Assessing the impact of polymers on the pH-induced precipitation behavior of poorly water soluble compounds using synchrotron wide angle X-Ray scattering

Journal of Pharmaceutical Sciences

Volumn 103, Issue 9, 2014, Pages 2724-2735

  Hsieh, Yi Ling ^a,c   Box, Karl ^b   Taylor, Lynne S ^a  

^a PURDUE UNIVERSITY   (United States)

^b Sirius Analytical Ltd   (United Kingdom)

^c ALLERGAN INC   (United States)

Author keywords

acid base; amorphous; bioavailability; crystallization; X ray powder diffractometry

Indexed keywords

(HYDROXYPROPYLMETHYL CELLULOSE ACETATE SUCCINATE; CARBOXYMETHYLCELLULOSE; CARBOXYMETHYLCELLULOSE ACETATE BUTYRATE; CELLULOSE ACETATE PROPIONATE ADIPATE; DIPYRIDAMOLE; EUDRAGIT; GLIBENCLAMIDE; HYDROXYPROPYLMETHYLCELLULOSE; PAPAVERINE; POLYACRYLIC ACID; POLYMER; POLYVINYLPYRROLIDONE VINYL ACETATE; POVIDONE; UNCLASSIFIED DRUG; WARFARIN; SOLUTION AND SOLUBILITY; WATER;

AQUEOUS SOLUTION; ARTICLE; BIREFRINGENCE; CHEMICAL ANALYSIS; CLINICAL EVALUATION; CONCENTRATION PROCESS; CRYSTALLIZATION; DRUG SOLUBILITY; DRUG STABILITY; MICROSCOPY; OUTCOME ASSESSMENT; PH; PH INDUCED PRECIPITATION BEHAVIOR; POLYMERIZATION; PRECIPITATION; RADIATION SCATTERING; SOLID STATE; STRUCTURE ANALYSIS; SYNCHROTRON RADIATION; SYNCHROTRON WIDE ANGLE X RAY SCATTERING; TITRIMETRY; CHEMISTRY; PROCEDURES; SMALL ANGLE SCATTERING; SOLUBILITY; SOLUTION AND SOLUBILITY; SYNCHROTRON; X RAY CRYSTALLOGRAPHY;

CHEMICAL PRECIPITATION; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; HYDROGEN-ION CONCENTRATION; PHARMACEUTICAL SOLUTIONS; POLYMERS; SCATTERING, SMALL ANGLE; SOLUBILITY; SYNCHROTRONS; WATER;

EID: 84906319769     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.23890     Document Type: Article

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