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Volumn 64, Issue , 2015, Pages 82-90

Immunogenetics of autoimmune thyroid diseases: A comprehensive review

Author keywords

Autoimmune thyroid disease; Autoimmunity; Graves' disease; Hashimoto's thyroiditis; Immunogenetics; Polymorphism

Indexed keywords

CD40 ANTIGEN; CHEMOKINE RECEPTOR CXCR4; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; HLA DR3 ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA; NOTCH4 RECEPTOR; THYROID ANTIBODY; THYROTROPIN RECEPTOR; TRANSCRIPTION FACTOR FOXP3;

EID: 84946471067     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2015.07.009     Document Type: Review
Times cited : (251)

References (130)
  • 1
    • 0031240055 scopus 로고    scopus 로고
    • Epidemiology and estimated population burden of selected autoimmune diseases in the United States
    • Jacobson D.L., Gange S.J., Rose N.R., Graham N.M. Epidemiology and estimated population burden of selected autoimmune diseases in the United States. Clin. Immunol. Immunopathol. 1997, 84:223-243.
    • (1997) Clin. Immunol. Immunopathol. , vol.84 , pp. 223-243
    • Jacobson, D.L.1    Gange, S.J.2    Rose, N.R.3    Graham, N.M.4
  • 3
    • 84897019743 scopus 로고    scopus 로고
    • Mechanisms of autoimmune thyroid diseases: from genetics to epigenetics
    • Tomer Y. Mechanisms of autoimmune thyroid diseases: from genetics to epigenetics. Annu. Rev. Pathol. 2014, 9:147-156.
    • (2014) Annu. Rev. Pathol. , vol.9 , pp. 147-156
    • Tomer, Y.1
  • 5
    • 0141801751 scopus 로고    scopus 로고
    • Searching for the autoimmune thyroid disease susceptibility genes: from gene mapping to gene function
    • Tomer Y., Davies T.F. Searching for the autoimmune thyroid disease susceptibility genes: from gene mapping to gene function. Endocr. Rev. 2003, 24:694-717.
    • (2003) Endocr. Rev. , vol.24 , pp. 694-717
    • Tomer, Y.1    Davies, T.F.2
  • 6
    • 0042144871 scopus 로고
    • Familial studies of autoimmune thyroiditis
    • Hall R., Stanbury J.B. Familial studies of autoimmune thyroiditis. Clin. Exp. Immunol. 1967, 2(Suppl.):719-725.
    • (1967) Clin. Exp. Immunol. , vol.2 , pp. 719-725
    • Hall, R.1    Stanbury, J.B.2
  • 8
    • 84857855590 scopus 로고    scopus 로고
    • Twin studies as a model for exploring the aetiology of autoimmune thyroid disease
    • Brix T.H., Hegedus L. Twin studies as a model for exploring the aetiology of autoimmune thyroid disease. Clin. Endocrinol. 2012, 76:457-464.
    • (2012) Clin. Endocrinol. , vol.76 , pp. 457-464
    • Brix, T.H.1    Hegedus, L.2
  • 9
    • 0035095887 scopus 로고    scopus 로고
    • Evidence for a major role of heredity in Graves' disease: a population-based study of two Danish twin cohorts
    • Brix T.H., Kyvik K.O., Christensen K., Hegedus L. Evidence for a major role of heredity in Graves' disease: a population-based study of two Danish twin cohorts. J. Clin. Endocrinol. Metab. 2001, 86:930-934.
    • (2001) J. Clin. Endocrinol. Metab. , vol.86 , pp. 930-934
    • Brix, T.H.1    Kyvik, K.O.2    Christensen, K.3    Hegedus, L.4
  • 12
  • 13
    • 80052260527 scopus 로고    scopus 로고
    • A genome-wide association study identifies two new risk loci for Graves' disease
    • Chu X., Pan C.M., Zhao S.X., Liang J., Gao G.Q., Zhang X.M., et al. A genome-wide association study identifies two new risk loci for Graves' disease. Nat. Genet. 2011, 43:897-901.
    • (2011) Nat. Genet. , vol.43 , pp. 897-901
    • Chu, X.1    Pan, C.M.2    Zhao, S.X.3    Liang, J.4    Gao, G.Q.5    Zhang, X.M.6
  • 14
    • 78649740926 scopus 로고    scopus 로고
    • Thyroid stimulating hormone receptor (TSHR) intron 1 variants are major risk factors for Graves' disease in three European Caucasian cohorts
    • Ploski R., Brand O.J., Jurecka-Lubieniecka B., Franaszczyk M., Kula D., Krajewski P., et al. Thyroid stimulating hormone receptor (TSHR) intron 1 variants are major risk factors for Graves' disease in three European Caucasian cohorts. PLoS One 2010, 5:e15512.
    • (2010) PLoS One , vol.5 , pp. e15512
    • Ploski, R.1    Brand, O.J.2    Jurecka-Lubieniecka, B.3    Franaszczyk, M.4    Kula, D.5    Krajewski, P.6
  • 16
    • 84906706946 scopus 로고    scopus 로고
    • Genetic-epigenetic dysregulation of thymic TSH receptor gene expression triggers thyroid autoimmunity
    • Stefan M., Wei C., Lombardi A., Li C.W., Concepcion E.S., Inabnet W.B., et al. Genetic-epigenetic dysregulation of thymic TSH receptor gene expression triggers thyroid autoimmunity. Proc. Natl. Acad. Sci. U. S. A. 2014, 111:12562-12567.
    • (2014) Proc. Natl. Acad. Sci. U. S. A. , vol.111 , pp. 12562-12567
    • Stefan, M.1    Wei, C.2    Lombardi, A.3    Li, C.W.4    Concepcion, E.S.5    Inabnet, W.B.6
  • 17
    • 80051705017 scopus 로고    scopus 로고
    • Association of an SNP with intrathymic transcription of TSHR and Graves' disease: a role for defective thymic tolerance
    • Colobran R., Armengol Mdel P., Faner R., Gartner M., Tykocinski L.O., Lucas A., et al. Association of an SNP with intrathymic transcription of TSHR and Graves' disease: a role for defective thymic tolerance. Hum. Mol. Genet. 2011, 20:3415-3423.
    • (2011) Hum. Mol. Genet. , vol.20 , pp. 3415-3423
    • Colobran, R.1    Armengol Mdel, P.2    Faner, R.3    Gartner, M.4    Tykocinski, L.O.5    Lucas, A.6
  • 19
    • 17344379513 scopus 로고    scopus 로고
    • Five years on the wings of fork head
    • Kaufmann E., Knochel W. Five years on the wings of fork head. Mech. Dev. 1996, 57:3-20.
    • (1996) Mech. Dev. , vol.57 , pp. 3-20
    • Kaufmann, E.1    Knochel, W.2
  • 20
    • 0035162560 scopus 로고    scopus 로고
    • Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
    • Brunkow M.E., Jeffery E.W., Hjerrild K.A., Paeper B., Clark L.B., Yasayko S.A., et al. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat. Genet. 2001, 27:68-73.
    • (2001) Nat. Genet. , vol.27 , pp. 68-73
    • Brunkow, M.E.1    Jeffery, E.W.2    Hjerrild, K.A.3    Paeper, B.4    Clark, L.B.5    Yasayko, S.A.6
  • 21
    • 0035813231 scopus 로고    scopus 로고
    • Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation
    • Schubert L.A., Jeffery E., Zhang Y., Ramsdell F., Ziegler S.F. Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation. J. Biol. Chem. 2001, 276:37672-37679.
