Is FCRL3 a New General Autoimmunity Gene?

Human Immunology

Volumn 68, Issue 5, 2007, Pages 375-383

  Chistiakov, Dimitry A ^a   Chistiakov, Alexander P ^b  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b N N BLOKHIN NATIONAL MEDICAL RESEARCH CENTER OF ONCOLOGY   (Russian Federation)

Author keywords

autoimmunity; FCRL3; rheumatoid arthritis; susceptibility; systemic lupus erythematosus

Indexed keywords

FC RECEPTOR; FC RECEPTOR LIKE 3; UNCLASSIFIED DRUG;

AUTOIMMUNE DISEASE; AUTOIMMUNE THYROIDITIS; AUTOIMMUNITY; GENE LOCUS; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; HUMAN; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; PRIORITY JOURNAL; REVIEW; RHEUMATOID ARTHRITIS; SYSTEMIC LUPUS ERYTHEMATOSUS;

ARTHRITIS, RHEUMATOID; AUTOIMMUNE DISEASES; AUTOIMMUNITY; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MULTIGENE FAMILY; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, IMMUNOLOGIC; THYROIDITIS, AUTOIMMUNE;

EID: 34247213251     PISSN: 01988859     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humimm.2007.01.013     Document Type: Review

References (50)

1. Lee Y.H., Rho P.A., Choi S.J., Ji J.D., Song G.G., Nath S.K., and Harley J.B. The PTPN22 C1858T functional polymorphism and autoimmune diseases - a meta-analysis. Rheumatology (Oxford) 46 (2007) 49
2. Pearce S.H., and Merriman T.R. Genetic progress towards the molecular basis of autoimmunity. Trends Mol Med 12 (2006) 90
3. Martinez A., Valdivia A., Pascual-Salcedo D., Balsa A., Fernandez-Gutierrez B., De La Concha E., and Urcelay E. Role of SLC22A4, SLC22A5, and RUNX1 genes in rheumatoid arthritis. J Rheumatol 33 (2006) 842
4. Onnie C., Fisher S.A., King K., Mirza M., Roberts R., Forbes A., Sanderson J., Lewis C.M., and Mathew C.G. Sequence variation, linkage disequilibrium and association with Crohn's disease on chromosome 5q31. Genes Immun 7 (2006) 359
5. Fisher S.A., Hampe J., Onnie C.M., Daly M.J., Curley C., Purcell S., Sanderson J., Mansfield J., Annese V., Forbes A., Lewis C.M., Schreiber S., Rioux J.D., and Mathew C.G. Direct or indirect association in a complex disease: the role of SLC22A4 and SLC22A5 functional variants in Crohn disease. Hum Mutat 27 (2006) 778
6. Kochi Y., Yamada R., Suzuki A., Harley J.B., Shirasawa S., Sawada T., Bae S.C., Tokuhiro S., Chang X., Sekine A., Takanashi A., Tsunoda T., Ohnishi Y., Kaufman K.M., Kang C.P., Otsubo S., Yumura W., Mimori A., Koike T., Nakamura Y., Sasazuki T., and Yamamoto K. A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities. Nat Genet 37 (2005) 478
7. Ikari K., Momohara S., Nakamura T., Hara M., Yamanaka H., Tomatsu T., and Kamatani N. Supportive evidence for a genetic association of the FCRL3 promoter polymorphism with rheumatoid arthritis. Ann Rheum Dis 2006 65 (2006) 671
8. Davis R.S., Wang Y.-H., Kubagawa H., and Cooper M.D. Identification of a family of Fc receptor homologs with preferential B cell expression. Proc Natl Acad Sci USA 98 (2001) 9772
9. Miller I., Hatzivassiliou G., Cattoretti G., Mendelsohn C., and Dalla-Favera R. IRTAs: a new family of immunoglobulin-like receptors differentially expressed in B cells. Blood 99 (2002) 2662
10. Shen N., and Tsao B.P. Current advances in the human lupus genetics. Curr Rheumatol Rep 6 (2004) 391
