
, pp. 71
-
-
Brignone, C.1
Gutierrez, M.2
Mefti, F.3
-
121
-
-
84879085032
-
A Phase i study of IMP321 and gemcitabine as the front-line therapy in patients with advanced pancreatic adenocarcinoma
-
Wang-Gillam A, Plambeck-Suess S, Goedegebuure P et al. A Phase I study of IMP321 and gemcitabine as the front-line therapy in patients with advanced pancreatic adenocarcinoma. Invest. New Drugs 31(3), 707-713 (2013).
-
(2013)
Invest. New Drugs
, vol.31
, Issue.3
, pp. 707-713
-
-
Wang-Gillam, A.1
Plambeck-Suess, S.2
Goedegebuure, P.3
-
122
-
-
84899083535
-
MART-1 peptide vaccination plus IMP321 (LAG-3Ig fusion protein) in patients receiving autologous PBMCs after lymphodepletion: Results of a Phase i trial
-
Romano E, Michielin O, Voelter V et al. MART-1 peptide vaccination plus IMP321 (LAG-3Ig fusion protein) in patients receiving autologous PBMCs after lymphodepletion: results of a Phase I trial. J. Transl. Med. 12, 97 (2014).
-
(2014)
J. Transl. Med
, vol.12
, pp. 97
-
-
Romano, E.1
Michielin, O.2
Voelter, V.3
-
123
-
-
0037810670
-
BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1
-
Watanabe N, Gavrieli M, Sedy JR et al. BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1. Nat. Immunol. 4(7), 670-679 (2003).
-
(2003)
Nat. Immunol
, vol.4
, Issue.7
, pp. 670-679
-
-
Watanabe, N.1
Gavrieli, M.2
Sedy, J.R.3
-
124
-
-
84876481083
-
Interfering with coinhibitory molecules: BTLA/HVEM as new targets to enhance anti-tumor immunity
-
Pasero C, Olive D. Interfering with coinhibitory molecules: BTLA/HVEM as new targets to enhance anti-tumor immunity. Immunol. Lett. 151(1-2), 71-75 (2013).
-
(2013)
Immunol. Lett
, vol.151
, Issue.1-2
, pp. 71-75
-
-
Pasero, C.1
Olive, D.2
-
125
-
-
84921823501
-
Programmed death 1 and B and T lymphocyte attenuator immunoreceptors and their association with malignant T-lymphoproliferative disorders: Brief review
-
Karakatsanis S, Bertsias G, Roussou P, Boumpas D. Programmed death 1 and B and T lymphocyte attenuator immunoreceptors and their association with malignant T-lymphoproliferative disorders: brief review. Hematol. Oncol. 32(3), 113-119 (2014).
-
(2014)
Hematol. Oncol
, vol.32
, Issue.3
, pp. 113-119
-
-
Karakatsanis, S.1
Bertsias, G.2
Roussou, P.3
Boumpas, D.4
-
126
-
-
70349560843
-
High expression of the inhibitory receptor BTLA in T-follicular helper cells and in B-cell small lymphocytic lymphoma/chronic lymphocytic leukemia
-
M'hidi H, Thibult ML, Chetaille B et al. High expression of the inhibitory receptor BTLA in T-follicular helper cells and in B-cell small lymphocytic lymphoma/chronic lymphocytic leukemia. Am. J. Clin. Pathol. 132(4), 589-596 (2009).
-
(2009)
Am. J. Clin. Pathol
, vol.132
, Issue.4
, pp. 589-596
-
-
M'Hidi, H.1
Thibult, M.L.2
Chetaille, B.3
-
127
-
-
84890277184
-
BTLA, a key regulator of Vgamma9Vdelta2 T-cell proliferation
-
Gertner-Dardenne J, Fauriat C, Olive D. BTLA, a key regulator of Vgamma9Vdelta2 T-cell proliferation. Oncoimmunology 2(9), e25853 (2013).
-
(2013)
Oncoimmunology
, vol.2
, Issue.9
, pp. e25853
-
-
Gertner-Dardenne, J.1
Fauriat, C.2
Olive, D.3
-
128
-
-
84862841841
-
B and T lymphocyte attenuator mediates inhibition of tumor-reactive CD8+ T cells in patients after allogeneic stem cell transplantation
-
Hobo W, Norde WJ, Schaap N et al. B and T lymphocyte attenuator mediates inhibition of tumor-reactive CD8+ T cells in patients after allogeneic stem cell transplantation. J. Immunol. 189(1), 39-49 (2012).
-
(2012)
J. Immunol
, vol.189
, Issue.1
, pp. 39-49
-
-
Hobo, W.1
Norde, W.J.2
Schaap, N.3
-
129
-
-
84916242923
-
Ectopic expression of B and T lymphocyte attenuator in gastric cancer: A potential independent prognostic factor in patients with gastric cancer
-
Feng XY, Wen XZ, Tan XJ et al. Ectopic expression of B and T lymphocyte attenuator in gastric cancer: a potential independent prognostic factor in patients with gastric cancer. Mol. Med. Rep. 11(1), 658-664 (2015).
