메뉴 건너뛰기




Volumn 7, Issue 11, 2015, Pages 1169-1186

Emerging targets in cancer immunotherapy: Beyond CTLA-4 and PD-1

Author keywords

B7 family; checkpoint proteins; immunotherapy; TNFR superfamily; translational medicine

Indexed keywords

B7 ANTIGEN; B7H3 ANTIGEN; CD137 ANTIGEN; CD137 LIGAND; CD27 ANTIGEN; CD40 ANTIGEN; CD40 LIGAND; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GLUCOCORTICOID INDUCED TUMOR NECROSIS FACTOR RECEPTOR; HHLA2 ANTIGEN; LAG 3 PROTEIN; OX40 LIGAND; PROGRAMMED DEATH 1 LIGAND 1; PROGRAMMED DEATH 1 LIGAND 2; PROTEIN; TIM 3 PROTEIN; TRYPTOPHAN; UNCLASSIFIED DRUG; URELUMAB; V SET DOMAIN CONTAINING T CELL ACTIVATION INHIBITOR 1; VISTA PROTEIN; ANTINEOPLASTIC AGENT; CD223 ANTIGEN; CD274 PROTEIN, HUMAN; LEUKOCYTE ANTIGEN; PROGRAMMED DEATH 1 RECEPTOR; TUMOR NECROSIS FACTOR;

EID: 84948167851     PISSN: 1750743X     EISSN: 17507448     Source Type: Journal    
DOI: 10.2217/imt.15.78     Document Type: Review
Times cited : (45)

References (145)
  • 1
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 144(5), 646-674 (2011).
    • (2011) Cell , vol.144 , Issue.5 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 79953151458 scopus 로고    scopus 로고
    • Cancer immunoediting: Integrating immunity's roles in cancer suppression and promotion
    • Schreiber RD, Old LJ, Smyth MJ. Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion. Science 331(6024), 1565-1570 (2011).
    • (2011) Science , vol.331 , Issue.6024 , pp. 1565-1570
    • Schreiber, R.D.1    Old, L.J.2    Smyth, M.J.3
  • 3
    • 84960949820 scopus 로고
    • Cancer: A biological approach III. Viruses associated with neoplastic conditions. IV. Practical applications
    • Burnet M. Cancer: a biological approach. III. Viruses associated with neoplastic conditions. IV. Practical applications. Br. Med. J. 1(5023), 841-847 (1957).
    • (1957) Br. Med. J , vol.1 , Issue.5023 , pp. 841-847
    • Burnet, M.1
  • 4
    • 22144465860 scopus 로고    scopus 로고
    • A critical function for type i interferons in cancer immunoediting
    • Dunn GP, Bruce AT, Sheehan KC et al. A critical function for type I interferons in cancer immunoediting. Nat. Immunol. 6(7), 722-729 (2005).
    • (2005) Nat. Immunol , vol.6 , Issue.7 , pp. 722-729
    • Dunn, G.P.1    Bruce, A.T.2    Sheehan, K.C.3
  • 5
    • 33749319703 scopus 로고    scopus 로고
    • Type, density, and location of immune cells within human colorectal tumors predict clinical outcome
    • Galon J, Costes A, Sanchez-Cabo F et al. Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science 313(5795), 1960-1964 (2006).
    • (2006) Science , vol.313 , Issue.5795 , pp. 1960-1964
    • Galon, J.1    Costes, A.2    Sanchez-Cabo, F.3
  • 6
    • 29144514645 scopus 로고    scopus 로고
    • Effector memory T cells, early metastasis, and survival in colorectal cancer
    • Pages F, Berger A, Camus M et al. Effector memory T cells, early metastasis, and survival in colorectal cancer. N. Engl. J. Med. 353(25), 2654-2666 (2005).
    • (2005) N. Engl. J. Med , vol.353 , Issue.25 , pp. 2654-2666
    • Pages, F.1    Berger, A.2    Camus, M.3
  • 7
    • 84898948823 scopus 로고    scopus 로고
    • Emerging immunologic biomarkers: Setting the (TNM-immune) stage
    • Taube JM. Emerging immunologic biomarkers: setting the (TNM-immune) stage. Clin. Cancer Res. 20(8), 2023-2025 (2014).
    • (2014) Clin. Cancer Res , vol.20 , Issue.8 , pp. 2023-2025
    • Taube, J.M.1
  • 8
    • 44349150012 scopus 로고    scopus 로고
    • Inhibitory B7-family molecules in the tumour microenvironment
    • Zou W, Chen L. Inhibitory B7-family molecules in the tumour microenvironment. Nat. Rev. Immunol. 8(6), 467-477 (2008).
    • (2008) Nat. Rev. Immunol , vol.8 , Issue.6 , pp. 467-477
    • Zou, W.1    Chen, L.2
  • 9
    • 0025322552 scopus 로고
    • T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1
    • Linsley PS, Clark EA, Ledbetter JA. T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1. Proc. Natl Acad. Sci. USA 87(13), 5031-5035 (1990).
    • (1990) Proc. Natl Acad. Sci. USA , vol.87 , Issue.13 , pp. 5031-5035
    • Linsley, P.S.1    Clark, E.A.2    Ledbetter, J.A.3
  • 10
    • 0029120245 scopus 로고
    • CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation
    • Krummel MF, Allison JP. CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J. Exp. Med. 182(2), 459-465 (1995).
    • (1995) J. Exp. Med , vol.182 , Issue.2 , pp. 459-465
    • Krummel, M.F.1    Allison, J.P.2
  • 11
    • 0028484545 scopus 로고
    • CTLA-4 can function as a negative regulator of T cell activation
    • Walunas TL, Lenschow DJ, Bakker CY et al. CTLA-4 can function as a negative regulator of T cell activation. Immunity 1(5), 405-413 (1994).
    • (1994) Immunity , vol.1 , Issue.5 , pp. 405-413
    • Walunas, T.L.1    Lenschow, D.J.2    Bakker, C.Y.3
  • 12
    • 34848831575 scopus 로고    scopus 로고
    • The B7 family and cancer therapy: Costimulation and coinhibition
    • Zang X, Allison JP. The B7 family and cancer therapy: costimulation and coinhibition. Clin. Cancer Res. 13(18 Pt 1), 5271-5279 (2007).
    • (2007) Clin. Cancer Res , vol.13 , Issue.18 , pp. 5271-5279
    • Zang, X.1    Allison, J.P.2
  • 13
    • 0029947568 scopus 로고    scopus 로고
    • Enhancement of antitumor immunity by CTLA-4 blockade
    • Leach DR, Krummel MF, Allison JP. Enhancement of antitumor immunity by CTLA-4 blockade. Science 271(5256), 1734-1736 (1996).
    • (1996) Science , vol.271 , Issue.5256 , pp. 1734-1736
    • Leach, D.R.1    Krummel, M.F.2    Allison, J.P.3
  • 14
    • 0033517152 scopus 로고    scopus 로고
    • Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colony-stimulating factor (GMCSF)-producing vaccines induces rejection of subcutaneous and metastatic tumors accompanied by autoimmune depigmentation
    • Van Elsas A, Hurwitz AA, Allison JP. Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colony-stimulating factor (GMCSF)-producing vaccines induces rejection of subcutaneous and metastatic tumors accompanied by autoimmune depigmentation. J. Exp. Med. 190(3), 355-366 (1999).
    • (1999) J. Exp. Med , vol.190 , Issue.3 , pp. 355-366
    • Van Elsas, A.1    Hurwitz, A.A.2    Allison, J.P.3
  • 15
    • 0033592924 scopus 로고    scopus 로고
    • Elimination of residual metastatic prostate cancer after surgery and adjunctive cytotoxic T lymphocyte-associated antigen 4 (CTLA-4 ) blockade immunotherapy
    • Kwon ED, Foster BA, Hurwitz AA et al. Elimination of residual metastatic prostate cancer after surgery and adjunctive cytotoxic T lymphocyte-associated antigen 4 (CTLA-4 ) blockade immunotherapy. Proc. Natl Acad. Sci. USA 96(26), 15074-15079 (1999).
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , Issue.26 , pp. 15074-15079
    • Kwon, E.D.1    Foster, B.A.2    Hurwitz, A.A.3
  • 16
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • Hodi FS, O'day SJ, Mcdermott DF et al. Improved survival with ipilimumab in patients with metastatic melanoma. N. Engl. J. Med. 363(8), 711-723 (2010).
    • (2010) N. Engl. J. Med , vol.363 , Issue.8 , pp. 711-723
    • Hodi, F.S.1    O'Day, S.J.2    McDermott, D.F.3
  • 17
    • 0026700235 scopus 로고
    • Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death
    • Ishida Y, Agata Y, Shibahara K, Honjo T. Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. EMBO J. 11(11), 3887-3895 (1992).
    • (1992) EMBO J , vol.11 , Issue.11 , pp. 3887-3895
    • Ishida, Y.1    Agata, Y.2    Shibahara, K.3    Honjo, T.4
  • 18
    • 0030005099 scopus 로고    scopus 로고
    • Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes
    • Agata Y, Kawasaki A, Nishimura H et al. Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes. Int. Immunol. 8(5), 765-772 (1996).
    • (1996) Int. Immunol , vol.8 , Issue.5 , pp. 765-772
    • Agata, Y.1    Kawasaki, A.2    Nishimura, H.3
  • 19
    • 77950525439 scopus 로고    scopus 로고
    • Programmed death-1-induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection
    • Said EA, Dupuy FP, Trautmann L et al. Programmed death-1-induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection. Nat. Med. 16(4), 452-459 (2010).