11. Giardina E., Sinibaldi C., Chini L., Moschese V., Marulli G., Provini A., Rossi P., Paradisi M., Chimenti S., Galli E., Brunetti F., Girolomoni G., and Novelli G. Co-localization of susceptibility loci for psoriasis (PSORS4) and atopic dermatitis (ATOD2) on human chromosome 1q21. Hum Hered 61 (2006) 229
12. Marti{dotless}nez A., Sanchez E., Valdivia A., Orozco G., Lopez-Nevot M.A., Pascual-Salcedo D., Balsa A., Fernandez-Gutierrez B., de la Concha E.G., Garci{dotless}a-Sanchez A., Koeleman B.P.C., Urcelay E., and Marti{dotless}n J. Epistatic interaction between FCRL3 and NFκB1 genes in Spanish patients with rheumatoid arthritis. Ann Rheum Dis 65 (2006) 1188
13. Eyre S., Bowes J., Potter C., Worthington J., and Barton A. Association of the FCRL3 gene with rheumatoid arthritis: a further example of population specificity?. Arthritis Res Ther 8 (2006) R117
14. Hu X., Chang M., Saiki R.K., Cargill M.A., Begovich A.B., Ardlie K.G., Criswell L.A., Seldin M.F., Amos C.I., Gregersen P.K., Kastner D.L., and Remmers E.F. The functional -169T/C single-nucleotide polymorphism in FCRL3 is not associated with rheumatoid arthritis in white North Americans. Arthritis Rheum 54 (2006) 1022
15. Karban A.S., Okazaki T., Panhuysen C.I., Gallegos T., Potter J.J., Bailey-Wilson J.E., Silverberg M.S., Duerr R.H., Cho J.H., Gregersen P.K., Wu J., Achkar J.P., Dassopoulos T., Mezey E., Bayless T.M., Nouvet F.J., and Brant S.R. Functional annotation of a novel NFKB1 promoter polymorphism that increases risk for ulcerative colitis. Hum Mol Genet 13 (2004) 35
16. Newman W.G., Zhang Q., Liu X., Walker E., Ternan H., Owen J., Johnson B., Greer B., Mosher D.P., Maksymowych W.P., Bykerk V.P., Keystone E.C., Amos C.I., and Siminovich K.A. Rheumatoid arthritis association with the FCRL3 -169C polymorphism is restricted to PTPN22 1858T-homozygous individuals in a Canadian population. Arthritis Rheum 54 (2006) 3820
17. Simmonds M.J., Heward J.M., Carr-Smith J., Foxall H., Franklyn J.A., and Gough S.C. Contribution of single nucleotide polymorphisms within FCRL3 and MAP3K7IP2 to the pathogenesis of Graves' disease. J Clin Endocrinol Metab 91 (2006) 1056
18. Tsao B.P., Cantor R.M., Grossman J.M., Kim S.K., Strong N., Lau C.S., Chen C.J., Shen N., Goldstein R., Kalunian K.C., Arnett F.C., Wallace D.J., and Hahn B.H. Linkage and interaction of loci on 1q23 and 16q12 may contribute to susceptibility to systemic lupus erythematosus. Arthritis Rheum 46 (2002) 2928
19. Cantor R.M., Yuan J., Napier S., Kono N., Grossman J.M., Hahn B.H., and Tsao B.P. Systemic lupus erythematosus genome scan: support for linkage at 1q23, 2q33, 16q12-13, and 17q21-23 and novel evidence at 3p24, 10q23-24, 13q32, and 18q22-23. Arthritis Rheum 50 (2004) 3203
20. Kuogoku C., Dijstenbloem H.M., Tsuchiya N., Hatta Y., Kato H., Yamaguchi A., Fukazawa T., Jansen M.D., Hashimoto H., van de Winkel J.G., Kallenberg C.G., and Tokunaga K. Fcgamma receptor gene polymorphisms in Japanese patients with systemic lupus erythematosus: contribution of FCGR2B to genetic susceptibility. Arthritis Rheum 46 (2002) 1242
21. Eldberg J.C., Landefeld C.D., Wu J., Moder K.L., Kaufman K.M., Kelly J., bansal V., Brown W.M., Salmon E., Rich S.S., Harley J.B., and Kimberly R.P. Genetic linkage and association of Fcgamma receptor IIIA (CD16A) on chromosome 1q23 with human systemic lupus erythematosus. Arthritis Rheum 46 (2002) 2132
