메뉴 건너뛰기




Volumn 9, Issue , 2014, Pages 147-156

Mechanisms of autoimmune thyroid diseases: From genetics to epigenetics

Author keywords

Autoimmunity; Graves disease; Hashimoto's thyroiditis; Thyroid

Indexed keywords

AUTOIMMUNE DISEASE; GENETIC ASSOCIATION; GENETIC EPIGENESIS; GENETIC PREDISPOSITION; GENETICS; HUMAN; REVIEW; THYROID DISEASE;

EID: 84897019743     PISSN: 15534006     EISSN: 15534014     Source Type: Book Series    
DOI: 10.1146/annurev-pathol-012513-104713     Document Type: Article
Times cited : (218)

References (63)
  • 1
    • 0036173697 scopus 로고    scopus 로고
    • Serum TSH, T4, and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III
    • Hollowell JG, Staehling NW, Flanders WD, Hannon WH, Gunter EW, et al. 2002. Serum TSH, T4, and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J. Clin. Endocrinol. Metab. 87:489-99
    • (2002) J. Clin. Endocrinol. Metab. , vol.87 , pp. 489-499
    • Hollowell, J.G.1    Staehling, N.W.2    Flanders, W.D.3    Hannon, W.H.4    Gunter, E.W.5
  • 2
    • 0031240055 scopus 로고    scopus 로고
    • Epidemiology and estimated population burden of selected autoimmune diseases in the United States
    • Jacobson DL, Gange SJ, Rose NR, Graham NM. 1997. Epidemiology and estimated population burden of selected autoimmune diseases in the United States. Clin. Immunol. Immunopathol. 84:223-43
    • (1997) Clin. Immunol. Immunopathol. , vol.84 , pp. 223-243
    • Jacobson, D.L.1    Gange, S.J.2    Rose, N.R.3    Graham, N.M.4
  • 4
    • 0029046372 scopus 로고
    • The incidence of thyroid disorders in the community: A twenty-year follow-up of the Whickham survey
    • Vanderpump MPJ, Tunbridge WMG, French JM, Appleton D, Bates D, et al. 1995. The incidence of thyroid disorders in the community: a twenty-year follow-up of the Whickham survey. Clin. Endocrinol. 43:55-68
    • (1995) Clin. Endocrinol. , vol.43 , pp. 55-68
    • Vanderpump, M.P.J.1    Tunbridge, W.M.G.2    French, J.M.3    Appleton, D.4    Bates, D.5
  • 5
    • 0037357196 scopus 로고    scopus 로고
    • The prevalence of antithyroid peroxidase antibodies and autoimmune thyroiditis in children and adolescents in an iodine replete area
    • Kabelitz M, Liesenkotter KP, Stach B, Willgerodt H, Stablein W, et al. 2003. The prevalence of antithyroid peroxidase antibodies and autoimmune thyroiditis in children and adolescents in an iodine replete area. Eur. J. Endocrinol. 148:301-7
    • (2003) Eur. J. Endocrinol. , vol.148 , pp. 301-307
    • Kabelitz, M.1    Liesenkotter, K.P.2    Stach, B.3    Willgerodt, H.4    Stablein, W.5
  • 6
    • 1642340689 scopus 로고    scopus 로고
    • Toward precise forecasting of autoimmune endocrinopathy
    • Pearce SH, Leech NJ. 2004. Toward precise forecasting of autoimmune endocrinopathy. J. Clin. Endocrinol. Metab. 89:544-47
    • (2004) J. Clin. Endocrinol. Metab. , vol.89 , pp. 544-547
    • Pearce, S.H.1    Leech, N.J.2
  • 7
    • 0002982436 scopus 로고    scopus 로고
    • Graves diseases: Pathogenesis
    • ed. LE Braverman, RD Utiger Philadelphia: Lippincott Williams and Wilkins. 8th ed.
    • Davies TF. 2000. Graves diseases: pathogenesis. In Werner and Ingbars The Thyroid: A Fundamental and Clinical Text, ed. LE Braverman, RD Utiger, pp. 518-30. Philadelphia: Lippincott Williams and Wilkins. 8th ed.
