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Volumn 61, Issue 4, 2012, Pages 459-469

Correction of metabolic abnormalities in a rodent model of obesity, metabolic syndrome, and type 2 diabetes mellitus by inhibitors of hepatic protein kinase C-ι

Author keywords

[No Author keywords available]

Indexed keywords

1H IMIDAZOLE 4 CARBOXAMIDE; 5 AMINO 1 [2,3 DIHYDROXY 4[(PHOSPHONO OXY)METHYL]CYCLOPENTYL [1R (1A,2B,3B,4A)]; AUROTHIOMALATE; INSULIN; PROTEIN KINASE B; PROTEIN KINASE C INHIBITOR; UNCLASSIFIED DRUG;

EID: 84858439965     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2011.12.008     Document Type: Article
Times cited : (28)

References (18)
  • 1
    • 2942530449 scopus 로고    scopus 로고
    • Insulin-induced activation of atypical protein kinase C, but not protein kinase B, is maintained in diabetic (ob/ob and Goto-Kakazaki) liver: Contrasting insulin signaling patterns in liver versus muscle define phenotypes of type 2 diabetic and high fat-induced insulin-resistant states
    • DOI 10.1074/jbc.M402440200
    • M.L. Standaert, M.P. Sajan, and A. Mirua Insulin-induced activation of atypical protein kinase C, but not protein kinase B, is maintained in diabetic ob/ob and Goto-Kakizaki liver. Contrasting insulin signaling patterns in liver versus muscle define phenotypes of type 2 diabetic and high fat-induced insulin-resistant states J Biol Chem 279 2004 24929 24934 (Pubitemid 38756740)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.24 , pp. 24929-24934
    • Standaert, M.L.1    Sajan, M.P.2    Miura, A.3    Kanoh, Y.4    Chen, H.C.5    Farese Jr., R.V.6    Farese, R.V.7
  • 2
    • 67650564157 scopus 로고    scopus 로고
    • Critical role of atypical protein kinase C in activating hepatic SREBP-1c and NFκB in obesity
    • M.P. Sajan, M.L. Standaert, and S. Nimal Critical role of atypical protein kinase C in activating hepatic SREBP-1c and NFκB in obesity J Lipid Res 50 2009 1133 1145
    • (2009) J Lipid Res , vol.50 , pp. 1133-1145
    • Sajan, M.P.1    Standaert, M.L.2    Nimal, S.3
  • 3
    • 67349090336 scopus 로고    scopus 로고
    • Role of atypical protein kinase C in activation of sterol regulatory element binding protein-1c and nuclear factor kappa B (NFkappaB) in liver of rodents used as model of diabetes, and relationships to hyperlipidaemia and insulin resistance
    • M.P. Sajan, M.L. Standaert, and J. Rivas Role of atypical protein kinase C in activation of sterol regulatory element binding protein-1c and nuclear factor kappa B (NFkappaB) in liver of rodents used as model of diabetes, and relationships to hyperlipidaemia and insulin resistance Diabetologia 52 2009 1197 1207
    • (2009) Diabetologia , vol.52 , pp. 1197-1207
    • Sajan, M.P.1    Standaert, M.L.2    Rivas, J.3
  • 6
    • 5044228079 scopus 로고    scopus 로고
    • Tissue-specific differences in activation of atypical protein kinase C and protein kinase B in muscle, liver, and adipocytes of insulin receptor substrate-1 knockout mice
    • DOI 10.1210/me.2004-0045
    • M.P. Sajan, M.L. Standaert, and A. Miura Tissue-specific differences in activation of atypical protein kinase C and protein kinase B in muscle, liver and adipocytes of insulin receptor substrate-1 knockout mice Mol Endocrinol 18 2004 2513 2521 (Pubitemid 39335985)
