HO• radicals induce an unexpected high proportion of tandem base lesions refractory to repair by DNA glycosylases

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 12, 2010, Pages 5528-5533

  Bergeron, François ^a,b   Auvré, Frédéric ^b   Radicella, J Pablo ^b   Ravanat, Jean Luc ^a,b  

^a CEA GRENOBLE   (France)

^b CNRS   (France)

Author keywords

DNA damage; Dna repair; Peroxidation reaction; Tandem lesions

Indexed keywords

8 HYDROXYDEOXYADENOSINE; 8 HYDROXYDEOXYGUANOSINE; ADENOSINE DERIVATIVE; DNA GLYCOSYLTRANSFERASE; HYDROXYL RADICAL; UNCLASSIFIED DRUG; 2' DEOXY 7,8 DIHYDRO 8 OXOADENOSINE; 2'-DEOXY-7,8-DIHYDRO-8-OXOADENOSINE; 8-HYDROXY-2'-DEOXYGUANOSINE; DEOXYADENOSINE DERIVATIVE; DEOXYGUANOSINE; DNA; DRUG DERIVATIVE;

ARTICLE; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; ELECTRON TRANSPORT; ENZYME METABOLISM; EXCISION REPAIR; PEROXIDATION; PRIORITY JOURNAL; TANDEM REPEAT; ANIMAL; BIOLOGICAL MODEL; CATTLE; DRUG EFFECT; GAMMA RADIATION; IN VITRO STUDY; METABOLISM; OXIDATION REDUCTION REACTION; PHYSIOLOGY; RADIATION EXPOSURE;

ANIMALS; CATTLE; DEOXYADENOSINES; DEOXYGUANOSINE; DNA; DNA DAMAGE; DNA GLYCOSYLASES; DNA REPAIR; GAMMA RAYS; HYDROXYL RADICAL; MODELS, BIOLOGICAL; OXIDATION-REDUCTION;

EID: 77950479122     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1000193107     Document Type: Article

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