메뉴 건너뛰기




Volumn 23, Issue 1, 2012, Pages 43-55

Bile acid sequestrants: More than simple resins

Author keywords

bile acid sequestrants; bile acids; energy metabolism; glucose; hypercholesterolemia

Indexed keywords

ATORVASTATIN; BILE ACID; BILE ACID SEQUESTRANT; COLESEVELAM; COLESTIPOL; COLESTYRAMINE; EZETIMIBE; FENOFIBRATE; MEVINOLIN; NICOTINIC ACID; PLACEBO; RESIN; SIMVASTATIN;

EID: 84855850294     PISSN: 09579672     EISSN: 14736535     Source Type: Journal    
DOI: 10.1097/MOL.0b013e32834f0ef3     Document Type: Review
Times cited : (69)

References (113)
  • 1
    • 58249110568 scopus 로고    scopus 로고
    • Role of bile acids and bile acid receptors in metabolic regulation
    • Lefebvre P, Cariou B, Lien F, et al. Role of bile acids and bile acid receptors in metabolic regulation. Physiol Rev 2009; 89:147-191.
    • (2009) Physiol Rev , vol.89 , pp. 147-191
    • Lefebvre, P.1    Cariou, B.2    Lien, F.3
  • 3
    • 33751516736 scopus 로고
    • Studies in the bile acids the conjugated bile salts of certain primates
    • Wiggins HS, Wootton ID. Studies in the bile acids. The conjugated bile salts of certain primates. Biochem J 1958; 70:349-352.
    • (1958) Biochem J , vol.70 , pp. 349-352
    • Wiggins, H.S.1    Wootton, I.D.2
  • 4
    • 33645230000 scopus 로고    scopus 로고
    • How bile acids confer gut mucosal protection against bacteria
    • Hofmann AF, Eckmann L. How bile acids confer gut mucosal protection against bacteria. Proc Natl Acad Sci USA 2006; 103:4333-4334.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 4333-4334
    • Hofmann, A.F.1    Eckmann, L.2
  • 7
    • 0033026760 scopus 로고    scopus 로고
    • Endogenous bile acids are ligands for the nuclear receptor FXR/BAR
    • DOI 10.1016/S1097-2765(00)80348-2
    • Wang H, Chen J, Hollister K, et al. Endogenous bile acids are ligands for the nuclear receptor FXR/BAR. Mol Cell 1999; 3:543-553. (Pubitemid 29268438)
    • (1999) Molecular Cell , vol.3 , Issue.5 , pp. 543-553
    • Wang, H.1    Chen, J.2    Hollister, K.3    Sowers, L.C.4    Forman, B.M.5
  • 8
    • 10344224570 scopus 로고    scopus 로고
    • The constitutive androstane receptor and pregnane X receptor function coordinately to prevent bile acid-induced hepatotoxicity
    • DOI 10.1074/jbc.M409041200
    • Zhang J, Huang W, Qatanani M, et al. The constitutive androstane receptor and pregnane X receptor function coordinately to prevent bile acid-induced hepatotoxicity. J Biol Chem 2004; 279:49517-49522. (Pubitemid 39625839)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.47 , pp. 49517-49522
    • Zhang, J.1    Huang, W.2    Qatanani, M.3    Evans, R.M.4    Moore, D.D.5
  • 12
    • 77951996563 scopus 로고    scopus 로고
    • Regulation of bile acid synthesis by fat-soluble vitamins A and D
    • Schmidt DR, Holmstrom SR, Fon Tacer K, et al. Regulation of bile acid synthesis by fat-soluble vitamins A and D. J Biol Chem 2010; 285:14486-14494.
    • (2010) J Biol Chem , vol.285 , pp. 14486-14494
    • Schmidt, D.R.1    Holmstrom, S.R.2    Fon Tacer, K.3
  • 13
    • 10844273426 scopus 로고    scopus 로고
    • Mechanism of rifampicin and pregnane X receptor inhibition of human cholesterol 7α-hydroxylase gene transcription
    • DOI 10.1152/ajpgi.00258.2004
    • Li T, Chiang JY. Mechanism of rifampicin and pregnane X receptor inhibition of human cholesterol 7 alpha-hydroxylase gene transcription. Am J Physiol Gastrointest Liver Physiol 2005; 288:G74-G84. (Pubitemid 39665222)
    • (2005) American Journal of Physiology - Gastrointestinal and Liver Physiology , vol.288 , Issue.1
    • Li, T.1    Chiang, J.Y.L.2
  • 14
    • 0033636789 scopus 로고    scopus 로고
    • Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors
    • Lu TT, Makishima M, Repa JJ, et al. Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors. Mol Cell 2000; 6:507-515.
    • (2000) Mol Cell , vol.6 , pp. 507-515
    • Lu, T.T.1    Makishima, M.2    Repa, J.J.3
  • 15
    • 0037169541 scopus 로고    scopus 로고
    • Dual mechanisms for repression of the monomeric orphan receptor liver receptor homologous protein-1 by the orphan small heterodimer partner
    • DOI 10.1074/jbc.M105161200
    • Lee YK, Moore DD. Dual mechanisms for repression of the monomeric orphan receptor liver receptor homologous protein-1 by the orphan small heterodimer partner. J Biol Chem 2002; 277:2463-2467. (Pubitemid 34953268)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.4 , pp. 2463-2467
    • Lee, Y.-K.1    Moore, D.D.2
  • 16
    • 0033637121 scopus 로고    scopus 로고
    • A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis
    • Goodwin B, Jones SA, Price RR, et al. A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis. Mol Cell 2000; 6:517-526.
    • (2000) Mol Cell , vol.6 , pp. 517-526
    • Goodwin, B.1    Jones, S.A.2    Price, R.R.3
  • 18
    • 79957512391 scopus 로고    scopus 로고
    • LRH-1 is critical for adequate upregulation of Cyp7a1 gene transcription and bile salt synthesis during bile salt sequestration
    • Out C, Hageman J, Bloks VW, et al. LRH-1 is critical for adequate upregulation of Cyp7a1 gene transcription and bile salt synthesis during bile salt sequestration. Hepatology 2011; 53:2075-2085.
