-
1
-
-
0037208308
-
Property distributions: Differences between drugs, natural products, and molecules from combinatorial chemistry
-
Feher M, Schmidt JM. Property distributions: differences between drugs, natural products, and molecules from combinatorial chemistry. J. Chem. Inf. Comp. Sci. 43(1), 218-227 (2002).
-
(2002)
J. Chem. Inf. Comp. Sci.
, vol.43
, Issue.1
, pp. 218-227
-
-
Feher, M.1
Schmidt, J.M.2
-
2
-
-
35748934487
-
The influence of drug-like concepts on decision-making in medicinal chemistry
-
Leeson PD, Springthorpe B. The influence of drug-like concepts on decision-making in medicinal chemistry. Nat. Rev. Drug Discov. 6(11), 881-890 (2007).
-
(2007)
Nat. Rev. Drug Discov.
, vol.6
, Issue.11
, pp. 881-890
-
-
Leeson, P.D.1
Springthorpe, B.2
-
3
-
-
77749315417
-
Lipophilicity in drug discovery
-
Waring MJ. Lipophilicity in drug discovery. Expert Opin. Drug Discov. 5(3), 235-248 (2010).
-
(2010)
Expert Opin. Drug Discov.
, vol.5
, Issue.3
, pp. 235-248
-
-
Waring, M.J.1
-
4
-
-
69249149274
-
Drug-like property concepts in pharmaceutical design
-
Di L, Kerns EH, Carter GT. Drug-like property concepts in pharmaceutical design. Curr. Pharm. Design 15(19), 2184-2194 (2009).
-
(2009)
Curr. Pharm. Design
, vol.15
, Issue.19
, pp. 2184-2194
-
-
Di, L.1
Kerns, E.H.2
Carter, G.T.3
-
5
-
-
42149127078
-
Predicting drug absorption and the effects of food on oral bioavailability
-
Benet LZ, Wu CY, Custodio JM. Predicting drug absorption and the effects of food on oral bioavailability. Bull. Tech. Gattefossé 99, 9-16 (2006).
-
(2006)
Bull. Tech. Gattefossé
, vol.99
, pp. 9-16
-
-
Benet, L.Z.1
Wu, C.Y.2
Custodio, J.M.3
-
6
-
-
79955613841
-
Molecular obesity, potency and other addictions in drug discovery
-
Hann MM. Molecular obesity, potency and other addictions in drug discovery. Med. Chem. Comm 2(5), 349-355 (2011).
-
(2011)
Med. Chem. Comm
, vol.2
, Issue.5
, pp. 349-355
-
-
Hann, M.M.1
-
7
-
-
77955509080
-
Getting physical in drug discovery: A contemporary perspective on solubility and hydrophobicity
-
Hill AP, Young RJ. Getting physical in drug discovery: A contemporary perspective on solubility and hydrophobicity. Drug Discov. Today 15(15-16), 648-655 (2010).
-
(2010)
Drug Discov. Today
, vol.15
, Issue.15-16
, pp. 648-655
-
-
Hill, A.P.1
Young, R.J.2
-
8
-
-
0031024171
-
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
-
Lipinski CA, Lombardo F, Dominy BW, Feeney PJ. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug. Deliv. Rev. 23(1-3), 3-25 (1997).
-
(1997)
Adv. Drug. Deliv. Rev.
, vol.23
, Issue.1-3
, pp. 3-25
-
-
Lipinski, C.A.1
Lombardo, F.2
Dominy, B.W.3
Feeney, P.J.4
-
9
-
-
80052844344
-
Getting physical in drug discovery II: The impact of chromatographic hydrophobicity measurements and aromaticity
-
Young RJ, Green DVS, Luscombe CN, Hill AP. Getting physical in drug discovery II: The impact of chromatographic hydrophobicity measurements and aromaticity. Drug Discov. Today 16(17-18), 822-830 (2011).
-
(2011)
Drug Discov. Today
, vol.16
, Issue.17-18
, pp. 822-830
-
-
Young, R.J.1
Green, D.V.S.2
Luscombe, C.N.3
Hill, A.P.4
-
10
-
-
38549151817
-
Drugbank: A knowledge base for drugs, drug actions and drug targets
-
Wishart DS, Knox C, Guo AC et al. Drugbank: A knowledge base for drugs, drug actions and drug targets. Nucleic Acids Res. 36, D901-D906 (2008).
-
(2008)
Nucleic Acids Res.
, vol.36
, pp. D901-D906
-
-
Wishart, D.S.1
Knox, C.2
Guo, A.C.3
-
11
-
-
84865256887
-
Colloidal aggregation affects the efficacy of anticancer drugs in cell culture
-
Owen SC, Doak AK, Wassam P, Shoichet MS, Shoichet BK. Colloidal aggregation affects the efficacy of anticancer drugs in cell culture. ACS Chem. Biol. 7(8), 1429-1435 (2012).
-
(2012)
ACS Chem. Biol.
, vol.7
, Issue.8
, pp. 1429-1435
-
-
Owen, S.C.1
Doak, A.K.2
Wassam, P.3
Shoichet, M.S.4
Shoichet, B.K.5
-
12
-
-
77955283475
-
Aqueous solubility and true solutions
-
Loftsson T. Aqueous solubility and true solutions. Pharmazie 65(6), 404-407 (2010).
-
(2010)
Pharmazie
, vol.65
, Issue.6
, pp. 404-407
-
-
Loftsson, T.1
-
13
-
-
67649962669
-
Rapid assessment of a novel series of selective cb 2 agonists using parallel synthesis protocols: A lipophilic efficiency (lipe) analysis
-
Ryckmans T, Edwards MP, Horne VA et al. Rapid assessment of a novel series of selective cb 2 agonists using parallel synthesis protocols: A lipophilic efficiency (lipe) analysis. Bioorg. Med. Chem. Lett. 19(15), 4406-4409 (2009).
-
(2009)
Bioorg. Med. Chem. Lett.
, vol.19
, Issue.15
, pp. 4406-4409
-
-
Ryckmans, T.1
Edwards, M.P.2
Horne, V.A.3
-
14
-
-
1042298067
-
Phase transformation considerations during process development and manufacture of solid oral dosage forms
-
Zhang GGZ, Law D, Schmitt EA, Qiu Y. Phase transformation considerations during process development and manufacture of solid oral dosage forms. Adv. Drug. Deliv. Rev. 56(3), 371-390 (2004).
-
(2004)
Adv. Drug. Deliv. Rev.
, vol.56
, Issue.3
, pp. 371-390
-
-
Zhang, G.G.Z.1
Law, D.2
Schmitt, E.A.3
Qiu, Y.4
-
15
-
-
0025804183
-
Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (caco-2) cells
-
Artursson P, Karlsson J. Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (caco-2) cells. Biochem. Biophys. Res. Commun. 175(3), 880-885 (1991).
-
(1991)
Biochem. Biophys. Res. Commun.
, vol.175
, Issue.3
, pp. 880-885
-
-
Artursson, P.1
Karlsson, J.2
-
16
-
-
0020033025
-
Theoretical and experimental studies of transport of micelle-solubilized solutes
-
Amidon GE, Higuchi WI, Ho NFH. Theoretical and experimental studies of transport of micelle-solubilized solutes. J. Pharm. Sci. 71(1), 77-84 (1982).
