Bile acids and the membrane bile acid receptor TGR5 - Connecting nutrition and metabolism

Thyroid

Volumn 18, Issue 2, 2008, Pages 167-174

  Thomas, Charles ^a   Auwerx, Johan ^a,b   Schoonjans, Kristina ^a  

^a INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^b INSTITUT CLINIQUE DE LA SOURIS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BILE ACID; CHENODEOXYCHOLIC ACID; CHOLIC ACID; G PROTEIN COUPLED RECEPTOR; GLUCAGON LIKE PEPTIDE 1; IODOTHYRONINE; IODOTHYRONINE DEIODINASE 2; LITHOCHOLIC ACID; MEMBRANE BILE ACID RECEPTOR TGR5; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; THYROID HORMONE; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN;

CYTOLOGY; DIGESTION; ENERGY EXPENDITURE; ENTEROENDOCRINE CELL; FATTY ACID OXIDATION; FOOD AVAILABILITY; FOOD INTAKE; GALLBLADDER; GLUCOSE HOMEOSTASIS; HUMAN; NUTRIENT UPTAKE; OBESITY; PRIORITY JOURNAL; REVIEW; THYROID HORMONE METABOLISM;

ANIMALS; BILE ACIDS AND SALTS; ENDOPLASMIC RETICULUM; ENERGY METABOLISM; GLUCAGON-LIKE PEPTIDE 1; HEAT-SHOCK PROTEINS; HUMANS; IODIDE PEROXIDASE; MITOCHONDRIA; NUTRITION PHYSIOLOGY; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; THYROID GLAND; THYROID HORMONES; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRIIODOTHYRONINE;

EID: 39449124119     PISSN: 10507256     EISSN: None     Source Type: Journal    
DOI: 10.1089/thy.2007.0255     Document Type: Review

References (69)