22. Chu Z.T., Tsuchiya N., Kuogoku C., Ohashi J., Qian Y.P., Xu S.B., Mao C.Z., Chu J.Y., and Tokunaga K. Association of Fcgamma receptor IIb polymorphism with susceptibility to systemic lupus erythematosus in Chinese: a common susceptibility gene in the Asian populations. Tissue Antigens 63 (2004) 21
23. Siriboonrit U., Tsuchiya N., sirikong M., Kuogoku C., Bejrachandra S., Suthipinittharm P., Srinak D., Thongpradit R., Fijiwara K., Chandanayingyong D., and Tokunaga K. Association of Fcgamma receptor IIb and IIIb polymorphisms with susceptibility to systemic lupus erythematosus in Thais. Tissue Antigens 61 (2003) 374
24. Wu J., Metz C., Xu X., Abe R., Gibson A.W., Edberg J.C., Cooke J., Xie F., Cooper C.S., and Kimberly R.P. A novel polymorphic CAAT/enhancer-binding protein beta element in the FasL gene promoter alters Fas ligand expression: a candidate background gene in African American systemic lupus erythematosus patients. J Immunol 170 (2003) 132
25. Chen J.Y., Wang C.M., Ma C.C., Chow Y.H., and Luo S.F. The -844C/T polymorphism in the Fas ligand promoter associates with Taiwanese SLE. Genes Immun 6 (2005) 123
26. Nolsoe R.L., Kelly J.A., Pociot F., Moser K.L., Kristiansen O.P., Mandrup-Poulsen T., and Harley J.B. Functional promoter haplotypes of the human FAS gene are associated with the phenotype of SLE characterized by thrombocytopenia. Genes Immun 6 (2005) 699
27. Russell A.I., Cunninghame G.D.S., Sheperd C., Robertson C.A., Whittaker J., Meeks J., Rowell R.J., Isenberg D.A., Walport M.J., and Vyse T.J. Polymorphism at the C-reactive protein locus influences gene expression and predisposes to systemic lupus erythematosus. Hum Mol Genet 13 (2004) 137
28. Sanchez E., Callejas J.L., Sabio J.M., de Haro M., Camps M., de Ramon E., Garcia-Hernandez F.J., Koeleman B., Martin J., and Gonzales-Escribano M.F. Polymorphisms of the FCRL3 gene in a Spanish population of systemic lupus erythematosus patients. Rheumatology (Oxford) 45 (2006) 1044
29. Smyth D.J., Howson J.M.M., Payne F., Maier L.M., Bailey R., Holland K., Lowe C.E., Cooper J.D., Hulme J.S., Vella A., Dahlman I., Lam A.C., Nutland S., Walker N.M., Twells R.C.J., and Todd J.A. Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases. BMC Med Genet 7 (2006) 20
30. Turunen J.A., Wessman M., Kilpikari R., Parkkonen M., and Groop P.H. The functional variant -169C/T in the FCRL3 gene does not increase susceptibility to Type 1 diabetes. Diabet Med 23 (2006) 923
31. Umemura T., Ota M., Hamano H., Katsuyama Y., Kiyosama K., and Kama S. Genetic association of Fc receptor-like 3 polymorphisms with autoimmune pancreatitis in Japanese patients. Gut 55 (2006) 1367
32. Umemura T., Ota M., Yoshizawa K., Katsuyama Y., Ichijo T., Tanaka E., Kawa S., and Kiyosama K. Lack of association between FCRL3 and FcgammaRII polymorphisms in Japanese type 1 autoimmune hepatitis. Clin Immunol 122 (2007) 338
33. Xu M.J., Zhao R., Cao H., and Zhao Z.J. SPAP2, an Ig family receptor containing both ITIMs and ITAMs. Biochem Biophys Res Commun 293 (2002) 1037
34. Barrow A.D., and Trowsdale J. You say ITAM and I say ITIM, let's call the whole thing off: the ambiguity of immunoreceptor signalling. Eur J Immunol 36 (2006) 1646