-
(1982)
J. Pharm. Sci.
, vol.71
, Issue.1
, pp. 77-84
-
-
Amidon, G.E.1
Higuchi, W.I.2
Ho, N.F.H.3
-
17
-
-
77649191330
-
Possible reduction of effective thickness of intestinal unstirred water layer by particle drifting effect
-
Sugano K. Possible reduction of effective thickness of intestinal unstirred water layer by particle drifting effect. Int. J. Pharm. 387(1-2), 103-109 (2010).
-
(2010)
Int. J. Pharm.
, vol.387
, Issue.1-2
, pp. 103-109
-
-
Sugano, K.1
-
18
-
-
0029610127
-
Mechanisms of absorption enhancement by medium chain fatty acids in intestinal epithelial caco-2 cell monolayers
-
Lindmark T, Nikkilä T, Artursson P. Mechanisms of absorption enhancement by medium chain fatty acids in intestinal epithelial caco-2 cell monolayers. J. Pharmacol. Exp. Ther. 275(2), 958-964 (1995).
-
(1995)
J. Pharmacol. Exp. Ther.
, vol.275
, Issue.2
, pp. 958-964
-
-
Lindmark, T.1
Nikkilä, T.2
Artursson, P.3
-
19
-
-
0028071051
-
Effect of chitosan on the permeability of monolayers of intestinal epithelial cells (caco-2)
-
Artursson P, Lindmark T, Davis SS, Illum L. Effect of chitosan on the permeability of monolayers of intestinal epithelial cells (caco-2). Pharm. Res. 11(9), 1358-1361 (1994).
-
(1994)
Pharm. Res.
, vol.11
, Issue.9
, pp. 1358-1361
-
-
Artursson, P.1
Lindmark, T.2
Davis, S.S.3
Illum, L.4
-
20
-
-
84857617880
-
Absorption enhancers: Applications and advances
-
Aungst BJ. Absorption enhancers: applications and advances. AAPS J. 14(1), 10-18 (2012).
-
(2012)
AAPS J.
, vol.14
, Issue.1
, pp. 10-18
-
-
Aungst, B.J.1
-
21
-
-
0028948839
-
A theoretical basis for a biopharmaceutic drug classification: The correlation of in vitro drug product dissolution and in vivo bioavailability
-
Amidon GL, Lennernaes H, Shah VP, Crison JR. A theoretical basis for a biopharmaceutic drug classification: The correlation of in vitro drug product dissolution and in vivo bioavailability. Pharm. Res. 12(3), 413-420 (1995).
-
(1995)
Pharm. Res.
, vol.12
, Issue.3
, pp. 413-420
-
-
Amidon, G.L.1
Lennernaes, H.2
Shah, V.P.3
Crison, J.R.4
-
24
-
-
51249095402
-
Use of the biopharmaceutical classification system in early drug development
-
Ku MS. Use of the biopharmaceutical classification system in early drug development. AAPS J. 10(1), 208-212 (2008).
-
(2008)
AAPS J.
, vol.10
, Issue.1
, pp. 208-212
-
-
Ku, M.S.1
-
25
-
-
4644231090
-
Biopharmaceutic classification system: A scientific framework for pharmacokinetic optimization in drug research
-
Varma MVS, Khandavilli S, Ashokraj Y et al. Biopharmaceutic classification system: A scientific framework for pharmacokinetic optimization in drug research. Curr. Drug Metabol. 5(5), 375-388 (2004).
-
(2004)
Curr. Drug Metabol.
, vol.5
, Issue.5
, pp. 375-388
-
-
Varma, M.V.S.1
Khandavilli, S.2
Ashokraj, Y.3
-
26
-
-
14744272833
-
The use of biopharmaceutic classification of drugs in drug discovery and development: Current status and future extension
-
Lennernäs H, Abrahamsson B. The use of biopharmaceutic classification of drugs in drug discovery and development: current status and future extension. J. Pharm. Pharmacol. 57(3), 273-285 (2005).
-
(2005)
J. Pharm. Pharmacol.
, vol.57
, Issue.3
, pp. 273-285
-
-
Lennernäs, H.1
Abrahamsson, B.2
-
28
-
-
0027473738
-
Estimating the fraction dose absorbed from suspensions of poorly soluble compounds in humans: A mathematical model
-
Oh D-M, Curl R, Amidon G. Estimating the fraction dose absorbed from suspensions of poorly soluble compounds in humans: A mathematical model. Pharm. Res. 10(2), 264-270 (1993).
-
(1993)
Pharm. Res.
, vol.10
, Issue.2
, pp. 264-270
-
-
Oh, D.-M.1
Curl, R.2
Amidon, G.3
-
29
-
-
17644380257
-
Predicting drug disposition via application of BCS: Transport/absorption/elimination interplay and development of a biopharmaceutics drug disposition classification system
-
Wu C-Y, Benet LZ. Predicting drug disposition via application of BCS: transport/absorption/elimination interplay and development of a biopharmaceutics drug disposition classification system. Pharm. Res. 22(1), 11-23 (2005).
-
(2005)
Pharm. Res.
, vol.22
, Issue.1
, pp. 11-23
-
-
Wu, C.-Y.1
Benet, L.Z.2
-
30
-
-
84898006099
-
Distinguishing between the permeability relationships with absorption and metabolism to improve BCS and BDDCS predictions in early drug discovery
-
Larregieu CA, Benet LZ. Distinguishing between the permeability relationships with absorption and metabolism to improve BCS and BDDCS predictions in early drug discovery. Mol. Pharm. 11(4), 1335-1344 (2014).
-
(2014)
Mol. Pharm.
, vol.11
, Issue.4
, pp. 1335-1344
-
-
Larregieu, C.A.1
Benet, L.Z.2
-
31
-
-
78049495059
-
The developability classification system: Application of biopharmaceutics concepts to formulation development
-
Butler JM, Dressman JB. The developability classification system: application of biopharmaceutics concepts to formulation development. J. Pharm. Sci. 99(12), 4940-4954 (2010).
-
(2010)
J. Pharm. Sci.
, vol.99
, Issue.12
, pp. 4940-4954
-
-
Butler, J.M.1
Dressman, J.B.2
-
32
-
-
84870665478
-
The role of BCS (biopharmaceutics classification system) and BDDCS (biopharmaceutics drug disposition classification system) in drug development
-
Benet LZ. The role of BCS (biopharmaceutics classification system) and BDDCS (biopharmaceutics drug disposition classification system) in drug development. J. Pharm. Sci. 102(1), 34-42 (2013).
-
(2013)
J. Pharm. Sci.
, vol.102
, Issue.1
, pp. 34-42
-
-
Benet, L.Z.1
-
33
-
-
0021185679
-
Phenytoin prodrugs III: Water-soluble prodrugs for oral and/or parenteral use
-
Varia SA, Schuller S, Sloan KB, Stella VJ. Phenytoin prodrugs III: water-soluble prodrugs for oral and/or parenteral use. J. Pharm. Sci. 73(8), 1068-1073 (1984).
