Tissue-specific differences in activation of atypical protein kinase C and protein kinase B in muscle, liver, and adipocytes of insulin receptor substrate-1 knockout mice

Molecular Endocrinology

Volumn 18, Issue 10, 2004, Pages 2513-2521

  Sajan, Mini P ^a,b   Standaert, Mary L ^a,b   Miura, Atsushi ^a,b   Kahn, C Ron ^c   Farese, Robert V ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATYPICAL PROTEIN KINASE C; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN KINASE C; UNCLASSIFIED DRUG;

ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; INSULIN SENSITIVITY; KNOCKOUT MOUSE; LIVER; MALE; METABOLIC DISORDER; METABOLISM; MOUSE; MUSCLE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TISSUE SPECIFICITY; VASTUS LATERALIS MUSCLE;

ADIPOCYTES; ANIMALS; ENZYME ACTIVATION; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIVER; MALE; MICE; MICE, KNOCKOUT; MUSCLE, SKELETAL; PHOSPHOPROTEINS; PROTEIN KINASE C; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; SEQUENCE DELETION; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 5044228079     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2004-0045     Document Type: Article

References (40)

1. Bandyopadhyay G, Standaert ML, Sajan MP, Kanoh Y, Miura A, Braun U, Kruse F, Leitges M, Farese RV 2004 PKC-λ knockout in embryonic stem cells and adipocytes impairs insulin-stimulated glucose transport. Mol Endocrinol 18:373-383
2. Bandyopadhyay G, Kanoh Y, Sajan MP, Standaert ML, Farese RV 2000 Effects of adenoviral gene transfer of wild-type, constitutively active, and kinase-defective protein kinase C-λ on insulin-stimulated glucose transport in L6 myotubes. Endocrinology 141:4120-4127
3. Bae SS, Cho H, Mu J, Birnbaum MJ 2003 Isoform-specific regulation of insulin-dependent glucose uptake by Akt/protein kinase B. J Biol Chem 278:49530-49536
4. Wang Q, Somwar M, Bilan PJ, Liu Z, Woodgett JR, Klip A 1999 Protein kinase B/Akt participates in Glut4 translocation by insulin in L6 myoblasts. Mol Cell Biol 19: 4008-4018
5. Takata M, Ogawa W, Kitamura T, Hino Y, Kuroda S, Kotani K, Klip A, Gingras AC, Sonenberg N, Kasuga M 1999 Requirement for Akt (protein kinase B) in insulin-induced activation of glycogen synthase and phosphorylation of 4E-BP1 (PHAS-1). J Biol Chem 274: 20611-20618
6. Peak M, Rochford JJ, Borthwick AC, Yeaman SJ, Agius L 1998 Signalling pathways involved in the stimulation of glycogen synthesis in rat hepatocytes. Diabetologia 41: 16-25
7. Matsumoto M, Ogawa W, Akimoto K, Inoue H, Miyake K, Furukawa K, Hayashi Y, Iguchi H, Matsuki Y, Hiramatsu R, Shimano H, Yamada N, Ohno S, Kasuga M, Noda T 2003 PKCλ in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity. J Clin Invest 112:935-944
8. Daitoku H, Yamagata K, Matsuzaki H, Hatta M, Fukamizu A 2003 Regulation of PGC-1 promoter activity by protein kinase B and the forkhead transcription factor FKHR. Diabetes 52:642-649
9. Schmoll D, Walker KS, Alessi DR, Grempler R, Burchell A, Guo S, Walther R, Unterman TG 2000 Regulation of glucose-6-phosphatase gene expression by protein kinase Bα and the forkhead transcription factor FKHR. J Biol Chem 275:36324-36333
10. Alessi DR, Andjelkovic M, Caudwell B, Cron P, Morrice N, Cohen P, Hemmings BA 1996 Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J 15: 6541-6551
