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Volumn 7, Issue , 2012, Pages 247-265

Pathogenesis of NUT midline carcinoma

Author keywords

BET inhibitor; BRD4 NUT; Differentiation therapy; Histone acetyltransferase; Histone deacetylase inhibitor; http: www.NMCRegistry.org

Indexed keywords

ANTIINFLAMMATORY AGENT; BRD NUT PROTEIN; BRD3 NUT PROTEIN; BRD3 PROTEIN; BRD4 NUT PROTEIN; BRD4 PROTEIN; BROMODOMAIN AND EXTRATERMINAL DOMAIN CONTAINING PROTEIN INHIBITOR; HISTONE ACETYLTRANSFERASE; HISTONE DEACETYLASE INHIBITOR; NUT PROTEIN; PEPTIDES AND PROTEINS; UNCLASSIFIED DRUG;

EID: 84856857218     PISSN: 15534006     EISSN: 15534014     Source Type: Book Series    
DOI: 10.1146/annurev-pathol-011811-132438     Document Type: Review
Times cited : (211)

References (58)
  • 1
    • 79952321571 scopus 로고    scopus 로고
    • NUTmidline carcinoma in a newborn with multiorgan disseminated tumor and a 2-year-old with a pancreatic/hepatic primary
    • Shehata BM, Steelman CK, Abramowsky CR, Olson TA, French CA, et al. 2009.NUTmidline carcinoma in a newborn with multiorgan disseminated tumor and a 2-year-old with a pancreatic/hepatic primary. Pediatr. Dev. Pathol. 13:481-85
    • (2009) Pediatr. Dev. Pathol , vol.13 , pp. 481-85
    • Shehata, B.M.1    Steelman, C.K.2    Abramowsky, C.R.3    Olson, T.A.4    French, C.A.5
  • 4
    • 77953714098 scopus 로고    scopus 로고
    • Demystified molecular pathology of NUT midline carcinomas
    • French CA. 2010. Demystified molecular pathology of NUT midline carcinomas. J. Clin. Pathol. 63:492-96
    • (2010) J. Clin. Pathol. , vol.63 , pp. 492-96
    • French, C.A.1
  • 6
    • 77953082858 scopus 로고    scopus 로고
    • NUT gene rearrangement in a poorly differentiated carcinoma of the submandibular gland
    • Ziai J, French CA, Zambrano E. 2010. NUT gene rearrangement in a poorly differentiated carcinoma of the submandibular gland. Head Neck Pathol. 4:163-68
    • (2010) Head Neck Pathol. , vol.4 , pp. 163-68
    • Ziai, J.1    French, C.A.2    Zambrano, E.3
  • 8
    • 33646251400 scopus 로고    scopus 로고
    • Midline carcinoma with t(15;19) and BRD4-NUT fusion oncogene in a 30-year-old female with response to docetaxel and radiotherapy
    • Engleson J, Soller M, Panagopoulos I, Dahlen A, Dictor M, Jerkeman M. 2006. Midline carcinoma with t(15;19) and BRD4-NUT fusion oncogene in a 30-year-old female with response to docetaxel and radiotherapy. BMC Cancer 6:69
    • (2006) BMC Cancer , vol.6 , pp. 69
    • Engleson, J.1    Soller, M.2    Panagopoulos, I.3    Dahlen, A.4    Dictor, M.5    Jerkeman, M.6
  • 9
    • 77953462791 scopus 로고    scopus 로고
    • Establishment and characterization of a novel head and neck squamous cell carcinoma cell line USC-HN1
    • Liebertz DJ, Lechner MG, Masood R, Sinha UK, Han J, et al. 2010. Establishment and characterization of a novel head and neck squamous cell carcinoma cell line USC-HN1. Head Neck Oncol. 2:5
    • (2010) Head Neck Oncol. , vol.2 , pp. 5
    • Liebertz, D.J.1    Lechner, M.G.2    Masood, R.3    Sinha, U.K.4    Han, J.5
  • 11
    • 0030789242 scopus 로고    scopus 로고
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • DOI 10.1038/nm0797-730
