-
1
-
-
0027401607
-
The multistep nature of cancer
-
Vogelstein, B. & Kinzler, K. W. The multistep nature of cancer. Trends Genet. 9, 138-141 (1993).
-
(1993)
Trends Genet.
, vol.9
, pp. 138-141
-
-
Vogelstein, B.1
Kinzler, K.W.2
-
3
-
-
79952284127
-
Hallmarks of cancer: The next generation
-
Hanahan, D. & Weinberg, R. A. Hallmarks of cancer: the next generation. Cell 144, 646-674 (2011).
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
4
-
-
0742287062
-
Conditional animal models: A strategy to define when oncogenes will be effective targets to treat cancer
-
Giuriato, S., Rabin, K., Fan, A. C., Shachaf, C. M. & Felsher, D. W. Conditional animal models: a strategy to define when oncogenes will be effective targets to treat cancer. Semin. Cancer Biol. 14, 3-11 (2004).
-
(2004)
Semin. Cancer Biol.
, vol.14
, pp. 3-11
-
-
Giuriato, S.1
Rabin, K.2
Fan, A.C.3
Shachaf, C.M.4
Felsher, D.W.5
-
5
-
-
44849137232
-
Oncogene addiction versus oncogene amnesia: Perhaps more than just a bad habit?
-
Felsher, D. W. Oncogene addiction versus oncogene amnesia: perhaps more than just a bad habit? Cancer Res. 68, 3081-3086 (2008).
-
(2008)
Cancer Res.
, vol.68
, pp. 3081-3086
-
-
Felsher, D.W.1
-
6
-
-
33746961739
-
Mechanisms of disease: Oncogene addiction - A rationale for molecular targeting in cancer therapy
-
Weinstein, I. B. & Joe, A. K. Mechanisms of disease: oncogene addiction - a rationale for molecular targeting in cancer therapy. Nat. Clin. Pract. Oncol. 3, 448-457 (2006).
-
(2006)
Nat. Clin. Pract. Oncol.
, vol.3
, pp. 448-457
-
-
Weinstein, I.B.1
Joe, A.K.2
-
8
-
-
84919725208
-
Unintended consequences of expensive cancer therapeutics - The pursuit of marginal indications and a me-too mentality that stifles innovation and creativity: The John Conley lecture
-
Fojo, T., Mailankody, S. & Lo, A. Unintended consequences of expensive cancer therapeutics - the pursuit of marginal indications and a me-too mentality that stifles innovation and creativity: the John Conley Lecture. JAMA Otolaryngol. Head Neck Surg. 140, 1225-1236 (2014).
-
(2014)
JAMA Otolaryngol. Head Neck Surg.
, vol.140
, pp. 1225-1236
-
-
Fojo, T.1
Mailankody, S.2
Lo, A.3
-
9
-
-
84892805414
-
Resistance to RAF inhibitors revisited
-
Hartsough, E., Shao, Y. & Aplin, A. E. Resistance to RAF inhibitors revisited. J. Invest. Dermatol. 134, 319-325 (2014).
-
(2014)
J. Invest. Dermatol.
, vol.134
, pp. 319-325
-
-
Hartsough, E.1
Shao, Y.2
Aplin, A.E.3
-
10
-
-
84891738153
-
Targeted therapy for melanoma: Rational combinatorial approaches
-
Kwong, L. N. & Davies, M. A. Targeted therapy for melanoma: rational combinatorial approaches. Oncogene 33, 1-9 (2014).
-
(2014)
Oncogene
, vol.33
, pp. 1-9
-
-
Kwong, L.N.1
Davies, M.A.2
-
11
-
-
0026010995
-
Molecular themes in oncogenesis
-
Bishop, J. M. Molecular themes in oncogenesis. Cell 64, 235-248 (1991).
-
(1991)
Cell
, vol.64
, pp. 235-248
-
-
Bishop, J.M.1
-
12
-
-
48149083805
-
Gene expression profiling as a tool for basic analysis and clinical application of human cancer
-
García-Escudero, R. & Paramio, J.M. Gene expression profiling as a tool for basic analysis and clinical application of human cancer. Mol. Carcinog. 47, 573-579 (2008).
-
(2008)
Mol. Carcinog.
, vol.47
, pp. 573-579
-
-
García-Escudero, R.1
Paramio, J.M.2
-
13
-
-
0029980113
-
Mechanism for transcriptional gain of function resulting from chromosomal translocation in alveolar rhabdomyosarcoma
-
Bennicelli, J. L., Edwards, R. H. & Barr, F. G. Mechanism for transcriptional gain of function resulting from chromosomal translocation in alveolar rhabdomyosarcoma. Proc. Natl Acad. Sci. USA 93, 5455-5459 (1996).
-
(1996)
Proc. Natl Acad. Sci. USA
, vol.93
, pp. 5455-5459
-
-
Bennicelli, J.L.1
Edwards, R.H.2
Barr, F.G.3
-
14
-
-
84887320453
-
The MLL recombinome of acute leukemias in 2013
-
Meyer, C. et al. The MLL recombinome of acute leukemias in 2013. Leukemia 27, 2165-2176 (2013).
-
(2013)
Leukemia
, vol.27
, pp. 2165-2176
-
-
Meyer, C.1
-
15
-
-
33947581390
-
The impact of translocations and gene fusions on cancer causation
-
Mitelman, F., Johansson, B. & Mertens, F. The impact of translocations and gene fusions on cancer causation. Nat. Rev. Cancer 7, 233-245 (2007).
-
(2007)
Nat. Rev. Cancer
, vol.7
, pp. 233-245
-
-
Mitelman, F.1
Johansson, B.2
Mertens, F.3
-
16
-
-
0029787606
-
An EWS/ERG fusion with a truncated N-terminal domain of EWS in a Ewing's tumor
-
Peter, M. et al. An EWS/ERG fusion with a truncated N-terminal domain of EWS in a Ewing's tumor. Int. J. Cancer 67, 339-342 (1996).
