A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: The pattern of spread is determined by connectivity, not proximity

Acta Neuropathologica

Volumn 127, Issue 5, 2014, Pages 667-683

  Ahmed, Zeshan ^a   Cooper, Jane ^a   Murray, Tracey K ^a   Garn, Katya ^a   McNaughton, Emily ^a   Clarke, Hannah ^a   Parhizkar, Samira ^a   Ward, Mark A ^a   Cavallini, Annalisa ^a   Jackson, Samuel ^a   Bose, Suchira ^a   Clavaguera, Florence ^b   Tolnay, Markus ^b   Lavenir, Isabelle ^c   Goedert, Michel ^c   Hutton, Michael L ^a   O'Neill, Michael J ^a  

^a ELI LILLY AND COMPANY   (United States)

^b UNIVERSITY HOSPITAL BASEL   (Switzerland)

^c MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

Aggregation; Human P301S tau; Prion; Propagation; Tau; Transgenic mouse line

Indexed keywords

TAU PROTEIN; MAPT PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HIPPOCAMPUS; IN VIVO STUDY; MOUSE; NEUROFIBRILLARY TANGLE; NONHUMAN; PRIORITY JOURNAL; SYNAPSE; TAUOPATHY; WHITE MATTER; ANIMAL; BRAIN; C57BL MOUSE; DISEASE COURSE; DISEASE MODEL; FEMALE; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; METABOLISM; NERVE TRACT; PATHOLOGY; RANDOMIZATION; TIME; TRANSGENIC MOUSE;

ANIMALS; BRAIN; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; FEMALE; HIPPOCAMPUS; HUMANS; IMMUNOHISTOCHEMISTRY; MICE, INBRED C57BL; MICE, TRANSGENIC; NEURAL PATHWAYS; NEUROFIBRILLARY TANGLES; RANDOM ALLOCATION; SYNAPSES; TAU PROTEINS; TAUOPATHIES; TIME FACTORS; WHITE MATTER;

EID: 84899944338     PISSN: 00016322     EISSN: 14320533     Source Type: Journal    
DOI: 10.1007/s00401-014-1254-6     Document Type: Article

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