    • (2010) Nat. Med , vol.16 , Issue.4 , pp. 452-459
    • Said, E.A.1    Dupuy, F.P.2    Trautmann, L.3
  • 20
    • 0031685190 scopus 로고    scopus 로고
    • Immunological studies on PD-1 deficient mice: Implication of PD-1 as a negative regulator for B cell responses
    • Nishimura H, Minato N, Nakano T, Honjo T. Immunological studies on PD-1 deficient mice: implication of PD-1 as a negative regulator for B cell responses. Int. Immunol. 10(10), 1563-1572 (1998).
    • (1998) Int. Immunol , vol.10 , Issue.10 , pp. 1563-1572
    • Nishimura, H.1    Minato, N.2    Nakano, T.3    Honjo, T.4
  • 21
    • 32544459770 scopus 로고    scopus 로고
    • Restoring function in exhausted CD8 T cells during chronic viral infection
    • Barber DL, Wherry EJ, Masopust D et al. Restoring function in exhausted CD8 T cells during chronic viral infection. Nature 439(7077), 682-687 (2006).
    • (2006) Nature , vol.439 , Issue.7077 , pp. 682-687
    • Barber, D.L.1    Wherry, E.J.2    Masopust, D.3
  • 22
    • 81555226044 scopus 로고    scopus 로고
    • The PD-1/PD-L1 (B7-H1) pathway in chronic infection-induced cytotoxic T lymphocyte exhaustion
    • Hofmeyer KA, Jeon H, Zang X. The PD-1/PD-L1 (B7-H1) pathway in chronic infection-induced cytotoxic T lymphocyte exhaustion. J. Biomed. Biotechnol. 2011, 451694 (2011).
    • (2011) J. Biomed. Biotechnol. , vol.2011 , pp. 451694
    • Hofmeyer, K.A.1    Jeon, H.2    Zang, X.3
  • 23
    • 77953747963 scopus 로고    scopus 로고
    • The PD-1 pathway in tolerance and autoimmunity
    • Francisco LM, Sage PT, Sharpe AH. The PD-1 pathway in tolerance and autoimmunity. Immunol. Rev. 236, 219-242 (2010).
    • (2010) Immunol. Rev , vol.236 , pp. 219-242
    • Francisco, L.M.1    Sage, P.T.2    Sharpe, A.H.3
  • 24
    • 85045863267 scopus 로고    scopus 로고
    • A randomized controlled comparison of pembrolizumab and chemotherapy in patients with ipilimumab-refractory melanoma
    • Dummer R, Daud A, Puzanov I et al. A randomized controlled comparison of pembrolizumab and chemotherapy in patients with ipilimumab-refractory melanoma. J. Transl. Med. 13, 2062 (2015).
    • (2015) J. Transl. Med , vol.13 , pp. 2062
    • Dummer, R.1    Daud, A.2    Puzanov, I.3
  • 25
    • 84908354848 scopus 로고    scopus 로고
    • Anti-programmeddeath-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: A randomised dose-comparison cohort of a Phase 1 trial
    • Robert C, Ribas A, Wolchok JD et al. Anti-programmeddeath-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: a randomised dose-comparison cohort of a Phase 1 trial. Lancet 384(9948), 1109-1117 (2014).
    • (2014) Lancet , vol.384 , Issue.9948 , pp. 1109-1117
    • Robert, C.1    Ribas, A.2    Wolchok, J.D.3
  • 26
    • 77954899030 scopus 로고    scopus 로고
    • Phase i study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: Safety, clinical activity, pharmacodynamics, and immunologic correlates
    • Brahmer JR, Drake CG, Wollner I et al. Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates. J. Clin. Oncol. 28(19), 3167-3175 (2010).
    • (2010) J. Clin. Oncol , vol.28 , Issue.19 , pp. 3167-3175
    • Brahmer, J.R.1    Drake, C.G.2    Wollner, I.3
  • 27
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • Topalian SL, Hodi FS, Brahmer JR et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N. Engl. J. Med. 366(26), 2443-2454 (2012).
    • (2012) N. Engl. J. Med , vol.366 , Issue.26 , pp. 2443-2454
    • Topalian, S.L.1    Hodi, F.S.2    Brahmer, J.R.3
  • 28
    • 84879777241 scopus 로고    scopus 로고
    • Nivolumab plus ipilimumab in advanced melanoma
    • Wolchok JD, Kluger H, Callahan MK et al. Nivolumab plus ipilimumab in advanced melanoma. N. Engl. J. Med. 369(2), 122-133 (2013).
    • (2013) N. Engl. J. Med , vol.369 , Issue.2 , pp. 122-133
    • Wolchok, J.D.1    Kluger, H.2    Callahan, M.K.3
  • 29
    • 84925221855 scopus 로고    scopus 로고
    • PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma
    • Ansell SM, Lesokhin AM, Borrello I et al. PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma. N. Engl. J. Med. 372(4), 311-319 (2015).
    • (2015) N. Engl. J. Med , vol.372 , Issue.4 , pp. 311-319
    • Ansell, S.M.1    Lesokhin, A.M.2    Borrello, I.3
  • 30
    • 84948173672 scopus 로고    scopus 로고
    • Preliminary results of a phase i study of nivolumab (BMS-936558) in patients with relapsed or refractory lymphoid malignancies
    • Presented at: 56th ASH Annual Meeting and Exposition. CA, USA, 6-9 December 2014. 31 Weber JS, D'angelo SP, Minor D et al. Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, Phase 3 trial
    • Lesokhin AM, Ansell SM, Armand P et al. preliminary results of a phase i study of nivolumab (BMS-936558) in patients with relapsed or refractory lymphoid malignancies. Presented at: 56th ASH Annual Meeting and Exposition. CA, USA, 6-9 December 2014. 31 Weber JS, D'angelo SP, Minor D et al. Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, Phase 3 trial. Lancet Oncol. 16(4), 375-384 (2015).
    • (2015) Lancet Oncol , vol.16 , Issue.4 , pp. 375-384
    • Lesokhin, A.M.1    Ansell, S.M.2    Armand, P.3
  • 31
    • 85045862023 scopus 로고    scopus 로고
    • Nivolumab improved survival vs dacarbazine in patients with untreated advanced melanoma
    • Long GV, Atkinson V, Ascierto PA et al. Nivolumab improved survival vs dacarbazine in patients with untreated advanced melanoma. J. Transl. Med. 13, 2063 (2015).
    • (2015) J. Transl. Med , vol.13 , pp. 2063
    • Long, G.V.1    Atkinson, V.2    Ascierto, P.A.3
  • 32
    • 84936791837 scopus 로고    scopus 로고
    • Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer
    • Brahmer J, Reckamp KL, Baas P et al. Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer. N. Engl. J. Med. 373(2), 123-135 (2015).
    • (2015) N. Engl. J. Med , vol.373 , Issue.2 , pp. 123-135
    • Brahmer, J.1    Reckamp, K.L.2    Baas, P.3
  • 33
    • 84925529257 scopus 로고    scopus 로고
    • Human cancer immunotherapy with antibodies to the PD-1 and PD-L1 pathway
    • Ohaegbulam KC, Assal A, Lazar-Molnar E, Yao Y, Zang X. Human cancer immunotherapy with antibodies to the PD-1 and PD-L1 pathway. Trends Mol. Med. 21(1), 24-33 (2015).
    • (2015) Trends Mol. Med , vol.21 , Issue.1 , pp. 24-33
    • Ohaegbulam, K.C.1    Assal, A.2    Lazar-Molnar, E.3    Yao, Y.4    Zang, X.5
  • 34
    • 84948155687 scopus 로고    scopus 로고
    • Phase I, open-label study of MEDI0680, an anti-programmed cell death-1 (PD-1) antibody, in combination with MEDI4736, an anti-programmed cell death ligand-1 (PD-L1) antibody, in patients with advanced malignancies
    • Presented at IL, USA, 29 May-2 June
    • Hamid O, Chow LQM, Tavakkoli F et al. Phase I, open-label study of MEDI0680, an anti-programmed cell death-1 (PD-1) antibody, in combination with MEDI4736, an anti-programmed cell death ligand-1 (PD-L1) antibody, in patients with advanced malignancies. Presented at: 51st Annual Meeting of American Society of Clinical Oncology. IL, USA, 29 May-2 June 2015.
    • (2015) 51st Annual Meeting of American Society of Clinical Oncology
    • Hamid, O.1    Chow, L.Q.M.2    Tavakkoli, F.3
  • 35
    • 84948158374 scopus 로고    scopus 로고
    • A Phase I, multicenter, open-label, first-in-human study to evaluate MEDI0680, an anti-programmed cell death-1 antibody, in patients with advanced malignancies
    • Presented at IL, USA, 29 May-02 June
    • Infante JR, Goel S, Tavakkoli F et al. A Phase I, multicenter, open-label, first-in-human study to evaluate MEDI0680, an anti-programmed cell death-1 antibody, in patients with advanced malignancies. Presented at: 51st Annual Meeting of American Society of Clinical Oncology. IL, USA, 29 May-02 June 2015.
    • (2015) 51st Annual Meeting of American Society of Clinical Oncology
    • Infante, J.R.1    Goel, S.2    Tavakkoli, F.3
  • 36
    • 0032736029 scopus 로고    scopus 로고
    • B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion
    • Dong H, Zhu G, Tamada K, Chen L. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nat. Med. 5(12), 1365-1369 (1999).
