메뉴 건너뛰기




Volumn 5, Issue SUPPL. 1, 2013, Pages 47-53

Immunotherapy of melanoma with the immune costimulatory monoclonal antibodies targeting CD137

Author keywords

anti CD137 monoclonal antibodies; BMS 663513; Immune costimulator molecule

Indexed keywords

CANCER VACCINE; CD137 ANTIBODY; CD137 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; DACARBAZINE; GAMMA INTERFERON; GLYCOPROTEIN GP 100; IPILIMUMAB; MONOCLONAL ANTIBODY; PROGRAMMED DEATH 1 RECEPTOR; RAG1 PROTEIN; RITUXIMAB; SIPULEUCEL T; TICILIMUMAB; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 1; UNCLASSIFIED DRUG; URELUMAB; VASCULAR CELL ADHESION MOLECULE 1;

EID: 84884822262     PISSN: None     EISSN: 11791438     Source Type: Journal    
DOI: 10.2147/CPAA.S46199     Document Type: Review
Times cited : (39)

References (50)
  • 2
    • 84874276048 scopus 로고    scopus 로고
    • Historical review of melanoma treatment and outcomes
    • Lee C, Collichio F, Ollila D, Moschos S. Historical review of melanoma treatment and outcomes. Clin Dermatol. 2013;31(2):141-147.
    • (2013) Clin Dermatol. , vol.31 , Issue.2 , pp. 141-147
    • Lee, C.1    Collichio, F.2    Ollila, D.3    Moschos, S.4
  • 3
    • 84885840329 scopus 로고    scopus 로고
    • Immune correlates of melanoma survival in adoptive cell therapy
    • Lee AF, Sieling PA, Lee DJ. Immune correlates of melanoma survival in adoptive cell therapy. Oncoimmunology. 2013;2(2):e22889.
    • (2013) Oncoimmunology. , vol.2 , Issue.2
    • Lee, A.F.1    Sieling, P.A.2    Lee, D.J.3
  • 4
    • 84865553349 scopus 로고    scopus 로고
    • How recent advances in immunotherapy are changing the standard of care for patients with metastatic melanoma
    • viii15-viii21
    • Wolchok J. How recent advances in immunotherapy are changing the standard of care for patients with metastatic melanoma. Ann Oncol. 2012;23 Suppl 8:viii15-viii21.
    • (2012) Ann Oncol. , vol.23 , Issue.SUPPL. 8
    • Wolchok, J.1
  • 5
    • 84865559786 scopus 로고    scopus 로고
    • Melanoma as a model tumour for immuno-oncology
    • viii10-viii14
    • Maio M. Melanoma as a model tumour for immuno-oncology. Ann Oncol. 2012;23 Suppl 8:viii10-viii14.
    • (2012) Ann Oncol. , vol.23 , Issue.SUPPL. 8
    • Maio, M.1
  • 6
    • 84871581221 scopus 로고    scopus 로고
    • The evolution in melanoma treatment as a reflection of precision-oriented medicine
    • Kushnir I, Merimsky O. The evolution in melanoma treatment as a reflection of precision-oriented medicine. Oncol Lett. 2013;5(2):424-426.
    • (2013) Oncol Lett. , vol.5 , Issue.2 , pp. 424-426
    • Kushnir, I.1    Merimsky, O.2
  • 7
    • 33747661085 scopus 로고    scopus 로고
    • Update on immunotherapy for melanoma
    • Ribas A. Update on immunotherapy for melanoma. J Natl Compr Canc Netw. 2006;4(7):687-694.
    • (2006) J Natl Compr Canc Netw. , vol.4 , Issue.7 , pp. 687-694
    • Ribas, A.1
  • 9
    • 35748972927 scopus 로고    scopus 로고
    • From cancer immunosurveillance to cancer immunotherapy
    • Stagg J, Johnstone RW, Smyth MJ. From cancer immunosurveillance to cancer immunotherapy. Immunol Rev. 2007;220:82-101.
    • (2007) Immunol Rev. , vol.220 , pp. 82-101
    • Stagg, J.1    Johnstone, R.W.2    Smyth, M.J.3
  • 12
    • 77954721060 scopus 로고    scopus 로고
    • Regulatory T cells in tumor immunity
    • Nishikawa H, Sakaguchi S. Regulatory T cells in tumor immunity. Int J Cancer. 2010;127(4):759-767.
