GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2

Genes and Development

Volumn 29, Issue 22, 2015, Pages 2331-2336

  Ye, Jiangbin ^a   Palm, Wilhelm ^a   Peng, Min ^a   King, Bryan ^a   Lindsten, Tullia ^a   Li, Ming O ^a   Koumenis, Constantinos ^b   Thompson, Craig B ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Amino acid deprivation; GCN2; MTORC1; Sestrin

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; ARGININE; GENERAL CONTROL NONDEREPRESSIBLE 2; GLUTAMINE; HEAT SHOCK PROTEIN; ISOLEUCINE; LEUCINE; LYSINE; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHOSERINE; PROTEIN KINASE; SESTRIN 2; THAPSIGARGIN; UNCLASSIFIED DRUG; AMINO ACID; ATF4 PROTEIN, HUMAN; EIF2AK4 PROTEIN, HUMAN; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; NUCLEAR PROTEIN; PROTEIN SERINE THREONINE KINASE; SESN2 PROTEIN, HUMAN; TARGET OF RAPAMYCIN KINASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL SURVIVAL; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DYNAMICS; EMBRYO; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FIBROBLAST; GENE CONTROL; GENE INDUCTION; GENE REPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; LYSOSOME MEMBRANE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION SITE; UPREGULATION; ANIMAL; CELL LINE; GENE EXPRESSION REGULATION; GENETICS; HEK293 CELL LINE; LYSOSOME; METABOLISM; TUMOR CELL LINE;

ACTIVATING TRANSCRIPTION FACTOR 4; AMINO ACIDS; ANIMALS; CELL LINE; CELL LINE, TUMOR; CELL SURVIVAL; GENE EXPRESSION REGULATION; HEK293 CELLS; HUMANS; LYSOSOMES; MICE; MULTIPROTEIN COMPLEXES; NUCLEAR PROTEINS; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84947914958     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.269324.115     Document Type: Article

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