    • (2000) Werner and Ingbars the Thyroid: A Fundamental and Clinical Text , pp. 518-530
    • Davies, T.F.1
  • 8
    • 0002093905 scopus 로고    scopus 로고
    • Chronic autoimmune thyroiditis
    • ed. LE Braverman, RD Utiger Philadelphia: Lippincott Williams and Wilkins. 8th ed.
    • Weetman AP. 2000. Chronic autoimmune thyroiditis. In Werner and Ingbars The Thyroid: A Fundamental and Clinical Text, ed. LE Braverman, RD Utiger, pp. 721-32. Philadelphia: Lippincott Williams and Wilkins. 8th ed.
    • (2000) Werner and Ingbars the Thyroid: A Fundamental and Clinical Text , pp. 721-732
    • Weetman, A.P.1
  • 9
    • 53849120957 scopus 로고    scopus 로고
    • Joint genetic susceptibility to type 1 diabetes and autoimmune thyroiditis: From epidemiology to mechanisms
    • Huber A, Menconi F, Corathers S, Jacobson EM, Tomer Y. 2008. Joint genetic susceptibility to type 1 diabetes and autoimmune thyroiditis: from epidemiology to mechanisms. Endocr. Rev. 29:697-725
    • (2008) Endocr. Rev. , vol.29 , pp. 697-725
    • Huber, A.1    Menconi, F.2    Corathers, S.3    Jacobson, E.M.4    Tomer, Y.5
  • 10
    • 67349199596 scopus 로고    scopus 로고
    • The etiology of autoimmune thyroid disease: A story of genes and environment
    • Tomer Y, Huber A. 2009. The etiology of autoimmune thyroid disease: a story of genes and environment. J. Autoimmun. 32:231-39
    • (2009) J. Autoimmun. , vol.32 , pp. 231-239
    • Tomer, Y.1    Huber, A.2
  • 11
    • 59649097252 scopus 로고    scopus 로고
    • Type 1 diabetes and autoimmune thyroiditis: The genetic connection
    • Tomer Y, Menconi F. 2009. Type 1 diabetes and autoimmune thyroiditis: the genetic connection. Thyroid 19:99-102
    • (2009) Thyroid , vol.19 , pp. 99-102
    • Tomer, Y.1    Menconi, F.2
  • 14
    • 0034453053 scopus 로고    scopus 로고
    • A population-based study of chronic autoimmune hypothyroidism in Danish twins
    • Brix TH, Kyvik KO, Hegedus L. 2000. A population-based study of chronic autoimmune hypothyroidism in Danish twins. J. Clin. Endocrinol. Metab. 85:536-39
    • (2000) J. Clin. Endocrinol. Metab. , vol.85 , pp. 536-539
    • Brix, T.H.1    Kyvik, K.O.2    Hegedus, L.3
  • 15
    • 0035095887 scopus 로고    scopus 로고
    • Evidence for a major role of heredity in Graves disease: A population-based study of two Danish twin cohorts
    • Brix TH, Kyvik KO, Christensen K, Hegedus L. 2001. Evidence for a major role of heredity in Graves disease: a population-based study of two Danish twin cohorts. J. Clin. Endocrinol. Metab. 86:930-34
    • (2001) J. Clin. Endocrinol. Metab. , vol.86 , pp. 930-934
    • Brix, T.H.1    Kyvik, K.O.2    Christensen, K.3    Hegedus, L.4
  • 16
    • 23644456322 scopus 로고    scopus 로고
    • Thyrotropin receptor-Associated diseases: From adenomata to Graves disease
    • Davies TF, Ando T, Lin RY, Tomer Y, Latif R. 2005. Thyrotropin receptor-Associated diseases: from adenomata to Graves disease. J. Clin. Investig. 115:1972-83
    • (2005) J. Clin. Investig. , vol.115 , pp. 1972-1983
    • Davies, T.F.1    Ando, T.2    Lin, R.Y.3    Tomer, Y.4    Latif, R.5
  • 17
    • 85047683478 scopus 로고    scopus 로고
    • Thyrotropin receptor polymorphisms and thyroid diseases
    • Tonacchera M, Pinchera A. 2000. Thyrotropin receptor polymorphisms and thyroid diseases. J. Clin. Endocrinol. Metab. 85:2637-39
    • (2000) J. Clin. Endocrinol. Metab. , vol.85 , pp. 2637-2639
    • Tonacchera, M.1    Pinchera, A.2
  • 18
    • 33644790167 scopus 로고    scopus 로고