    • (2001) J. Biol. Chem. , vol.276 , pp. 37672-37679
    • Schubert, L.A.1    Jeffery, E.2    Zhang, Y.3    Ramsdell, F.4    Ziegler, S.F.5
  • 22
    • 33746228122 scopus 로고    scopus 로고
    • FOXP3 controls regulatory T cell function through cooperation with NFAT
    • Wu Y., Borde M., Heissmeyer V., Feuerer M., Lapan A.D., Stroud J.C., et al. FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell 2006, 126:375-387.
    • (2006) Cell , vol.126 , pp. 375-387
    • Wu, Y.1    Borde, M.2    Heissmeyer, V.3    Feuerer, M.4    Lapan, A.D.5    Stroud, J.C.6
  • 24
    • 33847220736 scopus 로고    scopus 로고
    • Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells
    • Zheng Y., Josefowicz S.Z., Kas A., Chu T.T., Gavin M.A., Rudensky A.Y. Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells. Nature 2007, 445:936-940.
    • (2007) Nature , vol.445 , pp. 936-940
    • Zheng, Y.1    Josefowicz, S.Z.2    Kas, A.3    Chu, T.T.4    Gavin, M.A.5    Rudensky, A.Y.6
  • 25
    • 34247215187 scopus 로고    scopus 로고
    • Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
    • Ono M., Yaguchi H., Ohkura N., Kitabayashi I., Nagamura Y., Nomura T., et al. Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1. Nature 2007, 446:685-689.
    • (2007) Nature , vol.446 , pp. 685-689
    • Ono, M.1    Yaguchi, H.2    Ohkura, N.3    Kitabayashi, I.4    Nagamura, Y.5    Nomura, T.6
  • 26
    • 84868087600 scopus 로고    scopus 로고
    • Forkhead transcription factor FOXP3 upregulates CD25 expression through cooperation with RelA/NF-kappaB
    • Camperio C., Caristi S., Fanelli G., Soligo M., Del Porto P., Piccolella E. Forkhead transcription factor FOXP3 upregulates CD25 expression through cooperation with RelA/NF-kappaB. PLoS One 2012, 7:e48303.
    • (2012) PLoS One , vol.7 , pp. e48303
    • Camperio, C.1    Caristi, S.2    Fanelli, G.3    Soligo, M.4    Del Porto, P.5    Piccolella, E.6
  • 27
    • 0035554676 scopus 로고    scopus 로고
    • Regulatory T cells in the control of immune pathology
    • Maloy K.J., Powrie F. Regulatory T cells in the control of immune pathology. Nat. Immunol. 2001, 2:816-822.
    • (2001) Nat. Immunol. , vol.2 , pp. 816-822
    • Maloy, K.J.1    Powrie, F.2
  • 28
    • 0035180065 scopus 로고    scopus 로고
    • Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance
    • Sakaguchi S., Sakaguchi N., Shimizu J., Yamazaki S., Sakihama T., Itoh M., et al. Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance. Immunol. Rev. 2001, 182:18-32.
    • (2001) Immunol. Rev. , vol.182 , pp. 18-32
    • Sakaguchi, S.1    Sakaguchi, N.2    Shimizu, J.3    Yamazaki, S.4    Sakihama, T.5    Itoh, M.6
  • 29
    • 0034526617 scopus 로고    scopus 로고
    • JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome
    • Chatila T.A., Blaeser F., Ho N., Lederman H.M., Voulgaropoulos C., Helms C., et al. JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome. J. Clin. Invest. 2000, 106:R75-R81.
    • (2000) J. Clin. Invest. , vol.106 , pp. R75-R81
    • Chatila, T.A.1    Blaeser, F.2    Ho, N.3    Lederman, H.M.4    Voulgaropoulos, C.5    Helms, C.6
  • 30
    • 0035167967 scopus 로고    scopus 로고
    • The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3
    • Bennett C.L., Christie J., Ramsdell F., Brunkow M.E., Ferguson P.J., Whitesell L., et al. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat. Genet. 2001, 27:20-21.
    • (2001) Nat. Genet. , vol.27 , pp. 20-21
    • Bennett, C.L.1    Christie, J.2    Ramsdell, F.3    Brunkow, M.E.4    Ferguson, P.J.5    Whitesell, L.6
  • 31
    • 0035163909 scopus 로고    scopus 로고
    • X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy
    • Wildin R.S., Ramsdell F., Peake J., Faravelli F., Casanova J.L., Buist N., et al. X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy. Nat. Genet. 2001, 27:18-20.
    • (2001) Nat. Genet. , vol.27 , pp. 18-20
    • Wildin, R.S.1    Ramsdell, F.2    Peake, J.3    Faravelli, F.4    Casanova, J.L.5    Buist, N.6
  • 32
    • 28444434811 scopus 로고    scopus 로고
    • IPEX and FOXP3: clinical and research perspectives
    • Wildin R.S., Freitas A. IPEX and FOXP3: clinical and research perspectives. J. Autoimmun. 2005, (25 Suppl.):56-62.
    • (2005) J. Autoimmun. , Issue.25 , pp. 56-62
    • Wildin, R.S.1    Freitas, A.2
  • 33
    • 84875936395 scopus 로고    scopus 로고
    • FOXP3: genetic and epigenetic implications for autoimmunity
    • Katoh H., Zheng P., Liu Y. FOXP3: genetic and epigenetic implications for autoimmunity. J. Autoimmun. 2013, 41:72-78.
    • (2013) J. Autoimmun. , vol.41 , pp. 72-78
    • Katoh, H.1    Zheng, P.2    Liu, Y.3
  • 34
    • 34249309946 scopus 로고    scopus 로고
    • The regulatory T cell gene FOXP3 and genetic susceptibility to thyroid autoimmunity: an association analysis in Caucasian and Japanese cohorts
    • Ban Y., Tozaki T., Tobe T., Ban Y., Jacobson E.M., Concepcion E.S., et al. The regulatory T cell gene FOXP3 and genetic susceptibility to thyroid autoimmunity: an association analysis in Caucasian and Japanese cohorts. J. Autoimmun. 2007, 28:201-207.
    • (2007) J. Autoimmun. , vol.28 , pp. 201-207
    • Ban, Y.1    Tozaki, T.2    Tobe, T.3    Ban, Y.4    Jacobson, E.M.5    Concepcion, E.S.6
  • 35
    • 79952471752 scopus 로고    scopus 로고
    • Association of functional polymorphisms related to the transcriptional level of FOXP3 with prognosis of autoimmune thyroid diseases
    • Inoue N., Watanabe M., Morita M., Tomizawa R., Akamizu T., Tatsumi K., et al. Association of functional polymorphisms related to the transcriptional level of FOXP3 with prognosis of autoimmune thyroid diseases. Clin. Exp. Immunol. 2010, 162:402-406.
    • (2010) Clin. Exp. Immunol. , vol.162 , pp. 402-406
    • Inoue, N.1    Watanabe, M.2    Morita, M.3    Tomizawa, R.4    Akamizu, T.5    Tatsumi, K.6
  • 36
    • 59649092679 scopus 로고    scopus 로고
    • Autoimmune thyroiditis and diabetes: dissecting the joint genetic susceptibility in a large cohort of multiplex families
    • Villano M.J., Huber A.K., Greenberg D.A., Golden B.K., Concepcion E., Tomer Y. Autoimmune thyroiditis and diabetes: dissecting the joint genetic susceptibility in a large cohort of multiplex families. J. Clin. Endocrinol. Metab. 2009, 94:1458-1466.
