The Importance of Diagnosing NUT Midline Carcinoma

Head and Neck Pathology

Volumn 7, Issue 1, 2013, Pages 11-16

  French, Christopher A ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

BETi; BRD3; BRD4; HDAC; NUT; NUT midline carcinoma; p300; Squamous cell carcinoma

Indexed keywords

EID: 84874973263     PISSN: 1936055X     EISSN: 19360568     Source Type: Journal    
DOI: 10.1007/s12105-013-0428-1     Document Type: Article

References (16)

1. French CA, Kutok JL, Faquin WC, et al. Midline carcinoma of children and young adults with NUT rearrangement. J Clin Oncol. 2004; 22: 4135-9.
2. Bauer D, Mitchell C, Strait K, et al. Clinicopathologic features and long-term outcomes of NUT midline carcinoma. Clin Cancer Res. 2012; 18: 5773-9.
3. Haack H, Johnson LA, Fry CJ, et al. Diagnosis of NUT midline carcinoma using a NUT-specific monoclonal antibody. Am J Surg Pathol. 2009; 33: 984-91.
4. French CA, Miyoshi I, Kubonishi I, et al. BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. Cancer Res. 2003; 63: 304-7.
5. French CA, Ramirez CL, Kolmakova J, et al. BRD-NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells. Oncogene. 2008; 27: 2237-42.
6. Wartchow EP, Moore TS, French CA, et al. Ultrastructural features of NUT midline carcinoma. Ultrastruct Pathol. 2012; 36: 280-4.
7. French CA. Pathogenesis of NUT midline carcinoma. Annu Rev Pathol Mech Dis. 2012; 7: 247-65.
8. Bishop JA, Westra WH. NUT midline carcinomas of the sinonasal tract. Am J Surg Pathol. 2012; 36: 1216-21.
9. Stelow EB, Bellizzi AM, Taneja K, et al. NUT rearrangement in undifferentiated carcinomas of the upper aerodigestive tract. Am J Surg Pathol. 2008; 32: 828-34.
10. Shehata B, Steelman CK, Abramowsky CR, et al. NUT midline carcinoma in a newborn with multiorgan disseminated tumor and a two-year-old with a pancreatic/hepatic primary. Pediatr Dev Pathol. 2010; 13: 481-5.
11. den Bakker MA, Beverloo BH, van den Heuvel-Eibrink MM, et al. NUT midline carcinoma of the parotid gland with mesenchymal differentiation. Am J Surg Pathol. 2009; 33: 1253-8.
12. Ziai J, French CA, Zambrano E. NUT gene rearrangement in a poorly-differentiated carcinoma of the submandibular gland. Head Neck Pathol. 2010; 4: 163-8.
13. Tanaka M, Kato K, Gomi K, et al. NUT midline carcinoma: report of 2 cases suggestive of pulmonary origin. Am J Surg Pathol. 2012; 36: 381-8.
14. Filippakopoulos P, Qi J, Picaud S, et al. Selective inhibition of BET bromodomains. Nature. 2010; 468: 1067-73.
15. Reynoird N, Schwartz BE, Delvecchio M, et al. Oncogenesis by sequestration of CBP/p300 in transcriptionally inactive hyperacetylated chromatin domains. EMBO J. 2010; 29: 2943-52.
16. Schwartz BE, Hofer MD, Lemieux ME, et al. Differentiation of NUT midline carcinoma by epigenomic reprogramming. Cancer Res. 2011; 71: 2686-96.