    • Association of the TSHR gene with Graves disease: The first disease specific locus
    • Dechairo BM, Zabaneh D, Collins J, Brand O, Dawson GJ, et al. 2005. Association of the TSHR gene with Graves disease: the first disease specific locus. Eur. J. Hum. Genet. 13:1223-30
    • (2005) Eur. J. Hum. Genet. , vol.13 , pp. 1223-1230
    • Dechairo, B.M.1    Zabaneh, D.2    Collins, J.3    Brand, O.4    Dawson, G.J.5
  • 19
    • 84872069859 scopus 로고    scopus 로고
    • Fine mapping of loci linked to autoimmune thyroid disease identifies novel susceptibility genes
    • Tomer Y, Hasham A, Davies TF, Stefan M, Concepcion E, et al. 2013. Fine mapping of loci linked to autoimmune thyroid disease identifies novel susceptibility genes. J. Clin. Endocrinol. Metab. 98:E144-52
    • (2013) J. Clin. Endocrinol. Metab. , vol.98 , pp. E144-E152
    • Tomer, Y.1    Hasham, A.2    Davies, T.F.3    Stefan, M.4    Concepcion, E.5
  • 20
    • 0026802536 scopus 로고
    • Cloning and sequencing of a 1.3 kb variant of human thyrotropin receptor mRNA lacking the transmembrane domain
    • Graves PN, Tomer Y, Davies TF. 1992. Cloning and sequencing of a 1.3 kb variant of human thyrotropin receptor mRNA lacking the transmembrane domain. Biochem. Biophys. Res. Commun. 187:1135-43
    • (1992) Biochem. Biophys. Res. Commun. , vol.187 , pp. 1135-1143
    • Graves, P.N.1    Tomer, Y.2    Davies, T.F.3
  • 21
    • 0024385963 scopus 로고
    • Immune mechanisms in autoimmune thyroiditis
    • Charreire J. 1989. Immune mechanisms in autoimmune thyroiditis. Adv. Immunol. 46:263-334
    • (1989) Adv. Immunol. , vol.46 , pp. 263-334
    • Charreire, J.1
  • 22
    • 79955720569 scopus 로고    scopus 로고
    • CDNA immunization of mice with human thyroglobulin generates both humoral and T cell responses: A novel model of thyroid autoimmunity
    • Jacobson EM, Concepcion E, Ho K, Kopp P, Toniolo JV, Tomer Y. 2011. cDNA immunization of mice with human thyroglobulin generates both humoral and T cell responses: a novel model of thyroid autoimmunity. PLoS ONE 6:e19200
    • (2011) PLoS ONE , vol.6 , pp. e19200
    • Jacobson, E.M.1    Concepcion, E.2    Ho, K.3    Kopp, P.4    Toniolo, J.V.5    Tomer, Y.6
  • 23
    • 77956034726 scopus 로고    scopus 로고
    • Antibodies to thyroid peroxidase arise spontaneously with age in NOD.H-2h4 mice and appear after thyroglobulin antibodies
    • Chen CR, Hamidi S, Braley-Mullen H, Nagayama Y, Bresee C, et al. 2010. Antibodies to thyroid peroxidase arise spontaneously with age in NOD.H-2h4 mice and appear after thyroglobulin antibodies. Endocrinology 151:4583-93
    • (2010) Endocrinology , vol.151 , pp. 4583-4593
    • Chen, C.R.1    Hamidi, S.2    Braley-Mullen, H.3    Nagayama, Y.4    Bresee, C.5
  • 24
    • 0142059659 scopus 로고    scopus 로고
    • Commonand unique susceptibility loci in Graves and Hashimoto diseases: Results of whole-genome screening in a data set of 102 multiplex families
    • TomerY, Ban Y, ConcepcionE, Barbesino G, Villanueva R, et al. 2003.Commonand unique susceptibility loci in Graves and Hashimoto diseases: results of whole-genome screening in a data set of 102 multiplex families. Am. J. Hum. Genet. 73:736-47
    • (2003) Am. J. Hum. Genet. , vol.73 , pp. 736-747
    • Tomer, Y.1    Ban, Y.2    Concepcion, E.3    Barbesino, G.4    Villanueva, R.5
  • 25
    • 0344303638 scopus 로고    scopus 로고
    • Amino acid substitutions in the thyroglobulin gene are associated with susceptibility to human and murine autoimmune thyroid disease