    • (1999) Nat. Med. , vol.5 , Issue.12 , pp. 1365-1369
    • Dong, H.1    Zhu, G.2    Tamada, K.3    Chen, L.4
  • 37
    • 0034596948 scopus 로고    scopus 로고
    • Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
    • Freeman GJ, Long AJ, Iwai Y et al. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J. Exp. Med. 192(7), 1027-1034 (2000).
    • (2000) J. Exp. Med , vol.192 , Issue.7 , pp. 1027-1034
    • Freeman, G.J.1    Long, A.J.2    Iwai, Y.3
  • 38
    • 34347371572 scopus 로고    scopus 로고
    • Interaction between B7-H1 and PD-1 determines initiation and reversal of T-cell anergy
    • Tsushima F, Yao S, Shin T et al. Interaction between B7-H1 and PD-1 determines initiation and reversal of T-cell anergy. Blood 110(1), 180-185 (2007).
    • (2007) Blood , vol.110 , Issue.1 , pp. 180-185
    • Tsushima, F.1    Yao, S.2    Shin, T.3
  • 39
    • 43549115533 scopus 로고    scopus 로고
    • B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells
    • Azuma T, Yao S, Zhu G, Flies AS, Flies SJ, Chen L. B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells. Blood 111(7), 3635-3643 (2008).
    • (2008) Blood , vol.111 , Issue.7 , pp. 3635-3643
    • Azuma, T.1    Yao, S.2    Zhu, G.3    Flies, A.S.4    Flies, S.J.5    Chen, L.6
  • 40
    • 34447646310 scopus 로고    scopus 로고
    • Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses
    • Butte MJ, Keir ME, Phamduy TB, Sharpe AH, Freeman GJ. Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses. Immunity 27(1), 111-122 (2007).
    • (2007) Immunity , vol.27 , Issue.1 , pp. 111-122
    • Butte, M.J.1    Keir, M.E.2    Phamduy, T.B.3    Sharpe, A.H.4    Freeman, G.J.5
  • 41
    • 77956496386 scopus 로고    scopus 로고
    • B7-H1/CD80 interaction is required for the induction and maintenance of peripheral T-cell tolerance
    • Park JJ, Omiya R, Matsumura Y et al. B7-H1/CD80 interaction is required for the induction and maintenance of peripheral T-cell tolerance. Blood 116(8), 1291-1298 (2010).
    • (2010) Blood , vol.116 , Issue.8 , pp. 1291-1298
    • Park, J.J.1    Omiya, R.2    Matsumura, Y.3
  • 42
    • 5844264920 scopus 로고    scopus 로고
    • PD-L2 is a second ligand for PD-1 and inhibits T cell activation
    • Latchman Y, Wood CR, Chernova T et al. PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat. Immunol. 2(3), 261-268 (2001).
    • (2001) Nat. Immunol , vol.2 , Issue.3 , pp. 261-268
    • Latchman, Y.1    Wood, C.R.2    Chernova, T.3
  • 43
    • 0035794314 scopus 로고    scopus 로고
    • B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells
    • Tseng SY, Otsuji M, Gorski K et al. B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells. J. Exp. Med. 193(7), 839-846 (2001).
    • (2001) J. Exp. Med , vol.193 , Issue.7 , pp. 839-846
    • Tseng, S.Y.1    Otsuji, M.2    Gorski, K.3
  • 44
    • 0037111483 scopus 로고    scopus 로고
    • Expression of programmed death 1 ligands by murine T cells and APC
    • Yamazaki T, Akiba H, Iwai H et al. Expression of programmed death 1 ligands by murine T cells and APC. J. Immunol. 169(10), 5538-5545 (2002).
    • (2002) J. Immunol , vol.169 , Issue.10 , pp. 5538-5545
    • Yamazaki, T.1    Akiba, H.2    Iwai, H.3
  • 45
    • 84899758346 scopus 로고    scopus 로고
    • RGMb is a novel binding partner for PD-L2 and its engagement with PD-L2 promotes respiratory tolerance
    • Xiao Y, Yu S, Zhu B et al. RGMb is a novel binding partner for PD-L2 and its engagement with PD-L2 promotes respiratory tolerance. J. Exp. Med. 211(5), 943-959 (2014).
    • (2014) J. Exp. Med , vol.211 , Issue.5 , pp. 943-959
    • Xiao, Y.1    Yu, S.2    Zhu, B.3
  • 46
    • 84862903106 scopus 로고    scopus 로고
    • Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
    • Brahmer JR, Tykodi SS, Chow LQ et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N. Engl. J. Med. 366(26), 2455-2465 (2012).
    • (2012) N. Engl. J. Med , vol.366 , Issue.26 , pp. 2455-2465
    • Brahmer, J.R.1    Tykodi, S.S.2    Chow, L.Q.3
  • 47
    • 79952713568 scopus 로고    scopus 로고
    • 6th Annual European Antibody Congress 2010: 29 November-1 December 2010
    • Beck A, Wurch T, Reichert JM. 6th Annual European Antibody Congress 2010: 29 November-1 December 2010, Geneva, Switzerland. mAbs 3(2), 111-132 (2011).
    • (2011) Geneva, Switzerland. MAbs , vol.3 , Issue.2 , pp. 111-132
    • Beck, A.1    Wurch, T.2    Reichert, J.M.3
  • 48
    • 84922634440 scopus 로고    scopus 로고
    • A Phase 1 study to evaluate the safety and tolerability of MEDI4736, an anti-PD-L1 antibody, in combination with tremelimumab in patients with advanced solid tumors
    • Presented at IL, USA, 30 May-03 June
    • Callahan MK, Ott PA, Odunsi K et al. A Phase 1 study to evaluate the safety and tolerability of MEDI4736, an anti-PD-L1 antibody, in combination with tremelimumab in patients with advanced solid tumors. Presented at: 50th Annual Meeting of American Society of Clinical Oncology. IL, USA, 30 May-03 June 2014.
    • (2014) 50th Annual Meeting of American Society of Clinical Oncology
    • Callahan, M.K.1    Ott, P.A.2    Odunsi, K.3
  • 49
    • 84905698694 scopus 로고    scopus 로고
    • Inhibition of PD-L1 by MPDL3280A and clinical activity in pts with metastatic urothelial bladder cancer (UBC)
    • Presented at IL, USA, 30 May-03 June
    • Powles T, Vogelzang NJ, Fine GD et al. Inhibition of PD-L1 by MPDL3280A and clinical activity in pts with metastatic urothelial bladder cancer (UBC). Presented at: 50th Annual Meeting of American Society of Clinical Oncology. IL, USA, 30 May-03 June 2014.
    • (2014) 50th Annual Meeting of American Society of Clinical Oncology
    • Powles, T.1    Vogelzang, N.J.2    Fine, G.D.3
  • 50
    • 84912134974 scopus 로고    scopus 로고
    • Phase i open-label, multiple ascending dose trial of MSB0010718C, an anti-PD-L1 monoclonal antibody, in advanced solid malignancies
    • Presented at IL, USA, 30 May-03 June
    • Heery CR, O'sullivan Coyne GH, Madan RA et al. Phase I open-label, multiple ascending dose trial of MSB0010718C, an anti-PD-L1 monoclonal antibody, in advanced solid malignancies. Presented at: 50th Annual Meeting of American Society of Clinical Oncology. IL, USA, 30 May-03 June 2014.
    • (2014) 50th Annual Meeting of American Society of Clinical Oncology
    • Heery, C.R.1    O'Sullivan Coyne, G.H.2    Madan, R.A.3
  • 51
    • 84948177530 scopus 로고    scopus 로고
    • Antibody dependent cellular cytotoxicity activity of a novel anti-PD-L1 antibody, avelumab (MSB0010718C), on human tumor cells
    • Presented at IL, USA, 29 May-2 June
    • Tsang K-Y, Boyerinas B, Jochems C et al. Antibody dependent cellular cytotoxicity activity of a novel anti-PD-L1 antibody, avelumab (MSB0010718C), on human tumor cells. Presented at: 51st Annual Meeting of American Society of Clinical Oncology. IL, USA, 29 May-2 June 2015.
    • (2015) 51st Annual Meeting of American Society of Clinical Oncology
    • Tsang, K.-Y.1    Boyerinas, B.2    Jochems, C.3
  • 52
  • 53
    • 0038094524 scopus 로고    scopus 로고
    • B7-H4, a molecule of the B7 family, negatively regulates T cell immunity
    • Sica GL, Choi IH, Zhu G et al. B7-H4, a molecule of the B7 family, negatively regulates T cell immunity. Immunity 18(6), 849-861 (2003).
    • (2003) Immunity , vol.18 , Issue.6 , pp. 849-861
    • Sica, G.L.1    Choi, I.H.2    Zhu, G.3
  • 54
    • 0038433329 scopus 로고    scopus 로고
    • B7S1, a novel B7 family member that negatively regulates T cell activation
    • Prasad DV, Richards S, Mai XM, Dong C. B7S1, a novel B7 family member that negatively regulates T cell activation. Immunity 18(6), 863-873 (2003).
    • (2003) Immunity , vol.18 , Issue.6 , pp. 863-873
    • Prasad, D.V.1    Richards, S.2    Mai, X.M.3    Dong, C.4
  • 55
    • 84866166646 scopus 로고    scopus 로고
    • Tissue-expressed B7x affects the immune response to and outcome of lethal pulmonary infection
    • Hofmeyer KA, Scandiuzzi L, Ghosh K, Pirofski LA, Zang X. Tissue-expressed B7x affects the immune response to and outcome of lethal pulmonary infection. J. Immunol. 189(6), 3054-3063 (2012).