-
(1996)
Int. J. Cancer
, vol.67
, pp. 339-342
-
-
Peter, M.1
-
17
-
-
0029990114
-
Gene fusions encoding chimaeric transcription factors in solid tumours
-
Sorensen, P. H. & Triche, T. J. Gene fusions encoding chimaeric transcription factors in solid tumours. Semin. Cancer Biol. 7, 3-14 (1996).
-
(1996)
Semin. Cancer Biol.
, vol.7
, pp. 3-14
-
-
Sorensen, P.H.1
Triche, T.J.2
-
18
-
-
56049124569
-
Chromosomal translocations in cancer
-
Nambiar, M., Kari, V. & Raghavan, S. C. Chromosomal translocations in cancer. Biochim. Biophys. Acta 1786, 139-152 (2008).
-
(2008)
Biochim. Biophys. Acta
, vol.1786
, pp. 139-152
-
-
Nambiar, M.1
Kari, V.2
Raghavan, S.C.3
-
19
-
-
84901021839
-
Cancer genomics identifies disrupted epigenetic genes
-
Simó-Riudalbas, L. & Esteller, M. Cancer genomics identifies disrupted epigenetic genes. Hum. Genet. 133, 713-725 (2014).
-
(2014)
Hum. Genet.
, vol.133
, pp. 713-725
-
-
Simó-Riudalbas, L.1
Esteller, M.2
-
20
-
-
84892833777
-
Discovery and saturation analysis of cancer genes across 21 tumour types
-
Lawrence, M. S. et al. Discovery and saturation analysis of cancer genes across 21 tumour types. Nature 505, 495-501 (2014).
-
(2014)
Nature
, vol.505
, pp. 495-501
-
-
Lawrence, M.S.1
-
21
-
-
84930183600
-
Mutant cohesin drives chromosomal instability in early colorectal adenomas
-
Cucco, F. et al. Mutant cohesin drives chromosomal instability in early colorectal adenomas. Hum. Mol. Genet. 23, 6773-6778 (2014).
-
(2014)
Hum. Mol. Genet.
, vol.23
, pp. 6773-6778
-
-
Cucco, F.1
-
22
-
-
84903590872
-
Cohesin gene mutations in tumorigenesis: From discovery to clinical significance
-
Solomon, D. A., Kim, J. S. & Waldman, T. Cohesin gene mutations in tumorigenesis: from discovery to clinical significance. BMB Rep. 47, 299-310 (2014).
-
(2014)
BMB Rep.
, vol.47
, pp. 299-310
-
-
Solomon, D.A.1
Kim, J.S.2
Waldman, T.3
-
23
-
-
84875717832
-
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer
-
Bojesen, S. E. et al. Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nat. Genet. 45, 371-384 (2013).
-
(2013)
Nat. Genet.
, vol.45
, pp. 371-384
-
-
Bojesen, S.E.1
-
24
-
-
84907909016
-
Concurrent alterations in TERT, KDM6A, and the BRCA pathway in bladder cancer
-
Nickerson, M. L. et al. Concurrent alterations in TERT, KDM6A, and the BRCA pathway in bladder cancer. Clin. Cancer Res. 20, 4935-4948 (2014).
-
(2014)
Clin. Cancer Res.
, vol.20
, pp. 4935-4948
-
-
Nickerson, M.L.1
-
25
-
-
84929465598
-
TERT promoter mutation status as an independent prognostic factor in cutaneous melanoma
-
Griewank, K. G. et al. TERT promoter mutation status as an independent prognostic factor in cutaneous melanoma. J. Natl Cancer Inst. 106, doi: 10.1093/jnci/dju246 (2014).
-
(2014)
J. Natl Cancer Inst.
, pp. 106
-
-
Griewank, K.G.1
-
26
-
-
84917710235
-
An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element
-
Mansour, M. R. et al. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element. Science 346, 1373-1377 (2014).
-
(2014)
Science
, vol.346
, pp. 1373-1377
-
-
Mansour, M.R.1
-
27
-
-
84878602763
-
Function of oncogenes in cancer development: A changing paradigm
-
Vicente-Dueñas, C., Romero-Camarero, I., Cobaleda, C. & Sánchez-García, I. Function of oncogenes in cancer development: a changing paradigm. EMBO J. 32, 1502-1513 (2013).
-
(2013)
EMBO J.
, vol.32
, pp. 1502-1513
-
-
Vicente-Dueñas, C.1
Romero-Camarero, I.2
Cobaleda, C.3
Sánchez-García, I.4
-
29
-
-
84867021989
-
Transcriptional amplification in tumor cells with elevated c-Myc
-
Lin, C. Y. et al. Transcriptional amplification in tumor cells with elevated c-Myc. Cell 151, 56-67 (2012).
-
(2012)
Cell
, vol.151
, pp. 56-67
-
-
Lin, C.Y.1
-
30
-
-
80051513341
-
An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance
-
Zuber, J. et al. An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance. Genes Dev. 25, 1628-1640 (2011).
-
(2011)
Genes Dev.
, vol.25
, pp. 1628-1640
-
-
Zuber, J.1
-
31
-
-
84908040646
-
Tripartite interactions between Wnt signaling, Notch and Myb for stem/progenitor cell functions during intestinal tumorigenesis
-
Germann, M. et al. Tripartite interactions between Wnt signaling, Notch and Myb for stem/progenitor cell functions during intestinal tumorigenesis. Stem Cell Res. 13, 355-366 (2014).
-
(2014)
Stem Cell Res.
, vol.13
, pp. 355-366
-
-
Germann, M.1
-
32
-
-
70350241343
-
Chromosomes in leukemia and beyond: From irrelevant to central players
-
Rowley, J. D. Chromosomes in leukemia and beyond: from irrelevant to central players. Annu. Rev. Genom. Hum. Genet. 10, 1-18 (2009).
-
(2009)
Annu. Rev. Genom. Hum. Genet.
, vol.10
, pp. 1-18
-
-
Rowley, J.D.1
-
33
-
-
84878372012
-
Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia
-
Cancer Genome Atlas Research Network. Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. N. Engl. J. Med. 368, 2059-2074 (2013).