    • Bonnet D, Dick JE. 1997. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopietic cell. Nat. Med. 3:730-37 (Pubitemid 27298715)
    • (1997) Nature Medicine , vol.3 , Issue.7 , pp. 730-737
    • Bonnet, D.1    Dick, J.E.2
  • 12
    • 24644480749 scopus 로고    scopus 로고
    • Molecular requirements for epithelial-mesenchymal transition during tumor progression
    • DOI 10.1016/j.ceb.2005.08.001, PII S0955067405001043
    • HuberMA, KrautN, BeugH. 2005. Molecular requirements for epithelial-mesenchymal transition during tumor progression. Curr. Opin. Cell Biol. 17:548-58 (Pubitemid 41267170)
    • (2005) Current Opinion in Cell Biology , vol.17 , Issue.SPEC. ISS. 5 , pp. 548-558
    • Huber, M.A.1    Kraut, N.2    Beug, H.3
  • 13
    • 33244463813 scopus 로고    scopus 로고
    • Complex networks orchestrate epithelial-mesenchymal transitions
    • DOI 10.1038/nrm1835, PII NRM1835
    • Thiery JP, Sleeman JP. 2006. Complex networks orchestrate epithelial-mesenchymal transitions. Nat. Rev. Mol. Cell Biol. 7:131-42 (Pubitemid 43278296)
    • (2006) Nature Reviews Molecular Cell Biology , vol.7 , Issue.2 , pp. 131-142
    • Thiery, J.P.1    Sleeman, J.P.2
  • 14
    • 77956394108 scopus 로고    scopus 로고
    • Oncogenesis by sequestration of CBP/p300 in transcriptionally inactive hyperacetylated chromatin domains
    • Reynoird N, Schwartz BE, Delvecchio M, Sadoul K, Meyers D, et al. 2010. Oncogenesis by sequestration of CBP/p300 in transcriptionally inactive hyperacetylated chromatin domains. EMBO J. 29:2943-52
    • (2010) EMBO J. , vol.29 , pp. 2943-52
    • Reynoird, N.1    Schwartz, B.E.2    Delvecchio, M.3    Sadoul, K.4    Meyers, D.5
  • 20
    • 0025742958 scopus 로고
    • Novel t(15;19)(q15;p13) chromosome abnormality in a thymic carcinoma
    • Kubonishi I, Takehara N, Iwata J, Sonobe H, Ohtsuki Y, et al. 1991. Novel t(15;19)(q15;p13) chromosome abnormality in a thymic carcinoma. Cancer Res. 51:3327-28
    • (1991) Cancer Res , vol.51 , pp. 3327-28
    • Kubonishi, I.1    Takehara, N.2    Iwata, J.3    Sonobe, H.4    Ohtsuki, Y.5
  • 21
    • 0025720075 scopus 로고
    • Intrathoracic carcinoma in an 11-year-old girl showing a translocation t(15;19)
    • Kees UR, Mulcahy MT, Willoughby ML. 1991. Intrathoracic carcinoma in an 11-year-old girl showing a translocation t(15;19). Am. J. Pediatr. Hematol. Oncol. 13:459-64
    • (1991) Am. J. Pediatr. Hematol. Oncol , vol.13 , pp. 459-64
    • Kees, U.R.1    Mulcahy, M.T.2    Willoughby, M.L.3
  • 22
    • 0027275415 scopus 로고
    • Disseminated mediastinal carcinoma with chromosomal translocation (15;19): A distinctive clinicopathologic syndrome
    • Lee AC, Kwong YI, Fu KH, Chan GC, Ma L, Lau YL. 1993. Disseminated mediastinal carcinoma with chromosomal translocation (15;19). A distinctive clinicopathologic syndrome. Cancer 72:2273-76 (Pubitemid 23280160)
    • (1993) Cancer , vol.72 , Issue.7 , pp. 2273-2276
    • Lee, A.C.W.1    Kwong, Y.-L.2    Fu, K.H.3    Chan, G.C.F.4    Ma, L.5    Lau, Y.-L.6
  • 23
    • 0035446797 scopus 로고    scopus 로고
    • Upper respiratory tract carcinoma with chromosomal translocation 15;19: Evidence for a distinct disease entity of young patients with a rapidly fatal course