    • (2012) J. Immunol , vol.189 , Issue.6 , pp. 3054-3063
    • Hofmeyer, K.A.1    Scandiuzzi, L.2    Ghosh, K.3    Pirofski, L.A.4    Zang, X.5
  • 56
    • 84867321651 scopus 로고    scopus 로고
    • B7x in the periphery abrogates pancreas-specific damage mediated by self-reactive CD8 T cells
    • Lee JS, Scandiuzzi L, Ray A et al. B7x in the periphery abrogates pancreas-specific damage mediated by self-reactive CD8 T cells. J. Immunol. 189(8), 4165-4174 (2012).
    • (2012) J. Immunol , vol.189 , Issue.8 , pp. 4165-4174
    • Lee, J.S.1    Scandiuzzi, L.2    Ray, A.3
  • 57
    • 79961147546 scopus 로고    scopus 로고
    • Tissue-specific expression of B7x protects from CD4 T cell-mediated autoimmunity
    • Wei J, Loke P, Zang X, Allison JP. Tissue-specific expression of B7x protects from CD4 T cell-mediated autoimmunity. J. Exp. Med. 208(8), 1683-1694 (2011).
    • (2011) J. Exp. Med , vol.208 , Issue.8 , pp. 1683-1694
    • Wei, J.1    Loke, P.2    Zang, X.3    Allison, J.P.4
  • 58
    • 84886944592 scopus 로고    scopus 로고
    • B7x and myeloid-derived suppressor cells in the tumor microenvironment: A tale of two cities
    • Jeon H, Ohaegbulam KC, Abadi YM, Zang X. B7x and myeloid-derived suppressor cells in the tumor microenvironment: a tale of two cities. Oncoimmunology 2(7), e24744 (2013).
    • (2013) Oncoimmunology , vol.2 , Issue.7 , pp. e24744
    • Jeon, H.1    Ohaegbulam, K.C.2    Abadi, Y.M.3    Zang, X.4
  • 59
    • 37649013179 scopus 로고    scopus 로고
    • B7-H3 and B7x are highly expressed in human prostate cancer and associated with disease spread and poor outcome
    • Zang X, Thompson RH, Al-Ahmadie HA et al. B7-H3 and B7x are highly expressed in human prostate cancer and associated with disease spread and poor outcome. Proc. Natl Acad. Sci. USA 104(49), 19458-19463 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , Issue.49 , pp. 19458-19463
    • Zang, X.1    Thompson, R.H.2    Al-Ahmadie, H.A.3
  • 60
    • 33745886516 scopus 로고    scopus 로고
    • B7-H4 expression in renal cell carcinoma and tumor vasculature: Associations with cancer progression and survival
    • Krambeck AE, Thompson RH, Dong H et al. B7-H4 expression in renal cell carcinoma and tumor vasculature: associations with cancer progression and survival. Proc. Natl Acad. Sci. USA 103(27), 10391-10396 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , Issue.27 , pp. 10391-10396
    • Krambeck, A.E.1    Thompson, R.H.2    Dong, H.3
  • 61
    • 77958067744 scopus 로고    scopus 로고
    • Tumor expression of B7-H4 predicts poor survival of patients suffering from gastric cancer
    • Jiang J, Zhu Y, Wu C et al. Tumor expression of B7-H4 predicts poor survival of patients suffering from gastric cancer. Cancer Immunol. Immunother. 59(11), 1707-1714 (2010).
    • (2010) Cancer Immunol. Immunother , vol.59 , Issue.11 , pp. 1707-1714
    • Jiang, J.1    Zhu, Y.2    Wu, C.3
  • 62
    • 33745605153 scopus 로고    scopus 로고
    • B7-H3 and B7-H4 expression in non-small-cell lung cancer
    • Sun Y, Wang Y, Zhao J et al. B7-H3 and B7-H4 expression in non-small-cell lung cancer. Lung Cancer 53(2), 143-151 (2006).
    • (2006) Lung Cancer , vol.53 , Issue.2 , pp. 143-151
    • Sun, Y.1    Wang, Y.2    Zhao, J.3
  • 63
    • 34250183451 scopus 로고    scopus 로고
    • B7-H4 (DDO110) is overexpressed in high risk uterine endometrioid adenocarcinomas and inversely correlated with tumor T-cell infiltration
    • Miyatake T, Tringler B, Liu W et al. B7-H4 (DDO110) is overexpressed in high risk uterine endometrioid adenocarcinomas and inversely correlated with tumor T-cell infiltration. Gynecol Oncol. 106(1), 119-127 (2007).
    • (2007) Gynecol Oncol , vol.106 , Issue.1 , pp. 119-127
    • Miyatake, T.1    Tringler, B.2    Liu, W.3
  • 64
    • 84919775114 scopus 로고    scopus 로고
    • Structure and cancer immunotherapy of the B7 family member B7x
    • Jeon H, Vigdorovich V, Garrett-Thomson SC et al. Structure and cancer immunotherapy of the B7 family member B7x. Cell Rep. 9(3), 1089-1098 (2014).
    • (2014) Cell Rep , vol.9 , Issue.3 , pp. 1089-1098
    • Jeon, H.1    Vigdorovich, V.2    Garrett-Thomson, S.C.3
  • 65
    • 84878990597 scopus 로고    scopus 로고
    • HHLA2 is a member of the B7 family and inhibits human CD4 and CD8 T-cell function
    • Zhao R, Chinai JM, Buhl S et al. HHLA2 is a member of the B7 family and inhibits human CD4 and CD8 T-cell function. Proc. Natl Acad. Sci. USA 110(24), 9879-9884 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , Issue.24 , pp. 9879-9884
    • Zhao, R.1    Chinai, J.M.2    Buhl, S.3
  • 66
    • 84879668353 scopus 로고    scopus 로고
    • B7-H5 costimulates human T cells via CD28H
    • Zhu Y, Yao S, Iliopoulou BP et al. B7-H5 costimulates human T cells via CD28H. Nat. Commun. 4, 2043 (2013).
    • (2013) Nat. Commun , vol.4 , pp. 2043
    • Zhu, Y.1    Yao, S.2    Iliopoulou, B.P.3
  • 67
    • 84938317531 scopus 로고    scopus 로고
    • Expression, clinical significance, and receptor identification of the newest B7 family member HHLA2 protein
    • Janakiram M, Chinai JM, Fineberg S et al. Expression, clinical significance, and receptor identification of the newest B7 family member HHLA2 protein. Clin. Cancer Res. 21(10), 2359-2366 (2015).
    • (2015) Clin. Cancer Res , vol.21 , Issue.10 , pp. 2359-2366
    • Janakiram, M.1    Chinai, J.M.2    Fineberg, S.3
  • 68
    • 5844252552 scopus 로고    scopus 로고
    • B7-H3: A costimulatory molecule for T cell activation and IFN-gamma production
    • Chapoval AI, Ni J, Lau JS et al. B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production. Nat. Immunol. 2(3), 269-274 (2001).
    • (2001) Nat. Immunol. , vol.2 , Issue.3 , pp. 269-274
    • Chapoval, A.I.1    Ni, J.2    Lau, J.S.3
  • 69
    • 0041381300 scopus 로고    scopus 로고
    • The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses
    • Suh WK, Gajewska BU, Okada H et al. The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses. Nat. Immunol. 4(9), 899-906 (2003).
    • (2003) Nat. Immunol , vol.4 , Issue.9 , pp. 899-906
    • Suh, W.K.1    Gajewska, B.U.2    Okada, H.3
  • 70
    • 78650151049 scopus 로고    scopus 로고
    • B7-H3 ligand expression by primary breast cancer and associated with regional nodal metastasis
    • Arigami T, Narita N, Mizuno R et al. B7-H3 ligand expression by primary breast cancer and associated with regional nodal metastasis. Ann. Surg. 252(6), 1044-1051 (2010).
    • (2010) Ann. Surg , vol.252 , Issue.6 , pp. 1044-1051
    • Arigami, T.1    Narita, N.2    Mizuno, R.3
  • 72
    • 84979860701 scopus 로고    scopus 로고
    • B7-H3 expression in donor T cells and host cells negatively regulates acute graft-versus-host disease lethality
    • Veenstra RG, Flynn R, Kreymborg K et al. B7-H3 expression in donor T cells and host cells negatively regulates acute graft-versus-host disease lethality. Blood 125(21), 3335-3346 (2015).
    • (2015) Blood , vol.125 , Issue.21 , pp. 3335-3346
    • Veenstra, R.G.1    Flynn, R.2    Kreymborg, K.3
  • 73
    • 84892544676 scopus 로고    scopus 로고
    • Association of T-cell co-regulatory protein expression with clinical outcomes following radical cystectomy for urothelial carcinoma of the bladder
    • Xylinas E, Robinson BD, Kluth LA et al. Association of T-cell co-regulatory protein expression with clinical outcomes following radical cystectomy for urothelial carcinoma of the bladder. Eur. J. Surg. Oncol. 40(1), 121-127 (2014).
    • (2014) Eur. J. Surg. Oncol , vol.40 , Issue.1 , pp. 121-127
    • Xylinas, E.1    Robinson, B.D.2    Kluth, L.A.3
  • 74
    • 77955172320 scopus 로고    scopus 로고
    • Tumor associated endothelial expression of B7-H3 predicts survival in ovarian carcinomas
    • Zang X, Sullivan PS, Soslow RA et al. Tumor associated endothelial expression of B7-H3 predicts survival in ovarian carcinomas. Mod. Pathol. 23(8), 1104-1112 (2010).