-
(1984)
J. Pharm. Sci.
, vol.73
, Issue.8
, pp. 1068-1073
-
-
Varia, S.A.1
Schuller, S.2
Sloan, K.B.3
Stella, V.J.4
-
34
-
-
84875739359
-
Optimizing solubility and permeability of a biopharmaceutics classification system (BCS) class 4 antibiotic drug using lipophilic fragments disturbing the crystal lattice
-
Tehler U, Fagerberg JH, Svensson R, Larhed M, Artursson P, Bergstrom CA. Optimizing solubility and permeability of a biopharmaceutics classification system (BCS) class 4 antibiotic drug using lipophilic fragments disturbing the crystal lattice. J. Med. Chem. 56(6), 2690-2694 (2013).
-
(2013)
J. Med. Chem.
, vol.56
, Issue.6
, pp. 2690-2694
-
-
Tehler, U.1
Fagerberg, J.H.2
Svensson, R.3
Larhed, M.4
Artursson, P.5
Bergstrom, C.A.6
-
35
-
-
0024166436
-
The design and bioactivation of presystemically stable prodrugs
-
Svensson L-A, Tunek A. The design and bioactivation of presystemically stable prodrugs. Drug Metabol. Rev. 19(2), 165-194 (1988).
-
(1988)
Drug Metabol. Rev.
, vol.19
, Issue.2
, pp. 165-194
-
-
Svensson, L.-A.1
Tunek, A.2
-
36
-
-
84888382217
-
Inhibitory effect of hydroxypropyl methylcellulose acetate succinate on drug recrystallization from a supersaturated solution assessed using nuclear magnetic resonance measurements
-
Ueda K, Higashi K, Yamamoto K, Moribe K. Inhibitory effect of hydroxypropyl methylcellulose acetate succinate on drug recrystallization from a supersaturated solution assessed using nuclear magnetic resonance measurements. Mol. Pharm. 10(10), 3801-3811 (2013).
-
(2013)
Mol. Pharm.
, vol.10
, Issue.10
, pp. 3801-3811
-
-
Ueda, K.1
Higashi, K.2
Yamamoto, K.3
Moribe, K.4
-
37
-
-
84881358308
-
Formulation of a danazol cocrystal with controlled supersaturation plays an essential role in improving bioavailability
-
Childs SL, Kandi P, Lingireddy SR. Formulation of a danazol cocrystal with controlled supersaturation plays an essential role in improving bioavailability. Mol. Pharm. 10(8), 3112-3127 (2013).
-
(2013)
Mol. Pharm.
, vol.10
, Issue.8
, pp. 3112-3127
-
-
Childs, S.L.1
Kandi, P.2
Lingireddy, S.R.3
-
38
-
-
84881322355
-
Evaluation of the structural determinants of polymeric precipitation inhibitors using solvent shift methods and principle component ana-lysis
-
Warren DB, Bergström CAS, Benameur H, Porter CJH, Pouton CW. Evaluation of the structural determinants of polymeric precipitation inhibitors using solvent shift methods and principle component ana-lysis. Mol. Pharm. 10(8), 2823-2848 (2013).
-
(2013)
Mol. Pharm.
, vol.10
, Issue.8
, pp. 2823-2848
-
-
Warren, D.B.1
Bergström, C.A.S.2
Benameur, H.3
Porter, C.J.H.4
Pouton, C.W.5
-
39
-
-
84868233981
-
Application of mixtures of polymeric carriers for dissolution enhancement of oxeglitazar using hot-melt extrusion
-
Kalivoda A, Fischbach M, Kleinebudde P. Application of mixtures of polymeric carriers for dissolution enhancement of oxeglitazar using hot-melt extrusion. Int. J. Pharm. 439(1), 145-156 (2012).
-
(2012)
Int. J. Pharm.
, vol.439
, Issue.1
, pp. 145-156
-
-
Kalivoda, A.1
Fischbach, M.2
Kleinebudde, P.3
-
40
-
-
21644480172
-
Equilibria in non-electrolyte solutions in relation to the vapor pressures and densities of the components
-
Scatchard G. Equilibria in non-electrolyte solutions in relation to the vapor pressures and densities of the components. Chem. Rev. 8(2), 321-333 (1931).
-
(1931)
Chem. Rev.
, vol.8
, Issue.2
, pp. 321-333
-
-
Scatchard, G.1
-
41
-
-
0001085722
-
The linear free-energy relationship between partition coefficients and the aqueous solubility of organic liquids
-
Hansch C, Quinlan JE, Lawrence GL. The linear free-energy relationship between partition coefficients and the aqueous solubility of organic liquids. J. Organ. Chem. 33(1), 347-350 (1968).
-
(1968)
J. Organ. Chem.
, vol.33
, Issue.1
, pp. 347-350
-
-
Hansch, C.1
Quinlan, J.E.2
Lawrence, G.L.3
-
42
-
-
0019166075
-
Solubility and partitioning I: Solubility of nonelectrolytes in water
-
Yalkowsky SH, Valvani SC. Solubility and partitioning I: solubility of nonelectrolytes in water. J. Pharm. Sci. 69(8), 912-922 (1980).
-
(1980)
J. Pharm. Sci.
, vol.69
, Issue.8
, pp. 912-922
-
-
Yalkowsky, S.H.1
Valvani, S.C.2
-
43
-
-
0035263415
-
Prediction of drug solubility by the general solubility equation (GSE)
-
Ran Y, Yalkowsky SH. Prediction of drug solubility by the general solubility equation (GSE). J. Chem. Inf. Comp. Sci. 41(2), 354-357 (2001).
-
(2001)
J. Chem. Inf. Comp. Sci.
, vol.41
, Issue.2
, pp. 354-357
-
-
Ran, Y.1
Yalkowsky, S.H.2
-
44
-
-
0001158366
-
Die berechnung der wasserstoffzahl des blutes auf der freien und gebundenen kohlensaure desselben, und die sauerstoffbindung des blutes als funktion der wasserstoffzahl
-
Hasselbalch KA. Die berechnung der wasserstoffzahl des blutes auf der freien und gebundenen kohlensaure desselben, und die sauerstoffbindung des blutes als funktion der wasserstoffzahl. Biochem. Z 78, 112-144 (1916).
-
(1916)
Biochem. Z
, vol.78
, pp. 112-144
-
-
Hasselbalch, K.A.1
-
45
-
-
3242717497
-
Accuracy of calculated pH-dependent aqueous drug solubility
-
Bergström CAS, Luthman K, Artursson P. Accuracy of calculated pH-dependent aqueous drug solubility. Eur. J. Pharm. Sci. 22(5), 387-398 (2004).
-
(2004)
Eur. J. Pharm. Sci.
, vol.22
, Issue.5
, pp. 387-398
-
-
Bergström, C.A.S.1
Luthman, K.2
Artursson, P.3
-
46
-
-
34548039925
-
Solubility of sparingly-soluble ionizable drugs
-
Avdeef A. Solubility of sparingly-soluble ionizable drugs. Adv. Drug. Deliv. Rev. 59(7), 568-590 (2007).
-
(2007)
Adv. Drug. Deliv. Rev.
, vol.59
, Issue.7
, pp. 568-590
-
-
Avdeef, A.1
-
47
-
-
84945556967
-
Phosphate precipitates and water-soluble aggregates in re analyzed solubility-pH data of twenty-five basic drugs
-
Avdeef A. Phosphate precipitates and water-soluble aggregates in re analyzed solubility-pH data of twenty-five basic drugs. ADMET DMPK 2(1), 43-55 (2014).