    • (2011) Hepatology , vol.53 , pp. 2075-2085
    • Out, C.1    Hageman, J.2    Bloks, V.W.3
  • 21
    • 0034625419 scopus 로고    scopus 로고
    • 1-Fetoprotein transcription factor is required for the expression of sterol 12α-hydroxylase, the specific enzyme for cholic acid synthesis. Potential role in the bile acid-mediated regulation of gene transcription
    • DOI 10.1074/jbc.M000996200
    • del Castillo-Olivares A, Gil G. Alpha 1-fetoprotein transcription factor is required for the expression of sterol 12alpha-hydroxylase, the specific enzyme for cholic acid synthesis. Potential role in the bile acid-mediated regulation of gene transcription. J Biol Chem 2000; 275:17793-17799. (Pubitemid 30430830)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.23 , pp. 17793-17799
    • Del Castillo-Olivares, A.1    Gil, G.2
  • 23
    • 34250894871 scopus 로고    scopus 로고
    • In vivo imaging of farnesoid X receptor activity reveals the ileum as the primary bile acid signaling tissue
    • DOI 10.1210/me.2007-0113
    • Houten SM, Volle DH, Cummins CL, et al. In vivo imaging of farnesoid X receptor activity reveals the ileum as the primary bile acid signaling tissue. Mol Endocrinol 2007; 21:1312-1323. (Pubitemid 46984739)
    • (2007) Molecular Endocrinology , vol.21 , Issue.6 , pp. 1312-1323
    • Houten, S.M.1    Volle, D.H.2    Cummins, C.L.3    Mangelsdorf, D.J.4    Auwerx, J.5
  • 25
    • 27844546989 scopus 로고    scopus 로고
    • Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis
    • Inagaki T, Choi M, Moschetta A, et al. Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. Cell Metab 2005; 2:217-225.
    • (2005) Cell Metab , vol.2 , pp. 217-225
    • Inagaki, T.1    Choi, M.2    Moschetta, A.3
  • 29
    • 66449085572 scopus 로고    scopus 로고
    • FGF15/FGFR4 integrates growth factor signaling with hepatic bile acid metabolism and insulin action
    • Shin DJ, Osborne TF. FGF15/FGFR4 integrates growth factor signaling with hepatic bile acid metabolism and insulin action. J Biol Chem 2009; 284:11110-11120.
    • (2009) J Biol Chem , vol.284 , pp. 11110-11120
    • Shin, D.J.1    Osborne, T.F.2
  • 30
    • 77957258271 scopus 로고    scopus 로고
    • Intestinal FXR-mediated FGF15 production contributes to diurnal control of hepatic bile acid synthesis in mice
    • Stroeve JH, Brufau G, Stellaard F, et al. Intestinal FXR-mediated FGF15 production contributes to diurnal control of hepatic bile acid synthesis in mice. Lab Invest 2010; 90:1457-1467.
    • (2010) Lab Invest , vol.90 , pp. 1457-1467
    • Stroeve, J.H.1    Brufau, G.2    Stellaard, F.3
  • 32
    • 79959525960 scopus 로고    scopus 로고
    • The bile acid membrane receptor TGR5: A valuable metabolic target
    • Pols TW, Noriega LG, Nomura M, et al. The bile acid membrane receptor TGR5: a valuable metabolic target. Dig Dis 2011; 29:37-44.
    • (2011) Dig Dis , vol.29 , pp. 37-44
    • Pols, T.W.1    Noriega, L.G.2    Nomura, M.3
  • 33
    • 77950602541 scopus 로고    scopus 로고
    • Bile salt sequestration induces hepatic de novo lipogenesis through farnesoid X receptor-and liver X receptor alpha-controlled metabolic pathways in mice
    • Herrema H, Meissner M, van Dijk TH, et al. Bile salt sequestration induces hepatic de novo lipogenesis through farnesoid X receptor-and liver X receptor alpha-controlled metabolic pathways in mice.Hepatology 2010; 51:806-816.
    • (2010) Hepatology , vol.51 , pp. 806-816
    • Herrema, H.1    Meissner, M.2    Van Dijk, T.H.3
  • 34
    • 33645098531 scopus 로고    scopus 로고
    • Clinical utility of bile acid sequestrants in the treatment of dyslipidemia: A scientific review
    • Insull W Jr. Clinical utility of bile acid sequestrants in the treatment of dyslipidemia: a scientific review. South Med J 2006; 99:257-273.
    • (2006) South Med J , vol.99 , pp. 257-273
    • Insull Jr., W.1
  • 36
    • 0021792265 scopus 로고
    • Alterations in calcium, magnesium, iron, and zinc metabolism in dietary cholestyramine
    • DOI 10.1007/BF01318182
    • Watkins DW, Khalafi R, Cassidy MM, Vahouny GV. Alterations in calcium, magnesium, iron, and zinc metabolism by dietary cholestyramine. Dig Dis Sci 1985; 30:477-482. (Pubitemid 15051752)
    • (1985) Digestive Diseases and Sciences , vol.30 , Issue.5 , pp. 477-482
    • Watkins, D.W.1    Khalafi, R.2    Cassidy, M.M.3    Vahouny, G.V.4
  • 37
    • 0015608321 scopus 로고
    • Depression of the intestinal uptake of radio-vitamin B 12 by cholestyramine
    • Coronato A, Glass GB. Depression of the intestinal uptake of radio-vitamin B 12 by cholestyramine. Proc Soc Exp Biol Med 1973; 142:1341-1344.
    • (1973) Proc Soc Exp Biol Med , vol.142 , pp. 1341-1344
    • Coronato, A.1    Glass, G.B.2
  • 38
    • 0016630136 scopus 로고
    • The effect of cholestyramine on intestinal absorption
    • West RJ, Lloyd JK. The effect of cholestyramine on intestinal absorption. Gut 1975; 16:93-98.
