Small-molecule inhibition of c-MYC:MAX leucine zipper formation is revealed by ion mobility mass spectrometry

Journal of the American Chemical Society

Volumn 134, Issue 47, 2012, Pages 19384-19392

  Harvey, Sophie R ^a   Porrini, Massimiliano ^a   Stachl, Christiane ^a   MacMillan, Derek ^b   Zinzalla, Giovanna ^c   Barran, Perdita E ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

COLLISION CROSS SECTIONS; DISORDERED SYSTEM; DRIFT TIME; GASPHASE; HELICAL COMPLEXES; ION MOBILITY-MASS SPECTROMETRY; LEUCINE ZIPPERS; MD SIMULATION; NMR MEASUREMENTS; SMALL MOLECULES; SMALL-MOLECULE BINDINGS; SMALL-MOLECULE INHIBITORS;

CIRCULAR DICHROISM SPECTROSCOPY; MASS SPECTROMETRY; MOLECULAR DYNAMICS; MOLECULES; SYNTHESIS (CHEMICAL); TRANSCRIPTION FACTORS;

CONFORMATIONS;

LEUCINE ZIPPER PROTEIN; MAX PROTEIN; MYC PROTEIN; PEPTIDE; PROTEIN INHIBITOR;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CIRCULAR DICHROISM; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; DRIFT TIME ION MOBILITY MASS SPECTROMETRY; GAS; ION MOBILITY SPECTROMETRY; MASS SPECTROMETRY; MOLECULAR DYNAMICS; PEPTIDE SYNTHESIS; PROTEIN CONFORMATION; PROTEIN PROTEIN INTERACTION; SIMULATION;

CIRCULAR DICHROISM; LEUCINE ZIPPERS; MASS SPECTROMETRY; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MOLECULAR WEIGHT; PROTO-ONCOGENE PROTEINS C-MYC; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES; TIME FACTORS;

EID: 84870336361     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja306519h     Document Type: Article

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