11. LeGood JA, Ziegler WH, Parakh DB, Alessi DR, Cohen P, Parker PJ 1998 Protein kinase C isotopes controlled by phosphoinositide 3-kinase through protein kinase PDK1. Science 281:2042-2045
12. Chou MM, How W, Johnson J, Graham LK, Lee MH, Chen CH, Newton AC, Schaffhause BS, Toker A 1998 Regulation of protein kinase Cζ by PI 3-kinase and PDK-1. Curr Biol 8:1069-1077
13. Standaert ML, Galloway L, Kamam P, Bandyopadhyay G, Moscat J, Farese RV 1997 Protein kinase C-ζ as a downstream effector of phosphatidylinositol 3-kinase during insulin stimulation in rat adipocytes. Potential role in glucose transport. J Biol Chem 272:30075-30082
14. 3 activate PKC-ζ by mechanisms that are dependent and independent of phosphorylation of activation loop (T410) and autophosphorylation (560) sites. Biochemistry 40:249-255
15. Ueki K, Yamauchi T, Tamemoto H, Tobe K, Yamamoto-Honda R, Kaburagi Y, Akanuma Y, Yazaki Y, Aizawa S, Nagai R, Kadowaki T 2000 Restored insulin sensitivity in IRS-1-deficient mice treated by adenovirus-mediated gene therapy. J Clin Invest 105:1437-1445
16. Yamouchi T, Tobe K, Tamemoto H, Ueki K, Kaburagi Y, Yamamoto-Honda R, Takahashi Y, Yoshizawa F, Aizawa S, Sonenberg N, Yazaki Y, Kadowaki T 1996 Insulin signaling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice. Mol Cell Biol 16:3074-3084
17. Higaki Y, Wojtaszewski JFP, Hirshman MF, Withers DJ, Towery H, Whiten MF, Goodyear LJ 1999 Insulin receptor substrate-2 is not necessary for insulin-stimulated glucose transport in skeletal muscle. J Biol Chem 274: 20791-20795
18. Valverde AM, Kahn CR, Benito M 1999 Insulin signaling in insulin receptor substrate (IRS)-1-deficient brown adipocytes. Requirement of IRS-1 for lipid synthesis. Diabetes 48:2122-2131
19. Arribas M, Valverde AM, Burks D, Klein J, Farese RV, White MF, Benito M 2003 Essential role of protein kinase Cζ in the impairment of insulin-induced glucose transport in IRS-2-deficient brown adipocytes. FEBS Lett 536: 161-166
20. Tseng Y-H, Ueki H, Kriauciunas KM, Kahn CR 2002 Differential roles of insulin receptor substrates in the anti-apoptotic function of insulin-like growth factor and insulin. J Biol Chem 277:31601-31611
21. Valverde AM, Burks DJ, Fabregat I, Fisher TL, Carretero J, White MF, Benito M 2003 Molecular mechanisms of insulin resistance in IRS-2-deficient hepatocytes. Diabetes 52:2239-2248
22. Araki E, Lipes MA, Patti ME, Bruning JC, Haag III B, Johnson RS, Kahn CR 1994 Alternative pathway of insulin signaling in mice with targeted disruption of the IRS-1 gene. Nature 372:186-190
23. Tamemoto H, Kadowaki T, Tobe K, Yagi T, Sakura H, Hayakawa T, Terauchi Y, Ueki K, Kaburagi Y, Satoh S, Sekihara H, Yoshioka S, Horikoshi H, Furuta Y, Ikawa Y, Kasuga M, Yazaki Y, Aizawa S 1994 Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1. Nature 372:182-186
24. Gazdag AC, Dumke CL, Kahn CR, Cartee GD 1999 Calorie restriction increases insulin-stimulated glucose transport in skeletal muscle from IRS-1 knockout mice. Diabetes 48:1930-1936
25. Kanoh Y, Bandyopadhyay G, Sajan MP, Standaert ML, Farese RV 2000 Thiazolidinedione treatment enhances insulin effects on protein kinase C-ζ/λ and glucose transport in adipocytes of nondiabetic and Goto-Kakazaki type II diabetic rats. J Biol Chem 275:16690-16696