    • (2009) J. Clin. Endocrinol. Metab. , vol.94 , pp. 1458-1466
    • Villano, M.J.1    Huber, A.K.2    Greenberg, D.A.3    Golden, B.K.4    Concepcion, E.5    Tomer, Y.6
  • 38
    • 0034647916 scopus 로고    scopus 로고
    • Splicing factors induce cystic fibrosis transmembrane regulator exon 9 skipping through a nonevolutionary conserved intronic element
    • Pagani F., Buratti E., Stuani C., Romano M., Zuccato E., Niksic M., et al. Splicing factors induce cystic fibrosis transmembrane regulator exon 9 skipping through a nonevolutionary conserved intronic element. J. Biol. Chem. 2000, 275:21041-21047.
    • (2000) J. Biol. Chem. , vol.275 , pp. 21041-21047
    • Pagani, F.1    Buratti, E.2    Stuani, C.3    Romano, M.4    Zuccato, E.5    Niksic, M.6
  • 39
    • 0035058812 scopus 로고    scopus 로고
    • 2+ exchanger intron 2 activates splicing
    • 2+ exchanger intron 2 activates splicing. Eur. J. Biochem. FEBS 2001, 268:1076-1083.
    • (2001) Eur. J. Biochem. FEBS , vol.268 , pp. 1076-1083
    • Gabellini, N.1
  • 40
    • 84919835108 scopus 로고    scopus 로고
    • Dissecting the role of the FOXP3 gene in the joint genetic susceptibility to autoimmune thyroiditis and diabetes: a genetic and functional analysis
    • Li C.W., Concepcion E., Tomer Y. Dissecting the role of the FOXP3 gene in the joint genetic susceptibility to autoimmune thyroiditis and diabetes: a genetic and functional analysis. Gene 2015, 556:142-148.
    • (2015) Gene , vol.556 , pp. 142-148
    • Li, C.W.1    Concepcion, E.2    Tomer, Y.3
  • 41
    • 84893466383 scopus 로고    scopus 로고
    • Multiple autoimmune-associated variants confer decreased IL-2R signaling in CD4+ CD25(hi) T cells of type 1 diabetic and multiple sclerosis patients
    • Cerosaletti K., Schneider A., Schwedhelm K., Frank I., Tatum M., Wei S., et al. Multiple autoimmune-associated variants confer decreased IL-2R signaling in CD4+ CD25(hi) T cells of type 1 diabetic and multiple sclerosis patients. PLoS One 2013, 8:e83811.
    • (2013) PLoS One , vol.8 , pp. e83811
    • Cerosaletti, K.1    Schneider, A.2    Schwedhelm, K.3    Frank, I.4    Tatum, M.5    Wei, S.6
  • 42
    • 15544384475 scopus 로고    scopus 로고
    • Essential role for interleukin-2 for CD4(+)CD25(+) T regulatory cell development during the neonatal period
    • Bayer A.L., Yu A., Adeegbe D., Malek T.R. Essential role for interleukin-2 for CD4(+)CD25(+) T regulatory cell development during the neonatal period. J. Exp. Med. 2005, 201:769-777.
    • (2005) J. Exp. Med. , vol.201 , pp. 769-777
    • Bayer, A.L.1    Yu, A.2    Adeegbe, D.3    Malek, T.R.4
  • 43
    • 33947274768 scopus 로고    scopus 로고
    • Association of the interleukin-2 receptor alpha (IL-2Ralpha)/CD25 gene region with Graves' disease using a multilocus test and tag SNPs
    • Brand O.J., Lowe C.E., Heward J.M., Franklyn J.A., Cooper J.D., Todd J.A., et al. Association of the interleukin-2 receptor alpha (IL-2Ralpha)/CD25 gene region with Graves' disease using a multilocus test and tag SNPs. Clin. Endocrinol. 2007, 66:508-512.
    • (2007) Clin. Endocrinol. , vol.66 , pp. 508-512
    • Brand, O.J.1    Lowe, C.E.2    Heward, J.M.3    Franklyn, J.A.4    Cooper, J.D.5    Todd, J.A.6
  • 45
    • 80053494417 scopus 로고    scopus 로고
    • A variant of the Il2ra/Cd25 gene predisposing to graves' disease is associated with increased levels of soluble interleukin-2 receptor
    • Chistiakov D.A., Chistiakova E.I., Voronova N.V., Turakulov R.I., Savost'anov K.V. A variant of the Il2ra/Cd25 gene predisposing to graves' disease is associated with increased levels of soluble interleukin-2 receptor. Scand. J. Immunol. 2011, 74:496-501.
    • (2011) Scand. J. Immunol. , vol.74 , pp. 496-501
    • Chistiakov, D.A.1    Chistiakova, E.I.2    Voronova, N.V.3    Turakulov, R.I.4    Savost'anov, K.V.5
  • 46
    • 0029851224 scopus 로고    scopus 로고
    • Costimulatory B7 molecules in the pathogenesis of infectious and autoimmune diseases
    • Reiser H., Stadecker M.J. Costimulatory B7 molecules in the pathogenesis of infectious and autoimmune diseases. N. Engl. J. Med. 1996, 335:1369-1377.
    • (1996) N. Engl. J. Med. , vol.335 , pp. 1369-1377
    • Reiser, H.1    Stadecker, M.J.2
  • 48
    • 70349085260 scopus 로고    scopus 로고
    • Functional roles for T cell CD40 in infection and autoimmune disease: the role of CD40 in lymphocyte homeostasis
    • Munroe M.E. Functional roles for T cell CD40 in infection and autoimmune disease: the role of CD40 in lymphocyte homeostasis. Semin. Immunol. 2009, 21:283-288.
    • (2009) Semin. Immunol. , vol.21 , pp. 283-288
    • Munroe, M.E.1
  • 50
    • 12344336336 scopus 로고    scopus 로고
    • The role of CD40-CD154 interactions in autoimmunity and the benefit of disrupting this pathway
    • Toubi E., Shoenfeld Y. The role of CD40-CD154 interactions in autoimmunity and the benefit of disrupting this pathway. Autoimmunity 2004, 37:457-464.
    • (2004) Autoimmunity , vol.37 , pp. 457-464
    • Toubi, E.1    Shoenfeld, Y.2
  • 51
    • 0038658816 scopus 로고    scopus 로고
    • The CD40-CD154 interaction in B cell-T cell liaisons
    • Bishop G.A., Hostager B.S. The CD40-CD154 interaction in B cell-T cell liaisons. Cytokine Growth Factor Rev. 2003, 14:297-309.
    • (2003) Cytokine Growth Factor Rev. , vol.14 , pp. 297-309
    • Bishop, G.A.1    Hostager, B.S.2
  • 52
    • 70349093062 scopus 로고    scopus 로고
    • The many faces of CD40: multiple roles in normal immunity and disease
    • Bishop G.A. The many faces of CD40: multiple roles in normal immunity and disease. Semin. Immunol. 2009, 21:255-256.
