Endosomal escape and siRNA delivery with cationic shell crosslinked knedel-like nanoparticles with tunable buffering capacities

Biomaterials

Volumn 33, Issue 33, 2012, Pages 8557-8568

  Shrestha, Ritu ^a   Elsabahy, Mahmoud ^a,c   Florez Malaver, Stephanie ^a   Samarajeewa, Sandani ^a   Wooley, Karen L ^a,b  

^a TEXAS A AND M UNIVERSITY   (United States)

^b Texas AandM University   (United States)

^c Assiut University   (Egypt)

Author keywords

Cationic nanoparticles; Endosomal escape; Histamine; Immunotoxicity; SiRNA delivery; Transfection

Indexed keywords

CATIONIC NANOPARTICLES; ENDOSOMAL ESCAPE; HISTAMINE; IMMUNOTOXICITY; SIRNA DELIVERY; TRANSFECTION;

BINDING ENERGY; BIOCOMPATIBILITY; EFFICIENCY; GENETIC ENGINEERING; RNA; TITRATION; TOXICITY; VOLTAMMETRY;

NANOPARTICLES;

AMINE; BAFILOMYCIN A1; CATIONIC SHELL CROSSLINKED KNEDEL LIKE NANOPARTICLE; HISTAMINE; NANOCARRIER; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ACIDIFICATION; ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; BIOCOMPATIBILITY; CHEMICAL BINDING; CHEMICAL COMPOSITION; CHEMICAL MODIFICATION; CONTROLLED STUDY; CROSS LINKING; CYTOTOXICITY; DRUG CYTOTOXICITY; ENDOSOME; FEMALE; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOGENICITY; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PARTICLE SIZE; POTENTIOMETRY; PRIORITY JOURNAL; PRODUCTIVITY; SYNTHESIS;

ANIMALS; CELL LINE; ENDOSOMES; GENE SILENCING; MICE; MICROSCOPY, CONFOCAL; NANOPARTICLES; NANOTECHNOLOGY; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 84866144321     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2012.07.054     Document Type: Article

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