Drug solubility in luminal fluids from different regions of the small and large intestine of humans

Molecular Pharmaceutics

Volumn 7, Issue 5, 2010, Pages 1527-1532

  Fadda, H M ^a   Sousa, T ^a   Carlsson, A S ^b   Abrahamsson, B ^b   Williams, J G ^c   Kumar, D ^d   Basit, A W ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b ASTRAZENECA R AND D   (Sweden)

^c SWANSEA UNIVERSITY   (United Kingdom)

^d ST GEORGE S HOSPITAL   (United Kingdom)

Author keywords

Biopharmaceutics Classification System (BCS); colostomy; controlled release; ileostomy; lumen; mesalazine; surfactant

Indexed keywords

BUFFER; MESALAZINE; PHOSPHATIDYLCHOLINE; PREDNISOLONE; TAUROCHOLIC ACID;

ARTICLE; ASCENDING COLON; COLOSTOMY; CONTROLLED STUDY; CORRELATION ANALYSIS; DESCENDING COLON; DRUG SOLUBILITY; HUMAN; ILEOSTOMY; ILEUM; INTESTINE FLUID; JEJUNUM; LIPOPHILICITY; PH; PKA; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; TRANSVERSE COLON;

BIOLOGICAL AVAILABILITY; BODY FLUIDS; BUFFERS; CHEMISTRY, PHARMACEUTICAL; HUMANS; HYDROGEN-ION CONCENTRATION; INTESTINAL ABSORPTION; INTESTINE, LARGE; INTESTINE, SMALL; MESALAMINE; MODELS, BIOLOGICAL; PHARMACOKINETICS; PREDNISOLONE; SOLUBILITY;

EID: 77957744142     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp100198q     Document Type: Article

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