메뉴 건너뛰기




Volumn 24, Issue 2, 2012, Pages 217-224

Modulation of GITR for cancer immunotherapy

Author keywords

[No Author keywords available]

Indexed keywords

DENDRITIC CELL VACCINE; DNA VACCINE; GLUCOCORTICOID INDUCED TUMOR NECROSIS FACTOR RECEPTOR; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 4-1BB; MONOCLONAL ANTIBODY DTA-1; MONOCLONAL ANTIBODY OX-40; UNCLASSIFIED DRUG;

EID: 84858787656     PISSN: 09527915     EISSN: 18790372     Source Type: Journal    
DOI: 10.1016/j.coi.2011.12.011     Document Type: Review
Times cited : (122)

References (67)
  • 2
    • 0033525904 scopus 로고    scopus 로고
    • Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand
    • Kwon B., Yu K.Y., Ni J., Yu G.L., Jang I.K., Kim Y.J., Xing L., Liu D., Wang S.X., Kwon B.S. Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand. J Biol Chem 1999, 274:6056-6061.
    • (1999) J Biol Chem , vol.274 , pp. 6056-6061
    • Kwon, B.1    Yu, K.Y.2    Ni, J.3    Yu, G.L.4    Jang, I.K.5    Kim, Y.J.6    Xing, L.7    Liu, D.8    Wang, S.X.9    Kwon, B.S.10
  • 4
    • 14744285671 scopus 로고    scopus 로고
    • Triggering of OX40 (CD134) on CD4(+)CD25+ T cells blocks their inhibitory activity: a novel regulatory role for OX40 and its comparison with GITR
    • Valzasina B., Guiducci C., Dislich H., Killeen N., Weinberg A.D., Colombo M.P. Triggering of OX40 (CD134) on CD4(+)CD25+ T cells blocks their inhibitory activity: a novel regulatory role for OX40 and its comparison with GITR. Blood 2005, 105:2845-2851.
    • (2005) Blood , vol.105 , pp. 2845-2851
    • Valzasina, B.1    Guiducci, C.2    Dislich, H.3    Killeen, N.4    Weinberg, A.D.5    Colombo, M.P.6
  • 6
  • 7
    • 77952311199 scopus 로고    scopus 로고
    • Control of immunity by the TNFR-related molecule OX40 (CD134)
    • Croft M. Control of immunity by the TNFR-related molecule OX40 (CD134). Annu Rev Immunol 2010, 28:57-78.
    • (2010) Annu Rev Immunol , vol.28 , pp. 57-78
    • Croft, M.1
  • 9
    • 1642314780 scopus 로고    scopus 로고
    • Expression and function of 4-1BB during CD4 versus CD8 T cell responses in vivo
    • Dawicki W., Watts T.H. Expression and function of 4-1BB during CD4 versus CD8 T cell responses in vivo. Eur J Immunol 2004, 34:743-751.
    • (2004) Eur J Immunol , vol.34 , pp. 743-751
    • Dawicki, W.1    Watts, T.H.2
  • 10
    • 0036660176 scopus 로고    scopus 로고
    • Role of GITR in activation response of T lymphocytes
    • Ronchetti S., Nocentini G., Riccardi C., Pandolfi P.P. Role of GITR in activation response of T lymphocytes. Blood 2002, 100:350-352.
    • (2002) Blood , vol.100 , pp. 350-352
    • Ronchetti, S.1    Nocentini, G.2    Riccardi, C.3    Pandolfi, P.P.4
  • 11
    • 80054867338 scopus 로고    scopus 로고
    • T-cell intrinsic effects of GITR and 4-1BB during viral infection and cancer immunotherapy
    • Snell L.M., Lin G.H.Y., McPherson A.J., Moraes T.J., Watts T.H. T-cell intrinsic effects of GITR and 4-1BB during viral infection and cancer immunotherapy. Immunol Rev 2011, 244:197-217.
    • (2011) Immunol Rev , vol.244 , pp. 197-217
    • Snell, L.M.1    Lin, G.H.Y.2    McPherson, A.J.3    Moraes, T.J.4    Watts, T.H.5
  • 12
    • 24644515759 scopus 로고    scopus 로고
    • In vivo kinetics of GITR and GITR ligand expression and their functional significance in regulating viral immunopathology
    • Suvas S., Kim B., Sarangi P.P., Tone M., Waldmann H., Rouse B.T. In vivo kinetics of GITR and GITR ligand expression and their functional significance in regulating viral immunopathology. J Virol 2005, 79:11935-11942.