    • (2010) Mod. Pathol , vol.23 , Issue.8 , pp. 1104-1112
    • Zang, X.1    Sullivan, P.S.2    Soslow, R.A.3
  • 75
    • 79952717517 scopus 로고    scopus 로고
    • VISTA, a novel mouse Ig superfamily ligand that negatively regulates T cell responses
    • Wang L, Rubinstein R, Lines JL et al. VISTA, a novel mouse Ig superfamily ligand that negatively regulates T cell responses. J. Exp. Med. 208(3), 577-592 (2011).
    • (2011) J. Exp. Med , vol.208 , Issue.3 , pp. 577-592
    • Wang, L.1    Rubinstein, R.2    Lines, J.L.3
  • 76
    • 84897445677 scopus 로고    scopus 로고
    • VISTA is an immune checkpoint molecule for human T cells
    • Lines JL, Pantazi E, Mak J et al. VISTA is an immune checkpoint molecule for human T cells. Cancer Res. 74(7), 1924-1932 (2014).
    • (2014) Cancer Res , vol.74 , Issue.7 , pp. 1924-1932
    • Lines, J.L.1    Pantazi, E.2    Mak, J.3
  • 77
    • 84897429090 scopus 로고    scopus 로고
    • VISTA Regulates the development of protective antitumor immunity
    • Le Mercier I, Chen W, Lines JL et al. VISTA Regulates the development of protective antitumor immunity. Cancer Res. 74(7), 1933-1944 (2014).
    • (2014) Cancer Res , vol.74 , Issue.7 , pp. 1933-1944
    • Le Mercier, I.1    Chen, W.2    Lines, J.L.3
  • 78
    • 79951822440 scopus 로고    scopus 로고
    • Role of CD27/CD70 pathway of activation in immunity and tolerance
    • Denoeud J, Moser M. Role of CD27/CD70 pathway of activation in immunity and tolerance. J. Leukoc. Biol. 89(2), 195-203 (2011).
    • (2011) J. Leukoc. Biol , vol.89 , Issue.2 , pp. 195-203
    • Denoeud, J.1    Moser, M.2
  • 79
    • 34249722182 scopus 로고    scopus 로고
    • Eradication of lymphoma by CD8 T cells following anti-CD40 monoclonal antibody therapy is critically dependent on CD27 costimulation
    • French RR, Taraban VY, Crowther GR et al. Eradication of lymphoma by CD8 T cells following anti-CD40 monoclonal antibody therapy is critically dependent on CD27 costimulation. Blood 109(11), 4810-4815 (2007).
    • (2007) Blood , vol.109 , Issue.11 , pp. 4810-4815
    • French, R.R.1    Taraban, V.Y.2    Crowther, G.R.3
  • 80
    • 84863918915 scopus 로고    scopus 로고
    • Development of a human monoclonal antibody for potential therapy of CD27-expressing lymphoma and leukemia
    • Vitale LA, He LZ, Thomas LJ et al. Development of a human monoclonal antibody for potential therapy of CD27-expressing lymphoma and leukemia. Clin. Cancer Res. 18(14), 3812-3821 (2012).
    • (2012) Clin. Cancer Res , vol.18 , Issue.14 , pp. 3812-3821
    • Vitale, L.A.1    He, L.Z.2    Thomas, L.J.3
  • 81
    • 84930944503 scopus 로고    scopus 로고
    • A Phase i study of an agonist anti-CD27 human antibody (CDX-1127) patients with advanced hematologic malignancies or solid tumors
    • Ansell S, Northfelt D, Flinn I et al. A Phase I study of an agonist anti-CD27 human antibody (CDX-1127) in patients with advanced hematologic malignancies or solid tumors. J. Immunother. Cancer 1(Suppl. 1), P259-P259 (2013).
    • (2013) J. Immunother. Cancer , vol.1 , pp. P259-P259
    • Ansell, S.1    Northfelt, D.2    Flinn, I.3
  • 82
    • 65349112520 scopus 로고    scopus 로고
    • The significance of OX40 and OX40L to T-cell biology and immune disease
    • Croft M, So T, Duan W, Soroosh P. The significance of OX40 and OX40L to T-cell biology and immune disease. Immunol. Rev. 229(1), 173-191 (2009).
    • (2009) Immunol. Rev , vol.229 , Issue.1 , pp. 173-191
    • Croft, M.1    So, T.2    Duan, W.3    Soroosh, P.4
  • 83
    • 84923537886 scopus 로고    scopus 로고
    • OX40 Agonists and combination immunotherapy: Putting the pedal to the metal
    • Linch SN, Mcnamara MJ, Redmond WL. OX40 Agonists and combination immunotherapy: putting the pedal to the metal. Front Oncol. 5, 34 (2015).
    • (2015) Front Oncol , vol.5 , pp. 34
    • Linch, S.N.1    Mcnamara, M.J.2    Redmond, W.L.3
  • 84
    • 42249097689 scopus 로고    scopus 로고
    • OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection
    • Piconese S, Valzasina B, Colombo MP. OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection. J. Exp. Med. 205(4), 825-839 (2008).
    • (2008) J. Exp. Med , vol.205 , Issue.4 , pp. 825-839
    • Piconese, S.1    Valzasina, B.2    Colombo, M.P.3
  • 85
    • 84891275907 scopus 로고    scopus 로고
    • OX40 is a potent immune-stimulating target in late-stage cancer patients
    • National Institues of Health
    • National Institues of Health. www.clinicaltrials.gov 87 Curti BD, Kovacsovics-Bankowski M, Morris N et al. OX40 is a potent immune-stimulating target in late-stage cancer patients. Cancer Res. 73(24), 7189-7198 (2013).
    • (2013) Cancer Res , vol.73 , Issue.24 , pp. 7189-7198
    • Kovacsovics-Bankowski, M.1    Morris, N.2
  • 86
    • 65349149089 scopus 로고    scopus 로고
    • Molecular mechanism and function of CD40/CD40L engagement in the immune system
    • Elgueta R, Benson MJ, De Vries VC, Wasiuk A, Guo Y, Noelle RJ. Molecular mechanism and function of CD40/CD40L engagement in the immune system. Immunol. Rev. 229(1), 152-172 (2009).
    • (2009) Immunol. Rev , vol.229 , Issue.1 , pp. 152-172
    • Elgueta, R.1    Benson, M.J.2    De Vries, V.C.3    Wasiuk, A.4    Guo, Y.5    Noelle, R.J.6
  • 87
    • 84863890977 scopus 로고    scopus 로고
    • Design of CD40 agonists and their use in growing B cells for cancer immunotherapy
    • Kornbluth RS, Stempniak M, Stone GW. Design of CD40 agonists and their use in growing B cells for cancer immunotherapy. Int. Rev. Immunol. 31(4), 279-288 (2012).
    • (2012) Int. Rev. Immunol. , vol.31 , Issue.4 , pp. 279-288
    • Kornbluth, R.S.1    Stempniak, M.2    Stone, G.W.3
  • 88
    • 0031977605 scopus 로고    scopus 로고
    • The role of CD40/CD154 interactions in the priming, differentiation, and effector function of helper and cytotoxic T cells
    • Mackey MF, Barth RJ Jr, Noelle RJ. The role of CD40/CD154 interactions in the priming, differentiation, and effector function of helper and cytotoxic T cells. J. Leukoc. Biol. 63(4), 418-428 (1998).
    • (1998) J. Leukoc. Biol , vol.63 , Issue.4 , pp. 418-428
    • Mackey, M.F.1    Barth, Jr.R.J.2    Noelle, R.J.3
  • 89
    • 0035397985 scopus 로고    scopus 로고
    • Phase i study of recombinant human CD40 ligand in cancer patients
    • Vonderheide RH, Dutcher JP, Anderson JE et al. Phase I study of recombinant human CD40 ligand in cancer patients. J. Clin. Oncol. 19(13), 3280-3287 (2001).
    • (2001) J. Clin. Oncol , vol.19 , Issue.13 , pp. 3280-3287
    • Vonderheide, R.H.1    Dutcher, J.P.2    Anderson, J.E.3
  • 90
    • 84903272348 scopus 로고    scopus 로고
    • A Phase II study of dacetuzumab (SGN-40) in patients with relapsed diffuse large B-cell lymphoma (DLBCL) and correlative analyses of patient-specific factors
    • De Vos S, Forero-Torres A, Ansell SM et al. A Phase II study of dacetuzumab (SGN-40) in patients with relapsed diffuse large B-cell lymphoma (DLBCL) and correlative analyses of patient-specific factors. J. Hematol. Oncol. 7, 44 (2014).
    • (2014) J. Hematol. Oncol , vol.7 , pp. 44
    • De Vos, S.1    Forero-Torres, A.2    Ansell, S.M.3
  • 91
    • 84866314973 scopus 로고    scopus 로고
    • A Phase 1 study of lucatumumab, a fully human anti-CD40 antagonist monoclonal antibody administered intravenously to patients with relapsed or refractory multiple myeloma
    • Bensinger W, Maziarz RT, Jagannath S et al. A Phase 1 study of lucatumumab, a fully human anti-CD40 antagonist monoclonal antibody administered intravenously to patients with relapsed or refractory multiple myeloma. Br. J. Haematol. 159(1), 58-66 (2012).
    • (2012) Br. J. Haematol , vol.159 , Issue.1 , pp. 58-66
    • Bensinger, W.1    Maziarz, R.T.2    Jagannath, S.3
  • 92
    • 84862739640 scopus 로고    scopus 로고
    • Immunotherapy of cancer with 4-1BB
    • Vinay DS, Kwon BS. Immunotherapy of cancer with 4-1BB. Mol. Cancer Ther. 11(5), 1062-1070 (2012).
