Molecular amino acid signatures in the MHC class II peptide-binding pocket predispose to autoimmune thyroiditis in humans and in mice

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 37, 2008, Pages 14034-14039

  Menconi, Francesca ^a   Monti, Maria C ^a,c   Greenberg, David A ^b   Oashi, Taiji ^d   Osman, Roman ^d   Davies, Terry F ^d   Ban, Yoshiyuki ^e   Jacobson, Eric M ^a   Concepcion, Erlinda S ^a   Cheuk, Wun Li ^a   Tomer, Yaron ^a,f  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c UNIVERSITY OF PAVIA   (Italy)

^d MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^e SHOWA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^f VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Gene; Hashimoto's thyroiditis; HLA; Major histocompatibility complex

Indexed keywords

ARGININE; ASPARTIC ACID; GLYCINE; LYSINE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PHENYLALANINE; TYROSINE; VALINE;

ADOLESCENT; ADULT; AGED; AMINO ACID SEQUENCE; ARTICLE; AUTOIMMUNE DISEASE; CHILD; CONTROLLED STUDY; DISEASE COURSE; DISEASE PREDISPOSITION; EXON; FEMALE; HAPLOTYPE; HASHIMOTO DISEASE; HUMAN; MAJOR CLINICAL STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING;

AMINO ACIDS; ANIMALS; BINDING SITES; DISEASE MODELS, ANIMAL; HLA-DR ANTIGENS; HUMANS; MICE; PEPTIDES; SEQUENCE ANALYSIS; THYROIDITIS, AUTOIMMUNE;

MURINAE; MUS;

EID: 52949091162     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0806584105     Document Type: Article

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