Limited genetic susceptibility to severe graves' ophthalmopathy: No role for CTLA-4 but evidence for an environmental etiology

Thyroid

Volumn 10, Issue 9, 2000, Pages 791-798

  Villanueva, R ^a   Inzerillo, A M ^a   Tomer, Y ^a   Barbesino, G ^b   Meltzer, M ^a   Concepcion, E S ^a   Greenberg, D A ^a   MacLaren, N ^c   Sun, Z S ^c   Zhang, D M ^c   Tucci, S ^a   Davies, T F ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PISA   (Italy)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; LEUKOCYTE ANTIGEN; LYMPHOTOXIN; THYROTROPIN RECEPTOR;

ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; ENDOCRINE OPHTHALMOPATHY; ENVIRONMENTAL FACTOR; FAMILY HISTORY; FEMALE; GENETIC ANALYSIS; GENETIC PREDISPOSITION; GRAVES DISEASE; HASHIMOTO DISEASE; HUMAN; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; PRIORITY JOURNAL; SEX DIFFERENCE; SMOKING;

EID: 0033774894     PISSN: 10507256     EISSN: None     Source Type: Journal    
DOI: 10.1089/thy.2000.10.791     Document Type: Article

References (33)

1. Endocrine ophthalmopathy: Current ideas concerning etiology, pathogenesis, and treatment
2. Untreated Graves' disease patients without clinical ophthalmopathy demonstrate a high frequency of extraocular muscle (EOM) enlargement by magnetic resonance
3. Thyroid-associated ophthalmopathy
4. Management of Graves' ophthalmopathy: Reality and perspectives
5. The immunogenetics of autoimmune diabetes and autoimmune thyroid disease
6. Thyroid antibodies: A study of first degree relatives
7. A population-based study of Graves' diseases in Danish twins
8. Immunology of human thyroid disease
9. Genetics of autoimmune thyroid disease: Lack of evidence for linkage to HLA within families
10. Mapping of a major susceptibility locus for Graves' disease (GD-1) to chromosome 14q31
11. Association of autoimmune thyroid disease with a microsatellite marker for the thyrotropin receptor gene and CTLA-4 in a Japanese population
12. CTLA4 gene polymorphism confers susceptibility to Graves' disease in Japanese
13. Cytotoxic T lymphocyte antigen-4 (CTLA-4) gene polymorphism confers susceptibility to thyroid associated orbitopathy
14. CTLA-4 and HLA gene susceptibility to thyroid-associated orbitopathy
15. Mapping the major susceptibility loci for facilial Graves' and Hashimoto's diseases: Evidence for genetic heterogeneity and gene interactions
16. The familial incidence of exophthalmic goiter
17. Abnormalities in thyroid function in relatives of patients with Graves' disease and Hashimoto's thyroiditis: Lack of correlation with inheritance of HLA-B8
18. Modification of the classification of the eye changes of Graves' disease
19. HLA-DRB1*08, DRB1*03/DRB3*0101, and DRB3*0202 are susceptibility genes for Graves' disease in North American Caucasians, whereas DRB1*07 is protective
20. Linkage analysis of candidate genes in autoimmune thyroid disease: I. Selected immunoregulatory genes
21. On estimating the relation between blood group and disease
22. CTLA4 alanine-17 confers genetic susceptibility to Graves' disease and to type 1 diabetes mellitus
23. The genetic susceptibility to Graves' disease
24. A simple method for testing two-locus models of inheritance
25. Detection, cellular localization, and modulation of heat shock proteins in cultured fibroblasts form patients with extrathyroidal manifestations of Graves' disease
26. Anti-heat shock protein (hsp)72 antibodies are present in patients with Graves' disease (GD) and in smoking control subjects
27. Heat shock protein 70 (HSP 70) and complement C4 genotypes in patients with hyperthyroid Graves' disease
28. Lack of an association between alleles of interleukin-1 alpha and interleukin-1 receptor antagonist genes and Graves' disease in a North American Caucasian population
29. Clinical utility of thyrotropin-receptor antibody assays: Comparison of radioreceptor and bioassay methods
30. Thyrotropin receptor expression in Graves' orbital adipose/connective tissues: Potential autoantigen in Graves' ophthalmopathy
31. Analysis of the thyrotropin receptor as a candidate gene in familial Graves' disease
32. Infection, thyroid disease and autoimmunity
33. Graves' disease with ophthalmopathy following radiotherapy for Hodgkin's disease