    • (1975) Gut , vol.16 , pp. 93-98
    • West, R.J.1    Lloyd, J.K.2
  • 40
    • 59949088249 scopus 로고    scopus 로고
    • Lowering low-density lipoprotein cholesterol: Statins, ezetimibe, bile acid sequestrants, and combinations: Comparative efficacy and safety
    • Hou R, Goldberg AC. Lowering low-density lipoprotein cholesterol: statins, ezetimibe, bile acid sequestrants, and combinations: comparative efficacy and safety. Endocrinol Metab Clin North Am 2009; 38:79-97.
    • (2009) Endocrinol Metab Clin North Am , vol.38 , pp. 79-97
    • Hou, R.1    Goldberg, A.C.2
  • 41
    • 0021350001 scopus 로고
    • The lipid research clinics coronary primary prevention trial results. I. Reduction in incidence of coronary heart disease
    • The Lipid Research Clinics Coronary Primary Prevention Trial results. I. Reduction in incidence of coronary heart disease. JAMA 1984; 251:351-364.
    • (1984) JAMA , vol.251 , pp. 351-364
  • 42
    • 0021322176 scopus 로고
    • Effects of therapy with cholestyramine on progression of coronary arteriosclerosis: Results of the NHLBI Type II Coronary Intervention Study
    • Brensike JF, Levy RI, Kelsey SF, et al. Effects of therapy with cholestyramine on progression of coronary arteriosclerosis: results of the NHLBI Type II Coronary Intervention Study. Circulation 1984; 69:313-324. (Pubitemid 14180337)
    • (1984) Circulation , vol.69 , Issue.2 , pp. 313-324
    • Brensike, J.F.1    Levy, R.I.2    Kelsey, S.F.3
  • 43
    • 0023879688 scopus 로고
    • A multicenter comparison of lovastatin and cholestyramine therapy for severe primary hypercholesterolemia.The Lovastatin Study Group III
    • A multicenter comparison of lovastatin and cholestyramine therapy for severe primary hypercholesterolemia. The Lovastatin Study Group III. JAMA 1988; 260:359-366.
    • (1988) JAMA , vol.260 , pp. 359-366
  • 44
    • 0001704782 scopus 로고
    • Dose-response study of colestipol tablets in patients with moderate hypercholesterolemia
    • Hunninghake DB, Stein EA, Bremner WF, et al. Dose-response study of colestipol tablets in patients with moderate hypercholesterolemia. Am J Ther 1995; 2:180-189.
    • (1995) Am J Ther , vol.2 , pp. 180-189
    • Hunninghake, D.B.1    Stein, E.A.2    Bremner, W.F.3
  • 45
    • 0034774221 scopus 로고    scopus 로고
    • Effectiveness of colesevelam hydrochloride in decreasing LDL cholesterol in patients with primary hypercholesterolemia: A 24-week randomized controlled trial
    • Insull W, Toth P, Mullican W, et al. Effectiveness of colesevelam hydrochloride in decreasing LDL cholesterol in patients with primary hypercholesterolemia: a 24-week randomized controlled trial. Mayo Clin Proc 2001; 76:971-982. (Pubitemid 32946008)
    • (2001) Mayo Clinic Proceedings , vol.76 , Issue.10 , pp. 971-982
    • Insull Jr., W.1    Toth, P.2    Mullican, W.3    Hunninghake, D.4    Burke, S.5    Donovan, J.M.6    Davidson, M.H.7
  • 46
    • 0028938873 scopus 로고
    • Efficacy of low-dose cholesterol-lowering drug therapy in men with moderate hypercholesterolemia
    • Denke MA, Grundy SM. Efficacy of low-dose cholesterol-lowering drug therapy in men with moderate hypercholesterolemia. Arch Intern Med 1995; 155:393-399.
    • (1995) Arch Intern Med , vol.155 , pp. 393-399
    • Denke, M.A.1    Grundy, S.M.2
  • 47
    • 84948007950 scopus 로고
    • Beneficial effects of combined colestipol-niacin therapy on coronary atherosclerosis and coronary venous bypass grafts
    • DOI 10.1001/jama.257.23.3233
    • Blankenhorn DH, Nessim SA, Johnson RL, et al. Beneficial effects of combined colestipol-niacin therapy on coronary atherosclerosis and coronary venous bypass grafts. JAMA 1987; 257:3233-3240. (Pubitemid 17078320)
    • (1987) Journal of the American Medical Association , vol.257 , Issue.23 , pp. 3233-3240
    • Blankenhorn, D.H.1    Nessim, S.A.2    Johnson, R.L.3
  • 48
    • 0025678697 scopus 로고
    • Beneficial effects of colestipol-niacin on coronary atherosclerosis.A 4-year follow-up
    • Cashin-Hemphill L, Mack WJ, Pogoda JM, et al. Beneficial effects of colestipol-niacin on coronary atherosclerosis. A 4-year follow-up. JAMA 1990; 264:3013-3017.