-
(2013)
N. Engl. J. Med.
, vol.368
, pp. 2059-2074
-
-
-
34
-
-
0034691092
-
AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation
-
Miyamoto, T., Weissman, I. L. & Akashi, K. AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation. Proc. Natl Acad. Sci. USA 97, 7521-7526 (2000).
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, pp. 7521-7526
-
-
Miyamoto, T.1
Weissman, I.L.2
Akashi, K.3
-
35
-
-
84894245627
-
Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia
-
Shlush, L. I. et al. Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia. Nature 506, 328-333 (2014).
-
(2014)
Nature
, vol.506
, pp. 328-333
-
-
Shlush, L.I.1
-
36
-
-
84894304555
-
Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission
-
Corces-Zimmerman, M. R., Hong, W. J., Weissman, I. L., Medeiros, B. C. & Majeti, R. Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission. Proc. Natl Acad. Sci. USA 111, 2548-2553 (2014).
-
(2014)
Proc. Natl Acad. Sci. USA
, vol.111
, pp. 2548-2553
-
-
Corces-Zimmerman, M.R.1
Hong, W.J.2
Weissman, I.L.3
Medeiros, B.C.4
Majeti, R.5
-
37
-
-
84926991134
-
Pre-leukemic evolution of hematopoietic stem cells: The importance of early mutations in leukemogenesis
-
Corces-Zimmerman, M. R. & Majeti, R. Pre-leukemic evolution of hematopoietic stem cells: the importance of early mutations in leukemogenesis. Leukemia 28, 2276-2282 (2014).
-
(2014)
Leukemia
, vol.28
, pp. 2276-2282
-
-
Corces-Zimmerman, M.R.1
Majeti, R.2
-
38
-
-
84861986053
-
Wnt/β-catenin signaling and disease
-
Clevers, H. & Nusse, R. Wnt/β-catenin signaling and disease. Cell 149, 1192-1205 (2012).
-
(2012)
Cell
, vol.149
, pp. 1192-1205
-
-
Clevers, H.1
Nusse, R.2
-
39
-
-
0030949463
-
Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC
-
Morin, P. J. et al. Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC. Science 275, 1787-1790 (1997).
-
(1997)
Science
, vol.275
, pp. 1787-1790
-
-
Morin, P.J.1
-
40
-
-
67649506174
-
Genetic prognostic and predictive markers in colorectal cancer
-
Walther, A. et al. Genetic prognostic and predictive markers in colorectal cancer. Nat. Rev. Cancer 9, 489-499 (2009).
-
(2009)
Nat. Rev. Cancer
, vol.9
, pp. 489-499
-
-
Walther, A.1
-
41
-
-
84915821343
-
Cohesin Rad21 mediates LOH and is up-regulated via Wnt promoting transcriptional dysregulation in GI tumors
-
Xu, H. et al. Cohesin Rad21 mediates LOH and is up-regulated via Wnt promoting transcriptional dysregulation in GI tumors. Cell Rep. 9, 1781-1797 (2014).
-
(2014)
Cell Rep.
, vol.9
, pp. 1781-1797
-
-
Xu, H.1
-
42
-
-
84901768304
-
ETS fusion genes in prostate cancer
-
Gasi Tandefelt, D., Boormans, J., Hermans, K. & Trapman, J. ETS fusion genes in prostate cancer. Endocr. Relat. Cancer 21, R143-R152 (2014).
-
(2014)
Endocr. Relat. Cancer
, vol.21
, pp. R143-R152
-
-
Gasi Tandefelt, D.1
Boormans, J.2
Hermans, K.3
Trapman, J.4
-
43
-
-
5044225888
-
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia
-
Weng, A. P. et al. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science 306, 269-271 (2004).
-
(2004)
Science
, vol.306
, pp. 269-271
-
-
Weng, A.P.1
-
44
-
-
84909975477
-
Notch activation as a driver of osteogenic sarcoma
-
Tao, J. et al. Notch activation as a driver of osteogenic sarcoma. Cancer Cell 26, 390-401 (2014).
-
(2014)
Cancer Cell
, vol.26
, pp. 390-401
-
-
Tao, J.1
-
45
-
-
79955460636
-
Notch signalling in solid tumours: A little bit of everything but not all the time
-
Ranganathan, P., Weaver, K. L. & Capobianco, A. J. Notch signalling in solid tumours: a little bit of everything but not all the time. Nat. Rev. Cancer 11, 338-351 (2011).
-
(2011)
Nat. Rev. Cancer
, vol.11
, pp. 338-351
-
-
Ranganathan, P.1
Weaver, K.L.2
Capobianco, A.J.3
-
46
-
-
84909957043
-
Recent insights into the biology of neuroblastoma
-
Schleiermacher, G., Janoueix-Lerosey, I. & Delattre, O. Recent insights into the biology of neuroblastoma. Int. J. Cancer 135, 2249-2261 (2014).
-
(2014)
Int. J. Cancer
, vol.135
, pp. 2249-2261
-
-
Schleiermacher, G.1
Janoueix-Lerosey, I.2
Delattre, O.3
-
47
-
-
0021261878
-
Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage
-
Brodeur, G. M., Seeger, R. C., Schwab, M., Varmus, H. E. & Bishop, J. M. Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage. Science 224, 1121-1124 (1984).
-
(1984)
Science
, vol.224
, pp. 1121-1124
-
-
Brodeur, G.M.1
Seeger, R.C.2
Schwab, M.3
Varmus, H.E.4
Bishop, J.M.5
-
48
-
-
84908339061
-
MYB-NFIB gene fusion in adenoid cystic carcinoma of the breast with special focus paid to the solid variant with basaloid features
-
D'Alfonso, T. M. et al. MYB-NFIB gene fusion in adenoid cystic carcinoma of the breast with special focus paid to the solid variant with basaloid features. Hum. Pathol. 45, 2270-2280 (2014).
-
(2014)
Hum. Pathol.
, vol.45
, pp. 2270-2280
-
-
D'Alfonso, T.M.1
-
49
-
-
77957557959
-
Comprehensive analysis of the MYB-NFIB gene fusion in salivary adenoid cystic carcinoma: Incidence, variability, and clinicopathologic significance
-
Mitani, Y. et al. Comprehensive analysis of the MYB-NFIB gene fusion in salivary adenoid cystic carcinoma: incidence, variability, and clinicopathologic significance. Clin. Cancer Res. 16, 4722-4731 (2010).