    • Ban Y, Greenberg DA, Concepcion E, Skrabanek L, Villanueva R, Tomer Y. 2003. Amino acid substitutions in the thyroglobulin gene are associated with susceptibility to human and murine autoimmune thyroid disease. Proc. Natl. Acad. Sci. USA 100:15119-24
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 15119-15124
    • Ban, Y.1    Greenberg, D.A.2    Concepcion, E.3    Skrabanek, L.4    Villanueva, R.5    Tomer, Y.6
  • 26
    • 33646523376 scopus 로고    scopus 로고
    • Possible interaction between HLADRβ1 and thyroglobulin variants in Graves disease
    • Hodge SE, Ban Y, Strug LJ, Greenberg DA, Davies TF, et al. 2006. Possible interaction between HLADRβ1 and thyroglobulin variants in Graves disease. Thyroid 16:351-55
    • (2006) Thyroid , vol.16 , pp. 351-355
    • Hodge, S.E.1    Ban, Y.2    Strug, L.J.3    Greenberg, D.A.4    Davies, T.F.5
  • 27
    • 71749105341 scopus 로고    scopus 로고
    • Employing a recombinant HLADR3 expression system to dissect MHC II-thyroglobulin peptide dynamism: A genetic, biochemical, and reverse immunological perspective
    • Jacobson EM, Yang H, Menconi F, Wang R, Osman R, et al. 2009. Employing a recombinant HLADR3 expression system to dissect MHC II-thyroglobulin peptide dynamism: a genetic, biochemical, and reverse immunological perspective. J. Biol. Chem. 284:34231-43
    • (2009) J. Biol. Chem. , vol.284 , pp. 34231-34243
    • Jacobson, E.M.1    Yang, H.2    Menconi, F.3    Wang, R.4    Osman, R.5
  • 28
    • 80052425160 scopus 로고    scopus 로고
    • Novel variant of thyroglobulin promoter triggers thyroid autoimmunity through an epigenetic interferon α-modulated mechanism
    • Stefan M, Jacobson EM, Huber AK, Greenberg DA, Li CW, et al. 2011. Novel variant of thyroglobulin promoter triggers thyroid autoimmunity through an epigenetic interferon α-modulated mechanism. J. Biol. Chem. 286:31168-79
    • (2011) J. Biol. Chem. , vol.286 , pp. 31168-31179
    • Stefan, M.1    Jacobson, E.M.2    Huber, A.K.3    Greenberg, D.A.4    Li, C.W.5
  • 29
    • 38049068750 scopus 로고    scopus 로고
    • The HLA gene complex in thyroid autoimmunity: From epidemiology to etiology
    • Jacobson EM, Huber A, Tomer Y. 2008. The HLA gene complex in thyroid autoimmunity: from epidemiology to etiology. J. Autoimmun. 30:58-62
    • (2008) J. Autoimmun. , vol.30 , pp. 58-62
    • Jacobson, E.M.1    Huber, A.2    Tomer, Y.3
  • 30
    • 52949091162 scopus 로고    scopus 로고
    • Molecular amino acid signatures in theMHCclass II peptide-binding pocket predispose to autoimmune thyroiditis in humans and in mice
    • Menconi F, Monti MC, Greenberg DA, Oashi T, Osman R, et al. 2008. Molecular amino acid signatures in theMHCclass II peptide-binding pocket predispose to autoimmune thyroiditis in humans and in mice. Proc. Natl. Acad. Sci. USA 105:14034-39
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 14034-14039
    • Menconi, F.1    Monti, M.C.2    Greenberg, D.A.3    Oashi, T.4    Osman, R.5
  • 31
    • 78049308447 scopus 로고    scopus 로고
    • Shared molecular amino acid signature in the HLA-DR peptide binding pocket predisposes to both autoimmune diabetes and thyroiditis
    • Menconi F, Osman R, Monti MC, Greenberg DA, Concepcion ES, Tomer Y. 2010. Shared molecular amino acid signature in the HLA-DR peptide binding pocket predisposes to both autoimmune diabetes and thyroiditis. Proc. Natl. Acad. Sci. USA 107:16899-903
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 16899-16903