    • (2010) Int J Cancer. , vol.127 , Issue.4 , pp. 759-767
    • Nishikawa, H.1    Sakaguchi, S.2
  • 13
    • 77950787458 scopus 로고    scopus 로고
    • Immunotherapy of melanoma
    • Hersey P. Immunotherapy of melanoma. Asia Pac J Clin Oncol. 2010;6 Suppl 1:S2-S8.
    • (2010) Asia Pac J Clin Oncol. , vol.6 , Issue.SUPPL. 1
    • Hersey, P.1
  • 14
    • 78449237499 scopus 로고    scopus 로고
    • Clinical experiences with anti-CD137 and anti-PD1 therapeutic antibodies
    • Ascierto PA, Simeone E, Sznol M, Fu YX, Melero I. Clinical experiences with anti-CD137 and anti-PD1 therapeutic antibodies. Semin Oncol. 2010;37(5):508-516.
    • (2010) Semin Oncol. , vol.37 , Issue.5 , pp. 508-516
    • Ascierto, P.A.1    Simeone, E.2    Sznol, M.3    Fu, Y.X.4    Melero, I.5
  • 15
    • 1442324410 scopus 로고    scopus 로고
    • Role of 4-1BB:4-1BB ligand in cancer immunotherapy
    • Cheuk AT, Mufti GJ, Guinn BA. Role of 4-1BB:4-1BB ligand in cancer immunotherapy. Cancer Gene Ther. 2004;11(3):215-226.
    • (2004) Cancer Gene Ther. , vol.11 , Issue.3 , pp. 215-226
    • Cheuk, A.T.1    Mufti, G.J.2    Guinn, B.A.3
  • 17
    • 33644823867 scopus 로고    scopus 로고
    • Immunotherapy with agonistic anti-CD137: Two sides of a coin
    • Sun Y, Chen JH, Fu Y. Immunotherapy with agonistic anti-CD137: two sides of a coin. Cell Mol Immunol. 2004;1(1):31-36.
    • (2004) Cell Mol Immunol. , vol.1 , Issue.1 , pp. 31-36
    • Sun, Y.1    Chen, J.H.2    Fu, Y.3
  • 18
    • 41149173311 scopus 로고    scopus 로고
    • The promise of 4-1BB (CD137)-mediated immunomodulation and the immunotherapy of cancer
    • Lynch DH. The promise of 4-1BB (CD137)-mediated immunomodulation and the immunotherapy of cancer. Immunol Rev. 2008;222: 277-286.
    • (2008) Immunol Rev. , vol.222 , pp. 277-286
    • Lynch, D.H.1
  • 19
    • 77953715389 scopus 로고    scopus 로고
    • 4-1BB as a therapeutic target for human disease
    • Lee SW, Croft M. 4-1BB as a therapeutic target for human disease. Adv Exp Med Biol. 2009;647:120-129.
    • (2009) Adv Exp Med Biol. , vol.647 , pp. 120-129
    • Lee, S.W.1    Croft, M.2
  • 20
    • 84862739640 scopus 로고    scopus 로고
    • Immunotherapy of cancer with 4-1BB
    • Vinay DS, Kwon BS. Immunotherapy of cancer with 4-1BB. Mol Cancer Ther. 2012;11(5):1062-1070.
    • (2012) Mol Cancer Ther. , vol.11 , Issue.5 , pp. 1062-1070
    • Vinay, D.S.1    Kwon, B.S.2
  • 21
    • 0031007143 scopus 로고    scopus 로고
    • Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors
    • Melero I, Shuford WW, Newby SA, et al. Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors. Nat Med. 1997;3(6):682-685.
    • (1997) Nat Med. , vol.3 , Issue.6 , pp. 682-685
    • Melero, I.1    Shuford, W.W.2    Newby, S.A.3
  • 22
    • 0033571176 scopus 로고    scopus 로고
    • Anti-4-1BB monoclonal antibodies abrogate T cell-dependent humoral immune responses in vivo through the induction of helper T cell anergy
    • Mittler RS, Bailey TS, Klussman K, Trailsmith MD, Hoffmann MK. Anti-4-1BB monoclonal antibodies abrogate T cell-dependent humoral immune responses in vivo through the induction of helper T cell anergy. J Exp Med. 1999;190(10):1535-1540.
    • (1999) J Exp Med. , vol.190 , Issue.10 , pp. 1535-1540
    • Mittler, R.S.1    Bailey, T.S.2    Klussman, K.3    Trailsmith, M.D.4    Hoffmann, M.K.5
  • 23
    • 0034074135 scopus 로고    scopus 로고
