MYB-NFIB gene fusion in adenoid cystic carcinoma of the breast with special focus paid to the solid variant with basaloid features

Human Pathology

Volumn 45, Issue 11, 2014, Pages 2270-2280

  D'Alfonso, Timothy M ^a   Mosquera, Juan Miguel ^a,b   Macdonald, Theresa Y ^a   Padilla, Jessica ^b   Liu, Yi Fang ^a   Rubin, Mark A ^a,b   Shin, Sandra J ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b NEW YORK PRESBYTERIAN HOSPITAL   (United States)

Author keywords

Adenoid cystic carcinoma; Breast; Fluorescence in situ hybridization (FISH); MYB NFIB; Solid variant with basaloid features

Indexed keywords

HYBRID PROTEIN; MYB NFIB FUSION PROTEIN; UNCLASSIFIED DRUG; NFIB PROTEIN, HUMAN; NUCLEAR FACTOR I; ONCOPROTEIN;

ADENOID CYSTIC CARCINOMA; ADULT; AGED; ARTICLE; AXILLARY LYMPH NODE; BREAST CARCINOMA; CLINICAL ARTICLE; DISTANT METASTASIS; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; FOLLOW UP; GENE REARRANGEMENT; HUMAN; LYMPH NODE METASTASIS; MIDDLE AGED; RECURRENT DISEASE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOLID VARIANT WITH BASALOID FEATURE; TUMOR GROWTH; YOUNG ADULT; BREAST TUMOR; GENE FUSION; GENE TRANSLOCATION; GENETICS; PATHOLOGY; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; BREAST NEOPLASMS; CARCINOMA, ADENOID CYSTIC; FEMALE; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MIDDLE AGED; NFI TRANSCRIPTION FACTORS; ONCOGENE FUSION; ONCOGENE PROTEINS V-MYB; TRANSLOCATION, GENETIC;

EID: 84908339061     PISSN: 00468177     EISSN: 15328392     Source Type: Journal    
DOI: 10.1016/j.humpath.2014.07.013     Document Type: Article

References (36)