    • (1990) JAMA , vol.264 , pp. 3013-3017
    • Cashin-Hemphill, L.1    MacK, W.J.2    Pogoda, J.M.3
  • 50
    • 0034994041 scopus 로고    scopus 로고
    • Low-dose combination therapy with colesevelam hydrochloride and lovastatin effectively decreases low-density lipoprotein cholesterol in patients with primary hypercholesterolemia
    • Davidson MH, Toth P, Weiss S, et al. Low-dose combination therapy with colesevelam hydrochloride and lovastatin effectively decreases low-density lipoprotein cholesterol in patients with primary hypercholesterolemia. Clin Cardiol 2001; 24:467-474. (Pubitemid 32520218)
    • (2001) Clinical Cardiology , vol.24 , Issue.6 , pp. 467-474
    • Davidson, M.H.1    Toth, P.2    Weiss, S.3    McKenney, J.4    Hunninghake, D.5    Isaacsohn, J.6    Donovan, J.M.7    Burke, S.K.8
  • 52
    • 0034802407 scopus 로고    scopus 로고
    • Coadministration of colesevelam hydrochloride with atorvastatin lowers LDL cholesterol additively
    • DOI 10.1016/S0021-9150(01)00437-3, PII S0021915001004373
    • Hunninghake D, Insull W Jr, Toth P, et al. Coadministration of colesevelam hydrochloride with atorvastatin lowers LDL cholesterol additively. Atherosclerosis 2001; 158:407-416. (Pubitemid 32913651)
    • (2001) Atherosclerosis , vol.158 , Issue.2 , pp. 407-416
    • Hunninghake, D.1    Insull Jr., W.2    Toth, P.3    Davidson, D.4    Donovan, J.M.5    Burke, S.K.6
  • 53
    • 36749062943 scopus 로고    scopus 로고
    • Effects of adding extended-release niacin and colesevelam to statin therapy on lipid levels in subjects with atherosclerotic disease
    • DOI 10.1016/j.jacl.2007.09.001, PII S1933287407002802
    • Moore A, Phan BA, Challender C, et al. Effects of adding extended-release niacin and colesevelam to statin therapy on lipid levels in subjects with atherosclerotic disease. J Clin Lipidol 2007; 1:620-625. (Pubitemid 350215509)
    • (2007) Journal of Clinical Lipidology , vol.1 , Issue.6 , pp. 620-625
    • Moore, A.1    Phan, B.A.P.2    Challender, C.3    Williamson, J.4    Marcovina, S.5    Zhao, X.-Q.6
  • 54
    • 33751238477 scopus 로고    scopus 로고
    • Lipid-lowering effects of colesevelam HCl in combination with ezetimibe
    • DOI 10.1185/030079906X148436
    • Bays H, Rhyne J, Abby S, et al. Lipid-lowering effects of colesevelam HCl in combination with ezetimibe. Curr Med Res Opin 2006; 22:2191-2200. (Pubitemid 44789984)
    • (2006) Current Medical Research and Opinion , vol.22 , Issue.11 , pp. 2191-2200
    • Bays, H.1    Rhyne, J.2    Abby, S.3    Lai, Y.-L.4    Jones, M.5
  • 55
    • 33751533148 scopus 로고    scopus 로고
    • Lipoprotein effects of combined ezetimibe and colesevelam hydrochloride versus ezetimibe alone in hypercholesterolemic subjects: A pilot study
    • DOI 10.1016/j.metabol.2006.08.013, PII S002604950600309X
    • Knopp R, Tsunehara C, Retzlaff B, et al. Lipoprotein effects of combined ezetimibe and colesevelam hydrochloride versus ezetimibe alone in hypercholesterolemic subjects: a pilot study. Metabolism 2006; 55:1697-1703. (Pubitemid 44830137)
    • (2006) Metabolism: Clinical and Experimental , vol.55 , Issue.12 , pp. 1697-1703
    • Knopp, R.H.1    Tsunehara, C.2    Retzlaff, B.M.3    Fish, B.4    Nguyen, H.5    Anderson, S.6    Nguyen, T.7
  • 56
    • 25844513563 scopus 로고    scopus 로고
    • Colesevelam HCl and ezetimibe combination therapy provides effective lipid-lowering in difficult-to-treat patients with hypercholesterolemia
    • DOI 10.1097/01.mjt.0000155109.69831.a3
    • Zema MJ. Colesevelam HCl and ezetimibe combination therapy provides effective lipid-lowering in difficult-to-treat patients with hypercholesterolemia. Am J Ther 2005; 12:306-310. (Pubitemid 41391808)
    • (2005) American Journal of Therapeutics , vol.12 , Issue.4 , pp. 306-310
    • Zema, M.J.1
  • 57
    • 25444497513 scopus 로고    scopus 로고
    • Safety and efficacy of colesevelam hydrochloride in combination with fenofibrate for the treatment of mixed hyperlipidemia
    • DOI 10.1185/030079905X59157
    • McKenney J, Jones M, Abby S. Safety and efficacy of colesevelam hydrochloride in combination with fenofibrate for the treatment of mixed hyperlipidemia. Curr Med Res Opin 2005; 21:1403-1412. (Pubitemid 41368572)
    • (2005) Current Medical Research and Opinion , vol.21 , Issue.9 , pp. 1403-1412
    • McKenney, J.1    Jones, M.2    Abby, S.3
  • 58
    • 0021344798 scopus 로고
    • The influence of changes in lipid values induced by cholestyramine and diet on progression of coronary artery disease: Results of the NHLBI Type II Coronary Intervention Study
    • Levy RI, Brensike JF, Epstein SE, et al. The influence of changes in lipid values induced by cholestyramine and diet on progression of coronary artery disease: results of NHLBI Type II Coronary Intervention Study. Circulation 1984; 69:325-337. (Pubitemid 14180338)
    • (1984) Circulation , vol.69 , Issue.2 , pp. 325-337
    • Levy, R.I.1    Brensike, J.F.2    Epstein, S.E.3
  • 59
    • 0026582213 scopus 로고
    • Effects on coronary artery disease of lipidlowering diet, or diet plus cholestyramine, in the St Thomas' Atherosclerosis Regression Study (STARS)
    • Watts GF, Lewis B, Brunt JN, et al. Effects on coronary artery disease of lipidlowering diet, or diet plus cholestyramine, in the St Thomas' Atherosclerosis Regression Study (STARS). Lancet 1992; 339:563-569.