    • DOI 10.1002/1097-0142(20010901)92:5<1195::AID-CNCR1438>3.0.CO;2-3
    • Vargas SO, French CA, Faul PN, Fletcher JA, Davis IJ, et al. 2001. Upper respiratory tract carcinoma with chromosomal translocation 15;19: evidence for a distinct disease entity of young patients with a rapidly fatal course. Cancer 92:1195-203 (Pubitemid 32861669)
    • (2001) Cancer , vol.92 , Issue.5 , pp. 1195-1203
    • Vargas, S.O.1    French, C.A.2    Faul, P.N.3    Fletcher, J.A.4    Davis, I.J.5    DalCin, P.6    Perez-Atayde, A.R.7
  • 25
    • 2042468820 scopus 로고    scopus 로고
    • Interaction of the bovine papillomavirus E2 protein with Brd4 tethers the viral DNA to host mitotic chromosomes
    • DOI 10.1016/S0092-8674(04)00402-7, PII S0092867404004027
    • You J, Croyle JL, Nishimura A, Ozato K, Howley PM. 2004. Interaction of the bovine papillomavirus E2 protein with Brd4 tethers the viral DNA to host mitotic chromosomes. Cell 117:349-60 (Pubitemid 38534541)
    • (2004) Cell , vol.117 , Issue.3 , pp. 349-360
    • You, J.1    Croyle, J.L.2    Nishimura, A.3    Ozato, K.4    Howley, P.M.5
  • 26
    • 70349669271 scopus 로고    scopus 로고
    • Cooperative binding of two acetylation marks on a histone tail by a single bromodomain
    • Moriniere J, Rousseaux S, Steuerwald U, Soler-Lopez M, Curtet S, et al. 2009. Cooperative binding of two acetylation marks on a histone tail by a single bromodomain. Nature 461:664-68
    • (2009) Nature , vol.461 , pp. 664-68
    • Moriniere, J.1    Rousseaux, S.2    Steuerwald, U.3    Soler-Lopez, M.4    Curtet, S.5
  • 28
    • 0033519641 scopus 로고    scopus 로고
    • Structure and ligand of a histone acetyltransferase bromodomain
    • DOI 10.1038/20974
    • Dhalluin C, Carlson JE, Zeng L, He C, Aggarwal AK, Zhou MM. 1999. Structure and ligand of a histone acetyltransferase bromodomain. Nature 399:491-96 (Pubitemid 29258857)
    • (1999) Nature , vol.399 , Issue.6735 , pp. 491-496
    • Dhalluin, C.1    Carlson, J.E.2    Zeng, L.3    He, C.4    Aggarwal, A.K.5    Zhou, M.-M.6
  • 30
    • 23744514308 scopus 로고    scopus 로고
    • The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription
    • DOI 10.1016/j.molcel.2005.06.027, PII S1097276505014322
    • Jang MK, Mochizuki K, Zhou M, Jeong HS, Brady JN, Ozato K. 2005. The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNApolymerase II-dependent transcription. Mol. Cell 19:523-34 (Pubitemid 41140009)
    • (2005) Molecular Cell , vol.19 , Issue.4 , pp. 523-534
    • Moon, K.J.1    Mochizuki, K.2    Zhou, M.3    Jeong, H.-S.4    Brady, J.N.5    Ozato, K.6
  • 31
    • 42049095157 scopus 로고    scopus 로고
    • The bromodomain protein Brd4 stimulates G1 gene transcription and promotes progression to S phase
    • Mochizuki K, Nishiyama A, Jang MK, Dey A, Ghosh A, et al. 2008. The bromodomain protein Brd4 stimulates G1 gene transcription and promotes progression to S phase. J. Biol. Chem. 283:9040-48
    • (2008) J. Biol. Chem , vol.283 , pp. 9040-48
    • Mochizuki, K.1    Nishiyama, A.2    Jang, M.K.3    Dey, A.4    Ghosh, A.5
  • 32
    • 23744467035 scopus 로고    scopus 로고
    • Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4