1. B. Ghabach, W.F. Anderson, and R.E. Curtis Adenoid cystic carcinoma of the breast in the United States (1977 to 2006): a population-based cohort study Breast Cancer Res 12 2010 R54
2. N. Kulkarni, C.M. Pezzi, and J.M. Greif Rare breast cancer: 933 adenoid cystic carcinomas from the National Cancer Data Base Ann Surg Oncol 20 2013 2236 2241
3. K. Thompson, J. Grabowski, S.L. Saltzstein, G.R. Sadler, and S.L. Blair Adenoid cystic breast carcinoma: is axillary staging necessary in all cases? Results from the California Cancer Registry Breast J 17 2011 485 489
4. D. Wetterskog, M.A. Lopez-Garcia, and M.B. Lambros Adenoid cystic carcinomas constitute a genomically distinct subgroup of triple-negative and basal-like breast cancers J Pathol 226 2012 84 96
5. B. Weigelt, H.M. Horlings, and B. Kreike Refinement of breast cancer classification by molecular characterization of histological special types J Pathol 216 2008 141 150
6. G. Arpino, G.M. Clark, S. Mohsin, V.J. Bardou, and R.M. Elledge Adenoid cystic carcinoma of the breast: molecular markers, treatment, and clinical outcome Cancer 94 2002 2119 2127
7. E. Montagna, P. Maisonneuve, and N. Rotmensz Heterogeneity of triple-negative breast cancer: histologic subtyping to inform the outcome Clin Breast Cancer 13 2013 31 39
8. S.J. Shin, and P.P. Rosen Solid variant of mammary adenoid cystic carcinoma with basaloid features: a study of nine cases Am J Surg Pathol 26 2002 413 420
9. K. Fukuoka, M. Hirokawa, and M. Shimizu Basaloid type adenoid cystic carcinoma of the breast APMIS 107 1999 762 766
10. I. Silva, V. Tome, and J. Oliveira Adenoid cystic carcinoma of the breast with cerebral metastisation: a clinical novelty BMJ Case Rep 2011 2011
11. M. Persson, Y. Andren, and J. Mark Recurrent fusion of MYB and NFIB transcription factor genes in carcinomas of the breast and head and neck Proc Natl Acad Sci U S A 106 2009 18740 18744
12. L.B. Brill, W.A. Kanner, and A. Fehr Analysis of MYB expression and MYB-NFIB gene fusions in adenoid cystic carcinoma and other salivary neoplasms Mod Pathol 24 2011 1169 1176
13. X. Zhu, J. Chen, and Y. Xing Adenoid cystic carcinoma of the breast: clinicopathologic and molecular analysis of 56 cases [abstract] Mod Pathol 25 2012 76A 77A
14. J.B. Hudson, and B.T. Collins MYB gene abnormalities t(6;9) in adenoid cystic carcinoma fine-needle aspiration biopsy using fluorescence in situ hybridization Arch Pathol Lab Med 138 2014 403 409
15. J.Y. Ro, E.G. Silva, and H.S. Gallager Adenoid cystic carcinoma of the breast Hum Pathol 18 1987 1276 1281
16. C.W. Elston, and I.O. Ellis Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up Histopathology 19 1991 403 410
17. S. Perner, F. Demichelis, and R. Beroukhim TMPRSS2:ERG fusion-associated deletions provide insight into the heterogeneity of prostate cancer Cancer Res 66 2006 8337 8341
18. A. Fehr, A. Kovacs, and T. Loning The MYB-NFIB gene fusion - a novel genetic link between adenoid cystic carcinoma and dermal cylindroma J Pathol 224 2011 322 327
19. T.M. D'Alfonso, P.S. Ginter, Y.F. Liu, and S.J. Shin Cystic hypersecretory (in situ) carcinoma of the breast: a clinicopathologic and immunohistochemical characterization of 10 cases with clinical follow-up Am J Surg Pathol 38 2014 45 53
20. H. Tsuda, T. Takarabe, F. Hasegawa, T. Fukutomi, and S. Hirohashi Large, central acellular zones indicating myoepithelial tumor differentiation in high-grade invasive ductal carcinomas as markers of predisposition to lung and brain metastases Am J Surg Pathol 24 2000 197 202
21. S.R. Lakhani, I.O. Ellis, S.J. Schnitt, P.H. Tan, and M. van de Vijver WHO classification of tumours of the breast 2012 IARC Press Lyon
22. J. Fordice, C. Kershaw, A. El-Naggar, and H. Goepfert Adenoid cystic carcinoma of the head and neck: predictors of morbidity and mortality Arch Otolaryngol Head Neck Surg 125 1999 149 152
23. R.G. Ramsay, and T.J. Gonda MYB function in normal and cancer cells Nat Rev Cancer 8 2008 523 534
24. Y. Mitani, J. Li, and P.H. Rao Comprehensive analysis of the MYB-NFIB gene fusion in salivary adenoid cystic carcinoma: Incidence, variability, and clinicopathologic significance Clin Cancer Res 16 2010 4722 4731
25. Y. Mitani, P.H. Rao, and P.A. Futreal Novel chromosomal rearrangements and break points at the t(6;9) in salivary adenoid cystic carcinoma: association with MYB-NFIB chimeric fusion, MYB expression, and clinical outcome Clin Cancer Res 17 2011 7003 7014
26. R.B. West, C. Kong, and N. Clarke MYB expression and translocation in adenoid cystic carcinomas and other salivary gland tumors with clinicopathologic correlation Am J Surg Pathol 35 2011 92 99
27. F. Bhaijee, D.J. Pepper, K.T. Pitman, and D. Bell New developments in the molecular pathogenesis of head and neck tumors: a review of tumor-specific fusion oncogenes in mucoepidermoid carcinoma, adenoid cystic carcinoma, and NUT midline carcinoma Ann Diagn Pathol 15 2011 69 77
28. P.A. Szanto, M.A. Luna, M.E. Tortoledo, and R.A. White Histologic grading of adenoid cystic carcinoma of the salivary glands Cancer 54 1984 1062 1069
29. C.G. Kleer, and H.A. Oberman Adenoid cystic carcinoma of the breast: value of histologic grading and proliferative activity Am J Surg Pathol 22 1998 569 575
30. E.A. Rakha, M.E. El-Sayed, and A.H. Lee Prognostic significance of Nottingham histologic grade in invasive breast carcinoma J Clin Oncol 26 2008 3153 3158
31. E. Slodkowska, S. Sahoo, M. Akram, J. Catalano, and D. Giri Adenoid cystic carcinoma of the breast - a morphologic study of 41 cases Mod Pathol 25 2012 67A
32. M.G. Mastropasqua, E. Maiorano, and G. Pruneri Immunoreactivity for c-kit and p63 as an adjunct in the diagnosis of adenoid cystic carcinoma of the breast Mod Pathol 18 2005 1277 1282
33. A.H. Qizilbash, M.C. Patterson, and K.F. Oliveira Adenoid cystic carcinoma of the breast. Light and electron microscopy and a brief review of the literature Arch Pathol Lab Med 101 1977 302 306
34. J. Lamovec, M. Us-Krasovec, A. Zidar, and A. Kljun Adenoid cystic carcinoma of the breast: a histologic, cytologic, and immunohistochemical study Semin Diagn Pathol 6 1989 153 164
35. R.R. Seethala, J.L. Hunt, Z.W. Baloch, V.A. Livolsi, and Barnes E. Leon Adenoid cystic carcinoma with high-grade transformation: a report of 11 cases and a review of the literature Am J Surg Pathol 31 2007 1683 1694
36. J. Lamovec, G. Falconieri, T. Salviato, and S. Pizzolitto Basaloid carcinoma of the breast: a review of 9 cases, with delineation of a possible clinicopathologic entity Ann Diagn Pathol 12 2008 4 11