    • (2012) Mol. Cancer Ther , vol.11 , Issue.5 , pp. 1062-1070
    • Vinay, D.S.1    Kwon, B.S.2
  • 93
    • 17644389199 scopus 로고    scopus 로고
    • TNF/TNFR family members in costimulation of T cell responses
    • Watts TH. TNF/TNFR family members in costimulation of T cell responses. Annu. Rev. Immunol. 23, 23-68 (2005).
    • (2005) Annu. Rev. Immunol , vol.23 , pp. 23-68
    • Watts, T.H.1
  • 94
    • 84873372202 scopus 로고    scopus 로고
    • Advances in targeting cell surface signalling molecules for immune modulation
    • Yao S, Zhu Y, Chen L. Advances in targeting cell surface signalling molecules for immune modulation. Nat. Rev. Drug Discov. 12(2), 130-146 (2013).
    • (2013) Nat. Rev. Drug Discov , vol.12 , Issue.2 , pp. 130-146
    • Yao, S.1    Zhu, Y.2    Chen, L.3
  • 95
    • 0030845586 scopus 로고    scopus 로고
    • 4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses
    • Shuford WW, Klussman K, Tritchler DD et al. 4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses. J. Exp. Med. 186(1), 47-55 (1997).
    • (1997) J. Exp. Med , vol.186 , Issue.1 , pp. 47-55
    • Shuford, W.W.1    Klussman, K.2    Tritchler, D.D.3
  • 96
    • 77950403194 scopus 로고    scopus 로고
    • CD137 agonist antibody prevents cancer recurrence: Contribution of CD137 on both hematopoietic and nonhematopoietic cells
    • Narazaki H, Zhu Y, Luo L, Zhu G, Chen L. CD137 agonist antibody prevents cancer recurrence: contribution of CD137 on both hematopoietic and nonhematopoietic cells. Blood 115(10), 1941-1948 (2010).
    • (2010) Blood , vol.115 , Issue.10 , pp. 1941-1948
    • Narazaki, H.1    Zhu, Y.2    Luo, L.3    Zhu, G.4    Chen, L.5
  • 97
    • 0031007143 scopus 로고    scopus 로고
    • Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors
    • Melero I, Shuford WW, Newby SA et al. Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors. Nat. Med. 3(6), 682-685 (1997).
    • (1997) Nat. Med , vol.3 , Issue.6 , pp. 682-685
    • Melero, I.1    Shuford, W.W.2    Newby, S.A.3
  • 98
    • 79551524395 scopus 로고    scopus 로고
    • Agonist anti-CD137 mAb act on tumor endothelial cells to enhance recruitment of activated T lymphocytes
    • Palazon A, Teijeira A, Martinez-Forero I et al. Agonist anti-CD137 mAb act on tumor endothelial cells to enhance recruitment of activated T lymphocytes. Cancer Res. 71(3), 801-811 (2011).
    • (2011) Cancer Res , vol.71 , Issue.3 , pp. 801-811
    • Palazon, A.1    Teijeira, A.2    Martinez-Forero, I.3
  • 99
    • 84899112560 scopus 로고    scopus 로고
    • Trial Watch: Immunostimulatory monoclonal antibodies in cancer therapy
    • Aranda F, Vacchelli E, Eggermont A et al. Trial Watch: immunostimulatory monoclonal antibodies in cancer therapy. Oncoimmunology 3(1), e27297 (2014).
    • (2014) Oncoimmunology , vol.3 , Issue.1 , pp. e27297
    • Aranda, F.1    Vacchelli, E.2    Eggermont, A.3
  • 100
    • 84884822262 scopus 로고    scopus 로고
    • Immunotherapy of melanoma with the immune costimulatory monoclonal antibodies targeting CD137
    • Li SY, Liu Y. Immunotherapy of melanoma with the immune costimulatory monoclonal antibodies targeting CD137. Clin. Pharmacol. 5(Suppl. 1), 47-53 (2013).
    • (2013) Clin. Pharmacol , vol.5 , pp. 47-53
    • Li, S.Y.1    Liu, Y.2
  • 101
    • 78449237499 scopus 로고    scopus 로고
    • Clinical experiences with anti-CD137 and anti-PD1 therapeutic antibodies
    • Ascierto PA, Simeone E, Sznol M, Fu YX, Melero I. Clinical experiences with anti-CD137 and anti-PD1 therapeutic antibodies. Semin. Oncol. 37(5), 508-516 (2010).
    • (2010) Semin. Oncol , vol.37 , Issue.5 , pp. 508-516
    • Ascierto, P.A.1    Simeone, E.2    Sznol, M.3    Fu, Y.X.4    Melero, I.5
  • 102
    • 55949113750 scopus 로고    scopus 로고
    • Phase i study of BMS-663513, a fully human anti-CD137 agonist monoclonal antibody, in patients (pts) with advanced cancer (CA)
    • Presented at IL, USA, 30 May-02 June
    • Sznol M, Hodi FS, Margolin K et al. Phase I study of BMS-663513, a fully human anti-CD137 agonist monoclonal antibody, in patients (pts) with advanced cancer (CA). Presented at: 44th Annual Meeting of American Society of Clinical Oncology. IL, USA, 30 May-02 June 2008.
    • (2008) 44th Annual Meeting of American Society of Clinical Oncology
    • Sznol, M.1    Hodi, F.S.2    Margolin, K.3
  • 103
    • 84948159193 scopus 로고    scopus 로고
    • CD137 stimulation of natural killer cells to enhance the antilymphoma activity of rituximab
    • Presented at IL, USA, 4-8 June
    • Kohrt HE, Houot R, Goldstein M et al. CD137 stimulation of natural killer cells to enhance the antilymphoma activity of rituximab. Presented at: 46th Annual Meeting of American Society of Clinical Oncology. IL, USA, 4-8 June 2010.
    • (2010) 46th Annual Meeting of American Society of Clinical Oncology
    • Kohrt, H.E.1    Houot, R.2    Goldstein, M.3
  • 104
    • 84948181110 scopus 로고    scopus 로고
    • Targeting CD137 to enhance the antitumor efficacy of cetuximab by stimulation of innate and adaptive immunity
    • Presented at IL, USA, 31 May-4 June
    • Kohrt HE, Houot R, Weiskopf K et al. Targeting CD137 to enhance the antitumor efficacy of cetuximab by stimulation of innate and adaptive immunity. Presented at: 49th Annual Meeting of American Society of Clinical Oncology. IL, USA, 31 May-4 June 2013.
    • (2013) 49th Annual Meeting of American Society of Clinical Oncology
    • Kohrt, H.E.1    Houot, R.2    Weiskopf, K.3
  • 106
    • 0030962132 scopus 로고    scopus 로고
    • A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis
    • Nocentini G, Giunchi L, Ronchetti S et al. A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis. Proc. Natl Acad. Sci. USA 94(12), 6216-6221 (1997).
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , Issue.12 , pp. 6216-6221
    • Nocentini, G.1    Giunchi, L.2    Ronchetti, S.3
  • 109
    • 84893683548 scopus 로고    scopus 로고
    • Combined PD-1 blockade and GITR triggering induce a potent antitumor immunity in murine cancer models and synergizes with chemotherapeutic drugs
    • Lu L, Xu X, Zhang B, Zhang R, Ji H, Wang X. Combined PD-1 blockade and GITR triggering induce a potent antitumor immunity in murine cancer models and synergizes with chemotherapeutic drugs. J. Transl. Med. 12, 36 (2014).
    • (2014) J. Transl. Med , vol.12 , pp. 36
    • Lu, L.1    Xu, X.2    Zhang, B.3    Zhang, R.4    Ji, H.5    Wang, X.6
  • 110
    • 82255181369 scopus 로고    scopus 로고
    • Enhancement of anti-tumor immunity through local modulation of CTLA-4 and GITR by dendritic cells
    • Pruitt SK, Boczkowski D, De Rosa N et al. Enhancement of anti-tumor immunity through local modulation of CTLA-4 and GITR by dendritic cells. Eur. J. Immunol. 41(12), 3553-3563 (2011).
    • (2011) Eur. J. Immunol , vol.41 , Issue.12 , pp. 3553-3563
    • Pruitt, S.K.1    Boczkowski, D.2    De Rosa, N.3
  • 112
    • 33947190606 scopus 로고    scopus 로고
    • T cell immunoglobulin mucin-3 crystal structure reveals a galectin-9-independent ligand-binding surface
    • Cao E, Zang X, Ramagopal UA et al. T cell immunoglobulin mucin-3 crystal structure reveals a galectin-9-independent ligand-binding surface. Immunity 26(3), 311-321 (2007).
    • (2007) Immunity , vol.26 , Issue.3 , pp. 311-321
    • Cao, E.1    Zang, X.2    Ramagopal, U.A.3
  • 113
    • 36048963838 scopus 로고    scopus 로고
    • LAG-3 regulates CD8+ T cell accumulation and effector function in murine self-and tumor-tolerance systems
    • Grosso JF, Kelleher CC, Harris TJ et al. LAG-3 regulates CD8+ T cell accumulation and effector function in murine self-and tumor-tolerance systems. J. Clin. Invest. 117(11), 3383-3392 (2007).
    • (2007) J. Clin. Invest , vol.117 , Issue.11 , pp. 3383-3392
    • Grosso, J.F.1    Kelleher, C.C.2    Harris, T.J.3
  • 114
    • 19544374904 scopus 로고    scopus 로고
    • The negative regulatory function of the lymphocyte-activation gene-3 co-receptor (CD223) on human T cells
    • Macon-Lemaitre L, Triebel F. The negative regulatory function of the lymphocyte-activation gene-3 co-receptor (CD223) on human T cells. Immunology 115(2), 170-178 (2005).