-
(2014)
ADMET DMPK
, vol.2
, Issue.1
, pp. 43-55
-
-
Avdeef, A.1
-
48
-
-
33847095950
-
Solubility-excipient classification gradient maps
-
Avdeef A, Bendels S, Tsinman O, Tsinman K, Kansy M. Solubility-excipient classification gradient maps. Pharm. Res. 24(3), 530-545 (2007).
-
(2007)
Pharm. Res.
, vol.24
, Issue.3
, pp. 530-545
-
-
Avdeef, A.1
Bendels, S.2
Tsinman, O.3
Tsinman, K.4
Kansy, M.5
-
49
-
-
0021876419
-
Predictive relationships in the water solubility of salts of a nonsteroidal anti-inflammatory drug
-
Anderson B, Conradi R. Predictive relationships in the water solubility of salts of a nonsteroidal anti-inflammatory drug. J. Pharm. Sci. 74(8), 815-820 (1985).
-
(1985)
J. Pharm. Sci.
, vol.74
, Issue.8
, pp. 815-820
-
-
Anderson, B.1
Conradi, R.2
-
50
-
-
0021702316
-
General treatment of pH-solubility profiles of weak acids and bases and the effects of different acids on the solubility of a weak base
-
Streng WH, Hsi SK, Helms PE, Tan HG. General treatment of pH-solubility profiles of weak acids and bases and the effects of different acids on the solubility of a weak base. J. Pharm. Sci. 73(12), 1679-1684 (1984).
-
(1984)
J. Pharm. Sci.
, vol.73
, Issue.12
, pp. 1679-1684
-
-
Streng, W.H.1
Hsi, S.K.2
Helms, P.E.3
Tan, H.G.4
-
51
-
-
84945549374
-
Salt solubility products of diprenorphine hydrochloride, codeine and lidocaine hydrochlorides and phosphates-novel method of data analysis not dependent on explicit solubility equations
-
Völgyi G, Marosi A, Takács-Novák K, Avdeef A. Salt solubility products of diprenorphine hydrochloride, codeine and lidocaine hydrochlorides and phosphates-novel method of data analysis not dependent on explicit solubility equations. ADMET DMPK 1(4), 48-62 (2013).
-
(2013)
ADMET DMPK
, vol.1
, Issue.4
, pp. 48-62
-
-
Völgyi, G.1
Marosi, A.2
Takács-Novák, K.3
Avdeef, A.4
-
52
-
-
84899990647
-
Early pharmaceutical profiling to predict oral drug absorption: Current status and unmet needs
-
Bergström CAS, Holm R, Jørgensen SA et al. Early pharmaceutical profiling to predict oral drug absorption: current status and unmet needs. Eur. J. Pharm. Sci. 57(0), 173-199 (2014).
-
(2014)
Eur. J. Pharm. Sci.
, vol.57
, pp. 173-199
-
-
Bergström, C.A.S.1
Holm, R.2
Jørgensen, S.A.3
-
53
-
-
84879468832
-
In silico predictions of gastrointestinal drug absorption in pharmaceutical product development: Application of the mechanistic absorption model gi-sim
-
Sjögren E, Westergren J, Grant I et al. In silico predictions of gastrointestinal drug absorption in pharmaceutical product development: application of the mechanistic absorption model gi-sim. Eur. J. Pharm. Sci. 49(4), 679-698 (2013).
-
(2013)
Eur. J. Pharm. Sci.
, vol.49
, Issue.4
, pp. 679-698
-
-
Sjögren, E.1
Westergren, J.2
Grant, I.3
-
54
-
-
85153864330
-
Investigation and prediction of small intestinal precipitation of poorly soluble drugs: A study involving in silico, in vitro and in vivo assessment
-
Carlert S. Investigation and prediction of small intestinal precipitation of poorly soluble drugs: A study involving in silico, in vitro and in vivo assessment. Acta Univ. Ups. 164, 1651-6192 (2012).
-
(2012)
Acta Univ. Ups.
, vol.164
, pp. 1651-6192
-
-
Carlert, S.1
-
55
-
-
84899957723
-
Is the full potential of the biopharmaceutics classification system reached?
-
Bergström CAS, Andersson SBE, Fagerberg JH, Ragnarsson G, Lindahl A. Is the full potential of the biopharmaceutics classification system reached? Eur. J. Pharm. Sci. 57, 224-231 (2014).
-
(2014)
Eur. J. Pharm. Sci.
, vol.57
, pp. 224-231
-
-
Bergström, C.A.S.1
Andersson, S.B.E.2
Fagerberg, J.H.3
Ragnarsson, G.4
Lindahl, A.5
-
56
-
-
0034916430
-
The BCS: Where do we go from here?
-
Dressman J, Butler J, Hempenstall J, Reppas C. The BCS: where do we go from here? Pharm. Technol. 25(7), 68-77 (2001).
-
(2001)
Pharm. Technol.
, vol.25
, Issue.7
, pp. 68-77
-
-
Dressman, J.1
Butler, J.2
Hempenstall, J.3
Reppas, C.4
-
57
-
-
1242337282
-
The "high solubility" definition of the current FDA guidance on biopharmaceutical classification system may be too strict for acidic drugs
-
Yazdanian M, Briggs K, Jankovsky C, Hawi A. The "high solubility" definition of the current FDA guidance on biopharmaceutical classification system may be too strict for acidic drugs. Pharm. Res. 21(2), 293-299 (2004).
-
(2004)
Pharm. Res.
, vol.21
, Issue.2
, pp. 293-299
-
-
Yazdanian, M.1
Briggs, K.2
Jankovsky, C.3
Hawi, A.4
-
59
-
-
84899945997
-
The biopharmaceutics classification system: Subclasses for in vivo predictive dissolution (IPD) methodology and ivivc
-
Tsume Y, Mudie DM, Langguth P, Amidon GE, Amidon GL. The biopharmaceutics classification system: subclasses for in vivo predictive dissolution (IPD) methodology and ivivc. Eur. J. Pharm. Sci. 57, 152-163 (2014).
-
(2014)
Eur. J. Pharm. Sci.
, vol.57
, pp. 152-163
-
-
Tsume, Y.1
Mudie, D.M.2
Langguth, P.3
Amidon, G.E.4
Amidon, G.L.5
-
60
-
-
84899631569
-
A review of drug solubility in human intestinal fluids: Implications for the prediction of oral absorption
-
Augustijns P, Wuyts B, Hens B, Annaert P, Butler J, Brouwers J. A review of drug solubility in human intestinal fluids: implications for the prediction of oral absorption. Eur. J. Pharm. Sci. 57(0), 322-332 (2014).
-
(2014)
Eur. J. Pharm. Sci.
, vol.57
, pp. 322-332
-
-
Augustijns, P.1
Wuyts, B.2
Hens, B.3
Annaert, P.4
Butler, J.5
Brouwers, J.6
-
61
-
-
77957738361
-
Simulating fasted human intestinal fluids: Understanding the roles of lecithin and bile acids
-
Söderlind E, Karlsson E, Carlsson A et al. Simulating fasted human intestinal fluids: understanding the roles of lecithin and bile acids. Mol. Pharm. 7(5), 1498-1507 (2010).
-
(2010)
Mol. Pharm.
, vol.7
, Issue.5
, pp. 1498-1507
-
-
Söderlind, E.1
Karlsson, E.2
Carlsson, A.3
-
63
-
-
29244445764
-
The effects of food on the dissolution of poorly soluble drugs in human and in model small intestinal fluids
-
Persson EM, Gustafsson AS, Carlsson AS et al. The effects of food on the dissolution of poorly soluble drugs in human and in model small intestinal fluids. Pharm. Res. 22(12), 2141-2151 (2005).