-
(2010)
Clin. Cancer Res.
, vol.16
, pp. 4722-4731
-
-
Mitani, Y.1
-
50
-
-
73249115584
-
Recurrent fusion of MYB and NFIB transcription factor genes in carcinomas of the breast and head and neck
-
Persson, M. et al. Recurrent fusion of MYB and NFIB transcription factor genes in carcinomas of the breast and head and neck. Proc. Natl Acad. Sci. USA 106, 18740-18744 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 18740-18744
-
-
Persson, M.1
-
51
-
-
84874973263
-
The importance of diagnosing NUT midline carcinoma
-
French, C. A. The importance of diagnosing NUT midline carcinoma. Head Neck Pathol. 7, 11-16 (2013).
-
(2013)
Head Neck Pathol.
, vol.7
, pp. 11-16
-
-
French, C.A.1
-
52
-
-
84856857218
-
Pathogenesis of NUT midline carcinoma
-
French, C. A. Pathogenesis of NUT midline carcinoma. Annu. Rev. Pathol. 7, 247-265 (2012).
-
(2012)
Annu. Rev. Pathol.
, vol.7
, pp. 247-265
-
-
French, C.A.1
-
53
-
-
84902520020
-
JARID1B is a luminal lineage-driving oncogene in breast cancer
-
Yamamoto, S. et al. JARID1B is a luminal lineage-driving oncogene in breast cancer. Cancer Cell 25, 762-777 (2014).
-
(2014)
Cancer Cell
, vol.25
, pp. 762-777
-
-
Yamamoto, S.1
-
54
-
-
84862984571
-
Finding cancer's weakest link
-
Sodir, N. M. & Evan, G. I. Finding cancer's weakest link. Oncotarget 2, 1307-1313 (2011).
-
(2011)
Oncotarget
, vol.2
, pp. 1307-1313
-
-
Sodir, N.M.1
Evan, G.I.2
-
55
-
-
84873566930
-
Role and potential for therapeutic targeting of MYB in leukemia
-
Pattabiraman, D. R. & Gonda, T. J. Role and potential for therapeutic targeting of MYB in leukemia. Leukemia 27, 269-277 (2013).
-
(2013)
Leukemia
, vol.27
, pp. 269-277
-
-
Pattabiraman, D.R.1
Gonda, T.J.2
-
56
-
-
76649136927
-
C-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis
-
Jin, S. et al. c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis. J. Clin. Invest. 120, 593-606 (2010).
-
(2010)
J. Clin. Invest.
, vol.120
, pp. 593-606
-
-
Jin, S.1
-
57
-
-
84902089745
-
Interaction of c-Myb with p300 is required for the induction of acute myeloid leukemia (AML) by human AML oncogenes
-
Pattabiraman, D. R. et al. Interaction of c-Myb with p300 is required for the induction of acute myeloid leukemia (AML) by human AML oncogenes. Blood 123, 2682-2690 (2014).
-
(2014)
Blood
, vol.123
, pp. 2682-2690
-
-
Pattabiraman, D.R.1
-
58
-
-
45849137069
-
MYB function in normal and cancer cells
-
Ramsay, R. G. & Gonda, T. J. MYB function in normal and cancer cells. Nat. Rev. Cancer 8, 523-534 (2008).
-
(2008)
Nat. Rev. Cancer
, vol.8
, pp. 523-534
-
-
Ramsay, R.G.1
Gonda, T.J.2
-
59
-
-
81155126048
-
MYB is essential for mammary tumorigenesis
-
Miao, R. Y. et al. MYB is essential for mammary tumorigenesis. Cancer Res. 71, 7029-7037 (2011).
-
(2011)
Cancer Res.
, vol.71
, pp. 7029-7037
-
-
Miao, R.Y.1
-
60
-
-
84901821841
-
The mechanisms behind the therapeutic activity of BET bromodomain inhibition
-
Shi, J. & Vakoc, C. R. The mechanisms behind the therapeutic activity of BET bromodomain inhibition. Mol. Cell 54, 728-736 (2014).
-
(2014)
Mol. Cell
, vol.54
, pp. 728-736
-
-
Shi, J.1
Vakoc, C.R.2
-
61
-
-
84938415522
-
The role of JAK/STAT signalling in the pathogenesis, prognosis and treatment of solid tumours
-
Thomas, S. J., Snowden, J. A., Zeidler, M. P. & Danson, S. J. The role of JAK/STAT signalling in the pathogenesis, prognosis and treatment of solid tumours. Br. J. Cancer 113, 365-371 (2015).
-
(2015)
Br. J. Cancer
, vol.113
, pp. 365-371
-
-
Thomas, S.J.1
Snowden, J.A.2
Zeidler, M.P.3
Danson, S.J.4
-
62
-
-
84856213846
-
The diverse and complex roles of NF-κB subunits in cancer
-
Perkins, N. D. The diverse and complex roles of NF-κB subunits in cancer. Nat. Rev. Cancer 12, 121-132 (2012).
-
(2012)
Nat. Rev. Cancer
, vol.12
, pp. 121-132
-
-
Perkins, N.D.1
-
63
-
-
84931088974
-
Targeting the Hedgehog signaling pathway in cancer: Beyond Smoothened
-
Gonnissen, A., Isebaert, S. & Haustermans, K. Targeting the Hedgehog signaling pathway in cancer: beyond Smoothened. Oncotarget 6, 13899-13913 (2015).
-
(2015)
Oncotarget
, vol.6
, pp. 13899-13913
-
-
Gonnissen, A.1
Isebaert, S.2
Haustermans, K.3
-
64
-
-
55749116156
-
Stat3 contributes to resistance toward BCR-ABL inhibitors in a bone marrow microenvironment model of drug resistance
-
Bewry, N. N. et al. Stat3 contributes to resistance toward BCR-ABL inhibitors in a bone marrow microenvironment model of drug resistance. Mol. Cancer Ther. 7, 3169-3175 (2008).