    • (2005) Immunology , vol.115 , Issue.2 , pp. 170-178
    • Macon-Lemaitre, L.1    Triebel, F.2
  • 115
    • 5644263642 scopus 로고    scopus 로고
    • Role of LAG-3 in regulatory T cells
    • Huang CT, Workman CJ, Flies D et al. Role of LAG-3 in regulatory T cells. Immunity 21(4), 503-513 (2004).
    • (2004) Immunity , vol.21 , Issue.4 , pp. 503-513
    • Huang, C.T.1    Workman, C.J.2    Flies, D.3
  • 116
    • 84880682724 scopus 로고    scopus 로고
    • Novel antibodies targeting immune regulatory checkpoints for cancer therapy
    • Lee CS, Cragg M, Glennie M, Johnson P. Novel antibodies targeting immune regulatory checkpoints for cancer therapy. Br. J. Clin. Pharmacol. 76(2), 233-247 (2013).
    • (2013) Br. J. Clin. Pharmacol , vol.76 , Issue.2 , pp. 233-247
    • Lee, C.S.1    Cragg, M.2    Glennie, M.3    Johnson, P.4
  • 117
    • 84863115998 scopus 로고    scopus 로고
    • Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape
    • Woo SR, Turnis ME, Goldberg MV et al. Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape. Cancer Res. 72(4), 917-927 (2012).
    • (2012) Cancer Res , vol.72 , Issue.4 , pp. 917-927
    • Woo, S.R.1    Turnis, M.E.2    Goldberg, M.V.3
  • 118
    • 35748957791 scopus 로고    scopus 로고
    • A soluble form of lymphocyte activation gene-3 (IMP321) induces activation of a large range of human effector cytotoxic cells
    • Brignone C, Grygar C, Marcu M, Schakel K, Triebel F. A soluble form of lymphocyte activation gene-3 (IMP321) induces activation of a large range of human effector cytotoxic cells. J. Immunol. 179(6), 4202-4211 (2007).
    • (2007) J. Immunol , vol.179 , Issue.6 , pp. 4202-4211
    • Brignone, C.1    Grygar, C.2    Marcu, M.3    Schakel, K.4    Triebel, F.5
  • 119
    • 70349669259 scopus 로고    scopus 로고
    • A Phase i pharmacokinetic and biological correlative study of IMP321, a novel MHC class II agonist, in patients with advanced renal cell carcinoma
    • Brignone C, Escudier B, Grygar C, Marcu M, Triebel F. A Phase I pharmacokinetic and biological correlative study of IMP321, a novel MHC class II agonist, in patients with advanced renal cell carcinoma. Clin. Cancer Res. 15(19), 6225-6231 (2009).
    • (2009) Clin. Cancer Res , vol.15 , Issue.19 , pp. 6225-6231
    • Brignone, C.1    Escudier, B.2    Grygar, C.3    Marcu, M.4    Triebel, F.5
  • 120
    • 77955487541 scopus 로고    scopus 로고
    • First-line chemoimmunotherapy in metastatic breast carcinoma: Combination of paclitaxel and IMP321 (LAG-3Ig) enhances immune responses and antitumor activity
    • Brignone C, Gutierrez M, Mefti F et al. First-line chemoimmunotherapy in metastatic breast carcinoma: combination of paclitaxel and IMP321 (LAG-3Ig) enhances immune responses and antitumor activity. J. Transl. Med. 8, 71 (2010).
    • (2010) J. Transl. Med , vol.8 , pp. 71
    • Brignone, C.1    Gutierrez, M.2    Mefti, F.3
  • 121
    • 84879085032 scopus 로고    scopus 로고
    • A Phase i study of IMP321 and gemcitabine as the front-line therapy in patients with advanced pancreatic adenocarcinoma
    • Wang-Gillam A, Plambeck-Suess S, Goedegebuure P et al. A Phase I study of IMP321 and gemcitabine as the front-line therapy in patients with advanced pancreatic adenocarcinoma. Invest. New Drugs 31(3), 707-713 (2013).
    • (2013) Invest. New Drugs , vol.31 , Issue.3 , pp. 707-713
    • Wang-Gillam, A.1    Plambeck-Suess, S.2    Goedegebuure, P.3
  • 122
    • 84899083535 scopus 로고    scopus 로고
    • MART-1 peptide vaccination plus IMP321 (LAG-3Ig fusion protein) in patients receiving autologous PBMCs after lymphodepletion: Results of a Phase i trial
    • Romano E, Michielin O, Voelter V et al. MART-1 peptide vaccination plus IMP321 (LAG-3Ig fusion protein) in patients receiving autologous PBMCs after lymphodepletion: results of a Phase I trial. J. Transl. Med. 12, 97 (2014).
    • (2014) J. Transl. Med , vol.12 , pp. 97
    • Romano, E.1    Michielin, O.2    Voelter, V.3
  • 123
    • 0037810670 scopus 로고    scopus 로고
    • BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1
    • Watanabe N, Gavrieli M, Sedy JR et al. BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1. Nat. Immunol. 4(7), 670-679 (2003).
    • (2003) Nat. Immunol , vol.4 , Issue.7 , pp. 670-679
    • Watanabe, N.1    Gavrieli, M.2    Sedy, J.R.3
  • 124
    • 84876481083 scopus 로고    scopus 로고
    • Interfering with coinhibitory molecules: BTLA/HVEM as new targets to enhance anti-tumor immunity
    • Pasero C, Olive D. Interfering with coinhibitory molecules: BTLA/HVEM as new targets to enhance anti-tumor immunity. Immunol. Lett. 151(1-2), 71-75 (2013).
    • (2013) Immunol. Lett , vol.151 , Issue.1-2 , pp. 71-75
    • Pasero, C.1    Olive, D.2
  • 125
    • 84921823501 scopus 로고    scopus 로고
    • Programmed death 1 and B and T lymphocyte attenuator immunoreceptors and their association with malignant T-lymphoproliferative disorders: Brief review
    • Karakatsanis S, Bertsias G, Roussou P, Boumpas D. Programmed death 1 and B and T lymphocyte attenuator immunoreceptors and their association with malignant T-lymphoproliferative disorders: brief review. Hematol. Oncol. 32(3), 113-119 (2014).
    • (2014) Hematol. Oncol , vol.32 , Issue.3 , pp. 113-119
    • Karakatsanis, S.1    Bertsias, G.2    Roussou, P.3    Boumpas, D.4
  • 126
    • 70349560843 scopus 로고    scopus 로고
    • High expression of the inhibitory receptor BTLA in T-follicular helper cells and in B-cell small lymphocytic lymphoma/chronic lymphocytic leukemia
    • M'hidi H, Thibult ML, Chetaille B et al. High expression of the inhibitory receptor BTLA in T-follicular helper cells and in B-cell small lymphocytic lymphoma/chronic lymphocytic leukemia. Am. J. Clin. Pathol. 132(4), 589-596 (2009).
    • (2009) Am. J. Clin. Pathol , vol.132 , Issue.4 , pp. 589-596
    • M'Hidi, H.1    Thibult, M.L.2    Chetaille, B.3
  • 127
    • 84890277184 scopus 로고    scopus 로고
    • BTLA, a key regulator of Vgamma9Vdelta2 T-cell proliferation
    • Gertner-Dardenne J, Fauriat C, Olive D. BTLA, a key regulator of Vgamma9Vdelta2 T-cell proliferation. Oncoimmunology 2(9), e25853 (2013).
    • (2013) Oncoimmunology , vol.2 , Issue.9 , pp. e25853
    • Gertner-Dardenne, J.1    Fauriat, C.2    Olive, D.3
  • 128
    • 84862841841 scopus 로고    scopus 로고
    • B and T lymphocyte attenuator mediates inhibition of tumor-reactive CD8+ T cells in patients after allogeneic stem cell transplantation
    • Hobo W, Norde WJ, Schaap N et al. B and T lymphocyte attenuator mediates inhibition of tumor-reactive CD8+ T cells in patients after allogeneic stem cell transplantation. J. Immunol. 189(1), 39-49 (2012).
    • (2012) J. Immunol , vol.189 , Issue.1 , pp. 39-49
    • Hobo, W.1    Norde, W.J.2    Schaap, N.3
  • 129
    • 84916242923 scopus 로고    scopus 로고
    • Ectopic expression of B and T lymphocyte attenuator in gastric cancer: A potential independent prognostic factor in patients with gastric cancer
    • Feng XY, Wen XZ, Tan XJ et al. Ectopic expression of B and T lymphocyte attenuator in gastric cancer: a potential independent prognostic factor in patients with gastric cancer. Mol. Med. Rep. 11(1), 658-664 (2015).
    • (2015) Mol. Med. Rep , vol.11 , Issue.1 , pp. 658-664
    • Feng, X.Y.1    Wen, X.Z.2    Tan, X.J.3
  • 130
    • 84948182119 scopus 로고    scopus 로고
    • Association of BTLA upregulation with impaired cytotoxic CD8+ T-cell function and disease progression of patients with hepatocellular carcinoma
    • Presented at IL, USA, 30 May-03 June
    • Fu J, Zhou L, Hong Z, Chen Y, Wang F-S. Association of BTLA upregulation with impaired cytotoxic CD8+ T-cell function and disease progression of patients with hepatocellular carcinoma. Presented at: 50th Annual Meeting of American Society of Clinical Oncology. IL, USA, 30 May-03 June 2014.