-
(2005)
Pharm. Res.
, vol.22
, Issue.12
, pp. 2141-2151
-
-
Persson, E.M.1
Gustafsson, A.S.2
Carlsson, A.S.3
-
64
-
-
33646433407
-
A clinical single-pass perfusion investigation of the dynamic in vivo secretory response to a dietary meal in human proximal small intestine
-
Persson EM, Nilsson RG, Hansson GI et al. A clinical single-pass perfusion investigation of the dynamic in vivo secretory response to a dietary meal in human proximal small intestine. Pharm. Res. 23(4), 742-751 (2006).
-
(2006)
Pharm. Res.
, vol.23
, Issue.4
, pp. 742-751
-
-
Persson, E.M.1
Nilsson, R.G.2
Hansson, G.I.3
-
65
-
-
33845978357
-
Simultaneous assessment of lipid classes and bile acids in human intestinal fluid by solid-Phase extraction and hplc methods
-
Persson E, Löfgren L, Hansson G, Abrahamsson B, Lennernäs H, Nilsson R. Simultaneous assessment of lipid classes and bile acids in human intestinal fluid by solid-Phase extraction and hplc methods. J. Lipid Res. 48(1), 242-251 (2007).
-
(2007)
J. Lipid Res.
, vol.48
, Issue.1
, pp. 242-251
-
-
Persson, E.1
Löfgren, L.2
Hansson, G.3
Abrahamsson, B.4
Lennernäs, H.5
Nilsson, R.6
-
66
-
-
33747049558
-
Characterization of fasted-state human intestinal fluids collected from duodenum and jejunum
-
Perez De La Cruz Moreno M, Oth M, Deferme S et al. Characterization of fasted-state human intestinal fluids collected from duodenum and jejunum. J. Pharm. Pharmacol. 58(8), 1079-1089 (2006).
-
(2006)
J. Pharm. Pharmacol.
, vol.58
, Issue.8
, pp. 1079-1089
-
-
De La Cruz, P.M.M.1
Oth, M.2
Deferme, S.3
-
67
-
-
79960592269
-
Use of conventional surfactant media as surrogates for FaSSIF in simulating in vivo dissolution of BCS class II drugs
-
Lehto P, Kortejärvi H, Liimatainen A et al. Use of conventional surfactant media as surrogates for FaSSIF in simulating in vivo dissolution of BCS class II drugs. Eur. J. Pharm. Biopharm. 78(3), 531-538 (2011).
-
(2011)
Eur. J. Pharm. Biopharm.
, vol.78
, Issue.3
, pp. 531-538
-
-
Lehto, P.1
Kortejärvi, H.2
Liimatainen, A.3
-
68
-
-
77958610023
-
Can biorelevant media be simplified by using SLS and Tween 80 to replace bile compounds?
-
Taupitz T, Klein S. Can biorelevant media be simplified by using SLS and Tween 80 to replace bile compounds? Open Drug Deliv. J. 4(1), 30-37 (2010).
-
(2010)
Open Drug Deliv. J.
, vol.4
, Issue.1
, pp. 30-37
-
-
Taupitz, T.1
Klein, S.2
-
69
-
-
84962094390
-
Simplified biorelevant media for screening dissolution performance of poorly soluble drugs
-
Zoeller T, Klein S. Simplified biorelevant media for screening dissolution performance of poorly soluble drugs. Dissol. Technol. 14(4), 8-13 (2007).
-
(2007)
Dissol. Technol.
, vol.14
, Issue.4
, pp. 8-13
-
-
Zoeller, T.1
Klein, S.2
-
70
-
-
32644443825
-
Biorelevant dissolution media: Aggregation of amphiphiles and solubility of estradiol
-
Ilardia-Arana D, Kristensen HG, Müllertz A. Biorelevant dissolution media: aggregation of amphiphiles and solubility of estradiol. J. Pharm. Sci. 95(2), 248-255 (2006).
-
(2006)
J. Pharm. Sci.
, vol.95
, Issue.2
, pp. 248-255
-
-
Ilardia-Arana, D.1
Kristensen, H.G.2
Müllertz, A.3
-
71
-
-
44749087279
-
Dissolution media simulating conditions in the proximal human gastrointestinal tract: An update
-
Jantratid E, Janssen N, Reppas C, Dressman JB. Dissolution media simulating conditions in the proximal human gastrointestinal tract: an update. Pharm. Res. 25(7), 1663-1676 (2008).
-
(2008)
Pharm. Res.
, vol.25
, Issue.7
, pp. 1663-1676
-
-
Jantratid, E.1
Janssen, N.2
Reppas, C.3
Dressman, J.B.4
-
72
-
-
0032852499
-
Some relationships between the physical properties of various 3-acyloxymethyl prodrugs of phenytoin to structure: Potential in vivo performance implications
-
Stella VJ, Martodihardjo S, Terada K, Rao VM. Some relationships between the physical properties of various 3-acyloxymethyl prodrugs of phenytoin to structure: Potential in vivo performance implications. J. Pharm. Sci. 88(10), 1100 (1999).
-
(1999)
J. Pharm. Sci.
, vol.88
, Issue.10
, pp. 1100
-
-
Stella, V.J.1
Martodihardjo, S.2
Terada, K.3
Rao, V.M.4
-
73
-
-
14144250013
-
In vivo in vitro correlations for a poorly soluble drug, danazol, using the flow-through dissolution method with biorelevant dissolution media
-
Sunesen VH, Pedersen BL, Kristensen HG, Müllertz A. In vivo in vitro correlations for a poorly soluble drug, danazol, using the flow-through dissolution method with biorelevant dissolution media. Eur. J. Pharm. Sci. 24(4), 305-313 (2005).
-
(2005)
Eur. J. Pharm. Sci.
, vol.24
, Issue.4
, pp. 305-313
-
-
Sunesen, V.H.1
Pedersen, B.L.2
Kristensen, H.G.3
Müllertz, A.4
-
74
-
-
0031750861
-
Evaluation of various dissolution media for predicting in vivo performance of class i and II drugs
-
Galia E, Nicolaides E, Hörter D, Löbenberg R, Reppas C, Dressman JB. Evaluation of various dissolution media for predicting in vivo performance of class I and II drugs. Pharm. Res. 15, 698-705 (1998).
-
(1998)
Pharm. Res.
, vol.15
, pp. 698-705
-
-
Galia, E.1
Nicolaides, E.2
Hörter, D.3
Löbenberg, R.4
Reppas, C.5
Dressman, J.B.6
-
75
-
-
0019622519
-
Composition of soybean lecithin
-
Scholfield CR. Composition of soybean lecithin. J. Am. Oil Chem. Soc. 58(10), 889-892 (1981).
-
(1981)
J. Am. Oil Chem. Soc.
, vol.58
, Issue.10
, pp. 889-892
-
-
Scholfield, C.R.1
-
76
-
-
21544447265
-
Simulation of fasting gastric conditions and its importance for the in vivo dissolution of lipophilic compounds
-
Vertzoni M, Dressman J, Butler J, Hempenstall J, Reppas C. Simulation of fasting gastric conditions and its importance for the in vivo dissolution of lipophilic compounds. Eur. J. Pharm. Biopharm. 60(3), 413-417 (2005).