    • Menconi, F.1    Osman, R.2    Monti, M.C.3    Greenberg, D.A.4    Concepcion, E.S.5    Tomer, Y.6
  • 32
    • 3242784051 scopus 로고    scopus 로고
    • Arginine at position 74 of the HLA-DRβ1 chain is associated with Graves disease
    • Ban Y, Davies TF, Greenberg DA, Concepcion ES, Osman R, et al. 2004. Arginine at position 74 of the HLA-DRβ1 chain is associated with Graves disease. Genes Immun. 5:203-8
    • (2004) Genes Immun. , vol.5 , pp. 203-208
    • Ban, Y.1    Davies, T.F.2    Greenberg, D.A.3    Concepcion, E.S.4    Osman, R.5
  • 33
    • 19944422075 scopus 로고    scopus 로고
    • Regression mapping of association between the human leukocyte antigen region and Graves disease
    • Simmonds MJ, Howson JM, Heward JM, Cordell HJ, Foxall H, et al. 2005. Regression mapping of association between the human leukocyte antigen region and Graves disease. Am. J. Hum. Genet. 76:157-63
    • (2005) Am. J. Hum. Genet. , vol.76 , pp. 157-163
    • Simmonds, M.J.1    Howson, J.M.2    Heward, J.M.3    Cordell, H.J.4    Foxall, H.5
  • 35
    • 77954515296 scopus 로고    scopus 로고
    • The role of glutamic or aspartic acid in position four of the epitope bindingmotif and thyrotropin receptor-extracellular domain epitope selection in Graves disease
    • Inaba H, MartinW, ArditoM, De Groot AS, De Groot LJ. 2010. The role of glutamic or aspartic acid in position four of the epitope bindingmotif and thyrotropin receptor-extracellular domain epitope selection in Graves disease. J. Clin. Endocrinol. Metab. 95:2909-16
    • (2010) J. Clin. Endocrinol. Metab. , vol.95 , pp. 2909-2916
    • Inaba, H.1    Martin, W.2    Ardito, M.3    De Groot, A.S.4    De Groot, L.J.5
  • 36
    • 0035380479 scopus 로고    scopus 로고
    • Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes
    • Lee KH, Wucherpfennig KW, Wiley DC. 2001. Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes. Nat. Immunol. 2:501-7
    • (2001) Nat. Immunol. , vol.2 , pp. 501-507
    • Lee, K.H.1    Wucherpfennig, K.W.2    Wiley, D.C.3
  • 37
    • 34247575117 scopus 로고    scopus 로고
    • The CD40, CTLA-4, thyroglobulin, TSH receptor, and PTPN22 gene quintet and its contribution to thyroid autoimmunity: Back to the future
    • Jacobson EM, Tomer Y. 2007. The CD40, CTLA-4, thyroglobulin, TSH receptor, and PTPN22 gene quintet and its contribution to thyroid autoimmunity: back to the future. J. Autoimmun. 28:85-98
    • (2007) J. Autoimmun. , vol.28 , pp. 85-98
    • Jacobson, E.M.1    Tomer, Y.2
  • 38
    • 18844421908 scopus 로고    scopus 로고
    • A Graves disease-Associated Kozak sequence single-nucleotide polymorphism enhances the efficiency of CD40 gene translation: A case for translational pathophysiology
    • Jacobson EM, Concepcion E, Oashi T, Tomer Y. 2005. A Graves disease-Associated Kozak sequence single-nucleotide polymorphism enhances the efficiency of CD40 gene translation: a case for translational pathophysiology. Endocrinology 146:2684-91
    • (2005) Endocrinology , vol.146 , pp. 2684-2691
    • Jacobson, E.M.1    Concepcion, E.2    Oashi, T.3    Tomer, Y.4
  • 39
    • 84866184305 scopus 로고    scopus 로고
    • Genetically driven target tissue overexpression of CD40: A novel mechanism in autoimmune disease
    • Huber AK, Finkelman FD, Li CW, Concepcion E, Smith E, et al. 2012. Genetically driven target tissue overexpression of CD40: a novel mechanism in autoimmune disease. J. Immunol. 189:3043-53
    • (2012) J. Immunol. , vol.189 , pp. 3043-3053