    • (2014) 50th Annual Meeting of American Society of Clinical Oncology
    • Fu, J.1    Zhou, L.2    Hong, Z.3    Chen, Y.4    Wang, F.-S.5
  • 131
    • 74949125667 scopus 로고    scopus 로고
    • BTLA mediates inhibition of human tumor-specific CD8+ T cells that can be partially reversed by vaccination
    • Derre L, Rivals JP, Jandus C et al. BTLA mediates inhibition of human tumor-specific CD8+ T cells that can be partially reversed by vaccination. J. Clin. Invest. 120(1), 157-167 (2010).
    • (2010) J. Clin. Invest , vol.120 , Issue.1 , pp. 157-167
    • Derre, L.1    Rivals, J.P.2    Jandus, C.3
  • 132
    • 84926652188 scopus 로고    scopus 로고
    • Tryptophan-degrading enzymes in tumoral immune resistance
    • Van Baren N, Van Den Eynde BJ. Tryptophan-degrading enzymes in tumoral immune resistance. Front. Immunol. 6, 34 (2015).
    • (2015) Front. Immunol , vol.6 , pp. 34
    • Van Baren, N.1    Van Den Eynde, B.J.2
  • 133
    • 84935069042 scopus 로고    scopus 로고
    • Extensive profiling of the expression of the indoleamine 2,3-dioxygenase 1 protein in normal and tumoral human tissues
    • Theate I, Van Baren N, Pilotte L et al. Extensive profiling of the expression of the indoleamine 2,3-dioxygenase 1 protein in normal and tumoral human tissues. Cancer Immunol. Res. 3(2), 161-172 (2015).
    • (2015) Cancer Immunol. Res , vol.3 , Issue.2 , pp. 161-172
    • Theate, I.1    Van Baren, N.2    Pilotte, L.3
  • 134
    • 81255138408 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase expression in human cancers: Clinical and immunologic perspectives
    • Godin-Ethier J, Hanafi LA, Piccirillo CA, Lapointe R. Indoleamine 2,3-dioxygenase expression in human cancers: clinical and immunologic perspectives. Clin. Cancer Res. 17(22), 6985-6991 (2011).
    • (2011) Clin. Cancer Res , vol.17 , Issue.22 , pp. 6985-6991
    • Godin-Ethier, J.1    Hanafi, L.A.2    Piccirillo, C.A.3    Lapointe, R.4
  • 135
    • 76649088968 scopus 로고    scopus 로고
    • Hydroxyamidine inhibitors of indoleamine-2,3-dioxygenase potently suppress systemic tryptophan catabolism and the growth of IDO-expressing tumors
    • Koblish HK, Hansbury MJ, Bowman KJ et al. Hydroxyamidine inhibitors of indoleamine-2,3-dioxygenase potently suppress systemic tryptophan catabolism and the growth of IDO-expressing tumors. Mol. Cancer Ther. 9(2), 489-498 (2010).
    • (2010) Mol. Cancer Ther , vol.9 , Issue.2 , pp. 489-498
    • Koblish, H.K.1    Hansbury, M.J.2    Bowman, K.J.3
  • 136
    • 0142137237 scopus 로고    scopus 로고
    • Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase
    • Uyttenhove C, Pilotte L, Theate I et al. Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase. Nat. Med. 9(10), 1269-1274 (2003).
    • (2003) Nat. Med , vol.9 , Issue.10 , pp. 1269-1274
    • Uyttenhove, C.1    Pilotte, L.2    Theate, I.3
  • 137
    • 84860852600 scopus 로고    scopus 로고
    • Blocking IDO activity to enhance anti-tumor immunity
    • Munn DH. Blocking IDO activity to enhance anti-tumor immunity. Front. Biosci. (Elite Ed.) 4, 734-745 (2012).
    • (2012) Front. Biosci. (Elite Ed.) , vol.4 , pp. 734-745
    • Munn, D.H.1
  • 138
    • 16244408626 scopus 로고    scopus 로고
    • Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy
    • Muller AJ, Duhadaway JB, Donover PS, Sutanto-Ward E, Prendergast GC. Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy. Nat. Med. 11(3), 312-319 (2005).
    • (2005) Nat. Med , vol.11 , Issue.3 , pp. 312-319
    • Muller, A.J.1    Duhadaway, J.B.2    Donover, P.S.3    Sutanto-Ward, E.4    Prendergast, G.C.5
  • 139
    • 84907651092 scopus 로고    scopus 로고
    • First-in-human Phase 1 study of the novel indoleamine-2,3-dioxygenase (IDO) inhibitor NLG-919
    • Presented at IL, USA, 30 May-03 June
    • Khleif S, Munn D, Nyak-Kapoor A et al. First-in-human Phase 1 study of the novel indoleamine-2,3-dioxygenase (IDO) inhibitor NLG-919. Presented at: 50th Annual Meeting of American Society of Clinical Oncology. IL, USA, 30 May-03 June 2014.
    • (2014) 50th Annual Meeting of American Society of Clinical Oncology
    • Khleif, S.1    Munn, D.2    Nyak-Kapoor, A.3
  • 140
    • 84948147738 scopus 로고    scopus 로고
    • Phase 1/2 trial of the indoleamine 2,3-dioxygenase pathway (IDO) inhibitor indoximod plus ipilimumab for the treatment of unresectable stage 3 or 4 melanoma
    • Presented at IL, USA, 30 May-03 June
    • Kennedy E, Rossi GR, Vahanian NN, Link CJ. Phase 1/2 trial of the indoleamine 2,3-dioxygenase pathway (IDO) inhibitor indoximod plus ipilimumab for the treatment of unresectable stage 3 or 4 melanoma. Presented at: 50th Annual Meeting of American Society of Clinical Oncology. IL, USA, 30 May-03 June 2014.
    • (2014) 50th Annual Meeting of American Society of Clinical Oncology
    • Kennedy, E.1    Rossi, G.R.2    Vahanian, N.N.3    Link, C.J.4
  • 141
    • 84948180152 scopus 로고    scopus 로고
    • Safety and clinical activity of nivolumab (anti-PD-1, BMS-936558, ONO-4538) in combination with ipilimumab in patients (pts) with advanced melanoma (MEL)
    • Presented at IL, USA, 31 May-4 June
    • Wolchok JD, Kluger HM, Callahan MK et al. Safety and clinical activity of nivolumab (anti-PD-1, BMS-936558, ONO-4538) in combination with ipilimumab in patients (pts) with advanced melanoma (MEL). Presented at: 49th Annual Meeting of American Society of Clinical Oncology. IL, USA, 31 May-4 June 2013.
    • (2013) 49th Annual Meeting of American Society of Clinical Oncology
    • Wolchok, J.D.1    Kluger, H.M.2    Callahan, M.K.3
  • 142
    • 80053161751 scopus 로고    scopus 로고
    • Anti-PD-1 synergizes with cyclophosphamide to induce potent antitumor vaccine effects through novel mechanisms
    • Mkrtichyan M, Najjar YG, Raulfs EC et al. Anti-PD-1 synergizes with cyclophosphamide to induce potent antitumor vaccine effects through novel mechanisms. Eur. J. Immunol. 41(10), 2977-2986 (2011).
    • (2011) Eur. J. Immunol , vol.41 , Issue.10 , pp. 2977-2986
    • Mkrtichyan, M.1    Najjar, Y.G.2    Raulfs, E.C.3
  • 143
    • 84948141308 scopus 로고    scopus 로고
    • Abstract LB-193: Phase i study of safety, tolerability, pharmacokinetics, and pharmacodynamics of AMP-224 (B7-DC Fc fusion protein) in a regimen containing cyclophosphamide (CTX) in patients with advanced solid tumors
    • Lorusso PM, Powderly J, Burris HA et al. Abstract LB-193: Phase I study of safety, tolerability, pharmacokinetics, and pharmacodynamics of AMP-224 (B7-DC Fc fusion protein) in a regimen containing cyclophosphamide (CTX) in patients with advanced solid tumors. Cancer Res. 73(8 Suppl.), LB-193-LB-193 (2013).
    • (2013) Cancer Res , vol.73 , Issue.8 , pp. LB193-LB193
    • Lorusso, P.M.1    Powderly, J.2    Burris, H.A.3
  • 144
    • 84891373595 scopus 로고    scopus 로고
    • Safety and activity of PD1 blockade by pidilizumab in combination with rituximab in patients with relapsed follicular lymphoma: A single group, open-label, Phase 2 trial
    • Westin JR, Chu F, Zhang M et al. Safety and activity of PD1 blockade by pidilizumab in combination with rituximab in patients with relapsed follicular lymphoma: a single group, open-label, Phase 2 trial. Lancet Oncol. 15(1), 69-77 (2014).
    • (2014) Lancet Oncol , vol.15 , Issue.1 , pp. 69-77
    • Westin, J.R.1    Chu, F.2    Zhang, M.3
  • 145
    • 84948134920 scopus 로고    scopus 로고
    • A Phase II/III randomized trial of two doses of MK-3475 versus docetaxel in previously treated subjects with non-small cell lung cancer
    • Presented at IL USA, 30 May-03 June
    • Herbst RS, Gurpide A, Surmont V et al. A Phase II/III randomized trial of two doses of MK-3475 versus docetaxel in previously treated subjects with non-small cell lung cancer. Presented at: 50th Annual Meeting of American Society of Clinical Oncology. IL, USA, 30 May-03 June 2014.
    • (2014) 50th Annual Meeting of American Society of Clinical Oncology
    • Herbst, R.S.1    Gurpide, A.2    Surmont, V.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.