-
(2008)
Mol. Cancer Ther.
, vol.7
, pp. 3169-3175
-
-
Bewry, N.N.1
-
65
-
-
36649011653
-
The diagnosis of BCR/ABL-negative chronic myeloproliferative diseases (CMPD): A comprehensive approach based on morphology, cytogenetics, and molecular markers
-
Haferlach, T., Bacher, U., Kern, W., Schnittger, S. & Haferlach, C. The diagnosis of BCR/ABL-negative chronic myeloproliferative diseases (CMPD): a comprehensive approach based on morphology, cytogenetics, and molecular markers. Ann. Hematol. 87, 1-10 (2008).
-
(2008)
Ann. Hematol.
, vol.87
, pp. 1-10
-
-
Haferlach, T.1
Bacher, U.2
Kern, W.3
Schnittger, S.4
Haferlach, C.5
-
66
-
-
3442898002
-
Aberrant expression of β-catenin discriminates acute myeloid leukaemia from acute lymphoblastic leukaemia
-
Serinsöz, E. et al. Aberrant expression of β-catenin discriminates acute myeloid leukaemia from acute lymphoblastic leukaemia. Br. J. Haematol. 126, 313-319 (2004).
-
(2004)
Br. J. Haematol.
, vol.126
, pp. 313-319
-
-
Serinsöz, E.1
-
67
-
-
84896672554
-
NRAS mutation is the sole recurrent somatic mutation in large congenital melanocytic nevi
-
Charbel, C. et al. NRAS mutation is the sole recurrent somatic mutation in large congenital melanocytic nevi. J. Invest. Dermatol. 134, 1067-1074 (2014).
-
(2014)
J. Invest. Dermatol.
, vol.134
, pp. 1067-1074
-
-
Charbel, C.1
-
68
-
-
84879952154
-
NRAS and BRAF mutations in melanoma-associated nevi and uninvolved nevi
-
Tschandl, P. et al. NRAS and BRAF mutations in melanoma-associated nevi and uninvolved nevi. PLoS ONE 8, e69639 (2013).
-
(2013)
PLoS ONE
, vol.8
, pp. e69639
-
-
Tschandl, P.1
-
69
-
-
79953056443
-
The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset
-
Ceol, C. J. et al. The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset. Nature 471, 513-517 (2011).
-
(2011)
Nature
, vol.471
, pp. 513-517
-
-
Ceol, C.J.1
-
70
-
-
84913582190
-
Suppression of feedback loops mediated by PI3K/mTOR induces multiple overactivation of compensatory pathways: An unintended consequence leading to drug resistance
-
Rozengurt, E., Soares, H. P. & Sinnet-Smith, J. Suppression of feedback loops mediated by PI3K/mTOR induces multiple overactivation of compensatory pathways: an unintended consequence leading to drug resistance. Mol. Cancer Ther. 13, 2477-2478 (2014).
-
(2014)
Mol. Cancer Ther.
, vol.13
, pp. 2477-2478
-
-
Rozengurt, E.1
Soares, H.P.2
Sinnet-Smith, J.3
-
71
-
-
84865254848
-
Mechanisms of acquired resistance to targeted cancer therapies
-
Lackner, M. R., Wilson, T. R. & Settleman, J. Mechanisms of acquired resistance to targeted cancer therapies. Future Oncol. 8, 999-1014 (2012).
-
(2012)
Future Oncol.
, vol.8
, pp. 999-1014
-
-
Lackner, M.R.1
Wilson, T.R.2
Settleman, J.3
-
72
-
-
78651458656
-
AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity
-
Chandarlapaty, S. et al. AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity. Cancer Cell 19, 58-71 (2011).
-
(2011)
Cancer Cell
, vol.19
, pp. 58-71
-
-
Chandarlapaty, S.1
-
73
-
-
84891895334
-
Towards a unified model of RAF inhibitor resistance
-
Solit, D. B. & Rosen, N. Towards a unified model of RAF inhibitor resistance. Cancer Discov. 4, 27-30 (2014).
-
(2014)
Cancer Discov.
, vol.4
, pp. 27-30
-
-
Solit, D.B.1
Rosen, N.2
-
74
-
-
33745727112
-
HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors
-
Wang, S. E. et al. HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors. Cancer Cell 10, 25-38 (2006).
-
(2006)
Cancer Cell
, vol.10
, pp. 25-38
-
-
Wang, S.E.1
-
75
-
-
34249075147
-
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
-
Engelman, J. A. et al. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science 316, 1039-1043 (2007).
-
(2007)
Science
, vol.316
, pp. 1039-1043
-
-
Engelman, J.A.1
-
76
-
-
65949086609
-
PTEN loss contributes to erlotinib resistance in EGFR-mutant lung cancer by activation of Akt and EGFR
-
Sos, M. L. et al. PTEN loss contributes to erlotinib resistance in EGFR-mutant lung cancer by activation of Akt and EGFR. Cancer Res. 69, 3256-3261 (2009).
-
(2009)
Cancer Res.
, vol.69
, pp. 3256-3261
-
-
Sos, M.L.1
-
77
-
-
84898990827
-
Molecular pathways: Molecular basis for sensitivity and resistance to JAK kinase inhibitors
-
Meyer, S. C. & Levine, R. L. Molecular pathways: molecular basis for sensitivity and resistance to JAK kinase inhibitors. Clin. Cancer Res. 20, 2051-2059 (2014).
-
(2014)
Clin. Cancer Res.
, vol.20
, pp. 2051-2059
-
-
Meyer, S.C.1
Levine, R.L.2
-
78
-
-
57349152259
-
Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation
-
Nasr, R. et al. Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation. Nat. Med. 14, 1333-1342 (2008).
-
(2008)
Nat. Med.
, vol.14
, pp. 1333-1342
-
-
Nasr, R.1
-
79
-
-
77953048986
-
Acute promyelocytic leukemia: A paradigm for differentiation therapy
-
Grimwade, D., Mistry, A. R., Solomon, E. & Guidez, F. Acute promyelocytic leukemia: a paradigm for differentiation therapy. Cancer Treat. Res. 145, 219-235 (2010).