-
(2005)
Eur. J. Pharm. Biopharm.
, vol.60
, Issue.3
, pp. 413-417
-
-
Vertzoni, M.1
Dressman, J.2
Butler, J.3
Hempenstall, J.4
Reppas, C.5
-
77
-
-
33947348032
-
On the behavior of lecithin with bile salts, and the occurence of lecithin in bile
-
Long JH, Gephart F. On the behavior of lecithin with bile salts, and the occurence of lecithin in bile. J. Am. Chem. Soc. 30(8), 1312-1319 (1908).
-
(1908)
J. Am. Chem. Soc.
, vol.30
, Issue.8
, pp. 1312-1319
-
-
Long, J.H.1
Gephart, F.2
-
78
-
-
0014686224
-
Studies on simple and mixed bile salt micelles by nuclear magnetic resonance spectroscopy
-
Small DM, Penkett SA, Chapman D. Studies on simple and mixed bile salt micelles by nuclear magnetic resonance spectroscopy. Biochim. Biophys. Acta 176(1), 178-189 (1969).
-
(1969)
Biochim. Biophys. Acta
, vol.176
, Issue.1
, pp. 178-189
-
-
Small, D.M.1
Penkett, S.A.2
Chapman, D.3
-
80
-
-
33845378455
-
Micelle to vesicle transition in aqueous solutions of bile salt and lecithin
-
Schurtenberger P, Mazer N, Kaenzig W. Micelle to vesicle transition in aqueous solutions of bile salt and lecithin. J. Phys. Chem. 89(6), 1042-1049 (1985).
-
(1985)
J. Phys. Chem.
, vol.89
, Issue.6
, pp. 1042-1049
-
-
Schurtenberger, P.1
Mazer, N.2
Kaenzig, W.3
-
81
-
-
0032552891
-
Laser light scattering evidence for a common wormlike growth structure of mixed micelles in bile salt-and straight-chain detergent-phosphatidylcholine aqueous systems: Relevance to the micellar structure of bile
-
Cohen DE, Thurston GM, Chamberlin RA, Benedek GB, Carey MC. Laser light scattering evidence for a common wormlike growth structure of mixed micelles in bile salt-and straight-chain detergent-phosphatidylcholine aqueous systems: relevance to the micellar structure of bile. Biochemistry 37(42), 14798-14814 (1998).
-
(1998)
Biochemistry
, vol.37
, Issue.42
, pp. 14798-14814
-
-
Cohen, D.E.1
Thurston, G.M.2
Chamberlin, R.A.3
Benedek, G.B.4
Carey, M.C.5
-
82
-
-
33751390781
-
Organization of phosphatidylcholine and bile salt in rodlike mixed micelles
-
Hjelm RP Jr, Thiyagarajan P, Alkan-Onyuksel H. Organization of phosphatidylcholine and bile salt in rodlike mixed micelles. J. Phys. Chem. 96(21), 8653-8661 (1992).
-
(1992)
J. Phys. Chem.
, vol.96
, Issue.21
, pp. 8653-8661
-
-
Hjelm, R.P.1
Thiyagarajan, P.2
Alkan-Onyuksel, H.3
-
83
-
-
70349507792
-
Instant FaSSIF and FeSSIF-biorelevance meets practicality
-
Boni JE, Brickl RS, Dressman J, Pfefferle ML. Instant FaSSIF and FeSSIF-biorelevance meets practicality. Dissolution Technol. 16(3), 41-45 (2009).
-
(2009)
Dissolution Technol.
, vol.16
, Issue.3
, pp. 41-45
-
-
Boni, J.E.1
Brickl, R.S.2
Dressman, J.3
Pfefferle, M.L.4
-
84
-
-
82955240717
-
Liposome formation from bile salt-lipid micelles in the digestion and drug delivery model FaSSIF(mod) estimated by combined time-resolved neutron and dynamic light scattering
-
Nawroth T, Buch P, Buch K, Langguth P, Schweins R. Liposome formation from bile salt-lipid micelles in the digestion and drug delivery model FaSSIF(mod) estimated by combined time-resolved neutron and dynamic light scattering. Mol. Pharm. 8(6), 2162-2172 (2011).
-
(2011)
Mol. Pharm.
, vol.8
, Issue.6
, pp. 2162-2172
-
-
Nawroth, T.1
Buch, P.2
Buch, K.3
Langguth, P.4
Schweins, R.5
-
85
-
-
78649714856
-
Study of a standardized taurocholatelecithin powder for preparing the biorelevant media FeSSIF and FaSSIF
-
Kloefer B, Van Hoogevest P, Moloney R, Kuentz M, Leigh MLS, Dressman J. Study of a standardized taurocholatelecithin powder for preparing the biorelevant media FeSSIF and FaSSIF. Dissolution Technol. 17(3), 6-13 (2010).
-
(2010)
Dissolution Technol.
, vol.17
, Issue.3
, pp. 6-13
-
-
Kloefer, B.1
Van Hoogevest, P.2
Moloney, R.3
Kuentz, M.4
Leigh, M.L.S.5
Dressman, J.6
-
86
-
-
84890565421
-
Computational prediction of drug solubility in lipid based formulation excipients
-
Persson LC, Porter CJH, Charman WN, Bergström CAS. Computational prediction of drug solubility in lipid based formulation excipients. Pharm. Res. 30(12), 3225-3237 (2013).
-
(2013)
Pharm. Res.
, vol.30
, Issue.12
, pp. 3225-3237
-
-
Persson, L.C.1
Porter, C.J.H.2
Charman, W.N.3
Bergström, C.A.S.4
-
87
-
-
0036179239
-
Experimental and computational screening models for prediction of aqueous drug solubility
-
Bergström CAS, Norinder U, Luthman K, Artursson P. Experimental and computational screening models for prediction of aqueous drug solubility. Pharm. Res. 19(2), 182-188 (2002).
-
(2002)
Pharm. Res.
, vol.19
, Issue.2
, pp. 182-188
-
-
Bergström, C.A.S.1
Norinder, U.2
Luthman, K.3
Artursson, P.4
-
88
-
-
53849114636
-
Miniaturized rotating disk intrinsic dissolution rate measurement: Effects of buffer capacity in comparisons to traditional wood's apparatus
-
Avdeef A, Tsinman O. Miniaturized rotating disk intrinsic dissolution rate measurement: effects of buffer capacity in comparisons to traditional wood's apparatus. Pharm. Res. 25(11), 2613-2627 (2008).
-
(2008)
Pharm. Res.
, vol.25
, Issue.11
, pp. 2613-2627
-
-
Avdeef, A.1
Tsinman, O.2
-
89
-
-
84863318320
-
Ethanol effects on apparent solubility of poorly soluble drugs in simulated intestinal fluid
-
Fagerberg JH, Al-Tikriti Y, Ragnarsson G, BergströM CAS. Ethanol effects on apparent solubility of poorly soluble drugs in simulated intestinal fluid. Mol. Pharm. 9(7), 1942-1952 (2012).
-
(2012)
Mol. Pharm.