    • (2005) J Virol , vol.79 , pp. 11935-11942
    • Suvas, S.1    Kim, B.2    Sarangi, P.P.3    Tone, M.4    Waldmann, H.5    Rouse, B.T.6
  • 14
    • 38649090326 scopus 로고    scopus 로고
    • Evolution of GITRL immune function: murine GITRL exhibits unique structural and biochemical properties within the TNF superfamily
    • Chattopadhyay K., Ramagopal U.A., Brenowitz M., Nathenson S.G., Almo S.C. Evolution of GITRL immune function: murine GITRL exhibits unique structural and biochemical properties within the TNF superfamily. Proc Natl Acad Sci U S A 2008, 105:635-640.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 635-640
    • Chattopadhyay, K.1    Ramagopal, U.A.2    Brenowitz, M.3    Nathenson, S.G.4    Almo, S.C.5
  • 17
    • 1842424807 scopus 로고    scopus 로고
    • Cutting edge: ligation of the glucocorticoid-induced TNF receptor enhances autoreactive CD4+ T cell activation and experimental autoimmune encephalomyelitis
    • Kohm A.P., Williams J.S., Miller S.D. Cutting edge: ligation of the glucocorticoid-induced TNF receptor enhances autoreactive CD4+ T cell activation and experimental autoimmune encephalomyelitis. J Immunol 2004, 172:4686-4690.
    • (2004) J Immunol , vol.172 , pp. 4686-4690
    • Kohm, A.P.1    Williams, J.S.2    Miller, S.D.3
  • 19
    • 20444378564 scopus 로고    scopus 로고
    • Glucocorticoid-induced TNF receptor functions as a costimulatory receptor that promotes survival in early phases of T cell activation
    • Esparza E.M., Arch R.H. Glucocorticoid-induced TNF receptor functions as a costimulatory receptor that promotes survival in early phases of T cell activation. J Immunol 2005, 174:7869-7874.
    • (2005) J Immunol , vol.174 , pp. 7869-7874
    • Esparza, E.M.1    Arch, R.H.2
  • 20
    • 17644389199 scopus 로고    scopus 로고
    • TNF/TNFR family members in costimulation of T cell responses
    • Watts T.H. TNF/TNFR family members in costimulation of T cell responses. Annu Rev Immunol 2005, 23:23-68.
    • (2005) Annu Rev Immunol , vol.23 , pp. 23-68
    • Watts, T.H.1
  • 21
    • 78650668092 scopus 로고    scopus 로고
    • CD8 T cell-intrinsic GITR is required for T cell clonal expansion and mouse survival following severe influenza infection
    • Snell L.M., McPherson A.J., Lin G.H.Y., Sakaguchi S., Pandolfi P.P., Riccardi C., Watts T.H. CD8 T cell-intrinsic GITR is required for T cell clonal expansion and mouse survival following severe influenza infection. J Immunol 2010, 185:7223-7234.
    • (2010) J Immunol , vol.185 , pp. 7223-7234
    • Snell, L.M.1    McPherson, A.J.2    Lin, G.H.Y.3    Sakaguchi, S.4    Pandolfi, P.P.5    Riccardi, C.6    Watts, T.H.7
  • 22
    • 60549117865 scopus 로고    scopus 로고
    • Endogenous 4-1BB ligand plays a critical role in protection from influenza-induced disease
    • Lin G.H.Y., Sedgmen B.J., Moraes T.J., Snell L.M., Topham D.J., Watts T.H. Endogenous 4-1BB ligand plays a critical role in protection from influenza-induced disease. J Immunol 2009, 182:934-947.
    • (2009) J Immunol , vol.182 , pp. 934-947
    • Lin, G.H.Y.1    Sedgmen, B.J.2    Moraes, T.J.3    Snell, L.M.4    Topham, D.J.5    Watts, T.H.6
  • 23
    • 80051623629 scopus 로고    scopus 로고
    • Th2 responses to helminth parasites can be therapeutically enhanced by, but are not dependent upon, GITR-GITR ligand costimulation in vivo
    • van der Werf N., Redpath S.A., Phythian-Adams A.T., Azuma M., Allen J.E., Maizels R.M., MacDonald A.S., Taylor M.D. Th2 responses to helminth parasites can be therapeutically enhanced by, but are not dependent upon, GITR-GITR ligand costimulation in vivo. J Immunol 2011, 187:1411-1420.
