MART-1 peptide vaccination plus IMP321 (LAG-3Ig fusion protein) in patients receiving autologous PBMCs after lymphodepletion: Results of a Phase I trial

Journal of Translational Medicine

Volumn 12, Issue 1, 2014, Pages

  Romano, Emanuela ^a,b   Michielin, Olivier ^a,b   Voelter, Verena ^a   Laurent, Julien ^a,d   Bichat, Hélène ^a   Stravodimou, Athina ^a   Romero, Pedro ^b   Speiser, Daniel E ^b   Triebel, Frédéric ^c   Leyvraz, Serge ^a   Harari, Alexandre ^a,b  

^a LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

^c Immutep SA   (France)

^d Merck Serono GmbH   (Germany)

Author keywords

Adjuvant; Adoptive cell therapy; Immunization; Immunogenicity; Immunotherapy; LAG 3Ig; Melanoma; Tumor specific CD8 T cells

Indexed keywords

CD45RA ANTIGEN; CHEMOKINE RECEPTOR CCR7; CYCLOPHOSPHAMIDE; FLUDARABINE; HYBRID PROTEIN; IMP 321; MELAN A; PEPTIDE VACCINE; UNCLASSIFIED DRUG; CD223 ANTIGEN; LEUKOCYTE ANTIGEN; MLANA PROTEIN, HUMAN;

ADOPTIVE TRANSFER; ADULT; ADVANCED CANCER; ARTICLE; AUTOLOGOUS PERIPHERAL BLOOD STEM CELL TRANSPLANTATION; CANCER ADJUVANT THERAPY; CANCER CHEMOTHERAPY; CANCER STAGING; CD8+ T LYMPHOCYTE; CELL EXPANSION; CELLULAR IMMUNITY; CONTROLLED STUDY; DRUG EFFECT; EFFECTOR CELL; FEMALE; HUMAN; IMMUNOMODULATION; IMMUNOTHERAPY; LYMPHOCYTE COUNT; LYMPHODEPLETING CHEMOTHERAPY; MALE; MELANOMA; PHASE 1 CLINICAL TRIAL; REGULATORY T LYMPHOCYTE; TREATMENT RESPONSE; VACCINATION; AGED; CELL TRANSPLANTATION; CLINICAL TRIAL; FLOW CYTOMETRY; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; LYMPHOCYTE DEPLETION; MIDDLE AGED; MONOCYTE; TRANSPLANTATION;

ADULT; AGED; ANTIGENS, CD; CELL TRANSPLANTATION; FEMALE; FLOW CYTOMETRY; HUMANS; LYMPHOCYTE ACTIVATION; LYMPHOCYTE DEPLETION; MALE; MART-1 ANTIGEN; MIDDLE AGED; MONOCYTES; T-LYMPHOCYTES, REGULATORY;

EID: 84899083535     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/1479-5876-12-97     Document Type: Article

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