Bactericidal Antibiotics Induce Toxic Metabolic Perturbations that Lead to Cellular Damage

Cell Reports

Volumn 13, Issue 5, 2015, Pages 968-980

  Belenky, Peter ^a,b   Ye, Jonathan D ^a   Porter, Caroline B M ^c,d,e   Cohen, Nadia R ^c,e   Lobritz, Michael A ^c,d,e,g   Ferrante, Thomas ^e   Jain, Saloni ^a,c   Korry, Benjamin J ^b   Schwarz, Eric G ^a   Walker, Graham C ^f   Collins, James J ^c,d,e  

^a Boston University   (United States)

^b BROWN UNIVERSITY   (United States)

^c Massachusetts Institute of Technology Cambridge   (United States)

^d BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^e HARVARD UNIVERSITY   (United States)

^f MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^g MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Antibiotics; Double strand breaks; E. coli, metabolomics; Lipid peroxidation; Oxidative stress; Protein carbonylation DNA damage; Reactive oxygen species

Indexed keywords

AMINOGLYCOSIDE; BETA LACTAM; MALONALDEHYDE; QUINOLINE DERIVED ANTIINFECTIVE AGENT; REACTIVE OXYGEN METABOLITE; AMPICILLIN; ANTIINFECTIVE AGENT; KANAMYCIN; NORFLOXACIN;

ARTICLE; BACTERIAL METABOLISM; CELL DAMAGE; CONTROLLED STUDY; DOUBLE STRANDED DNA BREAK; DOWN REGULATION; DRUG EFFECT; ENERGY METABOLISM; ESCHERICHIA COLI; GLUTATHIONE METABOLISM; METABOLOME; NONHUMAN; NUCLEOTIDE METABOLISM; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN CARBONYLATION; DRUG EFFECTS;

AMPICILLIN; ANTI-BACTERIAL AGENTS; DNA BREAKS, DOUBLE-STRANDED; ESCHERICHIA COLI; KANAMYCIN; NORFLOXACIN; OXIDATIVE STRESS;

EID: 84947426625     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2015.09.059     Document Type: Article

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