    • (2009) Semin. Immunol. , vol.21 , pp. 255-256
    • Bishop, G.A.1
  • 53
    • 0031040964 scopus 로고    scopus 로고
    • Suppression of murine thyroiditis via blockade of the CD40-CD40L interaction
    • Carayanniotis G., Masters S.R., Noelle R.J. Suppression of murine thyroiditis via blockade of the CD40-CD40L interaction. Immunology 1997, 90:421-426.
    • (1997) Immunology , vol.90 , pp. 421-426
    • Carayanniotis, G.1    Masters, S.R.2    Noelle, R.J.3
  • 54
    • 0029876593 scopus 로고    scopus 로고
    • CD40-mediated signaling in B cells. Balancing cell survival, growth, and death
    • Kehry M.R. CD40-mediated signaling in B cells. Balancing cell survival, growth, and death. J. Immunol. 1996, 156:2345-2348.
    • (1996) J. Immunol. , vol.156 , pp. 2345-2348
    • Kehry, M.R.1
  • 55
    • 0036959340 scopus 로고    scopus 로고
    • A C/T single-nucleotide polymorphism in the region of the CD40 gene is associated with Graves' disease
    • Tomer Y., Concepcion E., Greenberg D.A. A C/T single-nucleotide polymorphism in the region of the CD40 gene is associated with Graves' disease. Thyroid Off. J. Am. Thyroid Assoc. 2002, 12:1129-1135.
    • (2002) Thyroid Off. J. Am. Thyroid Assoc. , vol.12 , pp. 1129-1135
    • Tomer, Y.1    Concepcion, E.2    Greenberg, D.A.3
  • 57
    • 33745203966 scopus 로고    scopus 로고
    • Association of a C/T single-nucleotide polymorphism in the 5' untranslated region of the CD40 gene with Graves' disease in Japanese
    • Ban Y., Tozaki T., Taniyama M., Tomita M., Ban Y. Association of a C/T single-nucleotide polymorphism in the 5' untranslated region of the CD40 gene with Graves' disease in Japanese. Thyroid Off. J. Am. Thyroid Assoc. 2006, 16:443-446.
    • (2006) Thyroid Off. J. Am. Thyroid Assoc. , vol.16 , pp. 443-446
    • Ban, Y.1    Tozaki, T.2    Taniyama, M.3    Tomita, M.4    Ban, Y.5
  • 58
    • 0242331183 scopus 로고    scopus 로고
    • A C/T polymorphism in the 5'-untranslated region of the CD40 gene is associated with Graves' disease in Koreans
    • Kim T.Y., Park Y.J., Hwang J.K., Song J.Y., Park K.S., Cho B.Y., et al. A C/T polymorphism in the 5'-untranslated region of the CD40 gene is associated with Graves' disease in Koreans. Thyroid Off. J. Am. Thyroid Assoc. 2003, 13:919-925.
    • (2003) Thyroid Off. J. Am. Thyroid Assoc. , vol.13 , pp. 919-925
    • Kim, T.Y.1    Park, Y.J.2    Hwang, J.K.3    Song, J.Y.4    Park, K.S.5    Cho, B.Y.6
  • 59
    • 34247610461 scopus 로고    scopus 로고
    • A CD40 Kozak sequence polymorphism and susceptibility to antibody-mediated autoimmune conditions: the role of CD40 tissue-specific expression
    • Jacobson E.M., Huber A.K., Akeno N., Sivak M., Li C.W., Concepcion E., et al. A CD40 Kozak sequence polymorphism and susceptibility to antibody-mediated autoimmune conditions: the role of CD40 tissue-specific expression. Genes Immun. 2007, 8:205-214.
    • (2007) Genes Immun. , vol.8 , pp. 205-214
    • Jacobson, E.M.1    Huber, A.K.2    Akeno, N.3    Sivak, M.4    Li, C.W.5    Concepcion, E.6
  • 60
    • 25644432043 scopus 로고    scopus 로고
    • A C/T polymorphism in the 5' untranslated region of the CD40 gene is associated with later onset of Graves' disease in Japanese
    • Mukai T., Hiromatsu Y., Fukutani T., Ichimura M., Kaku H., Miyake I., et al. A C/T polymorphism in the 5' untranslated region of the CD40 gene is associated with later onset of Graves' disease in Japanese. Endocr. J. 2005, 52:471-477.
    • (2005) Endocr. J. , vol.52 , pp. 471-477
    • Mukai, T.1    Hiromatsu, Y.2    Fukutani, T.3    Ichimura, M.4    Kaku, H.5    Miyake, I.6
  • 62
    • 84866184305 scopus 로고    scopus 로고
    • Genetically driven target tissue overexpression of CD40: a novel mechanism in autoimmune disease
    • Huber A.K., Finkelman F.D., Li C.W., Concepcion E., Smith E., Jacobson E., et al. Genetically driven target tissue overexpression of CD40: a novel mechanism in autoimmune disease. J. Immunol. 2012, 189:3043-3053.
    • (2012) J. Immunol. , vol.189 , pp. 3043-3053
    • Huber, A.K.1    Finkelman, F.D.2    Li, C.W.3    Concepcion, E.4    Smith, E.5    Jacobson, E.6
  • 63
    • 0029746674 scopus 로고    scopus 로고
    • Antibody to gp39, the ligand for CD40 significantly inhibits the humoral response from Graves' thyroid tissues xenografted into severe combined immunodeficient (SCID) mice
    • Resetkova E., Kawai K., Enomoto T., Arreaza G., Togun R., Foy T.M., et al. Antibody to gp39, the ligand for CD40 significantly inhibits the humoral response from Graves' thyroid tissues xenografted into severe combined immunodeficient (SCID) mice. Thyroid Off. J. Am. Thyroid Assoc. 1996, 6:267-273.
    • (1996) Thyroid Off. J. Am. Thyroid Assoc. , vol.6 , pp. 267-273
    • Resetkova, E.1    Kawai, K.2    Enomoto, T.3    Arreaza, G.4    Togun, R.5    Foy, T.M.6
  • 64
    • 18844421908 scopus 로고    scopus 로고
    • A Graves' disease-associated Kozak sequence single-nucleotide polymorphism enhances the efficiency of CD40 gene translation: a case for translational pathophysiology
    • Jacobson E.M., Concepcion E., Oashi T., Tomer Y. A Graves' disease-associated Kozak sequence single-nucleotide polymorphism enhances the efficiency of CD40 gene translation: a case for translational pathophysiology. Endocrinology 2005, 146:2684-2691.
    • (2005) Endocrinology , vol.146 , pp. 2684-2691
    • Jacobson, E.M.1    Concepcion, E.2    Oashi, T.3    Tomer, Y.4
  • 65
    • 84902592681 scopus 로고    scopus 로고
    • Genotype and phenotype predictors of relapse of graves' disease after antithyroid drug withdrawal
    • Wang P.W., Chen I.Y., Juo S.H., Hsi E., Liu R.T., Hsieh C.J. Genotype and phenotype predictors of relapse of graves' disease after antithyroid drug withdrawal. Eur. Thyroid J. 2013, 1:251-258.
    • (2013) Eur. Thyroid J. , vol.1 , pp. 251-258
    • Wang, P.W.1    Chen, I.Y.2    Juo, S.H.3    Hsi, E.4    Liu, R.T.5    Hsieh, C.J.6
  • 66
    • 0029862164 scopus 로고    scopus 로고
    • Increased expression of CD40 ligand on systemic lupus erythematosus lymphocytes
    • Koshy M., Berger D., Crow M.K. Increased expression of CD40 ligand on systemic lupus erythematosus lymphocytes. J. Clin. Invest. 1996, 98:826-837.