    • Monoclonal antibodies directed against the T-cell activation molecule CD137 (interleukin-A or 4-1BB) block human lymphocyte-mediated suppression of tumor xenografts in severe combined immunodeficient mice
    • Sabel MS, Conway TF, Chen FA, Bankert RB. Monoclonal antibodies directed against the T-cell activation molecule CD137 (interleukin-A or 4-1BB) block human lymphocyte-mediated suppression of tumor xenografts in severe combined immunodeficient mice. J Immunother. 2000;23(3):362-368.
    • (2000) J Immunother. , vol.23 , Issue.3 , pp. 362-368
    • Sabel, M.S.1    Conway, T.F.2    Chen, F.A.3    Bankert, R.B.4
  • 24
    • 0035266427 scopus 로고    scopus 로고
    • Divergent effects of 4-1BB antibodies on antitumor immunity and on tumor-reactive T-cell generation
    • Kim JA, Averbook BJ, Chambers K, et al. Divergent effects of 4-1BB antibodies on antitumor immunity and on tumor-reactive T-cell generation. Cancer Res. 2001;61(5):2031-2037.
    • (2001) Cancer Res. , vol.61 , Issue.5 , pp. 2031-2037
    • Kim, J.A.1    Averbook, B.J.2    Chambers, K.3
  • 25
    • 0036195860 scopus 로고    scopus 로고
    • Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors
    • Wilcox RA, Flies DB, Zhu G, et al. Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors. J Clin Invest. 2002;109(5):651-659.
    • (2002) J Clin Invest. , vol.109 , Issue.5 , pp. 651-659
    • Wilcox, R.A.1    Flies, D.B.2    Zhu, G.3
  • 26
    • 0037096878 scopus 로고    scopus 로고
    • Anti-4-1BB monoclonal antibody enhances rejection of large tumor burden by promoting survival but not clonal expansion of tumor-specific CD8+ T cells
    • May KF, Chen L, Zheng P, Liu Y. Anti-4-1BB monoclonal antibody enhances rejection of large tumor burden by promoting survival but not clonal expansion of tumor-specific CD8+ T cells. Cancer Res. 2002;62(12):3459-3465.
    • (2002) Cancer Res. , vol.62 , Issue.12 , pp. 3459-3465
    • May, K.F.1    Chen, L.2    Zheng, P.3    Liu, Y.4
  • 27
    • 0037103147 scopus 로고    scopus 로고
    • 4-1BB-specific monoclonal antibody promotes the generation of tumor-specific immune responses by direct activation of CD8 T cells in a CD40-dependent manner
    • Miller RE, Jones J, Le T, et al. 4-1BB-specific monoclonal antibody promotes the generation of tumor-specific immune responses by direct activation of CD8 T cells in a CD40-dependent manner. J Immunol. 2002;169(4):1792-1800.
    • (2002) J Immunol. , vol.169 , Issue.4 , pp. 1792-1800
    • Miller, R.E.1    Jones, J.2    Le, T.3
  • 28
    • 43049087388 scopus 로고    scopus 로고
    • Eradication of established renal cell carcinoma by a combination of 5-fluorouracil and anti-4-1BB monoclonal antibody in mice
    • Ju SA, Cheon SH, Park SM, et al. Eradication of established renal cell carcinoma by a combination of 5-fluorouracil and anti-4-1BB monoclonal antibody in mice. Int J Cancer. 2008;122(12):2784-2790.
    • (2008) Int J Cancer. , vol.122 , Issue.12 , pp. 2784-2790
    • Ju, S.A.1    Cheon, S.H.2    Park, S.M.3
  • 29
    • 79551524395 scopus 로고    scopus 로고
    • Agonist anti-CD137 mAb act on tumor endothelial cells to enhance recruitment of activated T lymphocytes
    • Palazón A, Teijeira A, Martínez-Forero I, et al. Agonist anti-CD137 mAb act on tumor endothelial cells to enhance recruitment of activated T lymphocytes. Cancer Res. 2011;71(3):801-811.
    • (2011) Cancer Res. , vol.71 , Issue.3 , pp. 801-811
    • Palazón, A.1    Teijeira, A.2    Martínez-Forero, I.3
