Computational prediction of drug solubility in fasted simulated and aspirated human intestinal fluid

Pharmaceutical Research

Volumn 32, Issue 2, 2015, Pages 578-589

  Fagerberg, Jonas H ^a   Karlsson, Eva ^b   Ulander, Johan ^b   Hanisch, Gunilla ^b   Bergström, Christel A S ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b ASTRAZENECA R AND D   (Sweden)

Author keywords

Biorelevant solubility; Human intestinal fluid; In silico; Prediction; Simulated intestinal fluid

Indexed keywords

ARTICLE; CHEMICAL STRUCTURE; COMPUTATIONAL PREDICTION; COMPUTER MODEL; CONTROLLED STUDY; DRUG SOLUBILITY; HUMAN; INTESTINE FLUID; LIPOPHILICITY; MEASUREMENT ACCURACY; MELTING POINT; PH; PHYSICAL CHEMISTRY; PREDICTION; PREDICTIVE VALUE; PRIORITY JOURNAL; SIMULATION; STATISTICAL MODEL; CHEMISTRY; COMPUTER SIMULATION; DIET RESTRICTION; FORECASTING; INTESTINAL SECRETIONS; INTESTINE ABSORPTION; MEDICINAL CHEMISTRY; METABOLISM; PHYSIOLOGY; PROCEDURES; SOLUBILITY;

DRUG;

CHEMISTRY, PHARMACEUTICAL; COMPUTER SIMULATION; FASTING; FORECASTING; HUMANS; INTESTINAL ABSORPTION; INTESTINAL SECRETIONS; PHARMACEUTICAL PREPARATIONS; SOLUBILITY;

EID: 84921441274     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-014-1487-z     Document Type: Article

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