1. Houten SM, Auwerx J 2004 The enterohepatic nuclear receptors are major regulators of the enterohepatic circulation of bile salts. Ann Med 36:482-491.
2. Ho KJ 1976 Circadian distribution of bile acids in the enterohepatic circulatory system in rats. Am J Physiol 230:1331-1335.
3. Engelking LR, Dasher CA, Hirschowitz BI 1980 Within-day fluctuations in serum bile-acid concentrations among normal control subjects and patients with hepatic disease. Am J Clin Pathol 73:196-201.
4. Everson GT 1987 Steady-state kinetics of serum bile acids in healthy human subjects: single and dual isotope techniques using stable isotopes and mass spectrometry. J Lipid Res 28:238-252.
5. Gupta S, Stravitz RT, Dent P, Hylemon PB 2001 Downregulation of cholesterol 7alpha-hydroxylase (CYP7A1) gene expression by bile acids in primary rat hepatocytes is mediated by the c-Jun N-terminal kinase pathway. J Biol Chem 276:15816-15822.
6. Qiao L, Han SI, Fang Y, Park JS, Gupta S, Gilfor D, Amorino G, Valerie K, Sealy L, Engelhardt JF, Grant S, Hylemon PB, Dent P 2003 Bile acid regulation of C/EBPbeta, CREB, and c-Jun function, via the extracellular signal-regulated kinase and c-Jun NH2-terminal kinase pathways, modulates the apoptotic response of hepatocytes. Mol Cell Biol 23:3052-3066.
7. Maruyama T, Miyamoto Y, Nakamura T, Tamai Y, Okada H, Sugiyama E, Itadani H, Tanaka K 2002 Identification of membrane-type receptor for bile acids (M-BAR). Biochem Biophys Res Commun 298:714-719.
8. Kawamata Y, Fujii R, Hosoya M, Harada M, Yoshida H, Miwa M, Fukusumi S, Habata Y, Itoh T, Shintani Y, Hinuma S, Fujisawa Y, Fujino M 2003 A G protein-coupled receptor responsive to bile acids. J Biol Chem 278:9435-9440.
9. Makishima M, Okamoto AY, Repa JJ, Tu H, Learned RM, Luk A, Hull MV, Lustig KD, Mangelsdorf DJ, Shan B 1999 Identification of nuclear receptors for bile acids. Science 284:1362-1365.
10. Parks DJ, Blanchard SG, Bledsoe RK, Chandra G, Consler TG, Kliewer SA, Stimmel JB, Willson TM, Zavacki AM, Moore DD, Lehman JM 1999 Bile acids: natural ligands for orphan nuclear receptors. Science 284:1365-1368.
11. Wang H, Chen J, Hollister K, Sowers LC, Forman BM 1999 Endogenous bile acids are ligands for the nuclear receptor FXR/BAR. Mol Cell 3:543-553.
12. Forman BM, Goode E, Chen J, Oro AE, Bradley DJ, Perlmann T, Nooman DJ, Burka LT, McMorris T, Lamph WW, Evans RM, Weinberger C 1995 Identification of a nuclear receptor that is activated by Farnesol metabolites. Cell 81:687-693.
13. Russell DW 2003 The enzymes, regulation, and genetics of bile acid synthesis. Annu Rev Biochem 72:137-174.
14. Houten SM, Watanabe M, Auwerx J 2006 Endocrine functions of bile acids. EMBO J 25:1419-1425.
15. Lee YK, Dell H, Dowhan DH, Hadzopoulou-Cladaras M, Moore DD 2000 The orphan nuclear receptor SHP inhibits hepatocyte nuclear factor 4 and retinoid X receptor transactivation: two mechanisms for repression. Mol Cell Biol 20:187-195.
16. Lu TT, Makishima M, Repa JJ, Schoonjans K, Kerr TA, Auwerx J, Mangelsdorf DJ 2000 Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors. Mol Cell 6:507-515.
17. Goodwin B, Jones SA, Price RR, Watson MA, McKee DD, Moore LB, Galardi C, Wilson JG, Lewis MC, Roth ME, Maloney PR, Willson TM, Kliewer SA 2000 A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis. Mol Cell 6:517-526.
18. Foord SM, Bonner TI, Neubig RR, Rosser EM, Pin JP, Davenport AP, Spedding M, Harmar AJ 2005 International Union of Pharmacology. XLVI. G protein-coupled receptor list. Pharmacol Rev 57:279-288.
19. Watanabe M, Houten SM, Mataki C, Christoffolete MA, Kim BW, Sato H, Messaddeq N, Harney JW, Ezaki O, Kodama T, Schoonjans K, Bianco AC, Auwerx J 2006 Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. Nature 439:484-489.
20. Vassileva G, Golovko A, Markowitz L, Abbondanzo SJ, Zeng M, Yang S, Hoos L, Tetzloff G, Levitan D, Murgolo NJ, Keane K, Davis HR, Jr., Hedrick J, Gustafson EL 2006 Targeted deletion of Gpbar1 protects mice from cholesterol gallstone formation. Biochem J 398:423-430.
21. Pellicciari R, Sato H, Gioiello A, Costantino G, Macchiarulo A, Sadeghpour BM, Giorgi G, Schoonjans K, Auwerx J 2007 Nongenomic actions of bile acids. Synthesis and preliminary characterization of 23- and 6,23-alkyl-substituted bile acid derivatives as selective modulators for the G-protein coupled receptor TGR5. J Med Chem 50:4265-4268.
22. Sato H, Genet C, Strehle A, Thomas C, Lobstein A, Wagner A, Mioskowski C, Auwerx J, Saladin R 2007 Antihyperglycemic activity of a TGR5 agonist isolated from Olea Europea. Biochem Biophys Res Commun 362:793-798.