35. Zoller K.E., MacNeil I.A., and Brugge J.S. Protein tyrosine kinases Syk and ZAP-70 display distinct requirements for Src family kinases in immune response receptor signal transduction. J Immunol 158 (1997) 1650
36. Fernandez-Arguero M., Figueredo M.A., Maluenda C., and da la Concha E.G. HLA-linked genes acting as additive susceptibility factors in celiac disease. Hum Immunol 42 (1995) 295
37. Thomas R. The TRAF6-NF kappa B signaling pathway in autoimmunity: not just inflammation. Arthritis Res Ther 7 (2005) 170
38. Lee B.O., Moyron-Qiroz J., Rangel-Moreno J., Kusser K.L., Hartson L., Sprague F., Lund F.E., and Randall T.D. CD40, but not CD154, expression on B cells is necessary for optimal primary B cell responses. J Immunol 171 (2003) 5707
39. Dalgostar H., Zarnegar B., Hoffmann A., Qin X.F., Truong U., Rao G., Baltimore D., and Cheng G. Cooperation of multiple signaling pathways in CD40-regulated gene expression in B lymphocytes. Proc Natl Acad Sci USA 99 (2002) 1497
40. Mcheyzer-Williams L.J., Malherbe L.P., and Mcheyzer-Williams M.G. Helper T cell-regulated B cell immunity. Curr Top Microbiol Immunol 311 (2006) 59
41. Krenn V., Schalhorn N., Greiner A., Molitoris R., Konig A., Gohlke F., and Muller-Hermelink H.K. Immunohistochemical analysis of proliferating and antigen-presenting cells in rheumatoid synovial tissue. Rheumatol Int 15 (1996) 239
42. Armengol M.P., Juan M., Lucas-Martin A., Fernández-Figueras M.T., Jaraquemada D., Gallart T., and Pujol-Borrell R. Thyroid autoimmune disease: demonstration of thyroid-antigen specific B cells and recombination-activating gene expression in chemokine-containing intrathyroidal active germinal centers. Am J Pathol 159 (2001) 861
43. Amft N., and Bowman S.J. Chemokines and cell trafficking in Sjogren's syndrome. Scand J Immunol 54 (2001) 62
44. Gregersen P.K., and Batliwalla F. PTPN22 and rheumatoid arthritis: gratifying replication. Arthritis Rheum 52 (2005) 1952
45. Mori M., Yamada R., Kobayashi K., Kawaida R., and Yamamoto K. Ethnic differences in allele frequency of autoimmune-disease associated SNPs. J Hum Genet 50 (2005) 264
46. Suzuki A., Yamada R., Chang X., Tokuhiro S., Sawada T., Suzuki M., Nagasaki M., Nakayma-Hamada M., Kawaida R., Ono M., Ohtsuki M., Furukawa H., Yoshino S., Yukioka M., Tohma S., Matsubara T., Wakitani S., Teshima R., Nishioka Y., Sekine A., Iida A., Takanashi A., Tsunoda T., Nakamura Y., and Yamamoto K. Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis. Nat Genet 34 (2003) 395
47. Barton A., Bowes J., Eyre S., Spreckley K., Hinks A., John S., and Worthington J. A functional haplotype of the PADI4 gene associated with rheumatoid arthritis in a Japanese population is not associated in a United Kingdom population. Arthritis Rheum 50 (2004) 1117
48. Caponi L., Petit-Teixeira E., Sebbag M., Bongiorni F., Moscato S., Pratesi F., Pierlot C., Osorio J., Chapuy-Regaud S., Guerrin M., Gornelis F., Serre G., and Migliorini P. A family based study shows no association between rheumatoid arthritis and the PADI4 gene in a white French population. Ann Rheum Dis 64 (2005) 587
49. Vang T., Congia M., Macis M.D., Musumeci L., Orru V., Zavattari P., Nika K., Tautz L., Tasken K., Cucca F., Mustelin T., and Bottini N. Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant. Nat Genet 37 (2005) 1317
50. Bland J.M., and Altman D.G. Statistics notes. The odds ratio. BMJ 320 (2000) 1468