    • (1992) Lancet , vol.339 , pp. 563-569
    • Watts, G.F.1    Lewis, B.2    Brunt, J.N.3
  • 60
    • 34248392648 scopus 로고    scopus 로고
    • Bile acids, farnesoid X receptor, atherosclerosis and metabolic control
    • DOI 10.1097/MOL.0b013e3281338d08, PII 0004143320070600000011
    • Kuipers F, Stroeve JH, Caron S, Staels B. Bile acids, farnesoid X receptor, atherosclerosis and metabolic control. Curr Opin Lipidol 2007; 18:289-297. (Pubitemid 46743053)
    • (2007) Current Opinion in Lipidology , vol.18 , Issue.3 , pp. 289-297
    • Kuipers, F.1    Stroeve, J.H.M.2    Caron, S.3    Staels, B.4
  • 61
    • 77957960122 scopus 로고    scopus 로고
    • Improved glycemic control with colesevelam treatment in patients with type 2 diabetes is not directly associated with changes in bile acid metabolism
    • Brufau G, Stellaard F, Prado K, et al. Improved glycemic control with colesevelam treatment in patients with type 2 diabetes is not directly associated with changes in bile acid metabolism. Hepatology 2010; 52:1455-1464.
    • (2010) Hepatology , vol.52 , pp. 1455-1464
    • Brufau, G.1    Stellaard, F.2    Prado, K.3
  • 66
    • 0034664729 scopus 로고    scopus 로고
    • Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis
    • Sinal CJ, Tohkin M, Miyata M, et al. Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis. Cell 2000; 102:731-744.
    • (2000) Cell , vol.102 , pp. 731-744
    • Sinal, C.J.1    Tohkin, M.2    Miyata, M.3
  • 68
    • 33644544672 scopus 로고    scopus 로고
    • Colesevelam HCl reduces LDL particle number and increases LDL size in hypercholesterolemia
    • Rosenson RS. Colesevelam HCl reduces LDL particle number and increases LDL size in hypercholesterolemia. Atherosclerosis 2006; 185:327-330.
    • (2006) Atherosclerosis , vol.185 , pp. 327-330
    • Rosenson, R.S.1
  • 69
    • 33645735636 scopus 로고    scopus 로고
    • Effects of colesevelam hydrochloride on low-density lipoprotein cholesterol and high-sensitivity C-reactive protein when added to statins in patients with hypercholesterolemia
    • Bays HE, Davidson M, Jones MR, Abby SL. Effects of colesevelam hydrochloride on low-density lipoprotein cholesterol and high-sensitivity C-reactive protein when added to statins in patients with hypercholesterolemia. Am J Cardiol 2006; 97:1198-1205.
    • (2006) Am J Cardiol , vol.97 , pp. 1198-1205
    • Bays, H.E.1    Davidson, M.2    Jones, M.R.3    Abby, S.L.4
  • 70
    • 33747160207 scopus 로고    scopus 로고
    • Effects of Colesevelam Hydrochloride (WelChol) on Biomarkers of Inflammation in Patients With Mild Hypercholesterolemia
    • DOI 10.1016/j.amjcard.2006.03.043, PII S0002914906009921
    • Devaraj S, Autret B, Jialal I. Effects of colesevelam hydrochloride (WelChol) on biomarkers of inflammation in patients with mild hypercholesterolemia. Am J Cardiol 2006; 98:641-643. (Pubitemid 44233461)
    • (2006) American Journal of Cardiology , vol.98 , Issue.5 , pp. 641-643
    • Devaraj, S.1    Autret, B.2    Jialal, I.3
  • 71
    • 0028575639 scopus 로고
    • Cholestyramine therapy for dyslipidemia in non-insulindependent diabetes mellitus: A short-term, double-blind, crossover trial
    • Garg A, Grundy SM. Cholestyramine therapy for dyslipidemia in non-insulindependent diabetes mellitus: a short-term, double-blind, crossover trial. Ann Intern Med 1994; 121:416-422.
    • (1994) Ann Intern Med , vol.121 , pp. 416-422
    • Garg, A.1    Grundy, S.M.2
  • 72
    • 78650224090 scopus 로고    scopus 로고
    • Colesevelam hydrochloride to treat hypercholesterolemia and improve glycemia in prediabetes: A randomized, prospective study
    • Handelsman Y, Goldberg RB, Garvey WT, et al. Colesevelam hydrochloride to treat hypercholesterolemia and improve glycemia in prediabetes: a randomized, prospective study. Endocr Pract 2010; 16:617-628.
    • (2010) Endocr Pract , vol.16 , pp. 617-628
    • Handelsman, Y.1    Goldberg, R.B.2    Garvey, W.T.3
  • 73
    • 33947610582 scopus 로고    scopus 로고
    • Effect of colestimide therapy for glycemic control in type 2 diabetes mellitus with hypercholesterolemia
    • DOI 10.1507/endocrj.K05-098
    • Yamakawa T, Takano T, Utsunomiya H, et al. Effect of colestimide therapy for glycemic control in type 2 diabetes mellitus with hypercholesterolemia. Endocr J 2007; 54:53-58. (Pubitemid 46481671)
    • (2007) Endocrine Journal , vol.54 , Issue.1 , pp. 53-58
    • Yamakawa, T.1    Takano, T.2    Utsunomiya, H.3    Kadonosono, K.4    Okamura, A.5
  • 74
    • 33947120281 scopus 로고    scopus 로고
    • Results of the glucose-lowering effect of WelChol study (GLOWS): A randomized, double-blind, placebo-controlled pilot study evaluating the effect of colesevelam hydrochloride on glycemic control in subjects with type 2 diabetes
    • DOI 10.1016/j.clinthera.2007.01.003, PII S0149291807000173
    • Zieve FJ, Kalin MF, Schwartz SL, et al. Results of the glucose-lowering effect of WelChol study (GLOWS): a randomized, double-blind, placebo-controlled pilot study evaluating the effect of colesevelam hydrochloride on glycemic control in subjects with type 2 diabetes. Clin Ther 2007; 29:74-83. (Pubitemid 46414026)
    • (2007) Clinical Therapeutics , vol.29 , Issue.1 , pp. 74-83
    • Zieve, F.J.1    Kalin, M.F.2    Schwartz, S.L.3    Jones, M.R.4    Bailey, W.L.5
  • 75
    • 49449087092 scopus 로고    scopus 로고
    • Efficacy and safety of colesevelam in patients with type 2 diabetes mellitus and inadequate glycemic control receiving insulin-based therapy
    • Goldberg RB, Fonseca VA, Truitt KE, Jones MR. Efficacy and safety of colesevelam in patients with type 2 diabetes mellitus and inadequate glycemic control receiving insulin-based therapy. Arch Intern Med 2008; 168:1531-1540.
