Translational Upregulation of an Individual p21Cip1 Transcript Variant by GCN2 Regulates Cell Proliferation and Survival under Nutrient Stress

PLoS Genetics

Volumn 11, Issue 6, 2015, Pages

  Lehman, Stacey L ^a   Cerniglia, George J ^a   Johannes, Gregg J ^b   Ye, Jiangbin ^a,d   Ryeom, Sandra ^c   Koumenis, Constantinos ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; CYCLIN DEPENDENT KINASE INHIBITOR 1; INITIATION FACTOR 2ALPHA; PROTEIN GCN2; PROTEIN SERINE THREONINE KINASE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; CDKN1A PROTEIN, MOUSE; CYCLIN DEPENDENT KINASE INHIBITOR 1A; EIF2AK4 PROTEIN, MOUSE; PROTEIN KINASE R;

5' UNTRANSLATED REGION; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; CELLULAR STRESS RESPONSE; COLORECTAL CARCINOMA; CONTROLLED STUDY; DNA DAMAGE; DOWN REGULATION; HEAD AND NECK SQUAMOUS CELL CARCINOMA; HUMAN; HUMAN CELL; INTERNAL RIBOSOME ENTRY SITE; MUTATIONAL ANALYSIS; OPEN READING FRAME; PHENOTYPE; POINT MUTATION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TRANSCRIPTION REGULATION; UPREGULATION; ANIMAL; CELL LINE; FOOD; GENETICS; METABOLISM; MOLECULAR GENETICS; MOUSE; NUCLEOTIDE SEQUENCE; PHYSIOLOGICAL STRESS; TUMOR CELL LINE;

EUKARYOTA;

ANIMALS; BASE SEQUENCE; CELL LINE; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; EIF-2 KINASE; FOOD; HUMANS; MICE; MOLECULAR SEQUENCE DATA; PROTEIN-SERINE-THREONINE KINASES; STRESS, PHYSIOLOGICAL; UP-REGULATION;

EID: 84937800137     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1005212     Document Type: Article

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