    • DOI 10.1016/j.molcel.2005.06.029, PII S1097276505014310
    • Yang Z, Yik JH, Chen R, He N, Jang MK, et al. 2005. Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4. Mol. Cell 19:535-45 (Pubitemid 41140010)
    • (2005) Molecular Cell , vol.19 , Issue.4 , pp. 535-545
    • Yang, Z.1    Yik, J.H.N.2    Chen, R.3    He, N.4    Moon, K.J.5    Ozato, K.6    Zhou, Q.7
  • 33
    • 56749096290 scopus 로고    scopus 로고
    • Solution structure of the extraterminal domain of the bromodomain-containing protein BRD4
    • Lin YJ, Umehara T, Inoue M, Saito K, Kigawa T, et al. 2008. Solution structure of the extraterminal domain of the bromodomain-containing protein BRD4. Protein Sci. 17:2174-79
    • (2008) Protein Sci , vol.17 , pp. 2174-79
    • Lin, Y.J.1    Umehara, T.2    Inoue, M.3    Saito, K.4    Kigawa, T.5
  • 34
    • 33750356102 scopus 로고    scopus 로고
    • 1 cell cycle arrest
    • DOI 10.1128/JVI.00804-06
    • Ottinger M, Christalla T, Nathan K, Brinkmann MM, Viejo-Borbolla A, Schulz TF. 2006. Kaposi's sarcoma-associated herpesvirus LANA-1 interacts with the short variant of BRD4 and releases cells from a BRD4- and BRD2/RING3-induced G1 cell cycle arrest. J. Virol. 80:10772-86 (Pubitemid 44628923)
    • (2006) Journal of Virology , vol.80 , Issue.21 , pp. 10772-10786
    • Ottinger, M.1    Christalla, T.2    Nathan, K.3    Brinkmann, M.M.4    Viejo-Borbolla, A.5    Schulz, T.F.6
  • 35
    • 77956394108 scopus 로고    scopus 로고
    • Oncogenesis by sequestration of CBP/p300 in transcriptionally inactive hyperacetylated chromatin domains
    • Reynoird N, Schwartz BE, Delvecchio M, Sadoul K, Meyers D, et al. 2010. Oncogenesis by sequestration of CBP/p300 in transcriptionally inactive hyperacetylated chromatin domains. EMBO J. 29:2943-52
    • (2010) EMBO J. , vol.29 , pp. 2943-52
    • Reynoird, N.1    Schwartz, B.E.2    Delvecchio, M.3    Sadoul, K.4    Meyers, D.5
  • 38
    • 0042090936 scopus 로고    scopus 로고
    • Acetylation-dependent chromatin reorganization by BRDT, a testis-specific bromodomain-containing protein
    • DOI 10.1128/MCB.23.15.5354-5365.2003
    • Pivot-Pajot C, Caron C, Govin J, Vion A, Rousseaux S, Khochbin S. 2003. Acetylation-dependent chromatin reorganization byBRDT, a testis-specific bromodomain-containing protein. Mol. Cell Biol. 23:5354-65 (Pubitemid 36950890)
    • (2003) Molecular and Cellular Biology , vol.23 , Issue.15 , pp. 5354-5365
    • Pivot-Pajot, C.1    Caron, C.2    Govin, J.3    Vion, A.4    Rousseaux, S.5    Khochbin, S.6
  • 40
    • 23744498520 scopus 로고    scopus 로고
    • Mutations in the receptor tyrosine kinase pathway are associated with clinical outcome in patients with acute myeloblastic leukemia harboring t(8;21)(q22;q22)
    • DOI 10.1038/sj.leu.2403803
    • Nanri T, Matsuno N, Kawakita T, Suzushima H, Kawano F, et al. 2005. Mutations in the receptor tyrosine kinase pathway are associated with clinical outcome in patients with acute myeloblastic leukemia harboring t(8;21)(q22;q22). Leukemia 19:1361-66 (Pubitemid 41136329)
    • (2005) Leukemia , vol.19 , Issue.8 , pp. 1361-1366
    • Nanri, T.1    Matsuno, N.2    Kawakita, T.3    Suzushima, H.4    Kawano, F.5    Mitsuya, H.6    Asou, N.7