    • (2011) J Immunol , vol.187 , pp. 1411-1420
    • van der Werf, N.1    Redpath, S.A.2    Phythian-Adams, A.T.3    Azuma, M.4    Allen, J.E.5    Maizels, R.M.6    MacDonald, A.S.7    Taylor, M.D.8
  • 31
    • 78349278492 scopus 로고    scopus 로고
    • Glucocorticoid-induced TNFR-related (GITR) protein and its ligand in antitumor immunity: functional role and therapeutic modulation
    • Placke T., Kopp H.G., Salih H.R. Glucocorticoid-induced TNFR-related (GITR) protein and its ligand in antitumor immunity: functional role and therapeutic modulation. Clin Dev Immunol 2010, 2010:p239083.
    • (2010) Clin Dev Immunol , vol.2010
    • Placke, T.1    Kopp, H.G.2    Salih, H.R.3
  • 33
    • 33646387978 scopus 로고    scopus 로고
    • Human plasmacytoid predendritic cells activate NK cells through glucocorticoid-induced tumor necrosis factor receptor-ligand (GITRL)
    • Hanabuchi S., Watanabe N., Wang Y.H., Ito T., Shaw J., Cao W., Qin F.X., Liu Y.J. Human plasmacytoid predendritic cells activate NK cells through glucocorticoid-induced tumor necrosis factor receptor-ligand (GITRL). Blood 2006, 107:3617-3623.
    • (2006) Blood , vol.107 , pp. 3617-3623
    • Hanabuchi, S.1    Watanabe, N.2    Wang, Y.H.3    Ito, T.4    Shaw, J.5    Cao, W.6    Qin, F.X.7    Liu, Y.J.8
  • 34
    • 43749101844 scopus 로고    scopus 로고
    • Glucocorticoid-induced tumor necrosis factor receptor negatively regulates activation of human primary natural killer (NK) cells by blocking proliferative signals and increasing NK cell apoptosis
    • Liu B., Li Z., Mahesh S.P., Pantanelli S., Hwang F.S., Siu W.O., Nussenblatt R.B. Glucocorticoid-induced tumor necrosis factor receptor negatively regulates activation of human primary natural killer (NK) cells by blocking proliferative signals and increasing NK cell apoptosis. J Biol Chem 2008, 283:8202-8210.
    • (2008) J Biol Chem , vol.283 , pp. 8202-8210
    • Liu, B.1    Li, Z.2    Mahesh, S.P.3    Pantanelli, S.4    Hwang, F.S.5    Siu, W.O.6    Nussenblatt, R.B.7
  • 35
  • 36
    • 77951042495 scopus 로고    scopus 로고
    • CD137 ligand mediates opposite effects in human and mouse NK cells and impairs NK-cell reactivity against human acute myeloid leukemia cells
    • Baessler T., Charton J.E., Schmiedel B.J., Grunebach F., Krusch M., Wacker A., Rammensee H.G., Salih H.R. CD137 ligand mediates opposite effects in human and mouse NK cells and impairs NK-cell reactivity against human acute myeloid leukemia cells. Blood 2010, 115:3058-3069.
    • (2010) Blood , vol.115 , pp. 3058-3069
    • Baessler, T.1    Charton, J.E.2    Schmiedel, B.J.3    Grunebach, F.4    Krusch, M.5    Wacker, A.6    Rammensee, H.G.7    Salih, H.R.8
  • 37
    • 0036170938 scopus 로고    scopus 로고
    • Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance
    • Shimizu J., Yamazaki S., Takahashi T., Ishida Y., Sakaguchi S. Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance. Nat Immunol 2002, 3:135-142.
    • (2002) Nat Immunol , vol.3 , pp. 135-142
    • Shimizu, J.1    Yamazaki, S.2    Takahashi, T.3    Ishida, Y.4    Sakaguchi, S.5
  • 38
    • 0036195161 scopus 로고    scopus 로고
    • CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor
    • McHugh R.S., Whitters M.J., Piccirillo C.A., Young D.A., Shevach E.M., Collins M., Byrne M.C. CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. Immunity 2002, 16:311-323.