-
(2015)
Mol. Med. Rep
, vol.11
, Issue.1
, pp. 658-664
-
-
Feng, X.Y.1
Wen, X.Z.2
Tan, X.J.3
-
130
-
-
84948182119
-
Association of BTLA upregulation with impaired cytotoxic CD8+ T-cell function and disease progression of patients with hepatocellular carcinoma
-
Presented at IL, USA, 30 May-03 June
-
Fu J, Zhou L, Hong Z, Chen Y, Wang F-S. Association of BTLA upregulation with impaired cytotoxic CD8+ T-cell function and disease progression of patients with hepatocellular carcinoma. Presented at: 50th Annual Meeting of American Society of Clinical Oncology. IL, USA, 30 May-03 June 2014.
-
(2014)
50th Annual Meeting of American Society of Clinical Oncology
-
-
Fu, J.1
Zhou, L.2
Hong, Z.3
Chen, Y.4
Wang, F.-S.5
-
131
-
-
74949125667
-
BTLA mediates inhibition of human tumor-specific CD8+ T cells that can be partially reversed by vaccination
-
Derre L, Rivals JP, Jandus C et al. BTLA mediates inhibition of human tumor-specific CD8+ T cells that can be partially reversed by vaccination. J. Clin. Invest. 120(1), 157-167 (2010).
-
(2010)
J. Clin. Invest
, vol.120
, Issue.1
, pp. 157-167
-
-
Derre, L.1
Rivals, J.P.2
Jandus, C.3
-
132
-
-
84926652188
-
Tryptophan-degrading enzymes in tumoral immune resistance
-
Van Baren N, Van Den Eynde BJ. Tryptophan-degrading enzymes in tumoral immune resistance. Front. Immunol. 6, 34 (2015).
-
(2015)
Front. Immunol
, vol.6
, pp. 34
-
-
Van Baren, N.1
Van Den Eynde, B.J.2
-
133
-
-
84935069042
-
Extensive profiling of the expression of the indoleamine 2,3-dioxygenase 1 protein in normal and tumoral human tissues
-
Theate I, Van Baren N, Pilotte L et al. Extensive profiling of the expression of the indoleamine 2,3-dioxygenase 1 protein in normal and tumoral human tissues. Cancer Immunol. Res. 3(2), 161-172 (2015).
-
(2015)
Cancer Immunol. Res
, vol.3
, Issue.2
, pp. 161-172
-
-
Theate, I.1
Van Baren, N.2
Pilotte, L.3
-
134
-
-
81255138408
-
Indoleamine 2,3-dioxygenase expression in human cancers: Clinical and immunologic perspectives
-
Godin-Ethier J, Hanafi LA, Piccirillo CA, Lapointe R. Indoleamine 2,3-dioxygenase expression in human cancers: clinical and immunologic perspectives. Clin. Cancer Res. 17(22), 6985-6991 (2011).
-
(2011)
Clin. Cancer Res
, vol.17
, Issue.22
, pp. 6985-6991
-
-
Godin-Ethier, J.1
Hanafi, L.A.2
Piccirillo, C.A.3
Lapointe, R.4
-
135
-
-
76649088968
-
Hydroxyamidine inhibitors of indoleamine-2,3-dioxygenase potently suppress systemic tryptophan catabolism and the growth of IDO-expressing tumors
-
Koblish HK, Hansbury MJ, Bowman KJ et al. Hydroxyamidine inhibitors of indoleamine-2,3-dioxygenase potently suppress systemic tryptophan catabolism and the growth of IDO-expressing tumors. Mol. Cancer Ther. 9(2), 489-498 (2010).
-
(2010)
Mol. Cancer Ther
, vol.9
, Issue.2
, pp. 489-498
-
-
Koblish, H.K.1
Hansbury, M.J.2
Bowman, K.J.3
-
136
-
-
0142137237
-
Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase
-
Uyttenhove C, Pilotte L, Theate I et al. Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase. Nat. Med. 9(10), 1269-1274 (2003).
-
(2003)
Nat. Med
, vol.9
, Issue.10
, pp. 1269-1274
-
-
Uyttenhove, C.1
Pilotte, L.2
Theate, I.3
-
137
-
-
84860852600
-
Blocking IDO activity to enhance anti-tumor immunity
-
Munn DH. Blocking IDO activity to enhance anti-tumor immunity. Front. Biosci. (Elite Ed.) 4, 734-745 (2012).
-
(2012)
Front. Biosci. (Elite Ed.)
, vol.4
, pp. 734-745
-
-
Munn, D.H.1
-
138
-
-
16244408626
-
Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy
-
Muller AJ, Duhadaway JB, Donover PS, Sutanto-Ward E, Prendergast GC. Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy. Nat. Med. 11(3), 312-319 (2005).