    • (2008) Arch Intern Med , vol.168 , pp. 1531-1540
    • Goldberg, R.B.1    Fonseca, V.A.2    Truitt, K.E.3    Jones, M.R.4
  • 76
    • 73949102364 scopus 로고    scopus 로고
    • Long-term safety and tolerability of colesevelam HCl in subjects with type 2 diabetes
    • Goldfine AB, Fonseca VA, Jones MR, et al. Long-term safety and tolerability of colesevelam HCl in subjects with type 2 diabetes. Horm Metab Res 2010; 42:23-30.
    • (2010) Horm Metab Res , vol.42 , pp. 23-30
    • Goldfine, A.B.1    Fonseca, V.A.2    Jones, M.R.3
  • 77
    • 54049103635 scopus 로고    scopus 로고
    • Colesevelam hydrochloride therapy in patients with type 2 diabetes mellitus treated with metformin: Glucose and lipid effects
    • Bays HE, Goldberg RB, Truitt KE, Jones MR. Colesevelam hydrochloride therapy in patients with type 2 diabetes mellitus treated with metformin: glucose and lipid effects. Arch Intern Med 2008; 168:1975-1983.
    • (2008) Arch Intern Med , vol.168 , pp. 1975-1983
    • Bays, H.E.1    Goldberg, R.B.2    Truitt, K.E.3    Jones, M.R.4
  • 78
    • 49649095014 scopus 로고    scopus 로고
    • Colesevelam HCl improves glycemic control and reduces LDL cholesterol in patients with inadequately controlled type 2 diabetes on sulfonylurea-based therapy
    • Fonseca VA, Rosenstock J, Wang AC, et al. Colesevelam HCl improves glycemic control and reduces LDL cholesterol in patients with inadequately controlled type 2 diabetes on sulfonylurea-based therapy. Diabetes Care 2008; 31:1479-1484.
    • (2008) Diabetes Care , vol.31 , pp. 1479-1484
    • Fonseca, V.A.1    Rosenstock, J.2    Wang, A.C.3
  • 79
    • 34347401852 scopus 로고    scopus 로고
    • Bile acid sequestrants and the treatment of type 2 diabetes mellitus
    • DOI 10.2165/00003495-200767100-00001
    • Staels B, Kuipers F. Bile acid sequestrants and the treatment of type 2 diabetes mellitus. Drugs 2007; 67:1383-1392. (Pubitemid 47026388)
    • (2007) Drugs , vol.67 , Issue.10 , pp. 1383-1392
    • Staels, B.1    Kuipers, F.2
  • 80
    • 54249157393 scopus 로고    scopus 로고
    • Novel pathways for glycaemic control in type 2 diabetes: Focus on bile acid modulation
    • Brinton EA. Novel pathways for glycaemic control in type 2 diabetes: focus on bile acid modulation. Diabetes Obes Metab 2008; 10:1004-1011.
    • (2008) Diabetes Obes Metab , vol.10 , pp. 1004-1011
    • Brinton, E.A.1
  • 81
    • 58149184379 scopus 로고    scopus 로고
    • Modulating LDL cholesterol and glucose in patients with type 2 diabetes mellitus: Targeting the bile acid pathway
    • Goldfine AB. Modulating LDL cholesterol and glucose in patients with type 2 diabetes mellitus: targeting the bile acid pathway. Curr Opin Cardiol 2008; 23:502-511.
    • (2008) Curr Opin Cardiol , vol.23 , pp. 502-511
    • Goldfine, A.B.1
  • 82
    • 34547150134 scopus 로고    scopus 로고
    • Rationale and design of a prospective clinical trial program to evaluate the glucose-lowering effects of colesevelam HCl in patients with type 2 diabetes mellitus
    • DOI 10.1185/030079907X210525
    • Bays HE, Cohen DE. Rationale and design of a prospective clinical trial program to evaluate the glucose-lowering effects of colesevelam HCl in patients with type 2 diabetes mellitus. Curr Med Res Opin 2007; 23:1673-1684. (Pubitemid 47122177)
    • (2007) Current Medical Research and Opinion , vol.23 , Issue.7 , pp. 1673-1684
    • Bays, H.E.1    Cohen, D.E.2
  • 83
    • 78650213711 scopus 로고    scopus 로고
    • Bile acid sequestrants: Glucose-lowering mechanisms
    • Prawitt J, Staels B. Bile acid sequestrants: glucose-lowering mechanisms. Metab Syndr Relat Disord 2010; 8 (Suppl. 1):S3-S8.
    • (2010) Metab Syndr Relat Disord , vol.8 , Issue.SUPPL. 1
    • Prawitt, J.1    Staels, B.2
  • 84
    • 77953766726 scopus 로고    scopus 로고
    • Cholestyramine reverses hyperglycemia and enhances glucose-stimulated glucagon-like peptide 1 release in Zucker diabetic fatty rats
    • Chen L, McNulty J, Anderson D, et al. Cholestyramine reverses hyperglycemia and enhances glucose-stimulated glucagon-like peptide 1 release in Zucker diabetic fatty rats. J Pharmacol Exp Ther 2010; 334:164-170.