    • (2002) Immunity , vol.16 , pp. 311-323
    • McHugh, R.S.1    Whitters, M.J.2    Piccirillo, C.A.3    Young, D.A.4    Shevach, E.M.5    Collins, M.6    Byrne, M.C.7
  • 39
    • 6344279933 scopus 로고    scopus 로고
    • Engagement of glucocorticoid-induced TNFR family-related receptor on effector T cells by its ligand mediates resistance to suppression by CD4+CD25+ T cells
    • Stephens G.L., McHugh R.S., Whitters M.J., Young D.A., Luxenberg D., Carreno B.M., Collins M., Shevach E.M. Engagement of glucocorticoid-induced TNFR family-related receptor on effector T cells by its ligand mediates resistance to suppression by CD4+CD25+ T cells. J Immunol 2004, 173:5008-5020.
    • (2004) J Immunol , vol.173 , pp. 5008-5020
    • Stephens, G.L.1    McHugh, R.S.2    Whitters, M.J.3    Young, D.A.4    Luxenberg, D.5    Carreno, B.M.6    Collins, M.7    Shevach, E.M.8
  • 40
    • 0022332785 scopus 로고
    • Down-regulation of the antitumor immune response
    • North R.J. Down-regulation of the antitumor immune response. Adv Cancer Res 1985, 45:1-43.
    • (1985) Adv Cancer Res , vol.45 , pp. 1-43
    • North, R.J.1
  • 42
    • 77955279163 scopus 로고    scopus 로고
    • Agonist anti-GITR monoclonal antibody induces melanoma tumor immunity in mice by altering regulatory T cell stability and intra-tumor accumulation
    • Cohen A.D., Schaer D.A., Liu C., Li Y., Hirschhorn-Cymmerman D., Kim S.C., Diab A., Rizzuto G., Duan F., Perales M.A., et al. Agonist anti-GITR monoclonal antibody induces melanoma tumor immunity in mice by altering regulatory T cell stability and intra-tumor accumulation. PLoS One 2010, 5:pe10436.
    • (2010) PLoS One , vol.5
    • Cohen, A.D.1    Schaer, D.A.2    Liu, C.3    Li, Y.4    Hirschhorn-Cymmerman, D.5    Kim, S.C.6    Diab, A.7    Rizzuto, G.8    Duan, F.9    Perales, M.A.10
  • 44
    • 65349153756 scopus 로고    scopus 로고
    • T-cell modulation combined with intratumoral CpG cures lymphoma in a mouse model without the need for chemotherapy
    • Houot R., Levy R. T-cell modulation combined with intratumoral CpG cures lymphoma in a mouse model without the need for chemotherapy. Blood 2009, 113:3546-3552.
    • (2009) Blood , vol.113 , pp. 3546-3552
    • Houot, R.1    Levy, R.2
  • 45
    • 38849154553 scopus 로고    scopus 로고
    • Pivotal roles of CD4+ effector T cells in mediating agonistic anti-GITR mAb-induced-immune activation and tumor immunity in CT26 tumors
    • Zhou P., L'Italien L., Hodges D., Schebye X.M. Pivotal roles of CD4+ effector T cells in mediating agonistic anti-GITR mAb-induced-immune activation and tumor immunity in CT26 tumors. J Immunol 2007, 179:7365-7375.
    • (2007) J Immunol , vol.179 , pp. 7365-7375
    • Zhou, P.1    L'Italien, L.2    Hodges, D.3    Schebye, X.M.4
  • 46
    • 70449637946 scopus 로고    scopus 로고
    • Dendritic cells engineered to secrete anti-GITR antibodies are effective adjuvants to dendritic cell-based immunotherapy
    • Boczkowski D., Lee J., Pruitt S., Nair S. Dendritic cells engineered to secrete anti-GITR antibodies are effective adjuvants to dendritic cell-based immunotherapy. Cancer Gene Ther 2009, 16:900-911.
    • (2009) Cancer Gene Ther , vol.16 , pp. 900-911
    • Boczkowski, D.1    Lee, J.2    Pruitt, S.3    Nair, S.4
  • 47
    • 48649083285 scopus 로고    scopus 로고
    • Regulatory T cell-resistant CD8+ T cells induced by glucocorticoid-induced tumor necrosis factor receptor signaling
    • Nishikawa H., Kato T., Hirayama M., Orito Y., Sato E., Harada N., Gnjatic S., Old L.J., Shiku H. Regulatory T cell-resistant CD8+ T cells induced by glucocorticoid-induced tumor necrosis factor receptor signaling. Cancer Res 2008, 68:5948-5954.
