Chemistry-based studies on oxidative DNA damage: Formation, repair, and mutagenesis

Free Radical Biology and Medicine

Volumn 33, Issue 4, 2002, Pages 450-456

  Kasai, Hiroshi ^a  

^a UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

Author keywords

2 Hydroxy dATP; 8 Hydroxy dG; Free radicals; MTH1

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ADENOSINE TRIPHOSPHATE DERIVATIVE; CELL DNA; DEOXYGUANOSINE DERIVATIVE; GLYOXAL DEOXYGUANOSINE; UNCLASSIFIED DRUG; 2 HYDROXYDEOXYADENOSINE TRIPHOSPHATE; 2-HYDROXYDEOXYADENOSINE TRIPHOSPHATE; 8-HYDROXY-2'-DEOXYGUANOSINE; ADENOSINE TRIPHOSPHATE; BACTERIAL DNA; BACTERIAL PROTEIN; DEOXYGUANOSINE; DNA DIRECTED DNA POLYMERASE; DRUG DERIVATIVE; FREE RADICAL; NUCLEOSIDE;

ARTICLE; CELLULAR, SUBCELLULAR AND MOLECULAR BIOLOGICAL PHENOMENA AND FUNCTIONS; DNA DAMAGE; DNA REPAIR; HUMAN; METHODOLOGY; MUTAGENESIS; NONHUMAN; OXIDATION; PRIORITY JOURNAL; URINALYSIS; CHEMISTRY; DNA ADDUCT; ENZYME LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI; GENETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; OXIDATION REDUCTION REACTION; REVIEW; URINE;

ADENOSINE TRIPHOSPHATE; BACTERIAL PROTEINS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DEOXYGUANOSINE; DNA ADDUCTS; DNA DAMAGE; DNA REPAIR; DNA, BACTERIAL; DNA-DIRECTED DNA POLYMERASE; ENZYME-LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI; FREE RADICALS; HUMAN; MUTAGENESIS; NUCLEOSIDES; OXIDATION-REDUCTION; HUMANS;

EID: 0037101878     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(02)00818-3     Document Type: Article

References (35)

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2. Detection and identification of mutagens and carcinogens as their adducts with guanosine derivatives
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4. Comparision of oxidation products from DNA components by γ-irradiation and Fenton-type reactions
5. Formation of 5-formyl-2′-deoxycytidine from 5-methyl-2′-deoxycytidine in duplex DNA by Fenton-type reactions and γ-irradiation
6. Photosensitized oxidation of 5-methyl-2′-deoxycytidine by 2-methyl-1,4-naphthoquinone: Characterization of 5-(hydroxymethyl)-2′-deoxycytidine and stable methyl group oxidation products
7. Formation of a mutagen, glyoxal, from DNA treated with oxygen free radicals
8. Glyoxal, a major product of DNA oxidation, induces mutations at G:C sites on a shuttle vector plasmid replicated in mammalian cells
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11. Induction of chromosomal gene mutations in Escherichia coli by direct incorporation of oxidatively damaged nucleotides
12. Two DNA polymerases of Escherichia coli display distinct misinsertion specificities for 2-hydroxy-dATP during DNA synthesis
13. Effects of sequence contexts on misincorporation of nucleotides opposite 2-hydroxyadenine
14. Genomic structure and chromosome location of the human mutT homologue gene MTH1 encoding 8-oxo-dGTPase for prevention of A:T to C:G transversion
15. The oxidized forms of dATP are substrates for the human MutT homologue, the hMTH1 protein
16. Human MTH1 protein hydrolyzes the oxidized ribonucleotide,2-hydroxy-ATP
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35. Isotope dilution high-performance liquid chromatography-electrospray tandem mass spectrometry assay for the measurement of 8-oxo-7,8-dihydro-2′-deoxyguanosine in biological samples