, vol.9
, Issue.7
, pp. 1942-1952
-
-
Fagerberg, J.H.1
Al-Tikriti, Y.2
Ragnarsson, G.3
BergströM, C.A.S.4
-
90
-
-
77957736510
-
Dissolution rate and apparent solubility of poorly soluble drugs in biorelevant dissolution media
-
Fagerberg JH, Tsinman O, Sun N, Tsinman K, Avdeef A, Bergström CAS. Dissolution rate and apparent solubility of poorly soluble drugs in biorelevant dissolution media. Mol. Pharm. 7(5), 1419-1430 (2010).
-
(2010)
Mol. Pharm.
, vol.7
, Issue.5
, pp. 1419-1430
-
-
Fagerberg, J.H.1
Tsinman, O.2
Sun, N.3
Tsinman, K.4
Avdeef, A.5
Bergström, C.A.S.6
-
91
-
-
84906319769
-
Assessing the impact of polymers on the pH-induced precipitation behavior of poorly water soluble compounds using synchrotron wide angle x-ray scattering
-
Hsieh Y-L, Box K, Taylor LS. Assessing the impact of polymers on the pH-induced precipitation behavior of poorly water soluble compounds using synchrotron wide angle x-ray scattering. J. Pharm. Sci. 103(9), 2724-2735 (2014).
-
(2014)
J. Pharm. Sci.
, vol.103
, Issue.9
, pp. 2724-2735
-
-
Hsieh, Y.-L.1
Box, K.2
Taylor, L.S.3
-
92
-
-
84866733801
-
PH-induced precipitation behavior of weakly basic compounds: Determination of extent and duration of supersaturation using potentiometric titration and correlation to solid state properties
-
Hsieh Y-L, Ilevbare GA, Van Eerdenbrugh B, Box KJ, Sanchez-Felix MV, Taylor LS. pH-induced precipitation behavior of weakly basic compounds: determination of extent and duration of supersaturation using potentiometric titration and correlation to solid state properties. Pharm. Res. 29(10), 2738-2753 (2012).
-
(2012)
Pharm. Res.
, vol.29
, Issue.10
, pp. 2738-2753
-
-
Hsieh, Y.-L.1
Ilevbare, G.A.2
Van Eerdenbrugh, B.3
Box, K.J.4
Sanchez-Felix, M.V.5
Taylor, L.S.6
-
93
-
-
84921441274
-
Computational prediction of drug solubility in fasted simulated and aspirated human intestinal fluid
-
Fagerberg JH, Karlsson E, Ulander J, Hanisch G, Bergström CAS. Computational prediction of drug solubility in fasted simulated and aspirated human intestinal fluid. Pharm. Res. 32(2), 578-589 (2015).
-
(2015)
Pharm. Res.
, vol.32
, Issue.2
, pp. 578-589
-
-
Fagerberg, J.H.1
Karlsson, E.2
Ulander, J.3
Hanisch, G.4
Bergström, C.A.S.5
-
95
-
-
77956228736
-
Computational oral absorption simulation of free base drugs
-
Sugano K. Computational oral absorption simulation of free base drugs. Int. J. Pharm. 398(1), 73-82 (2010).
-
(2010)
Int. J. Pharm.
, vol.398
, Issue.1
, pp. 73-82
-
-
Sugano, K.1
-
96
-
-
77957738213
-
A modified physiological BCS for prediction of intestinal absorption in drug discovery
-
Zaki NM, Artursson P, Bergström CAS. A modified physiological BCS for prediction of intestinal absorption in drug discovery. Mol. Pharm. 7(5), 1478-1487 (2010).
-
(2010)
Mol. Pharm.
, vol.7
, Issue.5
, pp. 1478-1487
-
-
Zaki, N.M.1
Artursson, P.2
Bergström, C.A.S.3
-
97
-
-
84883767546
-
Solubility profiling of HIV protease inhibitors in human intestinal fluids
-
Wuyts B, Brouwers J, Mols R, Tack J, Annaert P, Augustijns P. Solubility profiling of hiv protease inhibitors in human intestinal fluids. J. Pharm. Sci. 102(10), 3800-3807 (2013).
-
(2013)
J. Pharm. Sci.
, vol.102
, Issue.10
, pp. 3800-3807
-
-
Wuyts, B.1
Brouwers, J.2
Mols, R.3
Tack, J.4
Annaert, P.5
Augustijns, P.6
-
98
-
-
0033452575
-
Forecasting the in vivo performance of four low solubility drugs from their in vitro dissolution data
-
Nicolaides E, Galia E, Efthymiopoulos C, Dressman JB, Reppas C. Forecasting the in vivo performance of four low solubility drugs from their in vitro dissolution data. Pharm. Res. 16(12), 1876-1882 (1999).
-
(1999)
Pharm. Res.
, vol.16
, Issue.12
, pp. 1876-1882
-
-
Nicolaides, E.1
Galia, E.2
Efthymiopoulos, C.3
Dressman, J.B.4
Reppas, C.5
-
99
-
-
79151476463
-
Fraction of a dose absorbed estimation for structurally diverse low solubility compounds
-
Sugano K. Fraction of a dose absorbed estimation for structurally diverse low solubility compounds. Int. J. Pharm. 405(1-2), 79-89 (2011).
-
(2011)
Int. J. Pharm.
, vol.405
, Issue.1-2
, pp. 79-89
-
-
Sugano, K.1
-
100
-
-
79151482028
-
Equilibrium drug solubility measurements in 96-well plates reveal similar drug solubilities in phosphate buffer pH 6. 8 and human intestinal fluid
-
Heikkilä T, Karjalainen M, Ojala K et al. Equilibrium drug solubility measurements in 96-well plates reveal similar drug solubilities in phosphate buffer pH 6.8 and human intestinal fluid. Int. J. Pharm. 405(1), 132-136 (2011).
-
(2011)
Int. J. Pharm.
, vol.405
, Issue.1
, pp. 132-136
-
-
Heikkilä, T.1
Karjalainen, M.2
Ojala, K.3
-
101
-
-
79959606451
-
Intestinal drug solubility estimation based on simulated intestinal fluids: Comparison with solubility in human intestinal fluids
-
Clarysse S, Brouwers J, Tack J, Annaert P, Augustijns P. Intestinal drug solubility estimation based on simulated intestinal fluids: comparison with solubility in human intestinal fluids. Eur. J. Pharm. Sci. 43(4), 260-269 (2011).
-
(2011)
Eur. J. Pharm. Sci.
, vol.43
, Issue.4
, pp. 260-269
-
-
Clarysse, S.1
Brouwers, J.2
Tack, J.3
Annaert, P.4
Augustijns, P.5
-
102
-
-
73749083820
-
Ex vivo permeability experiments in excised rat intestinal tissue and in vitro solubility measurements in aspirated human intestinal fluids support age-dependent oral drug absorption
-
Annaert P, Brouwers J, Bijnens A, Lammert F, Tack J, Augustijns P. Ex vivo permeability experiments in excised rat intestinal tissue and in vitro solubility measurements in aspirated human intestinal fluids support age-dependent oral drug absorption. Eur. J. Pharm. Sci. 39(1), 15-22 (2010).
-
(2010)
Eur. J. Pharm. Sci.
, vol.39
, Issue.1
, pp. 15-22
-
-
Annaert, P.1
Brouwers, J.2
Bijnens, A.3
Lammert, F.4
Tack, J.5
Augustijns, P.6
-
103
-
-
77957744142
-
Drug solubility in luminal fluids from different regions of the small and large intestine of humans
-
Fadda HM, Sousa T, Carlsson AS et al. Drug solubility in luminal fluids from different regions of the small and large intestine of humans. Mol. Pharm. 7(5), 1527-1532 (2010).