    • (1996) J. Clin. Invest. , vol.98 , pp. 826-837
    • Koshy, M.1    Berger, D.2    Crow, M.K.3
  • 67
    • 0345700237 scopus 로고    scopus 로고
    • Monocyte-derived IL12, CD86 (B7-2) and CD40L expression in relapsing and progressive multiple sclerosis
    • Filion L.G., Matusevicius D., Graziani-Bowering G.M., Kumar A., Freedman M.S. Monocyte-derived IL12, CD86 (B7-2) and CD40L expression in relapsing and progressive multiple sclerosis. Clin. Immunol. 2003, 106:127-138.
    • (2003) Clin. Immunol. , vol.106 , pp. 127-138
    • Filion, L.G.1    Matusevicius, D.2    Graziani-Bowering, G.M.3    Kumar, A.4    Freedman, M.S.5
  • 68
    • 0141534421 scopus 로고    scopus 로고
    • Activated platelets are the source of elevated levels of soluble CD40 ligand in the circulation of inflammatory bowel disease patients
    • Danese S., Katz J.A., Saibeni S., Papa A., Gasbarrini A., Vecchi M., et al. Activated platelets are the source of elevated levels of soluble CD40 ligand in the circulation of inflammatory bowel disease patients. Gut 2003, 52:1435-1441.
    • (2003) Gut , vol.52 , pp. 1435-1441
    • Danese, S.1    Katz, J.A.2    Saibeni, S.3    Papa, A.4    Gasbarrini, A.5    Vecchi, M.6
  • 70
    • 49249089425 scopus 로고    scopus 로고
    • Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways
    • Fife B.T., Bluestone J.A. Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways. Immunol. Rev. 2008, 224:166-182.
    • (2008) Immunol. Rev. , vol.224 , pp. 166-182
    • Fife, B.T.1    Bluestone, J.A.2
  • 73
    • 0028483990 scopus 로고
    • Treatment of murine lupus with CTLA4Ig
    • Finck B.K., Linsley P.S., Wofsy D. Treatment of murine lupus with CTLA4Ig. Science 1994, 265:1225-1227.
    • (1994) Science , vol.265 , pp. 1225-1227
    • Finck, B.K.1    Linsley, P.S.2    Wofsy, D.3
  • 74
  • 75
    • 0029162499 scopus 로고
    • Collagen-induced arthritis in the BB rat. Prevention of disease by treatment with CTLA-4-Ig
    • Knoerzer D.B., Karr R.W., Schwartz B.D., Mengle-Gaw L.J. Collagen-induced arthritis in the BB rat. Prevention of disease by treatment with CTLA-4-Ig. J. Clin. Invest. 1995, 96:987-993.
    • (1995) J. Clin. Invest. , vol.96 , pp. 987-993
    • Knoerzer, D.B.1    Karr, R.W.2    Schwartz, B.D.3    Mengle-Gaw, L.J.4
  • 76
    • 16044371193 scopus 로고    scopus 로고
    • CD28/B7 regulation of Th1 and Th2 subsets in the development of autoimmune diabetes
    • Lenschow D.J., Herold K.C., Rhee L., Patel B., Koons A., Qin H.Y., et al. CD28/B7 regulation of Th1 and Th2 subsets in the development of autoimmune diabetes. Immunity 1996, 5:285-293.
    • (1996) Immunity , vol.5 , pp. 285-293
    • Lenschow, D.J.1    Herold, K.C.2    Rhee, L.3    Patel, B.4    Koons, A.5    Qin, H.Y.6
  • 77
    • 0031014716 scopus 로고    scopus 로고
    • CTLA4 alanine-17 confers genetic susceptibility to Graves' disease and to type 1 diabetes mellitus
    • Donner H., Rau H., Walfish P.G., Braun J., Siegmund T., Finke R., et al. CTLA4 alanine-17 confers genetic susceptibility to Graves' disease and to type 1 diabetes mellitus. J. Clin. Endocrinol. Metab. 1997, 82:143-146.
    • (1997) J. Clin. Endocrinol. Metab. , vol.82 , pp. 143-146
    • Donner, H.1    Rau, H.2    Walfish, P.G.3    Braun, J.4    Siegmund, T.5    Finke, R.6
  • 79
  • 82
    • 67349199596 scopus 로고    scopus 로고
    • The etiology of autoimmune thyroid disease: a story of genes and environment
    • Tomer Y., Huber A. The etiology of autoimmune thyroid disease: a story of genes and environment. J. Autoimmun. 2009, 32:231-239.
    • (2009) J. Autoimmun. , vol.32 , pp. 231-239
    • Tomer, Y.1    Huber, A.2
  • 84
    • 0030816688 scopus 로고    scopus 로고
    • A CTLA-4 gene polymorphism is associated with both Graves disease and autoimmune hypothyroidism
    • Kotsa K., Watson P.F., Weetman A.P. A CTLA-4 gene polymorphism is associated with both Graves disease and autoimmune hypothyroidism. Clin. Endocrinol. 1997, 46:551-554.
    • (1997) Clin. Endocrinol. , vol.46 , pp. 551-554
    • Kotsa, K.1    Watson, P.F.2    Weetman, A.P.3
  • 85
    • 2242465734 scopus 로고    scopus 로고
    • A common autoimmunity predisposing signal peptide variant of the cytotoxic T-lymphocyte antigen 4 results in inefficient glycosylation of the susceptibility allele
    • Anjos S., Nguyen A., Ounissi-Benkalha H., Tessier M.C., Polychronakos C. A common autoimmunity predisposing signal peptide variant of the cytotoxic T-lymphocyte antigen 4 results in inefficient glycosylation of the susceptibility allele. J. Biol. Chem. 2002, 277:46478-46486.
    • (2002) J. Biol. Chem. , vol.277 , pp. 46478-46486
    • Anjos, S.1    Nguyen, A.2    Ounissi-Benkalha, H.3    Tessier, M.C.4    Polychronakos, C.5
  • 86
    • 0037648405 scopus 로고    scopus 로고
    • Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease
    • Ueda H., Howson J.M., Esposito L., Heward J., Snook H., Chamberlain G., et al. Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature 2003, 423:506-511.
    • (2003) Nature , vol.423 , pp. 506-511
    • Ueda, H.1    Howson, J.M.2    Esposito, L.3    Heward, J.4    Snook, H.5    Chamberlain, G.6
  • 87
    • 38049068750 scopus 로고    scopus 로고
    • The HLA gene complex in thyroid autoimmunity: from epidemiology to etiology
    • Jacobson E.M., Huber A., Tomer Y. The HLA gene complex in thyroid autoimmunity: from epidemiology to etiology. J. Autoimmun. 2008, 30:58-62.
    • (2008) J. Autoimmun. , vol.30 , pp. 58-62
    • Jacobson, E.M.1    Huber, A.2    Tomer, Y.3
  • 88
    • 3242784051 scopus 로고    scopus 로고
    • Arginine at position 74 of the HLA-DR beta1 chain is associated with Graves' disease
    • Ban Y., Davies T.F., Greenberg D.A., Concepcion E.S., Osman R., Oashi T., et al. Arginine at position 74 of the HLA-DR beta1 chain is associated with Graves' disease. Genes Immun. 2004, 5:203-208.