-
(2005)
Nat. Med
, vol.11
, Issue.3
, pp. 312-319
-
-
Muller, A.J.1
Duhadaway, J.B.2
Donover, P.S.3
Sutanto-Ward, E.4
Prendergast, G.C.5
-
139
-
-
84907651092
-
First-in-human Phase 1 study of the novel indoleamine-2,3-dioxygenase (IDO) inhibitor NLG-919
-
Presented at IL, USA, 30 May-03 June
-
Khleif S, Munn D, Nyak-Kapoor A et al. First-in-human Phase 1 study of the novel indoleamine-2,3-dioxygenase (IDO) inhibitor NLG-919. Presented at: 50th Annual Meeting of American Society of Clinical Oncology. IL, USA, 30 May-03 June 2014.
-
(2014)
50th Annual Meeting of American Society of Clinical Oncology
-
-
Khleif, S.1
Munn, D.2
Nyak-Kapoor, A.3
-
140
-
-
84948147738
-
Phase 1/2 trial of the indoleamine 2,3-dioxygenase pathway (IDO) inhibitor indoximod plus ipilimumab for the treatment of unresectable stage 3 or 4 melanoma
-
Presented at IL, USA, 30 May-03 June
-
Kennedy E, Rossi GR, Vahanian NN, Link CJ. Phase 1/2 trial of the indoleamine 2,3-dioxygenase pathway (IDO) inhibitor indoximod plus ipilimumab for the treatment of unresectable stage 3 or 4 melanoma. Presented at: 50th Annual Meeting of American Society of Clinical Oncology. IL, USA, 30 May-03 June 2014.
-
(2014)
50th Annual Meeting of American Society of Clinical Oncology
-
-
Kennedy, E.1
Rossi, G.R.2
Vahanian, N.N.3
Link, C.J.4
-
141
-
-
84948180152
-
Safety and clinical activity of nivolumab (anti-PD-1, BMS-936558, ONO-4538) in combination with ipilimumab in patients (pts) with advanced melanoma (MEL)
-
Presented at IL, USA, 31 May-4 June
-
Wolchok JD, Kluger HM, Callahan MK et al. Safety and clinical activity of nivolumab (anti-PD-1, BMS-936558, ONO-4538) in combination with ipilimumab in patients (pts) with advanced melanoma (MEL). Presented at: 49th Annual Meeting of American Society of Clinical Oncology. IL, USA, 31 May-4 June 2013.
-
(2013)
49th Annual Meeting of American Society of Clinical Oncology
-
-
Wolchok, J.D.1
Kluger, H.M.2
Callahan, M.K.3
-
142
-
-
80053161751
-
Anti-PD-1 synergizes with cyclophosphamide to induce potent antitumor vaccine effects through novel mechanisms
-
Mkrtichyan M, Najjar YG, Raulfs EC et al. Anti-PD-1 synergizes with cyclophosphamide to induce potent antitumor vaccine effects through novel mechanisms. Eur. J. Immunol. 41(10), 2977-2986 (2011).
-
(2011)
Eur. J. Immunol
, vol.41
, Issue.10
, pp. 2977-2986
-
-
Mkrtichyan, M.1
Najjar, Y.G.2
Raulfs, E.C.3
-
143
-
-
84948141308
-
Abstract LB-193: Phase i study of safety, tolerability, pharmacokinetics, and pharmacodynamics of AMP-224 (B7-DC Fc fusion protein) in a regimen containing cyclophosphamide (CTX) in patients with advanced solid tumors
-
Lorusso PM, Powderly J, Burris HA et al. Abstract LB-193: Phase I study of safety, tolerability, pharmacokinetics, and pharmacodynamics of AMP-224 (B7-DC Fc fusion protein) in a regimen containing cyclophosphamide (CTX) in patients with advanced solid tumors. Cancer Res. 73(8 Suppl.), LB-193-LB-193 (2013).
-
(2013)
Cancer Res
, vol.73
, Issue.8
, pp. LB193-LB193
-
-
Lorusso, P.M.1
Powderly, J.2
Burris, H.A.3
-
144
-
-
84891373595
-
Safety and activity of PD1 blockade by pidilizumab in combination with rituximab in patients with relapsed follicular lymphoma: A single group, open-label, Phase 2 trial
-
Westin JR, Chu F, Zhang M et al. Safety and activity of PD1 blockade by pidilizumab in combination with rituximab in patients with relapsed follicular lymphoma: a single group, open-label, Phase 2 trial. Lancet Oncol. 15(1), 69-77 (2014).
-
(2014)
Lancet Oncol
, vol.15
, Issue.1
, pp. 69-77
-
-
Westin, J.R.1
Chu, F.2
Zhang, M.3
-
145
-
-
84948134920
-
A Phase II/III randomized trial of two doses of MK-3475 versus docetaxel in previously treated subjects with non-small cell lung cancer
-
Presented at IL USA, 30 May-03 June
-
Herbst RS, Gurpide A, Surmont V et al. A Phase II/III randomized trial of two doses of MK-3475 versus docetaxel in previously treated subjects with non-small cell lung cancer. Presented at: 50th Annual Meeting of American Society of Clinical Oncology. IL, USA, 30 May-03 June 2014.
-
(2014)
50th Annual Meeting of American Society of Clinical Oncology
-
-
Herbst, R.S.1
Gurpide, A.2
Surmont, V.3
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