    • Huber, A.K.1    Finkelman, F.D.2    Li, C.W.3    Concepcion, E.4    Smith, E.5
  • 40
    • 34247370193 scopus 로고    scopus 로고
    • Association analysis of CD40 polymorphisms with asthma and the level of serum total IgE
    • Park JH, Chang HS, Park CS, Jang AS, Park BL, et al. 2007. Association analysis of CD40 polymorphisms with asthma and the level of serum total IgE. Am. J. Respir. Crit. Care Med. 175:775-82
    • (2007) Am. J. Respir. Crit. Care Med. , vol.175 , pp. 775-782
    • Park, J.H.1    Chang, H.S.2    Park, C.S.3    Jang, A.S.4    Park, B.L.5
  • 41
    • 68049100306 scopus 로고    scopus 로고
    • Association of a singlenucleotide polymorphism in CD40 with the rate of joint destruction in rheumatoid arthritis
    • van der Linden MP, Feitsma AL, le Cessie S, Kern M, Olsson LM, et al. 2009. Association of a singlenucleotide polymorphism in CD40 with the rate of joint destruction in rheumatoid arthritis. Arthritis Rheum. 60:2242-47
    • (2009) Arthritis Rheum. , vol.60 , pp. 2242-2247
    • Van Der Linden, M.P.1    Feitsma, A.L.2    Le Cessie, S.3    Kern, M.4    Olsson, L.M.5
  • 42
    • 67649881102 scopus 로고    scopus 로고
    • Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20
    • Austr. N.Z. Mult. Scler. Genet. Consort. (ANZgene)
    • Austr. N.Z. Mult. Scler. Genet. Consort. (ANZgene). 2009. Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20. Nat. Genet. 41:824-28
    • (2009) Nat. Genet. , vol.41 , pp. 824-828
  • 43
    • 0035100320 scopus 로고    scopus 로고
    • Unraveling the genetic susceptibility to autoimmune thyroid diseases: CTLA-4 takes the stage
    • Tomer Y. 2001. Unraveling the genetic susceptibility to autoimmune thyroid diseases: CTLA-4 takes the stage. Thyroid 11:167-69
    • (2001) Thyroid , vol.11 , pp. 167-169
    • Tomer, Y.1
  • 44
    • 65349119978 scopus 로고    scopus 로고
    • CD28 and CTLA-4 coreceptor expression and signal transduction
    • Rudd CE, Taylor A, Schneider H. 2009. CD28 and CTLA-4 coreceptor expression and signal transduction. Immunol. Rev. 229:12-26
    • (2009) Immunol. Rev. , vol.229 , pp. 12-26
    • Rudd, C.E.1    Taylor, A.2    Schneider, H.3
  • 45
    • 0034548720 scopus 로고    scopus 로고
    • CTLA-4gene polymorphism at position 49 in exon 1 reduces the inhibitory function of CTLA-4 and contributes to the pathogenesis of Graves disease
    • KoukiT, Sawai Y, GardineCA, FisfalenME, AlegreML, DeGroot LJ. 2000.CTLA-4gene polymorphism at position 49 in exon 1 reduces the inhibitory function of CTLA-4 and contributes to the pathogenesis of Graves disease. J. Immunol. 165:6606-11
    • (2000) J. Immunol. , vol.165 , pp. 6606-6611
    • Kouki, T.1    Sawai, Y.2    Gardine, C.A.3    Fisfalen, M.E.4    Alegre, M.L.5    De Groot, L.J.6
  • 46
    • 0346102453 scopus 로고    scopus 로고
    • CTLA-4 AT-repeat polymorphism reduces the inhibitory function of CTLA-4 in Graves disease
    • Takara M, Kouki T, DeGroot LJ. 2003. CTLA-4 AT-repeat polymorphism reduces the inhibitory function of CTLA-4 in Graves disease. Thyroid 13:1083-89
    • (2003) Thyroid , vol.13 , pp. 1083-1089
    • Takara, M.1    Kouki, T.2    Degroot, L.J.3
  • 47
    • 3242723166 scopus 로고    scopus 로고
    • Analysis of the CTLA-4, CD28 and inducible co-stimulator (ICOS) genes in autoimmune thyroid disease
    • Ban Y, Davies TF, Greenberg DA, Kissin A, Marder B, et al. 2003. Analysis of the CTLA-4, CD28 and inducible co-stimulator (ICOS) genes in autoimmune thyroid disease. Genes Immun. 4:586-93