  • 30
    • 34249868241 scopus 로고    scopus 로고
    • Adoptive T cell therapy for cancer in the clinic
    • June CH. Adoptive T cell therapy for cancer in the clinic. J Clin Invest. 2007;117(6):1466-1476.
    • (2007) J Clin Invest. , vol.117 , Issue.6 , pp. 1466-1476
    • June, C.H.1
  • 31
    • 79953041310 scopus 로고    scopus 로고
    • Costimulation through the CD137/4-1BB pathway protects human melanoma tumor-infiltrating lymphocytes from activation-induced cell death and enhances antitumor effector function
    • Hernandez-Chacon JA, Li Y, Wu RC, et al. Costimulation through the CD137/4-1BB pathway protects human melanoma tumor-infiltrating lymphocytes from activation-induced cell death and enhances antitumor effector function. J Immunother. 2011;34(3):236-250.
    • (2011) J Immunother. , vol.34 , Issue.3 , pp. 236-250
    • Hernandez-Chacon, J.A.1    Li, Y.2    Wu, R.C.3
  • 32
    • 68049108195 scopus 로고    scopus 로고
    • CD137 enhances cytotoxicity of CD3(+)CD56(+) cells and their capacities to induce CD4(+) Th1 responses
    • Zhu BQ, Ju SW, Shu YQ. CD137 enhances cytotoxicity of CD3(+)CD56(+) cells and their capacities to induce CD4(+) Th1 responses. Biomed Pharmacother. 2009;63(7):509-516.
    • (2009) Biomed Pharmacother. , vol.63 , Issue.7 , pp. 509-516
    • Zhu, B.Q.1    Ju, S.W.2    Shu, Y.Q.3
  • 33
    • 0028103808 scopus 로고
    • A novel population of expanded human CD3+CD56+ cells derived from T cells with potent in vivo antitumor activity in mice with severe combined immunodeficiency
    • Lu PH, Negrin RS. A novel population of expanded human CD3+CD56+ cells derived from T cells with potent in vivo antitumor activity in mice with severe combined immunodeficiency. J Immunol. 1994;153(4): 1687-1696.
    • (1994) J Immunol. , vol.153 , Issue.4 , pp. 1687-1696
    • Lu, P.H.1    Negrin, R.S.2
  • 34
    • 20444503896 scopus 로고    scopus 로고
    • Low levels of Her2/neu expressed by Ewing's family tumor cell lines can redirect cytokine-induced killer cells
    • Verneris MR, Arshi A, Edinger M, et al. Low levels of Her2/neu expressed by Ewing's family tumor cell lines can redirect cytokine-induced killer cells. Clin Cancer Res. 2005;11(12):4561-4570.
    • (2005) Clin Cancer Res. , vol.11 , Issue.12 , pp. 4561-4570
    • Verneris, M.R.1    Arshi, A.2    Edinger, M.3
  • 36
    • 8544249166 scopus 로고    scopus 로고
    • Anti-CD137 monoclonal antibody administration augments the antitumor efficacy of dendritic cell-based vaccines
    • Ito F, Li Q, Shreiner AB, et al. Anti-CD137 monoclonal antibody administration augments the antitumor efficacy of dendritic cell-based vaccines. Cancer Res. 2004;64(22):8411-8419.
    • (2004) Cancer Res. , vol.64 , Issue.22 , pp. 8411-8419
    • Ito, F.1    Li, Q.2    Shreiner, A.B.3
  • 37
    • 33744987907 scopus 로고    scopus 로고
    • Eradication of established tumors in mice by a combination antibody-based therapy
    • Uno T, Takeda K, Kojima Y, et al. Eradication of established tumors in mice by a combination antibody-based therapy. Nat Med. 2006;12(6):693-698.
    • (2006) Nat Med. , vol.12 , Issue.6 , pp. 693-698
    • Uno, T.1    Takeda, K.2    Kojima, Y.3
  • 38
    • 33746924449 scopus 로고    scopus 로고
    • Combination therapy with anti-CTL antigen-4 and anti-4-1BB antibodies enhances cancer immunity and reduces autoimmunity