    • (2008) Cancer Res , vol.68 , pp. 5948-5954
    • Nishikawa, H.1    Kato, T.2    Hirayama, M.3    Orito, Y.4    Sato, E.5    Harada, N.6    Gnjatic, S.7    Old, L.J.8    Shiku, H.9
  • 49
    • 77649093452 scopus 로고    scopus 로고
    • Combining T-cell vaccination and application of agonistic anti-GITR mAb (DTA-1) induces complete eradication of HPV oncogene expressing tumors in mice
    • Hoffmann C., Stanke J., Kaufmann A.M., Loddenkemper C., Schneider A., Cichon G. Combining T-cell vaccination and application of agonistic anti-GITR mAb (DTA-1) induces complete eradication of HPV oncogene expressing tumors in mice. J Immunother 2010, 33:136-145.
    • (2010) J Immunother , vol.33 , pp. 136-145
    • Hoffmann, C.1    Stanke, J.2    Kaufmann, A.M.3    Loddenkemper, C.4    Schneider, A.5    Cichon, G.6
  • 51
    • 67449092763 scopus 로고    scopus 로고
    • Glucocorticoid-induced tumor necrosis factor receptor stimulation enhances the multifunctionality of adoptively transferred tumor antigen-specific CD8+ T cells with tumor regression
    • Imai N., Ikeda H., Tawara I., Wang L., Nishikawa H., Kato T., Shiku H. Glucocorticoid-induced tumor necrosis factor receptor stimulation enhances the multifunctionality of adoptively transferred tumor antigen-specific CD8+ T cells with tumor regression. Cancer Sci 2009, 100:1317-1325.
    • (2009) Cancer Sci , vol.100 , pp. 1317-1325
    • Imai, N.1    Ikeda, H.2    Tawara, I.3    Wang, L.4    Nishikawa, H.5    Kato, T.6    Shiku, H.7
  • 52
  • 54
    • 77958038643 scopus 로고    scopus 로고
    • Mature B cells are critical to T-cell-mediated tumor immunity induced by an agonist anti-GITR monoclonal antibody
    • Zhou P., Qiu J., L'Italien L., Gu D., Hodges D., Chao C.C., Schebye X.M. Mature B cells are critical to T-cell-mediated tumor immunity induced by an agonist anti-GITR monoclonal antibody. J Immunother 2010, 33:789-797.
    • (2010) J Immunother , vol.33 , pp. 789-797
    • Zhou, P.1    Qiu, J.2    L'Italien, L.3    Gu, D.4    Hodges, D.5    Chao, C.C.6    Schebye, X.M.7
  • 55
    • 79251553417 scopus 로고    scopus 로고
    • Stimulation of the glucocorticoid-induced TNF receptor family-related receptor on CD8 T cells induces protective and high-avidity T cell responses to tumor-specific antigens
    • Côté A.L., Zhang P., O'Sullivan J.A., Jacobs V.L., Clemis C.R., Sakaguchi S., Guevara-Patiño J.A., Turk M.J. Stimulation of the glucocorticoid-induced TNF receptor family-related receptor on CD8 T cells induces protective and high-avidity T cell responses to tumor-specific antigens. J Immunol 2011, 186:275-283.
    • (2011) J Immunol , vol.186 , pp. 275-283
    • Côté, A.L.1    Zhang, P.2    O'Sullivan, J.A.3    Jacobs, V.L.4    Clemis, C.R.5    Sakaguchi, S.6    Guevara-Patiño, J.A.7    Turk, M.J.8
  • 56
    • 79955785050 scopus 로고    scopus 로고
    • Combination CTLA-4 blockade and 4-1BB activation enhances tumor rejection by increasing T-cell infiltration, proliferation, and cytokine production
    • Curran M.A., Kim M., Montalvo W., Al-Shamkhani A., Allison J.P. Combination CTLA-4 blockade and 4-1BB activation enhances tumor rejection by increasing T-cell infiltration, proliferation, and cytokine production. PLoS One 2011, 6:pe19499.