  • 42
    • 66149092582 scopus 로고    scopus 로고
    • Exome sequencing takes centre stage in cancer profiling
    • Maher B. 2009. Exome sequencing takes centre stage in cancer profiling. Nature 459:146-47
    • (2009) Nature , vol.459 , pp. 146-47
    • Maher, B.1
  • 43
    • 33144469085 scopus 로고    scopus 로고
    • Glutamineexpanded ataxin-7 alters TFTC/STAGA recruitment and chromatin structure leading to photoreceptor dysfunction
    • Helmlinger D, Hardy S, Abou-Sleymane G, Eberlin A, Bowman AB, et al. 2006. Glutamineexpanded ataxin-7 alters TFTC/STAGA recruitment and chromatin structure leading to photoreceptor dysfunction. PLoS Biol. 4:e67
    • (2006) PLoS Biol , vol.4
    • Helmlinger, D.1    Hardy, S.2    Abou-Sleymane, G.3    Eberlin, A.4    Bowman, A.B.5
  • 48
    • 0030739980 scopus 로고    scopus 로고
    • Differentiation of t(5;17) variant acute promyelocytic leukemic blasts by all-trans retinoic acid
    • Redner RL, Corey SJ, Rush EA. 1997. Differentiation of t(5;17) variant acute promyelocytic leukemic blasts by all-trans retinoic acid. Leukemia 11:1014-16 (Pubitemid 27345950)
    • (1997) Leukemia , vol.11 , Issue.7 , pp. 1014-1016
    • Redner, R.L.1    Corey, S.J.2    Rush, E.A.3
  • 50
    • 62549083523 scopus 로고    scopus 로고
    • Long-term efficacy and safety of all-trans retinoic acid/arsenic trioxide-based therapy in newly diagnosed acute promyelocytic leukemia
    • Hu J, Liu YF, Wu CF, Xu F, Shen ZX, et al. 2009. Long-term efficacy and safety of all-trans retinoic acid/arsenic trioxide-based therapy in newly diagnosed acute promyelocytic leukemia. Proc. Natl. Acad. Sci. USA 106:3342-47
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 3342-47
    • Hu, J.1    Liu, Y.F.2    Wu, C.F.3    Xu, F.4    Shen, Z.X.5
  • 53
    • 0029947186 scopus 로고    scopus 로고
    • Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
    • Druker BJ, Tamura S, Buchdunger E, Ohno S, Segal GM, et al. 1996. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat. Med. 2:561-66
    • (1996) Nat. Med , vol.2 , pp. 561-66
    • Druker, B.J.1    Tamura, S.2    Buchdunger, E.3    Ohno, S.4    Segal, G.M.5
  • 54
    • 77956513286 scopus 로고    scopus 로고
    • Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma
    • Bollag G, Hirth P, Tsai J, Zhang J, Ibrahim PN, et al. 2010. Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma. Nature 467:596-99
    • (2010) Nature , vol.467 , pp. 596-99
    • Bollag, G.1    Hirth, P.2    Tsai, J.3    Zhang, J.4    Ibrahim, P.N.5
  • 56
    • 0031782323 scopus 로고    scopus 로고
    • The leukemic protein core binding factor β (CBFβ)-smooth-muscle myosin heavy chain sequesters CBFα2 into cytoskeletal filaments and aggregates
    • Adya N, Stacy T, Speck NA, Liu PP. 1998. The leukemic protein core binding factor (CBF)-smoothmuscle myosin heavy chain sequesters CBF2 into cytoskeletal filaments and aggregates. Mol. Cell Biol. 18:7432-43 (Pubitemid 28533062)
    • (1998) Molecular and Cellular Biology , vol.18 , Issue.12 , pp. 7432-7443
    • Adya, N.1    Stacy, T.2    Speck, N.A.3    Liu, P.P.4
  • 57


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