    • (2003) Genes Immun. , vol.4 , pp. 586-593
    • Ban, Y.1    Davies, T.F.2    Greenberg, D.A.3    Kissin, A.4    Marder, B.5
  • 48
    • 0037648405 scopus 로고    scopus 로고
    • Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease
    • Ueda H, Howson JM, Esposito L, Heward J, Snook H, et al. 2003. Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature 423:506-11
    • (2003) Nature , vol.423 , pp. 506-511
    • Ueda, H.1    Howson, J.M.2    Esposito, L.3    Heward, J.4    Snook, H.5
  • 49
    • 33847306066 scopus 로고    scopus 로고
    • CT60 genotype does not affect CTLA-4 isoform expression despite association to T1D and AITD in northern Sweden
    • Mayans S, Lackovic K, Nyholm C, Lindgren P, Ruikka K, et al. 2007. CT60 genotype does not affect CTLA-4 isoform expression despite association to T1D and AITD in northern Sweden. BMCMed. Genet. 8:3
    • (2007) BMCMed. Genet. , vol.8 , pp. 3
    • Mayans, S.1    Lackovic, K.2    Nyholm, C.3    Lindgren, P.4    Ruikka, K.5
  • 50
    • 84862744031 scopus 로고    scopus 로고
    • Ipilimumab: A novel immunomodulating therapy causing autoimmune hypophysitis: A case report and review
    • Juszczak A, Gupta A, Karavitaki N, Middleton MR, Grossman AB. 2012. Ipilimumab: a novel immunomodulating therapy causing autoimmune hypophysitis: a case report and review. Eur. J. Endocrinol. 167:1-5
    • (2012) Eur. J. Endocrinol. , vol.167 , pp. 1-5
    • Juszczak, A.1    Gupta, A.2    Karavitaki, N.3    Middleton, M.R.4    Grossman, A.B.5
  • 51
    • 81755179431 scopus 로고    scopus 로고
    • Why is PTPN22 a good candidate susceptibility gene for autoimmune disease?
    • Burn GL, Svensson L, Sanchez-Blanco C, Saini M, Cope AP. 2011. Why is PTPN22 a good candidate susceptibility gene for autoimmune disease? FEBS Lett. 585:3689-98
    • (2011) FEBS Lett. , vol.585 , pp. 3689-3698
    • Burn, G.L.1    Svensson, L.2    Sanchez-Blanco, C.3    Saini, M.4    Cope, A.P.5
  • 52
    • 8744266374 scopus 로고    scopus 로고
    • The codon 620 tryptophan allele of the lymphoid tyrosine phosphatase (LYP) gene is a major determinant of Graves disease
    • Velaga MR, Wilson V, Jennings CE, Owen CJ, Herington S, et al. 2004. The codon 620 tryptophan allele of the lymphoid tyrosine phosphatase (LYP) gene is a major determinant of Graves disease. J. Clin. Endocrinol. Metab. 89:5862-65
    • (2004) J. Clin. Endocrinol. Metab. , vol.89 , pp. 5862-5865
    • Velaga, M.R.1    Wilson, V.2    Jennings, C.E.3    Owen, C.J.4    Herington, S.5
  • 53
    • 3242713277 scopus 로고    scopus 로고
    • A missense singlenucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis
    • Begovich AB, Carlton VE, Honigberg LA, Schrodi SJ, Chokkalingam AP, et al. 2004. A missense singlenucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis. Am. J. Hum. Genet. 75:330-37
    • (2004) Am. J. Hum. Genet. , vol.75 , pp. 330-337
    • Begovich, A.B.1    Carlton, V.E.2    Honigberg, L.A.3    Schrodi, S.J.4    Chokkalingam, A.P.5
  • 54
    • 12144291502 scopus 로고    scopus 로고
    • A functional variant of lymphoid tyrosine phosphatase is associated with type i diabetes
    • Bottini N, Musumeci L, Alonso A, Rahmouni S, Nika K, et al. 2004. A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes. Nat. Genet. 36:337-38
    • (2004) Nat. Genet. , vol.36 , pp. 337-338
    • Bottini, N.1    Musumeci, L.2    Alonso, A.3    Rahmouni, S.4    Nika, K.5
  • 55
    • 34548323860 scopus 로고    scopus 로고