-
(2010)
Mol. Pharm.
, vol.7
, Issue.5
, pp. 1527-1532
-
-
Fadda, H.M.1
Sousa, T.2
Carlsson, A.S.3
-
104
-
-
67349204296
-
Postprandial changes in solubilizing capacity of human intestinal fluids for BCS class II drugs
-
Clarysse S, Psachoulias D, Brouwers J et al. Postprandial changes in solubilizing capacity of human intestinal fluids for BCS class II drugs. Pharm. Res. 26(6), 1456-1466 (2009).
-
(2009)
Pharm. Res.
, vol.26
, Issue.6
, pp. 1456-1466
-
-
Clarysse, S.1
Psachoulias, D.2
Brouwers, J.3
-
105
-
-
77956008536
-
In situ intestinal perfusion in knockout mice demonstrates inhibition of intestinal p-glycoprotein by ritonavir causing increased darunavir absorption
-
Holmstock N, Mols R, Annaert P, Augustijns P. In situ intestinal perfusion in knockout mice demonstrates inhibition of intestinal p-glycoprotein by ritonavir causing increased darunavir absorption. Drug Metab. Dispos. 38(9), 1407-1410 (2010).
-
(2010)
Drug Metab. Dispos.
, vol.38
, Issue.9
, pp. 1407-1410
-
-
Holmstock, N.1
Mols, R.2
Annaert, P.3
Augustijns, P.4
-
106
-
-
79955716668
-
Profiling and trend analysis of food effects on oral drug absorption considering micelle interaction and solubilization by bile micelles
-
Kawai Y, Fujii Y, Tabata F et al. Profiling and trend analysis of food effects on oral drug absorption considering micelle interaction and solubilization by bile micelles. Drug Metabol. Pharmacokinet. 26(2), 180-191 (2011).
-
(2011)
Drug Metabol. Pharmacokinet.
, vol.26
, Issue.2
, pp. 180-191
-
-
Kawai, Y.1
Fujii, Y.2
Tabata, F.3
-
107
-
-
77955992769
-
Drug supersaturation in simulated and human intestinal fluids representing different nutritional states
-
Bevernage J, Brouwers J, Clarysse S et al. Drug supersaturation in simulated and human intestinal fluids representing different nutritional states. J. Pharm. Sci. 99(11), 4525-4534 (2010).
-
(2010)
J. Pharm. Sci.
, vol.99
, Issue.11
, pp. 4525-4534
-
-
Bevernage, J.1
Brouwers, J.2
Clarysse, S.3
-
108
-
-
84879275084
-
Biorelevant solubility of poorly soluble drugs: Rivaroxaban, furosemide, papaverine and niflumic acid
-
Takács-Novák K, Szoke V, Völgyi G et al. Biorelevant solubility of poorly soluble drugs: rivaroxaban, furosemide, papaverine and niflumic acid. J. Pharm. Biomed. Anal. 83, 279-285 (2013).
-
(2013)
J. Pharm. Biomed. Anal.
, vol.83
, pp. 279-285
-
-
Takács-Novák, K.1
Szoke, V.2
Völgyi, G.3
-
109
-
-
34547127889
-
Pharmacokinetics of gefitinib in humans: The influence of gastrointestinal factors
-
Bergman E, Forsell P, Persson EM et al. Pharmacokinetics of gefitinib in humans: The influence of gastrointestinal factors. Int. J. Pharm. 341(1-2), 134-142 (2007).
-
(2007)
Int. J. Pharm.
, vol.341
, Issue.1-2
, pp. 134-142
-
-
Bergman, E.1
Forsell, P.2
Persson, E.M.3
-
110
-
-
84874936574
-
Exploring food effects on indinavir absorption with human intestinal fluids in the mouse intestine
-
Holmstock N, Bruyn TD, Bevernage J et al. Exploring food effects on indinavir absorption with human intestinal fluids in the mouse intestine. Eur. J. Pharm. Sci. 49(1), 27-32 (2013).
-
(2013)
Eur. J. Pharm. Sci.
, vol.49
, Issue.1
, pp. 27-32
-
-
Holmstock, N.1
Bruyn, T.D.2
Bevernage, J.3
-
111
-
-
77957371289
-
Predicting intestinal precipitation-A case example for a basic BCS class II drug
-
Carlert S, Palsson A, Hanisch G et al. Predicting intestinal precipitation-A case example for a basic BCS class II drug. Pharm. Res. 27(10), 2119-2130 (2010).
-
(2010)
Pharm. Res.
, vol.27
, Issue.10
, pp. 2119-2130
-
-
Carlert, S.1
Palsson, A.2
Hanisch, G.3
-
112
-
-
0022538998
-
Transit of pharmaceutical dosage forms through the small intestine
-
Davis S, Hardy J, Fara J. Transit of pharmaceutical dosage forms through the small intestine. Gut 27(8), 886-892 (1986).
-
(1986)
Gut
, vol.27
, Issue.8
, pp. 886-892
-
-
Davis, S.1
Hardy, J.2
Fara, J.3
-
113
-
-
0020540487
-
Regulation of the gastric emptying of glucose
-
Brener W, Hendrix TR, Mchugh PR. Regulation of the gastric emptying of glucose. Gastroenterology 85(1), 76-82 (1983).
-
(1983)
Gastroenterology
, vol.85
, Issue.1
, pp. 76-82
-
-
Brener, W.1
Hendrix, T.R.2
Mchugh, P.R.3
-
114
-
-
0020692519
-
Diagnostic value of serum bile acids and routine liver function tests in hepatobiliary diseases-sensitivity, specificity, and predictive value
-
Ferraris R, Colombatti G, Fiorentini MT, Carosso R, Arossa W, De La Pierre M. Diagnostic value of serum bile acids and routine liver function tests in hepatobiliary diseases-sensitivity, specificity, and predictive value. Digest. Dis. Sci. 28(2), 129-136 (1983).
-
(1983)
Digest. Dis. Sci.
, vol.28
, Issue.2
, pp. 129-136
-
-
Ferraris, R.1
Colombatti, G.2
Fiorentini, M.T.3
Carosso, R.4
Arossa, W.5
De La Pierre, M.6
-
115
-
-
35348860160
-
Modeling gastrointestinal drug absorption requires more in vivo biopharmaceutical data: Experience from in vivo dissolution and permeability studies in humans
-
Lennernäs H. Modeling gastrointestinal drug absorption requires more in vivo biopharmaceutical data: experience from in vivo dissolution and permeability studies in humans. Curr. Drug Metabol. 8(7), 645-657 (2007).
-
(2007)
Curr. Drug Metabol.
, vol.8
, Issue.7
, pp. 645-657
-
-
Lennernäs, H.1
-
116
-
-
84877037504
-
Early drug development predictions of glass-forming ability and physical stability of drugs
-
Mahlin D, Bergström CAS. Early drug development predictions of glass-forming ability and physical stability of drugs. Eur. J. Pharm. Sci. 49(2), 323-332 (2013).
-
(2013)
Eur. J. Pharm. Sci.
, vol.49
, Issue.2
, pp. 323-332
-
-
Mahlin, D.1
Bergström, C.A.S.2
|