    • (2010) J Pharmacol Exp Ther , vol.334 , pp. 164-170
    • Chen, L.1    McNulty, J.2    Anderson, D.3
  • 85
    • 77249142314 scopus 로고    scopus 로고
    • Colesevelam improves insulin resistance in a diet-induced obesity (F-DIO) rat model by increasing the release of GLP-1
    • Shang Q, Saumoy M, Holst JJ, et al. Colesevelam improves insulin resistance in a diet-induced obesity (F-DIO) rat model by increasing the release of GLP-1. Am J Physiol Gastrointest Liver Physiol 2010; 298:G419-G424.
    • (2010) Am J Physiol Gastrointest Liver Physiol , vol.298
    • Shang, Q.1    Saumoy, M.2    Holst, J.J.3
  • 86
    • 77956648921 scopus 로고    scopus 로고
    • Colesevelam HCl improves glucose metabolism and increases plasma glucagon-like peptide 1 and glucosedependent insulinotropic polypeptide concentrations in subjects with type 2 diabetes
    • Beysen C, Deines KC, Tsang EL, et al. Colesevelam HCl improves glucose metabolism and increases plasma glucagon-like peptide 1 and glucosedependent insulinotropic polypeptide concentrations in subjects with type 2 diabetes. Diabetologia 2009; 52:S77.
    • (2009) Diabetologia , vol.52
    • Beysen, C.1    Deines, K.C.2    Tsang, E.L.3
  • 90
    • 0026569478 scopus 로고
    • Chronic effect of oral cholestyramine, a bile salt sequestrant, and exogenous cholecystokinin on insulin release in rats
    • Kogire M, Gomez G, Uchida T, et al. Chronic effect of oral cholestyramine, a bile salt sequestrant, and exogenous cholecystokinin on insulin release in rats. Pancreas 1992; 7:15-20.
    • (1992) Pancreas , vol.7 , pp. 15-20
    • Kogire, M.1    Gomez, G.2    Uchida, T.3
  • 91
    • 78650670934 scopus 로고    scopus 로고
    • Effects of colesevelam on LDL-C, A1c and GLP-1 levels in patients with type 1 diabetes: A pilot randomized doubleblind trial
    • Garg SK, Ritchie PJ, Moser EG, et al. Effects of colesevelam on LDL-C, A1c and GLP-1 levels in patients with type 1 diabetes: a pilot randomized doubleblind trial. Diabetes Obes Metab 2011; 13:137-143.
    • (2011) Diabetes Obes Metab , vol.13 , pp. 137-143
    • Garg, S.K.1    Ritchie, P.J.2    Moser, E.G.3
  • 93
    • 2542435874 scopus 로고    scopus 로고
    • Bile acids regulate gluconeogenic gene expression via small heterodimer partner-mediated repression of hepatocyte nuclear factor 4 and Foxo1
    • DOI 10.1074/jbc.M314322200
    • Yamagata K, Daitoku H, Shimamoto Y, et al. Bile acids regulate gluconeogenic gene expression via small heterodimer partner-mediated repression of hepatocyte nuclear factor 4 and Foxo1. J Biol Chem 2004; 279:23158-23165. (Pubitemid 38685621)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.22 , pp. 23158-23165
    • Yamagata, K.1    Daitoku, H.2    Shimamoto, Y.3    Matsuzaki, H.4    Hirota, K.5    Ishida, J.6    Fukamizu, A.7
  • 94
    • 0141866661 scopus 로고    scopus 로고
    • Coordinated control of cholesterol catabolism to bile acids and of gluconeogenesis via a novel mechanism of transcription regulation linked to the fasted-to-fed cycle
    • DOI 10.1074/jbc.M305079200
    • De FE, Mitro N, Gilardi F, et al. Coordinated control of cholesterol catabolism to bile acids and of gluconeogenesis via a novel mechanism of transcription regulation linked to the fasted-to-fed cycle. J Biol Chem 2003; 278:39124-39132. (Pubitemid 37221815)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.40 , pp. 39124-39132
    • De Fabiani, E.1    Mitro, N.2    Gilardi, F.3    Caruso, D.4    Galli, G.5    Crestani, M.6
  • 95
    • 14244251495 scopus 로고    scopus 로고
    • Farnesoid X receptor: A new player in glucose metabolism?
    • DOI 10.1210/en.2004-1595
    • Cariou B, Duran-Sandoval D, Kuipers F, Staels B. Farnesoid X receptor: a new player in glucose metabolism? Endocrinology 2005; 146:981-983. (Pubitemid 40289283)
    • (2005) Endocrinology , vol.146 , Issue.3 , pp. 981-983
    • Cariou, B.1    Duran-Sandoval, D.2    Kuipers, F.3    Staels, B.4
  • 96
    • 33645509321 scopus 로고    scopus 로고
    • Farnesoid X receptor is essential for normal glucose homeostasis
    • Ma K, Saha P, Chan L, Moore D. Farnesoid X receptor is essential for normal glucose homeostasis. J Clin Invest 2006; 116:1102-1109.
    • (2006) J Clin Invest , vol.116 , pp. 1102-1109
    • Ma, K.1    Saha, P.2    Chan, L.3    Moore, D.4
  • 98
    • 79960695556 scopus 로고    scopus 로고
    • Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure
    • Watanabe M, Horai Y, Houten SM, et al. Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure. J Biol Chem 2011; 286:26913-26920.
    • (2011) J Biol Chem , vol.286 , pp. 26913-26920
    • Watanabe, M.1    Horai, Y.2    Houten, S.M.3
  • 99
    • 79953129095 scopus 로고    scopus 로고
    • FGF19 as a postprandial, insulinindependent activator of hepatic protein and glycogen synthesis
    • Kir S, Beddow SA, Samuel VT, et al. FGF19 as a postprandial, insulinindependent activator of hepatic protein and glycogen synthesis. Science 2011; 331:1621-1624.