    • (2011) PLoS One , vol.6
    • Curran, M.A.1    Kim, M.2    Montalvo, W.3    Al-Shamkhani, A.4    Allison, J.P.5
  • 58
    • 42249097689 scopus 로고    scopus 로고
    • OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection
    • Piconese S., Valzasina B., Colombo M.P. OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection. J Exp Med 2008, 205:825-839.
    • (2008) J Exp Med , vol.205 , pp. 825-839
    • Piconese, S.1    Valzasina, B.2    Colombo, M.P.3
  • 59
    • 33745851479 scopus 로고    scopus 로고
    • CTLA4 blockade and GM-CSF combination immunotherapy alters the intratumor balance of effector and regulatory T cells
    • Quezada S.A., Peggs K.S., Curran M.A., Allison J.P. CTLA4 blockade and GM-CSF combination immunotherapy alters the intratumor balance of effector and regulatory T cells. J Clin Invest 2006, 116:1935-1945.
    • (2006) J Clin Invest , vol.116 , pp. 1935-1945
    • Quezada, S.A.1    Peggs, K.S.2    Curran, M.A.3    Allison, J.P.4
  • 60
    • 77955515915 scopus 로고    scopus 로고
    • Depletion of regulatory T cells by anti-GITR mAb as a novel mechanism for cancer immunotherapy
    • Coe D., Begom S., Addey C., White M., Dyson J., Chai J.-G. Depletion of regulatory T cells by anti-GITR mAb as a novel mechanism for cancer immunotherapy. Cancer Immunol Immunother 2010, 59:1367-1377.
    • (2010) Cancer Immunol Immunother , vol.59 , pp. 1367-1377
    • Coe, D.1    Begom, S.2    Addey, C.3    White, M.4    Dyson, J.5    Chai, J.-G.6
  • 62
    • 34248342219 scopus 로고    scopus 로고
    • Tolerx Inc. Agonistic antibodies to human glucocorticoid-induced tumor necrosis factor receptor as potential stimulators of T cell immunity for the treatment of cancer and viral infections
    • Tolerx Inc. Agonistic antibodies to human glucocorticoid-induced tumor necrosis factor receptor as potential stimulators of T cell immunity for the treatment of cancer and viral infections. Expert Opin Ther Patents 2007, 17:567-575.
    • (2007) Expert Opin Ther Patents , vol.17 , pp. 567-575
  • 63
    • 78449237499 scopus 로고    scopus 로고
    • Clinical experiences with anti-CD137 and anti-PD1 therapeutic antibodies
    • Ascierto P.A., Simeone E., Sznol M., Fu Y.-X., Melero I. Clinical experiences with anti-CD137 and anti-PD1 therapeutic antibodies. Semin Oncol 2010, 37:508-516.
    • (2010) Semin Oncol , vol.37 , pp. 508-516
    • Ascierto, P.A.1    Simeone, E.2    Sznol, M.3    Fu, Y.-X.4    Melero, I.5
  • 66
    • 0038106763 scopus 로고    scopus 로고
    • Regulation of murine inflammatory bowel disease by CD25+ and CD25- CD4+ glucocorticoid-induced TNF receptor family-related gene+ regulatory T cells
    • Uraushihara K., Kanai T., Ko K., Totsuka T., Makita S., Iiyama R., Nakamura T., Watanabe M. Regulation of murine inflammatory bowel disease by CD25+ and CD25- CD4+ glucocorticoid-induced TNF receptor family-related gene+ regulatory T cells. J Immunol 2003, 171:708-716.
    • (2003) J Immunol , vol.171 , pp. 708-716
    • Uraushihara, K.1    Kanai, T.2    Ko, K.3    Totsuka, T.4    Makita, S.5    Iiyama, R.6    Nakamura, T.7    Watanabe, M.8
  • 67
    • 1642332369 scopus 로고    scopus 로고
    • Regulation of autoimmune diabetes by non-islet-specific T cells-a role for the glucocorticoid-induced TNF receptor
    • Suri A., Shimizu J., Katz J.D., Sakaguchi S., Unanue E.R., Kanagawa O. Regulation of autoimmune diabetes by non-islet-specific T cells-a role for the glucocorticoid-induced TNF receptor. Eur J Immunol 2004, 34:447-454.
    • (2004) Eur J Immunol , vol.34 , pp. 447-454
    • Suri, A.1    Shimizu, J.2    Katz, J.D.3    Sakaguchi, S.4    Unanue, E.R.5    Kanagawa, O.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.