Reductively responsive hydrogel nanoparticles with uniform size, shape, and tunable composition for systemic sirna delivery in vivo

Molecular Pharmaceutics

Volumn 12, Issue 10, 2015, Pages 3518-3526

  Ma, Da ^a,b   Tian, Shaomin ^a,b   Baryza, Jeremy ^c   Luft, J Christopher ^a,b,e   Desimone, Joseph M ^a,b,d,e,f,g  

^a Department of Chemistry ^*  (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^d UNC Hamner Institute for Drug Safety Sciences   (United States)

^e Institute for Advanced Materials Devices and Nanotechnology   (United States)

^f North Carolina State University   (United States)

^g MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Drug delivery; Gene therapy; Hydrogel; Nanoparticles; SiRNA

Indexed keywords

MESSENGER RNA; NANOPARTICLE; SMALL INTERFERING RNA; HYDROGEL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHEMICAL COMPOSITION; COMPLEX FORMATION; CONTROLLED STUDY; DISULFIDE BOND; FEMALE; GENE SILENCING; GENE TARGETING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HYDROGEL; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL; MOUSE; NANOFABRICATION; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; SURFACE PROPERTY; ZETA POTENTIAL; AGAR GEL ELECTROPHORESIS; ANIMAL; C57BL MOUSE; CHEMISTRY; DRUG DELIVERY SYSTEM; HELA CELL LINE; PROCEDURES; SCANNING ELECTRON MICROSCOPY; THERAPEUTIC USE;

ANIMALS; DRUG DELIVERY SYSTEMS; ELECTROPHORESIS, AGAR GEL; HELA CELLS; HUMANS; HYDROGELS; MICE, INBRED C57BL; MICROSCOPY, ELECTRON, SCANNING; NANOPARTICLES; PARTICLE SIZE; RNA, SMALL INTERFERING;

EID: 84947241067     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/acs.molpharmaceut.5b00054     Document Type: Article

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