    • (2011) Science , vol.331 , pp. 1621-1624
    • Kir, S.1    Beddow, S.A.2    Samuel, V.T.3
  • 100
    • 79958066536 scopus 로고    scopus 로고
    • FGF15/19 regulates hepatic glucose metabolism by inhibiting the CREB-PGC-1alpha pathway
    • Potthoff MJ, Boney-Montoya J, Choi M, et al. FGF15/19 regulates hepatic glucose metabolism by inhibiting the CREB-PGC-1alpha pathway. Cell Metab 2011; 13:729-738.
    • (2011) Cell Metab , vol.13 , pp. 729-738
    • Potthoff, M.J.1    Boney-Montoya, J.2    Choi, M.3
  • 101
    • 70149120326 scopus 로고    scopus 로고
    • Selective activation of FGFR4 by an FGF19 variant does not improve glucose metabolism in ob/ob mice
    • Wu X, Ge H, Lemon B, et al. Selective activation of FGFR4 by an FGF19 variant does not improve glucose metabolism in ob/ob mice. Proc Natl Acad Sci USA 2009; 106:14379-14384.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 14379-14384
    • Wu, X.1    Ge, H.2    Lemon, B.3
  • 102
    • 0023601883 scopus 로고
    • Feeding rats diets containing cheno- or ursodeoxycholic acid or cholestyramine modifies intestinal uptake of glucose and lipids
    • Thomson AB, Keelan M. Feeding rats diets containing cheno-or ursodeoxycholic acid or cholestyramine modifies intestinal uptake of glucose and lipids. Digestion 1987; 38:160-170. (Pubitemid 18054707)
    • (1987) Digestion , vol.38 , Issue.3 , pp. 160-170
    • Thomson, A.B.R.1    Keelan, M.2
  • 103
    • 77950620903 scopus 로고    scopus 로고
    • The effect of colesevelam hydrochloride on insulin sensitivity and secretion in patients with type 2 diabetes: A pilot study
    • Schwartz SL, Lai YL, Xu J, et al. The effect of colesevelam hydrochloride on insulin sensitivity and secretion in patients with type 2 diabetes: a pilot study. Metab Syndr Relat Disord 2010; 8:179-188.
    • (2010) Metab Syndr Relat Disord , vol.8 , pp. 179-188
    • Schwartz, S.L.1    Lai, Y.L.2    Xu, J.3
  • 105
    • 69149083245 scopus 로고    scopus 로고
    • TGR5-mediated bile acid sensing controls glucose homeostasis
    • Thomas C, Gioiello A, Noriega L, et al. TGR5-mediated bile acid sensing controls glucose homeostasis. Cell Metab 2009; 10:167-177.
    • (2009) Cell Metab , vol.10 , pp. 167-177
    • Thomas, C.1    Gioiello, A.2    Noriega, L.3
  • 106
    • 77956455354 scopus 로고    scopus 로고
    • Plasma bile acids are not associated with energy metabolism in humans
    • Brufau G, Bahr MJ, Staels B, et al. Plasma bile acids are not associated with energy metabolism in humans. Nutr Metab (Lond) 2010; 7:73.
    • (2010) Nutr Metab (Lond) , vol.7 , pp. 73
    • Brufau, G.1    Bahr, M.J.2    Staels, B.3
  • 107
    • 0025150480 scopus 로고
    • Pathophysiology and pathogenesis of cholesterol gallstone formation
    • Hay DW, Carey MC. Pathophysiology and pathogenesis of cholesterol gallstone formation. Semin Liver Dis 1990; 10:159-170. (Pubitemid 20299813)
    • (1990) Seminars in Liver Disease , vol.10 , Issue.3 , pp. 159-170
    • Hay, D.W.1    Carey, M.C.2
  • 108
    • 77956276608 scopus 로고    scopus 로고
    • Hydrophobic bile salts inhibit gallbladder smooth muscle function via stimulation of GPBAR1 receptors and activation of KATP channels
    • Lavoie B, Balemba OB, Godfrey C, et al. Hydrophobic bile salts inhibit gallbladder smooth muscle function via stimulation of GPBAR1 receptors and activation of KATP channels. J Physiol 2010; 588:3295-3305.
    • (2010) J Physiol , vol.588 , pp. 3295-3305
    • Lavoie, B.1    Balemba, O.B.2    Godfrey, C.3
  • 109
    • 0025847357 scopus 로고
    • Circadian dynamics of gastric acid secretion and pharmacodynamics of H2 receptor blockade
    • Moore JG. Circadian dynamics of gastric acid secretion and pharmacodynamics of H2 receptor blockade. Ann N Y Acad Sci 1991; 618:150-158.
    • (1991) Ann N y Acad Sci , vol.618 , pp. 150-158
    • Moore, J.G.1
  • 111
    • 0033952113 scopus 로고    scopus 로고
    • Association of diabetes, serum insulin, and C-peptide with gallbladder disease
    • Ruhl CE, Everhart JE. Association of diabetes, serum insulin, and C-peptide with gallbladder disease. Hepatology 2000; 31:299-303. (Pubitemid 30078591)
    • (2000) Hepatology , vol.31 , Issue.2 , pp. 299-303
    • Ruhl, C.E.1    Everhart, J.E.2
  • 112
    • 77949265935 scopus 로고    scopus 로고
    • The environment within: How gut microbiota may influence metabolism and body composition
    • Vrieze A, Holleman F, Zoetendal EG, et al. The environment within: how gut microbiota may influence metabolism and body composition. Diabetologia 2010; 53:606-613.
    • (2010) Diabetologia , vol.53 , pp. 606-613
    • Vrieze, A.1    Holleman, F.2    Zoetendal, E.G.3
  • 113
    • 84855855680 scopus 로고    scopus 로고
    • The therapeutic potential of manipulating gut microbiota in obesity and type 2 diabetes mellitus
    • (in press)
    • Kootte RS, Vrieze A, Holleman F, et al. The therapeutic potential of manipulating gut microbiota in obesity and type 2 diabetes mellitus. Diabetes Obes Metab 2011 (in press).
    • (2011) Diabetes Obes Metab
    • Kootte, R.S.1    Vrieze, A.2    Holleman, F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.