23. Kelley DE, He J, Menshikova EV, Ritov VB 2002 Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes. Diabetes 51:2944-2950.
24. Schrauwen P, Hesselink MK 2004 Oxidative capacity, lipotoxicity, and mitochondrial damage in type 2 diabetes. Diabetes 53:1412-1417.
25. Toledo FGS, Kelley DE 2005 Mitochondrial dysfunction in the pathogenesis of insulin resistance associated with obesity, diabetes, and aging. Curr Opin Endocrinol Metab 12:157-162.
26. Auwerx J 2006 Improving metabolism by increasing energy expenditure. Nat Med 12:44-45; discussion 45.
27. Puigserver P, Wu Z, Park CW, Graves R, Wright M, Spiegelman BM 1998 A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92:829-839.
28. Puigserver P, Spiegelman BM 2003 Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator. Endocr Rev 24:78-90.
29. Lin J, Handschin C, Spiegelman BM 2005 Metabolic control through the PGC-1 family of transcription coactivators. Cell Metab 1:361-370.
30. Lin J, Wu PH, Tarr PT, Lindenberg KS, St.-Pierre J, Zhang CY, Mootha VK, Jager S, Vianna CR, Reznick RM, Cui L, Manieri M, Donovan MX, Wu Z, Cooper MP, Fan MC, Rohas LM, Zavacki AM, Cinti S, Shulman GI, Lowell BB, Krainc D, Spiegelman BM 2004 Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice. Cell 119:121-135.
31. Leone TC, Lehman JJ, Finck BN, Schaeffer PJ, Wende AR, Boudina S, Courtois M, Wozniak DF, Sambandam N, Bernal-Mizrachi C, Chen Z, Holloszy JO, Medeiros DM, Schmidt RE, Saffitz JE, Abel ED, Semenkovich CF, Kelly DP 2005 PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis. PLoS Biol 3:e101.
32. Petersen KF, Dufour S, Befroy D, Garcia R, Shulman GI 2004 Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes. N Engl J Med 350:664-671.
33. Mootha VK, Lindgren CM, Eriksson KF, Subramanian A, Sihag S, Lehar J, Puigserver P, Carlsson E, Ridderstrale M, Laurila E, Houstis N, Daly MJ, Patterson N, Mesirov JP, Golub TR, Tamayo P, Spiegelman B, Lander ES, Hirschhorn JN, Altshuler D, Groop LC 2003 PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet 34:267-273.
34. Patti ME, Butte AJ, Crunkhorn S, Cusi K, Berria R, Kashyap S, Miyazaki Y, Kohane I, Costello M, Saccone R, Landaker EJ, Goldfine AB, Mun E, DeFronzo R, Finlayson J, Kahn CR, Mandarino LJ 2003 Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: potential role of PGC1 and NRF1. Proc Natl Acad Sci USA 100:8466-8471.
35. Tanaka T, Yamamoto J, Iwasaki S, Asaba H, Hamura H, Ikeda Y, Watanabe M, Magoori K, Ioka RX, Tachibana K, Watanabe Y, Uchiyama Y, Sumi K, Iguchi H, Ito S, Doi T, Hamakubo T, Naito M, Auwerx J, Yanagisawa M, Kodama T, Sakai J 2003 Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome. Proc Natl Acad Sci USA 100:15924-15929.
36. Mootha VK, Handschin C, Arlow D, Xie X, St. Pierre J, Sihag S, Yang W, Altshuler D, Puigserver P, Patterson N, Willy PJ, Schulman IG, Heyman RA, Lander ES, Spiegelman BM 2004 Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle. Proc Natl Acad Sci USA 101:6570-6575.
37. Wang YX, Zhang CL, Yu RT, Cho HK, Nelson MC, Bayuga-Ocampo CR, Ham J, Kang H, Evans RM 2004 Regulation of muscle fiber type and running endurance by PPARdelta. PLoS Biol 2:e294.
38. Houten SM, Auwerx J 2004 PGC-1alpha: turbocharging mitochondria. Cell 119:5-7.
39. Puigserver P, Adelmant G, Wu Z, Fan M, Xu J, O'Malley B, Spiegelman BM 1999 Activation of PPARgamma coactivator-1 through transcription factor docking. Science 286:1368-1371.
40. Picard F, Gehin M, Annicotte JS, Rocchi S, Champy MF, O'Malley B, Chambon P, Auwerx J 2002 SRC-1 and TIF2 control energy balance between white and brown adipose tissues. Cell 111:931-941.
41. Wallberg AE, Yamamura S, Malik S, Spiegelman BM, Roeder RG 2003 Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha. Mol Cell 12:1137-1149.
42. Rodgers JT, Lerin C, Haas W, Gygi SP, Spiegelman BM, Puigserver P 2005 Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature 434:113-118.
43. Lerin C, Rodgers JT, Kalume DE, Kim SH, Pandey A, Puigserver P 2006 GCN5 acetyltransferase complex controls glucose metabolism through transcriptional repression of PGC-1alpha. Cell Metab 3:429-438.
44. Lagouge M, Argmann C, Gerhart-Hines Z, Meziane H, Lerin C, Daussin F, Messadeq N, Milne J, Lambert P, Elliott P, Geny B, Laakso M, Puigserver P, Auwerx J 2006 Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell 127:1109-1122.
45. Forrest D, Vennstrom B 2000 Functions of thyroid hormone receptors in mice. Thyroid 10:41-52.
46. St. Germain DL, Galton VA 1997 The deiodinase family of selenoproteins. Thyroid 7:655-668.
47. Bianco AC, Salvatore D, Gereben B, Berry MJ, Larsen PR 2002 Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases. Endocr Rev 23:38-89.