-
(2010)
Cancer Treat. Res.
, vol.145
, pp. 219-235
-
-
Grimwade, D.1
Mistry, A.R.2
Solomon, E.3
Guidez, F.4
-
80
-
-
62549083523
-
Long-term efficacy and safety of all-trans retinoic acid/arsenic trioxide-based therapy in newly diagnosed acute promyelocytic leukemia
-
Hu, J. et al. Long-term efficacy and safety of all-trans retinoic acid/arsenic trioxide-based therapy in newly diagnosed acute promyelocytic leukemia. Proc. Natl Acad. Sci. USA 106, 3342-3347 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 3342-3347
-
-
Hu, J.1
-
81
-
-
84923647450
-
Computational and analytical challenges in single-cell transcriptomics
-
Stegle, O., Teichmann, S. A. & Marioni, J. C. Computational and analytical challenges in single-cell transcriptomics. Nat. Rev. Genet. 16, 133-145 (2015).
-
(2015)
Nat. Rev. Genet.
, vol.16
, pp. 133-145
-
-
Stegle, O.1
Teichmann, S.A.2
Marioni, J.C.3
-
82
-
-
0037133575
-
Small-molecule antagonists of Myc/Max dimerization inhibit Myc-induced transformation of chicken embryo fibroblasts
-
Berg, T. et al. Small-molecule antagonists of Myc/Max dimerization inhibit Myc-induced transformation of chicken embryo fibroblasts. Proc. Natl Acad. Sci. USA 99, 3830-3835 (2002).
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 3830-3835
-
-
Berg, T.1
-
83
-
-
84870336361
-
Small-molecule inhibition of c-MYC:MAX leucine zipper formation is revealed by ion mobility mass spectrometry
-
Harvey, S. R. et al. Small-molecule inhibition of c-MYC:MAX leucine zipper formation is revealed by ion mobility mass spectrometry. J. Am. Chem. Soc. 134, 19384-19392 (2012).
-
(2012)
J. Am. Chem. Soc.
, vol.134
, pp. 19384-19392
-
-
Harvey, S.R.1
-
84
-
-
84901399341
-
Targeting of the MYCN protein with small molecule c-MYC inhibitors
-
Müller, I. et al. Targeting of the MYCN protein with small molecule c-MYC inhibitors. PLoS ONE 9, e97285 (2014).
-
(2014)
PLoS ONE
, vol.9
, pp. e97285
-
-
Müller, I.1
-
85
-
-
84907484452
-
Molecular insights into dimerization inhibition of c-Maf transcription factor
-
Pellegrino, S. et al. Molecular insights into dimerization inhibition of c-Maf transcription factor. Biochim. Biophys. Acta 1844, 2108-2115 (2014).
-
(2014)
Biochim. Biophys. Acta
, vol.1844
, pp. 2108-2115
-
-
Pellegrino, S.1
-
86
-
-
0037678519
-
MYB and CBP: Physiological relevance of a biochemical interaction
-
Fung, S. M., Ramsay, G. & Katzen, A. L. MYB and CBP: physiological relevance of a biochemical interaction. Mech. Dev. 120, 711-720 (2003).
-
(2003)
Mech. Dev.
, vol.120
, pp. 711-720
-
-
Fung, S.M.1
Ramsay, G.2
Katzen, A.L.3
-
87
-
-
0029886810
-
Interaction of the co-activator CBP with Myb proteins: Effects on Myb-specific transactivation and on the cooperativity with NF-M
-
Oelgeschläger, M., Janknecht, R., Krieg, J., Schreek, S. & Lüscher, B. Interaction of the co-activator CBP with Myb proteins: effects on Myb-specific transactivation and on the cooperativity with NF-M. EMBO J. 15, 2771-2780 (1996).
-
(1996)
EMBO J.
, vol.15
, pp. 2771-2780
-
-
Oelgeschläger, M.1
Janknecht, R.2
Krieg, J.3
Schreek, S.4
Lüscher, B.5
-
88
-
-
84876931179
-
The Myb-p300-CREB axis modulates intestine homeostasis, radiosensitivity and tumorigenesis
-
Sampurno, S. et al. The Myb-p300-CREB axis modulates intestine homeostasis, radiosensitivity and tumorigenesis. Cell Death Dis. 4, e605 (2013).
-
(2013)
Cell Death Dis.
, vol.4
, pp. e605
-
-
Sampurno, S.1
-
89
-
-
84868145117
-
Inhibition of oncogenic Wnt signaling through direct targeting of β-catenin
-
Grossmann, T. N. et al. Inhibition of oncogenic Wnt signaling through direct targeting of β-catenin. Proc. Natl Acad. Sci. USA 109, 17942-17947 (2012).
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. 17942-17947
-
-
Grossmann, T.N.1
-
90
-
-
84934326597
-
Naphthol AS-E phosphate inhibits the activity of the transcription factor Myb by blocking the interaction with the KIX domain of the coactivator p300
-
Uttarkar, S. et al. Naphthol AS-E phosphate inhibits the activity of the transcription factor Myb by blocking the interaction with the KIX domain of the coactivator p300. Mol. Cancer Ther. 14, 1276-1285 (2015).
-
(2015)
Mol. Cancer Ther.
, vol.14
, pp. 1276-1285
-
-
Uttarkar, S.1
-
91
-
-
70449671729
-
Direct inhibition of the NOTCH transcription factor complex
-
Moellering, R. E. et al. Direct inhibition of the NOTCH transcription factor complex. Nature 462, 182-188 (2009).
-
(2009)
Nature
, vol.462
, pp. 182-188
-
-
Moellering, R.E.1
-
92
-
-
78649567717
-
In vitro cytotoxicity and in vivo efficacy, pharmacokinetics, and metabolism of 10074-G5, a novel small-molecule inhibitor of c-Myc/Max dimerization
-
Clausen, D. M. et al. In vitro cytotoxicity and in vivo efficacy, pharmacokinetics, and metabolism of 10074-G5, a novel small-molecule inhibitor of c-Myc/Max dimerization. J. Pharmacol. Exp. Ther. 335, 715-727 (2010).