    • (2004) Genes Immun. , vol.5 , pp. 203-208
    • Ban, Y.1    Davies, T.F.2    Greenberg, D.A.3    Concepcion, E.S.4    Osman, R.5    Oashi, T.6
  • 89
    • 52949091162 scopus 로고    scopus 로고
    • Molecular amino acid signatures in the MHC class II peptide-binding pocket predispose to autoimmune thyroiditis in humans and in mice
    • Menconi F., Monti M.C., Greenberg D.A., Oashi T., Osman R., Davies T.F., et al. Molecular amino acid signatures in the MHC class II peptide-binding pocket predispose to autoimmune thyroiditis in humans and in mice. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:14034-14039.
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105 , pp. 14034-14039
    • Menconi, F.1    Monti, M.C.2    Greenberg, D.A.3    Oashi, T.4    Osman, R.5    Davies, T.F.6
  • 91
    • 47949094690 scopus 로고    scopus 로고
    • Thyroglobulin peptides associate in vivo to HLA-DR in autoimmune thyroid glands
    • Muixi L., Carrascal M., Alvarez I., Daura X., Marti M., Armengol M.P., et al. Thyroglobulin peptides associate in vivo to HLA-DR in autoimmune thyroid glands. J. Immunol. 2008, 181:795-807.
    • (2008) J. Immunol. , vol.181 , pp. 795-807
    • Muixi, L.1    Carrascal, M.2    Alvarez, I.3    Daura, X.4    Marti, M.5    Armengol, M.P.6
  • 92
    • 0035875097 scopus 로고    scopus 로고
    • Identification of susceptibility loci for autoimmune thyroid disease to 5q31-q33 and Hashimoto's thyroiditis to 8q23-q24 by multipoint affected sib-pair linkage analysis in Japanese
    • Sakai K., Shirasawa S., Ishikawa N., Ito K., Tamai H., Kuma K., et al. Identification of susceptibility loci for autoimmune thyroid disease to 5q31-q33 and Hashimoto's thyroiditis to 8q23-q24 by multipoint affected sib-pair linkage analysis in Japanese. Hum. Mol. Genet. 2001, 10:1379-1386.
    • (2001) Hum. Mol. Genet. , vol.10 , pp. 1379-1386
    • Sakai, K.1    Shirasawa, S.2    Ishikawa, N.3    Ito, K.4    Tamai, H.5    Kuma, K.6
  • 93
    • 0142059659 scopus 로고    scopus 로고
    • Common and unique susceptibility loci in Graves and Hashimoto diseases: results of whole-genome screening in a data set of 102 multiplex families
    • Tomer Y., Ban Y., Concepcion E., Barbesino G., Villanueva R., Greenberg D.A., et al. Common and unique susceptibility loci in Graves and Hashimoto diseases: results of whole-genome screening in a data set of 102 multiplex families. Am. J. Hum. Genet. 2003, 73:736-747.
    • (2003) Am. J. Hum. Genet. , vol.73 , pp. 736-747
    • Tomer, Y.1    Ban, Y.2    Concepcion, E.3    Barbesino, G.4    Villanueva, R.5    Greenberg, D.A.6
  • 94
    • 0344303638 scopus 로고    scopus 로고
    • Amino acid substitutions in the thyroglobulin gene are associated with susceptibility to human and murine autoimmune thyroid disease
    • Ban Y., Greenberg D.A., Concepcion E., Skrabanek L., Villanueva R., Tomer Y. Amino acid substitutions in the thyroglobulin gene are associated with susceptibility to human and murine autoimmune thyroid disease. Proc. Natl. Acad. Sci. U. S. A. 2003, 100:15119-15124.
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 15119-15124
    • Ban, Y.1    Greenberg, D.A.2    Concepcion, E.3    Skrabanek, L.4    Villanueva, R.5    Tomer, Y.6
  • 96
    • 71749105341 scopus 로고    scopus 로고
    • Employing a recombinant HLA-DR3 expression system to dissect major histocompatibility complex II-thyroglobulin peptide dynamism: a genetic, biochemical, and reverse immunological perspective
    • Jacobson E.M., Yang H., Menconi F., Wang R., Osman R., Skrabanek L., et al. Employing a recombinant HLA-DR3 expression system to dissect major histocompatibility complex II-thyroglobulin peptide dynamism: a genetic, biochemical, and reverse immunological perspective. J. Biol. Chem. 2009, 284:34231-34243.
    • (2009) J. Biol. Chem. , vol.284 , pp. 34231-34243
    • Jacobson, E.M.1    Yang, H.2    Menconi, F.3    Wang, R.4    Osman, R.5    Skrabanek, L.6
  • 97
    • 84899582113 scopus 로고    scopus 로고
    • Identification of BACH2 as a susceptibility gene for Graves' disease in the Chinese Han population based on a three-stage genome-wide association study
    • Liu W., Wang H.N., Gu Z.H., Yang S.Y., Ye X.P., Pan C.M., et al. Identification of BACH2 as a susceptibility gene for Graves' disease in the Chinese Han population based on a three-stage genome-wide association study. Hum. Genet. 2014, 133:661-671.
    • (2014) Hum. Genet. , vol.133 , pp. 661-671
    • Liu, W.1    Wang, H.N.2    Gu, Z.H.3    Yang, S.Y.4    Ye, X.P.5    Pan, C.M.6
  • 98
    • 0032189224 scopus 로고    scopus 로고
    • Identification of Bach2 as a B-cell-specific partner for small maf proteins that negatively regulate the immunoglobulin heavy chain gene 3' enhancer
    • Muto A., Hoshino H., Madisen L., Yanai N., Obinata M., Karasuyama H., et al. Identification of Bach2 as a B-cell-specific partner for small maf proteins that negatively regulate the immunoglobulin heavy chain gene 3' enhancer. EMBO J. 1998, 17:5734-5743.
    • (1998) EMBO J. , vol.17 , pp. 5734-5743
    • Muto, A.1    Hoshino, H.2    Madisen, L.3    Yanai, N.4    Obinata, M.5    Karasuyama, H.6
  • 99
    • 36549033689 scopus 로고    scopus 로고
    • The role of Bach2 in nucleic acid-triggered antiviral innate immune responses
    • Hong S.W., Kim S., Lee D.K. The role of Bach2 in nucleic acid-triggered antiviral innate immune responses. Biochem. Biophys. Res. Commun. 2008, 365:426-432.
    • (2008) Biochem. Biophys. Res. Commun. , vol.365 , pp. 426-432
    • Hong, S.W.1    Kim, S.2    Lee, D.K.3
  • 100
    • 84881260633 scopus 로고    scopus 로고
    • Robust evidence for five new Graves' disease risk loci from a staged genome-wide association analysis
    • Zhao S.X., Xue L.Q., Liu W., Gu Z.H., Pan C.M., Yang S.Y., et al. Robust evidence for five new Graves' disease risk loci from a staged genome-wide association analysis. Hum. Mol. Genet. 2013, 22:3347-3362.