48. de Jesus LA, Carvalho SD, Ribeiro MO, Schneider M, Kim SW, Harney JW, Larsen PR, Bianco AC 2001 The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue. J Clin Invest 108:1379-1385.
49. Larsen PR, Silva JE, Kaplan MM 1981 Relationships between circulating and intracellular thyroid hormones: physiological and clinical implications. Endocr Rev 2:87-102.
50. Bianco AC, Silva JE 1988 Cold exposure rapidly induces virtual saturation of brown adipose tissue nuclear T3 receptors. Am J Physiol 255:E496- E503.
51. Bianco AC, Silva JE 1987 Intracellular conversion of thyroxine to triiodothyronine is required for the optimal thermogenic function of brown adipose tissue. J Clin Invest 79:295-300.
52. Bianco AC, Sheng XY, Silva JE 1988 Triiodothyronine amplifies norepinephrine stimulation of uncoupling protein gene transcription by a mechanism not requiring protein synthesis. J Biol Chem 263:18168-18175.
53. Carvalho SD, Kimura ET, Bianco AC, Silva JE 1991 Central role of brown adipose tissue thyroxine 5′-deiodinase on thyroid hormone-dependent thermogenic response to cold. Endocrinology 128:2149-2159.
54. Silva JE, Dick TE, Larsen PR 1978 The contribution of local tissue thyroxine monodeiodination to the nuclear 3,5,3′-triiodothyronine in pituitary, liver, and kidney of euthyroid rats. Endocrinology 103:1196-1207.
55. Crantz FR, Silva JE, Larsen PR 1982 An analysis of the sources and quantity of 3,5,3′-triiodothyronine specifically bound to nuclear receptors in rat cerebral cortex and cerebellum. Endocrinology 110:367-375.
56. Bianco AC, Silva JE 1987 Nuclear 3,5,30-triiodothyronine (T3) in brown adipose tissue: receptor occupancy and sources of T3 as determined by in vivo techniques. Endocrinology 120:55-62.
57. Raufman JP, Chen Y, Cheng K, Compadre C, Compadre L, Zimniak P 2002 Selective interaction of bile acids with muscarinic receptors: a case of molecular mimicry. Eur J Pharmacol 457:77-84.
58. Maruyama T, Tanaka K, Suzuki J, Miyoshi H, Harada N, Nakamura T, Miyamoto Y, Kanatani A, Tamai Y 2006 Targeted disruption of G protein-coupled bile acid receptor 1 (Gpbar1/M-Bar) in mice. J Endocrinol 191:197-205.
59. Croteau W, Davey JC, Galton VA, St. Germain DL 1996 Cloning of the mammalian type II iodothyronine deiodinase. A selenoprotein differentially expressed and regulated in human and rat brain and other tissues. J Clin Invest 98:405-417.
60. Salvatore D, Bartha T, Harney JW, Larsen PR 1996 Molecular, biological and biochemical characterization of the human type 2 selenodeiodinase. Endocrinology 137:3308-3315.
61. Hosoi Y, Murakami M, Mizuma H, Ogiwara T, Imamura M, Mori M 1999 Expression and regulation of type II iodothyronine deiodinase in cultured human skeletal muscle cells. J Clin Endocrinol Metab 84:3293-3300.
62. Peeters RP, Wouters PJ, Kaptein E, van Toor H, Visser TJ, van den Berghe G 2003 Reduced activation and increased inactivation of thyroid hormone in tissues of critically ill patients. J Clin Endocrinol Metab 88:3202-3211.
63. Canani LH, Capp C, Dora JM, Meyer EL, Wagner MS, Harney JW, Larsen PR, Gross JL, Bianco AC, Maia AL 2005 The type 2 deiodinase A/G (Thr92Ala) polymorphism is associated with decreased enzyme velocity and increased insulin resistance in patients with type 2 diabetes mellitus. J Clin Endocrinol Metab 90:3472-3478.
64. Mentuccia D, Proietti-Pannunzi L, Tanner K, Bacci V, Pollin TI, Poehlman ET, Shuldiner AR, Celi FS 2002 Association between a novel variant of the human type 2 deiodinase gene Thr92Ala and insulin resistance: evidence of interaction with the Trp64Arg variant of the beta-3-adrenergic receptor. Diabetes 51:880-883.
65. Grarup N, Andersen MK, Andreasen CH, Albrechtsen A, Borch-Johnsen K, Jorgensen T, Auwerx J, Schmitz O, Hansen T, Pedersen O 2007 Studies of the common DIO2 Thr92Ala polymorphism and metabolic phenotypes in 7342 Danish white subjects. J Clin Endocrinol Metab 92:363-366.
66. Katsuma S, Hirasawa A, Tsujimoto G 2005 Bile acids promote glucagon-like peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1. Biochem Biophys Res Commun 329:386-390.
67. Lim GE, Brubaker PL 2006 Glucagon-like peptide 1 secretion by the L-cell: the view from within. Diabetes 55:S70-S77.
68. Ozcan U, Yilmaz E, Ozcan L, Furuhashi M, Vaillancourt E, Smith RO, Gorgun CZ, Hotamisligil GS 2006 Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science 313:1137-1140.
69. Watanabe M, Houten SM, Wang L, Moschetta A, Mangelsdorf DJ, Heyman RA, Moore DD, Auwerx J 2004 Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c. J Clin Invest 113:1408-1418.