-
(2010)
J. Pharmacol. Exp. Ther.
, vol.335
, pp. 715-727
-
-
Clausen, D.M.1
-
93
-
-
84886808679
-
Chromatin proteins and modifications as drug targets
-
Helin, K. & Dhanak, D. Chromatin proteins and modifications as drug targets. Nature 502, 480-488 (2013).
-
(2013)
Nature
, vol.502
, pp. 480-488
-
-
Helin, K.1
Dhanak, D.2
-
94
-
-
37549022694
-
DNA methyltransferase and histone deacetylase inhibitors in the treatment of myelodysplastic syndromes
-
Griffiths, E. A. & Gore, S. D. DNA methyltransferase and histone deacetylase inhibitors in the treatment of myelodysplastic syndromes. Semin. Hematol. 45, 23-30 (2008).
-
(2008)
Semin. Hematol.
, vol.45
, pp. 23-30
-
-
Griffiths, E.A.1
Gore, S.D.2
-
95
-
-
0035755974
-
Histone deacetylases and cancer: Causes and therapies
-
Marks, P. et al. Histone deacetylases and cancer: causes and therapies. Nat. Rev. Cancer 1, 194-202 (2001).
-
(2001)
Nat. Rev. Cancer
, vol.1
, pp. 194-202
-
-
Marks, P.1
-
96
-
-
0023622097
-
Induction of transformed cells to terminal differentiation
-
Marks, P. A., Sheffery, M., Ramsay, R., Ikeda, K. & Rifkind, R. A. Induction of transformed cells to terminal differentiation. Ann. NY Acad. Sci. 511, 246-255 (1987).
-
(1987)
Ann. NY Acad. Sci.
, vol.511
, pp. 246-255
-
-
Marks, P.A.1
Sheffery, M.2
Ramsay, R.3
Ikeda, K.4
Rifkind, R.A.5
-
97
-
-
84886864184
-
Potent inhibition of DOT1L as treatment of MLL-fusion leukemia
-
Daigle, S. R. et al. Potent inhibition of DOT1L as treatment of MLL-fusion leukemia. Blood 122, 1017-1025 (2013).
-
(2013)
Blood
, vol.122
, pp. 1017-1025
-
-
Daigle, S.R.1
-
98
-
-
84901406956
-
DOT1L inhibition sensitizes MLL-rearranged AML to chemotherapy
-
Liu, W., Deng, L., Song, Y. & Redell, M. DOT1L inhibition sensitizes MLL-rearranged AML to chemotherapy. PLoS ONE 9, e98270 (2014).
-
(2014)
PLoS ONE
, vol.9
, pp. e98270
-
-
Liu, W.1
Deng, L.2
Song, Y.3
Redell, M.4
-
99
-
-
84901020086
-
Biochemical, cellular, and biophysical characterization of a potent inhibitor of mutant isocitrate dehydrogenase IDH1
-
Davis, M. I. et al. Biochemical, cellular, and biophysical characterization of a potent inhibitor of mutant isocitrate dehydrogenase IDH1. J. Biol. Chem. 289, 13717-13725 (2014).
-
(2014)
J. Biol. Chem.
, vol.289
, pp. 13717-13725
-
-
Davis, M.I.1
-
100
-
-
84877632013
-
An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells
-
Rohle, D. et al. An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells. Science 340, 626-630 (2013).
-
(2013)
Science
, vol.340
, pp. 626-630
-
-
Rohle, D.1
-
101
-
-
84883012780
-
BET inhibition silences expression of MYCN and BCL2 and induces cytotoxicity in neuroblastoma tumor models
-
Wyce, A. et al. BET inhibition silences expression of MYCN and BCL2 and induces cytotoxicity in neuroblastoma tumor models. PLoS ONE 8, e72967 (2013).
-
(2013)
PLoS ONE
, vol.8
, pp. e72967
-
-
Wyce, A.1
-
102
-
-
80052955256
-
BET bromodomain inhibition as a therapeutic strategy to target c-Myc
-
Delmore, J. E. et al. BET bromodomain inhibition as a therapeutic strategy to target c-Myc. Cell 146, 904-917 (2011).
-
(2011)
Cell
, vol.146
, pp. 904-917
-
-
Delmore, J.E.1
-
103
-
-
84937639611
-
BET bromodomain inhibition suppresses the function of hematopoietic transcription factors in acute myeloid leukemia
-
Roe, J. S., Mercan, F., Rivera, K., Pappin, D. J. & Vakoc, C. R. BET bromodomain inhibition suppresses the function of hematopoietic transcription factors in acute myeloid leukemia. Mol. Cell 58, 1028-1039 (2015).
-
(2015)
Mol. Cell
, vol.58
, pp. 1028-1039
-
-
Roe, J.S.1
Mercan, F.2
Rivera, K.3
Pappin, D.J.4
Vakoc, C.R.5
-
104
-
-
77951132901
-
Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles
-
Davis, M. E. et al. Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles. Nature 464, 1067-1070 (2010).
-
(2010)
Nature
, vol.464
, pp. 1067-1070
-
-
Davis, M.E.1
-
105
-
-
84903208336
-
PD-1 pathway inhibitors: Changing the landscape of cancer immunotherapy
-
Dolan, D. E. & Gupta, S. PD-1 pathway inhibitors: changing the landscape of cancer immunotherapy. Cancer Control 21, 231-237 (2014).
-
(2014)
Cancer Control
, vol.21
, pp. 231-237
-
-
Dolan, D.E.1
Gupta, S.2
-
106
-
-
84927574518
-
Immune modulation for cancer therapy
-
Naidoo, J., Page, D. B. & Wolchok, J. D. Immune modulation for cancer therapy. Br. J. Cancer 111, 2214-2219 (2014).
-
(2014)
Br. J. Cancer
, vol.111
, pp. 2214-2219
-
-
Naidoo, J.1
Page, D.B.2
Wolchok, J.D.3
-
107
-
-
84908054875
-
Optimizing DNA vaccines against nuclear oncogenes
-
Carpinteri, S. et al. Optimizing DNA vaccines against nuclear oncogenes. ImmunoGastroenterol. 1, 108-118 (2012).
