Inhibition of intestinal bile acid transporter Slc10a2 improves triglyceride metabolism and normalizes elevated plasma glucose levels in mice

PLoS ONE

Volumn 7, Issue 5, 2012, Pages

  Lundåsen, Thomas ^a,d   Andersson, Eva Marie ^b   Snaith, Michael ^b,c   Lindmark, Helena ^b   Lundberg, Johanna ^a   Östlund Lindqvist, Ann Margret ^b   Angelin, Bo ^a   Rudling, Mats ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b ASTRAZENECA R AND D   (Sweden)

^c MEDIMMUNE   (United States)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZD 7806; BILE ACID; CHOLESTEROL 7ALPHA MONOOXYGENASE; COTRANSPORTER; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 15; GLUCOSE; INSULIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; PROTEIN INHIBITOR; PROTEIN KINASE B; PROTEIN SLC10A2; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; SUCROSE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ARTICLE; BILE ACID SYNTHESIS; CONTROLLED STUDY; DIABETES MELLITUS; DRUG SPECIFICITY; ENZYME ACTIVITY; FATTY ACID SYNTHESIS; GENE DELETION; GENE EXPRESSION REGULATION; GENE TARGETING; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HYPERLIPIDEMIA; INSULIN BLOOD LEVEL; LIVER LEVEL; LIVER METABOLISM; MALE; MOUSE; NONHUMAN; PHARMACOLOGICAL BLOCKING; SIGNAL TRANSDUCTION; SUGAR INTAKE; TRIACYLGLYCEROL BLOOD LEVEL;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; BILE ACIDS AND SALTS; BLOOD GLUCOSE; CHOLESTEROL; CHOLESTEROL 7-ALPHA-HYDROXYLASE; DIET; FATTY ACIDS; FIBROBLAST GROWTH FACTORS; INTESTINES; LIVER; MALE; MAP KINASE KINASE 1; MAP KINASE KINASE 2; MICE; MICE, KNOCKOUT; MICE, OBESE; ORGANIC ANION TRANSPORTERS, SODIUM-DEPENDENT; PROTO-ONCOGENE PROTEINS C-AKT; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; SYMPORTERS; TRIGLYCERIDES;

MUS;

EID: 84861477433     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0037787     Document Type: Article

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