26. Kanoh Y, Bandyopadhyay G, Sajan MP, Standaert ML, Farese RV 2001 Rosiglitazone, insulin treatment, and fasting correct defective activation of protein kinase C-ζ/λ by insulin in vastus lateralis muscles and adipocytes of diabetic rats. Endocrinology 142:1595-1605.
27. Standaert ML, Ortmeyer HK, Hansen BC, Sajan MP, Kanoh Y, Bandyopadhyay G, Farese RV 2002 Skeletal muscle insulin resistance in obesity-associated type 2 diabetes mellitus in monkeys is linked to a defect in insulin activation of protein kinase C-ζ/λ/ι. Diabetes 51: 2936-2943
28. 3 is defective in muscle in type 2 diabetes and impaired glucose tolerance. Diabetes 52:1926-1934
29. Kim Y-B, Nikoulina SE, Ciaraldi TP, Henry RR, Kahn, BB 1999 Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase in muscle in type 2 diabetes. J Clin Invest 104: 733-741
30. Kim Y-B, Kotani K, Ciaraldi TP, Henry RR, Kahn BB 2003 Insulin-stimulated PKC-λ/ζ activity is reduced and PDK-1 activity is normal in muscle of insulin-resistant humans. Diabetes 52:1935-1942
31. Standaert ML, Sajan MP, Miura A, Kanoh Y, Chen HC, Farese Jr RV, Farese RV 2004 Insulin-induced activation of atypical protein kinase C, but not PKB, is maintained in diabetic (ob/ob and Goto-Kakazaki) liver. Contrasting insulin signaling patterns in liver versus muscle define phenotypes of type 2 diabetic and high fat-induced insulin-resistant states. J Biol Chem 279:24929-24934
32. 3 in skeletal muscle of rats following high-fat feeding and streptozotocin-induced diabetes. Endocrinology 144:947-954
33. Kaburagi Y, Satoh S, Tamemoto H, Yamamoto-Honda R, Tobe K, Veki K, Yamauchi T, Kono-Sugita E, Sekihara H, Aizawa S, Cushman SW, Akanuma Y, Kadowaki T 1997 Role of insulin receptor substrate-1 and pp60 in the regulation of insulin-induced glucose transport and GLUT4 translocation in primary adipocytes. J Biol Chem 272:25839-25844
34. Inoue G, Cheatham B, Emkey R, Kahn CR 1998 Dynamics of insulin signaling in 3T3/L1 adipocytes. Differential compartmentalization and trafficking of insulin receptor substrates (IRS)-1 and IRS-2. J Biol Chem 273: 11548-11555
35. Taniguchi CM, Ueki K, Kahn CR 2004 American Diabetes Association Program. Adenoviral-mediated RNA Interference reveals the relative role of IRS-1 and IRS-2 in hepatic insulin action. Diabetes 53:A37 (Abstract 159-O)
36. Lefebvre V, Mechin MC, Louckx MP, Rider MH, Hue L 1996 Signaling pathway involved in the activation of heart 6-phosphofructo-2-kinase by insulin. J Biol Chem 271:22289-22292
37. Deprez J, Vertommen D, Alessi DR, Hue L, Rider MH 1997 Phosphorylation and activation of heart 6-phosphofructo-2-kinase by protein kinase B and other protein kinases of the insulin signaling cascades. J Biol Chem 272:17269-17275
38. Cho H, Mu J, Kim JK, Crenshaw III EB, Kaestner KH, Bartolomei MS, Shulman GI, Birnbaum MJ 2001 Insulin resistance and a diabetes-like syndrome in mice lacking the protein kinase Akt2 (PKBβ). Science 292: 1728-1731
39. Cusi K, Maezono K, Osman A, Pendergrass M, Patti ME, Pratipanawatr T, DeFronzo RA, Kahn CR, Mandarine LJ 2000 Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in muscle of humans with type 2 diabetes mellitus. J Clin Invest 105: 311-320
40. Sajan MP, Standaert ML, Bandyopadhyay G, Quon MJ, Burke Jr TR, Farese RV 1999 Protein kinase C-ζ and phosphoinositide-dependent protein kinase-1 are required for insulin-induced activation of ERK in rat adipocytes. J Biol Chem 274:30495-30500