    • Kocak E, Lute K, Chang X, et al. Combination therapy with anti-CTL antigen-4 and anti-4-1BB antibodies enhances cancer immunity and reduces autoimmunity. Cancer Res. 2006;66(14):7276-7284.
    • (2006) Cancer Res. , vol.66 , Issue.14 , pp. 7276-7284
    • Kocak, E.1    Lute, K.2    Chang, X.3
  • 39
    • 54749092889 scopus 로고    scopus 로고
    • Combination therapy with cisplatin and anti-4-1BB: Synergistic anticancer effects and amelioration of cisplatin-induced nephrotoxicity
    • Kim YH, Choi BK, Kim KH, Kang SW, Kwon BS. Combination therapy with cisplatin and anti-4-1BB: synergistic anticancer effects and amelioration of cisplatin-induced nephrotoxicity. Cancer Res. 2008;68(18):7264-7269.
    • (2008) Cancer Res. , vol.68 , Issue.18 , pp. 7264-7269
    • Kim, Y.H.1    Choi, B.K.2    Kim, K.H.3    Kang, S.W.4    Kwon, B.S.5
  • 40
    • 0033137063 scopus 로고    scopus 로고
    • Cutting edge: 4-1BB is a bona fide CD8 T cell survival signal
    • Takahashi C, Mittler RS, Vella AT. Cutting edge: 4-1BB is a bona fide CD8 T cell survival signal. J Immunol. 1999;162(9):5037-5040.
    • (1999) J Immunol. , vol.162 , Issue.9 , pp. 5037-5040
    • Takahashi, C.1    Mittler, R.S.2    Vella, A.T.3
  • 41
    • 0346336784 scopus 로고    scopus 로고
    • Ligation of CD137 receptor prevents and reverses established anergy of CD8+ cytolytic T lymphocytes in vivo
    • Wilcox RA, Tamada K, Flies DB, et al. Ligation of CD137 receptor prevents and reverses established anergy of CD8+ cytolytic T lymphocytes in vivo. Blood. 2004;103(1):177-184.
    • (2004) Blood. , vol.103 , Issue.1 , pp. 177-184
    • Wilcox, R.A.1    Tamada, K.2    Flies, D.B.3
  • 42
    • 84884869462 scopus 로고    scopus 로고
    • Bristol-Myers Squibb. Available from: Accessed July 20, 2013
    • Bristol-Myers Squibb. Study of BMS-663513 in Patients With Advanced Cancer. Available from: http://clinicaltrials.gov/ct2/show/NCT00309023.NLM identifier: NCT00309023. Accessed July 20, 2013.
    • Study of BMS-663513 in Patients With Advanced Cancer
  • 44
    • 55949113750 scopus 로고    scopus 로고
    • Phase I study of BMS-663513, a fully human anti-CD137 agonist monoclonal antibody, in patients (pts) with advanced cancer (CA) [Abstract]
    • Sznol M, Hodi FS, Margolin K, et al. Phase I study of BMS-663513, a fully human anti-CD137 agonist monoclonal antibody, in patients (pts) with advanced cancer (CA) [Abstract]. J Clin Oncol (Meeting Abstracts). 2008;26(Suppl 15):3007.
    • (2008) J Clin Oncol (Meeting Abstracts). , vol.26 , Issue.SUPPL. 15 , pp. 3007
    • Sznol, M.1    Hodi, F.S.2    Margolin, K.3
  • 45
    • 84884883835 scopus 로고    scopus 로고
    • Bristol-Myers Squibb. Phase II, Available from: NLM identifier: NCT00612664. Accessed July 30, 2013
    • Bristol-Myers Squibb. Phase II, 2nd Line Melanoma-RAND Monotherapy. Available from: http://clinicaltrials.gov/show/NCT00612664. NLM identifier: NCT00612664. Accessed July 30, 2013.
    • 2nd Line Melanoma-RAND Monotherapy
  • 50
    • 84884842886 scopus 로고    scopus 로고
    • Bristol-Myers Squibb. Available from: NLM identifier: NCT00803374. Accessed July 20, 2013
    • Bristol-Myers Squibb. Combination of Anti-CD137 & Ipilimumab in Patients With Melanoma. Available from: http://clinicaltrials.gov/ct2/show/NCT00803374. NLM identifier: NCT00803374. Accessed July 20, 2013.
    • Combination of Anti-CD137 & Ipilimumab in Patients With Melanoma


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.