    • Protein tyrosine phosphatase PTPN22 in human autoimmunity
    • Vang T, Miletic AV, Bottini N, Mustelin T. 2007. Protein tyrosine phosphatase PTPN22 in human autoimmunity. Autoimmunity 40:453-61
    • (2007) Autoimmunity , vol.40 , pp. 453-461
    • Vang, T.1    Miletic, A.V.2    Bottini, N.3    Mustelin, T.4
  • 56
    • 33947274768 scopus 로고    scopus 로고
    • Association of the interleukin-2 receptor α(IL-2Rα)/CD25 gene region with Graves disease using a multilocus test and tag SNPs
    • Brand OJ, Lowe CE, Heward JM, Franklyn JA, Cooper JD, et al. 2007. Association of the interleukin-2 receptor α(IL-2Rα)/CD25 gene region with Graves disease using a multilocus test and tag SNPs. Clin. Endocrinol. 66:508-12
    • (2007) Clin. Endocrinol. , vol.66 , pp. 508-512
    • Brand, O.J.1    Lowe, C.E.2    Heward, J.M.3    Franklyn, J.A.4    Cooper, J.D.5
  • 57
    • 33746342994 scopus 로고    scopus 로고
    • Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease
    • Sakaguchi S, OnoM, Setoguchi R, Yagi H, Hori S, et al. 2006. Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease. Immunol. Rev. 212:8-27
    • (2006) Immunol. Rev. , vol.212 , pp. 8-27
    • Sakaguchi, S.1    Ono, M.2    Setoguchi, R.3    Yagi, H.4    Hori, S.5
  • 58
    • 34247598749 scopus 로고    scopus 로고
    • Balancing autoaggressive and protective T cell responses
    • Abbas AK, Lohr J, Knoechel B. 2007. Balancing autoaggressive and protective T cell responses. J. Autoimmun. 28:59-61
    • (2007) J. Autoimmun. , vol.28 , pp. 59-61
    • Abbas, A.K.1    Lohr, J.2    Knoechel, B.3
  • 59
    • 65649133976 scopus 로고    scopus 로고
    • Surveillance of antigen-presenting cells by CD4+ CD25+ regulatory T cells in autoimmunity: Immunopathogenesis and therapeutic implications
    • Andre S, Tough DF, Lacroix-Desmazes S, Kaveri SV, Bayry J. 2009. Surveillance of antigen-presenting cells by CD4+ CD25+ regulatory T cells in autoimmunity: immunopathogenesis and therapeutic implications. Am. J. Pathol. 174:1575-87
    • (2009) Am. J. Pathol. , vol.174 , pp. 1575-1587
    • Andre, S.1    Tough, D.F.2    Lacroix-Desmazes, S.3    Kaveri, S.V.4    Bayry, J.5
  • 60
    • 34249309946 scopus 로고    scopus 로고
    • The regulatory T cell gene FOXP3 and genetic susceptibility to thyroid autoimmunity: An association analysis in Caucasian and Japanese cohorts
    • Ban Y, Tozaki T, Tobe T, Ban Y, Jacobson EM, et al. 2007. The regulatory T cell gene FOXP3 and genetic susceptibility to thyroid autoimmunity: an association analysis in Caucasian and Japanese cohorts. J. Autoimmun. 28:201-7
    • (2007) J. Autoimmun. , vol.28 , pp. 201-207
    • Ban, Y.1    Tozaki, T.2    Tobe, T.3    Ban, Y.4    Jacobson, E.M.5
  • 61
    • 80052260527 scopus 로고    scopus 로고
    • A genome-wide association study identifies two new risk loci for Graves disease
    • Chu X, Pan CM, Zhao SX, Liang J, Gao GQ, et al. 2011. A genome-wide association study identifies two new risk loci for Graves disease. Nat. Genet. 43:897-901
    • (2011) Nat. Genet. , vol.43 , pp. 897-901
    • Chu, X.1    Pan, C.M.2    Zhao, S.X.3    Liang, J.4    Gao, G.Q.5
  • 63
    • 77950202883 scopus 로고    scopus 로고
    • What can we learn from epigenetics in the year 2009?
    • Jungel A, Ospelt C, Gay S. 2010. What can we learn from epigenetics in the year 2009? Curr. Opin. Rheumatol. 22:284-92
    • (2010) Curr. Opin. Rheumatol. , vol.22 , pp. 284-292
    • Jungel, A.1    Ospelt, C.2    Gay, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.