    • (2013) Hum. Mol. Genet. , vol.22 , pp. 3347-3362
    • Zhao, S.X.1    Xue, L.Q.2    Liu, W.3    Gu, Z.H.4    Pan, C.M.5    Yang, S.Y.6
  • 101
    • 84897386968 scopus 로고    scopus 로고
    • Signaling lymphocytic activation molecule (SLAM)/SLAM-associated protein pathway regulates human B-cell tolerance
    • Menard L., Cantaert T., Chamberlain N., Tangye S.G., Riminton S., Church J.A., et al. Signaling lymphocytic activation molecule (SLAM)/SLAM-associated protein pathway regulates human B-cell tolerance. J. allergy Clin. Immunol. 2014, 133:1149-1161.
    • (2014) J. allergy Clin. Immunol. , vol.133 , pp. 1149-1161
    • Menard, L.1    Cantaert, T.2    Chamberlain, N.3    Tangye, S.G.4    Riminton, S.5    Church, J.A.6
  • 102
    • 84924858509 scopus 로고    scopus 로고
    • RNASET2 tag SNP but not CCR6 polymorphisms is associated with autoimmune thyroid diseases in the Chinese Han population
    • Chen X.J., Gong X.H., Yan N., Meng S., Qin Q., Jiang Y.F., et al. RNASET2 tag SNP but not CCR6 polymorphisms is associated with autoimmune thyroid diseases in the Chinese Han population. BMC Med. Genet. 2015, 16:11.
    • (2015) BMC Med. Genet. , vol.16 , pp. 11
    • Chen, X.J.1    Gong, X.H.2    Yan, N.3    Meng, S.4    Qin, Q.5    Jiang, Y.F.6
  • 103
    • 84859590499 scopus 로고    scopus 로고
    • The replication of the association of the rs6832151 within chromosomal band 4p14 with Graves' disease in a Polish Caucasian population
    • Szymanski K., Bednarczuk T., Krajewski P., Ploski R. The replication of the association of the rs6832151 within chromosomal band 4p14 with Graves' disease in a Polish Caucasian population. Tissue Antigens 2012, 79:380-383.
    • (2012) Tissue Antigens , vol.79 , pp. 380-383
    • Szymanski, K.1    Bednarczuk, T.2    Krajewski, P.3    Ploski, R.4
  • 105
    • 33748796075 scopus 로고    scopus 로고
    • Association of the BTNL2 rs2076530 single nucleotide polymorphism with Graves' disease appears to be secondary to DRB1 exon 2 position beta74
    • Simmonds M.J., Heward J.M., Barrett J.C., Franklyn J.A., Gough S.C. Association of the BTNL2 rs2076530 single nucleotide polymorphism with Graves' disease appears to be secondary to DRB1 exon 2 position beta74. Clin. Endocrinol. 2006, 65:429-432.
    • (2006) Clin. Endocrinol. , vol.65 , pp. 429-432
    • Simmonds, M.J.1    Heward, J.M.2    Barrett, J.C.3    Franklyn, J.A.4    Gough, S.C.5
  • 106
    • 0026699666 scopus 로고
    • Transcriptional activation of the tumor necrosis factor alpha-inducible zinc finger protein, A20, is mediated by kappa B elements
    • Krikos A., Laherty C.D., Dixit V.M. Transcriptional activation of the tumor necrosis factor alpha-inducible zinc finger protein, A20, is mediated by kappa B elements. J. Biol. Chem. 1992, 267:17971-17976.
    • (1992) J. Biol. Chem. , vol.267 , pp. 17971-17976
    • Krikos, A.1    Laherty, C.D.2    Dixit, V.M.3
  • 108
    • 51649083559 scopus 로고    scopus 로고
    • Linkage analysis of thyroid antibody production: evidence for shared susceptibility to clinical autoimmune thyroid disease
    • Ban Y., Greenberg D.A., Davies T.F., Jacobson E., Concepcion E., Tomer Y. Linkage analysis of thyroid antibody production: evidence for shared susceptibility to clinical autoimmune thyroid disease. J. Clin. Endocrinol. Metab. 2008, 93:3589-3596.
    • (2008) J. Clin. Endocrinol. Metab. , vol.93 , pp. 3589-3596
    • Ban, Y.1    Greenberg, D.A.2    Davies, T.F.3    Jacobson, E.4    Concepcion, E.5    Tomer, Y.6
  • 109
    • 84901741541 scopus 로고    scopus 로고
    • Identification of novel genetic Loci associated with thyroid peroxidase antibodies and clinical thyroid disease
    • Medici M., Porcu E., Pistis G., Teumer A., Brown S.J., Jensen R.A., et al. Identification of novel genetic Loci associated with thyroid peroxidase antibodies and clinical thyroid disease. PLoS Genet. 2014, 10:e1004123.
    • (2014) PLoS Genet. , vol.10 , pp. e1004123
    • Medici, M.1    Porcu, E.2    Pistis, G.3    Teumer, A.4    Brown, S.J.5    Jensen, R.A.6
  • 110
    • 84931008634 scopus 로고    scopus 로고
    • Genome wide identification of new genes and pathways in patients with both autoimmune thyroiditis and type 1 diabetes
    • Tomer Y., Dolan L.M., Kahaly G., Divers J., D'Agostino R.B., Imperatore G., et al. Genome wide identification of new genes and pathways in patients with both autoimmune thyroiditis and type 1 diabetes. J. Autoimmun. 2015, 60:32-39.
    • (2015) J. Autoimmun. , vol.60 , pp. 32-39
    • Tomer, Y.1    Dolan, L.M.2    Kahaly, G.3    Divers, J.4    D'Agostino, R.B.5    Imperatore, G.6
  • 111
    • 0041344654 scopus 로고    scopus 로고
    • Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155
    • Jiang Y., Luo L., Gustafson E.L., Yadav D., Laverty M., Murgolo N., et al. Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155. J. Biol. Chem. 2003, 278:27652-27657.
    • (2003) J. Biol. Chem. , vol.278 , pp. 27652-27657
    • Jiang, Y.1    Luo, L.2    Gustafson, E.L.3    Yadav, D.4    Laverty, M.5    Murgolo, N.6
  • 112
    • 84937634779 scopus 로고    scopus 로고
    • Synergistic combined effect between CD40-1C>T and CTLA-4+6230G>A polymorphisms in Graves' disease
    • Chen X., Hu Z., Li W., Wu P., Liu M., Bao L., et al. Synergistic combined effect between CD40-1C>T and CTLA-4+6230G>A polymorphisms in Graves' disease. Gene 2015, 567:154-158.
    • (2015) Gene , vol.567 , pp. 154-158
    • Chen, X.1    Hu, Z.2    Li, W.3    Wu, P.4    Liu, M.5    Bao, L.6
  • 113
    • 84939997049 scopus 로고    scopus 로고
    • Associations of rs4810485 and rs1883832 polymorphisms of CD40 gene with susceptibility and clinical findings of Behcet's disease
    • Inal E.E., Rustemoglu A., Inanir A., Ekinci D., Gul U., Yigit S., et al. Associations of rs4810485 and rs1883832 polymorphisms of CD40 gene with susceptibility and clinical findings of Behcet's disease. Rheumatol. Int. 2015, 35:837-843.