-
(2012)
ImmunoGastroenterol.
, vol.1
, pp. 108-118
-
-
Carpinteri, S.1
-
108
-
-
50649089178
-
Induction of T cell-mediated immunity using a c-Myb DNA vaccine in a mouse model of colon cancer
-
Williams, B. B. et al. Induction of T cell-mediated immunity using a c-Myb DNA vaccine in a mouse model of colon cancer. Cancer Immunol. Immunother. 57, 1635-1645 (2008).
-
(2008)
Cancer Immunol. Immunother.
, vol.57
, pp. 1635-1645
-
-
Williams, B.B.1
-
109
-
-
84944875663
-
Therapeutic DNA vaccination against colorectal cancer by targeting the MYB oncoprotein
-
Cross, R. S. et al. Therapeutic DNA vaccination against colorectal cancer by targeting the MYB oncoprotein. Clin. Transl Immunol. 4, e30 (2015).
-
(2015)
Clin. Transl Immunol.
, vol.4
, pp. e30
-
-
Cross, R.S.1
-
110
-
-
84894658883
-
Estrogen receptor (ER) α mutations in breast cancer: Hidden in plain sight
-
Fuqua, S. A., Gu, G. & Rechoum, Y. Estrogen receptor (ER) α mutations in breast cancer: hidden in plain sight. Breast Cancer Res. Treat. 144, 11-19 (2014).
-
(2014)
Breast Cancer Res. Treat.
, vol.144
, pp. 11-19
-
-
Fuqua, S.A.1
Gu, G.2
Rechoum, Y.3
-
111
-
-
84942531832
-
BET inhibitor resistance emerges from leukaemia stem cells
-
Fong, C. Y. et al. BET inhibitor resistance emerges from leukaemia stem cells. Nature 525, 538-542 (2015).
-
(2015)
Nature
, vol.525
, pp. 538-542
-
-
Fong, C.Y.1
-
112
-
-
84887147170
-
MYC activation is a hallmark of cancer initiation and maintenance
-
Gabay, M., Li, Y. & Felsher, D. W. MYC activation is a hallmark of cancer initiation and maintenance. Cold Spring Harb. Perspect. Med. 4, a014241 (2014).
-
(2014)
Cold Spring Harb. Perspect. Med.
, vol.4
, pp. a014241
-
-
Gabay, M.1
Li, Y.2
Felsher, D.W.3
-
113
-
-
84928922929
-
MYB elongation is regulated by the nucleic acid binding of NFκB p50 to the intronic stem-loop region
-
Pereira, L. A. et al. MYB elongation is regulated by the nucleic acid binding of NFκB p50 to the intronic stem-loop region. PLoS ONE 10, e0122919 (2015).
-
(2015)
PLoS ONE
, vol.10
, pp. e0122919
-
-
Pereira, L.A.1
-
114
-
-
84864431042
-
Estrogen receptor-α recruits P-TEFb to overcome transcriptional pausing in intron 1 of the MYB gene
-
Mitra, P., Pereira, L. A., Drabsch, Y., Ramsay, R. G. & Gonda, T. J. Estrogen receptor-α recruits P-TEFb to overcome transcriptional pausing in intron 1 of the MYB gene. Nucleic Acids Res. 40, 5988-6000 (2012).
-
(2012)
Nucleic Acids Res.
, vol.40
, pp. 5988-6000
-
-
Mitra, P.1
Pereira, L.A.2
Drabsch, Y.3
Ramsay, R.G.4
Gonda, T.J.5
-
115
-
-
33846122993
-
Dimethyl sulfoxide to vorinostat: Development of this histone deacetylase inhibitor as an anticancer drug
-
Marks, P. A. & Breslow, R. Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug. Nat. Biotechnol. 25, 84-90 (2007).
-
(2007)
Nat. Biotechnol.
, vol.25
, pp. 84-90
-
-
Marks, P.A.1
Breslow, R.2
-
116
-
-
84944875663
-
Therapeutic DNA vaccination against colorectal cancer by targeting the MYB oncoprotein
-
Cross, R. S. et al. Therapeutic DNA vaccination against colorectal cancer by targeting the MYB oncoprotein. Clin. Transl Immunol. 4, e30 (2015).
-
(2015)
Clin. Transl Immunol.
, vol.4
, pp. e30
-
-
Cross, R.S.1
-
117
-
-
77955413261
-
Histone deacetylase inhibitors in lymphoma
-
Copeland, A., Buglio, D. & Younes, A. Histone deacetylase inhibitors in lymphoma. Curr. Opin. Oncol. 22, 431-436 (2010).
-
(2010)
Curr. Opin. Oncol.
, vol.22
, pp. 431-436
-
-
Copeland, A.1
Buglio, D.2
Younes, A.3
-
118
-
-
84879834815
-
Randomized phase II, double-blind, placebo-controlled study of exemestane with or without entinostat in postmenopausal women with locally recurrent or metastatic estrogen receptor-positive breast cancer progressing on treatment with a nonsteroidal aromatase inhibitor
-
Yardley, D. A. et al. Randomized phase II, double-blind, placebo-controlled study of exemestane with or without entinostat in postmenopausal women with locally recurrent or metastatic estrogen receptor-positive breast cancer progressing on treatment with a nonsteroidal aromatase inhibitor. J. Clin. Oncol. 31, 2128-2135 (2013).
-
(2013)
J. Clin. Oncol.
, vol.31
, pp. 2128-2135
-
-
Yardley, D.A.1
-
119
-
-
84926628784
-
DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia
-
Chen, C. W. et al. DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia. Nat. Med. 21, 335-343 (2015).
-
(2015)
Nat. Med.
, vol.21
, pp. 335-343
-
-
Chen, C.W.1
-
120
-
-
84859496041
-
Notch inhibition as a promising new approach to cancer therapy
-
Purow, B. Notch inhibition as a promising new approach to cancer therapy. Adv. Exp. Med. Biol. 727, 305-319 (2012).
-
(2012)
Adv. Exp. Med. Biol.
, vol.727
, pp. 305-319
-
-
Purow, B.1
|