    • (2015) Rheumatol. Int. , vol.35 , pp. 837-843
    • Inal, E.E.1    Rustemoglu, A.2    Inanir, A.3    Ekinci, D.4    Gul, U.5    Yigit, S.6
  • 114
    • 17744373659 scopus 로고    scopus 로고
    • Association analysis of the cytotoxic T lymphocyte antigen-4 (CTLA-4) and autoimmune regulator-1 (AIRE-1) genes in sporadic autoimmune Addison's disease
    • Vaidya B., Imrie H., Geatch D.R., Perros P., Ball S.G., Baylis P.H., et al. Association analysis of the cytotoxic T lymphocyte antigen-4 (CTLA-4) and autoimmune regulator-1 (AIRE-1) genes in sporadic autoimmune Addison's disease. J. Clin. Endocrinol. Metab. 2000, 85:688-691.
    • (2000) J. Clin. Endocrinol. Metab. , vol.85 , pp. 688-691
    • Vaidya, B.1    Imrie, H.2    Geatch, D.R.3    Perros, P.4    Ball, S.G.5    Baylis, P.H.6
  • 115
    • 33746945480 scopus 로고    scopus 로고
    • Influence of CTLA4 haplotypes on susceptibility and some extraglandular manifestations in primary Sjogren's syndrome
    • Downie-Doyle S., Bayat N., Rischmueller M., Lester S. Influence of CTLA4 haplotypes on susceptibility and some extraglandular manifestations in primary Sjogren's syndrome. Arthritis Rheum. 2006, 54:2434-2440.
    • (2006) Arthritis Rheum. , vol.54 , pp. 2434-2440
    • Downie-Doyle, S.1    Bayat, N.2    Rischmueller, M.3    Lester, S.4
  • 116
    • 17144378972 scopus 로고    scopus 로고
    • CTLA-4 polymorphisms and systemic lupus erythematosus (SLE): a meta-analysis
    • Lee Y.H., Harley J.B., Nath S.K. CTLA-4 polymorphisms and systemic lupus erythematosus (SLE): a meta-analysis. Hum. Genet. 2005, 116:361-367.
    • (2005) Hum. Genet. , vol.116 , pp. 361-367
    • Lee, Y.H.1    Harley, J.B.2    Nath, S.K.3
  • 119
    • 0034070032 scopus 로고    scopus 로고
    • CTLA-4 gene polymorphism confers susceptibility to primary biliary cirrhosis
    • Agarwal K., Jones D.E., Daly A.K., James O.F., Vaidya B., Pearce S., et al. CTLA-4 gene polymorphism confers susceptibility to primary biliary cirrhosis. J. Hepatol. 2000, 32:538-541.
    • (2000) J. Hepatol. , vol.32 , pp. 538-541
    • Agarwal, K.1    Jones, D.E.2    Daly, A.K.3    James, O.F.4    Vaidya, B.5    Pearce, S.6
  • 120
    • 84880898067 scopus 로고    scopus 로고
    • The CTLA-4 and MCP-1 polymorphisms and susceptibility to systemic sclerosis: a meta-analysis
    • Song G.G., Lee Y.H. The CTLA-4 and MCP-1 polymorphisms and susceptibility to systemic sclerosis: a meta-analysis. Immunol. Invest. 2013, 42:481-492.
    • (2013) Immunol. Invest. , vol.42 , pp. 481-492
    • Song, G.G.1    Lee, Y.H.2
  • 121
    • 8744266374 scopus 로고    scopus 로고
    • The codon 620 tryptophan allele of the lymphoid tyrosine phosphatase (LYP) gene is a major determinant of Graves' disease
    • Velaga M.R., Wilson V., Jennings C.E., Owen C.J., Herington S., Donaldson P.T., et al. The codon 620 tryptophan allele of the lymphoid tyrosine phosphatase (LYP) gene is a major determinant of Graves' disease. J. Clin. Endocrinol. Metab. 2004, 89:5862-5865.
    • (2004) J. Clin. Endocrinol. Metab. , vol.89 , pp. 5862-5865
    • Velaga, M.R.1    Wilson, V.2    Jennings, C.E.3    Owen, C.J.4    Herington, S.5    Donaldson, P.T.6
  • 122
    • 12144291502 scopus 로고    scopus 로고
    • A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes
    • Bottini N., Musumeci L., Alonso A., Rahmouni S., Nika K., Rostamkhani M., et al. A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes. Nat. Genet. 2004, 36:337-338.
    • (2004) Nat. Genet. , vol.36 , pp. 337-338
    • Bottini, N.1    Musumeci, L.2    Alonso, A.3    Rahmouni, S.4    Nika, K.5    Rostamkhani, M.6
  • 124
    • 4143105691 scopus 로고    scopus 로고
    • Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE
    • Kyogoku C., Langefeld C.D., Ortmann W.A., Lee A., Selby S., Carlton V.E., et al. Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE. Am. J. Hum. Genet. 2004, 75:504-507.
    • (2004) Am. J. Hum. Genet. , vol.75 , pp. 504-507
    • Kyogoku, C.1    Langefeld, C.D.2    Ortmann, W.A.3    Lee, A.4    Selby, S.5    Carlton, V.E.6
  • 125
    • 34247213251 scopus 로고    scopus 로고
    • Is FCRL3 a new general autoimmunity gene?
    • Chistiakov D.A., Chistiakov A.P. Is FCRL3 a new general autoimmunity gene?. Hum. Immunol. 2007, 68:375-383.
    • (2007) Hum. Immunol. , vol.68 , pp. 375-383
    • Chistiakov, D.A.1    Chistiakov, A.P.2
  • 126
    • 84961411383 scopus 로고    scopus 로고
    • Significant association between Fc receptor-like 3 polymorphisms (-1901A>G and -658C>T) and neuromyelitis optica (NMO) susceptibility in the chinese population
    • Epub ahead of print
    • Wang X., Yu T., Yan Q., Wang W., Meng N., Li X., et al. Significant association between Fc receptor-like 3 polymorphisms (-1901A>G and -658C>T) and neuromyelitis optica (NMO) susceptibility in the chinese population. Mol. Neurobiol. 2015, Epub ahead of print.
    • (2015) Mol. Neurobiol.
    • Wang, X.1    Yu, T.2    Yan, Q.3    Wang, W.4    Meng, N.5    Li, X.6
  • 127
    • 57649228039 scopus 로고    scopus 로고
    • Association between polymorphisms of FCRL3, a non-HLA gene, and Behcet's disease in a Chinese population with ophthalmic manifestations
    • Li K., Zhao M., Hou S., Du L., Kijlstra A., Yang P. Association between polymorphisms of FCRL3, a non-HLA gene, and Behcet's disease in a Chinese population with ophthalmic manifestations. Mol. Vis. 2008, 14:2136-2142.
    • (2008) Mol. Vis. , vol.14 , pp. 2136-2142
    • Li, K.1    Zhao, M.2    Hou, S.3    Du, L.4    Kijlstra, A.5    Yang, P.6
  • 128
    • 84961140181 scopus 로고    scopus 로고
    • Four FCRL3 gene polymorphisms (FCRL3_3, _5, _6, _8) confer susceptibility to multiple sclerosis: results from a case-control study
    • Epub ahead of print
    • Yuan M., Wei L., Zhou R., Bai Q., Wei Y., Zhang W., et al. Four FCRL3 gene polymorphisms (FCRL3_3, _5, _6, _8) confer susceptibility to multiple sclerosis: results from a case-control study. Mol. Neurobiol. 2015, Epub ahead of print.
    • (2015) Mol. Neurobiol.
    • Yuan, M.1    Wei, L.2    Zhou, R.3    Bai, Q.4    Wei, Y.5    Zhang, W.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.