    • (2004) Molecular Endocrinology , vol.18 , Issue.10 , pp. 2513-2521
    • Sajan, M.P.1    Standaert, M.L.2    Miura, A.3    Kahn, C.R.4    Farese, R.V.5
  • 7
    • 70249108137 scopus 로고    scopus 로고
    • The Irs1 branch of the insulin signaling cascade plays a dominant role in hepatic nutrient homeostasis
    • S. Guo, K.D. Copps, and S. Park The Irs1 branch of the insulin signaling cascade plays a dominant role in hepatic nutrient homeostasis Mol Cell Biol 29 2009 5070 5083
    • (2009) Mol Cell Biol , vol.29 , pp. 5070-5083
    • Guo, S.1    Copps, K.D.2    Park, S.3
  • 8
    • 77349127295 scopus 로고    scopus 로고
    • Metabolic functions of atypical protein kinase C: "Good and bad" as defined by nutritional status (invited review)
    • R.V. Farese, and M.P. Sajan Metabolic functions of atypical protein kinase C: "good and bad" as defined by nutritional status (invited review) Am J Physiol Endocrinol Metab 298 2010 E385 E394
    • (2010) Am J Physiol Endocrinol Metab , vol.298
    • Farese, R.V.1    Sajan, M.P.2
  • 11
    • 79953232778 scopus 로고    scopus 로고
    • ICA-1: A novel PKC-ι inhibitor that abrogates cell proliferation and induces apoptosis in neuroblastoma
    • P. Pillai, S. Desai, and R. Patel ICA-1: a novel PKC-ι inhibitor that abrogates cell proliferation and induces apoptosis in neuroblastoma Internat J Biochem and Cell Biol 43 2011 784 794
    • (2011) Internat J Biochem and Cell Biol , vol.43 , pp. 784-794
    • Pillai, P.1    Desai, S.2    Patel, R.3
  • 12
    • 32944470373 scopus 로고    scopus 로고
    • A novel small-molecule inhibitor of protein kinase Cι blocks transformed growth of non-small-cell lung cancer cells
    • DOI 10.1158/0008-5472.CAN-05-3405
    • M. Stallings-Mann, L. Jamieson, and R.P. Regala A novel small molecule inhibitor of protein kinase Cι blocks transformed growth of non-small cell lung cancer Cancer Res 66 2006 1767 1774 (Pubitemid 43259962)
    • (2006) Cancer Research , vol.66 , Issue.3 , pp. 1767-1774
    • Stailings-Mann, M.1    Jamieson, L.2    Regala, R.P.3    Weems, C.4    Murray, N.R.5    Fields, A.P.6
  • 14
    • 84858450402 scopus 로고    scopus 로고
    • Targeting the oncogenic protein kinase Ciota for the treatment of cancer
    • A.P. Fields, L.A. Frederick, and R.P. Regala Targeting the oncogenic protein kinase Ciota for the treatment of cancer Biochem Soc Trans 23 2007 1996 2000
    • (2007) Biochem Soc Trans , vol.23 , pp. 1996-2000
    • Fields, A.P.1    Frederick, L.A.2    Regala, R.P.3
  • 15
    • 48649092328 scopus 로고    scopus 로고
    • Atypical protein kinase Cι expression and aurothiomalate sensitivity in human lung cancer cells
    • R.P. Regala, E.A. Thompson, and A.P. Fields Atypical protein kinase Cι expression and aurothiomalate sensitivity in human lung cancer cells Cancer Res 68 2008 5888 5895
    • (2008) Cancer Res , vol.68 , pp. 5888-5895
    • Regala, R.P.1    Thompson, E.A.2    Fields, A.P.3
  • 17
    • 71949113900 scopus 로고    scopus 로고
    • Atypical protein kinase C activity in the hypothalamus is required for lipopolysaccharide-mediated sickness responses
    • 2009
    • J.P. Thaler, S.J. Choi, and M.P. Sajan Atypical protein kinase C activity in the hypothalamus is required for lipopolysaccharide-mediated sickness responses Endocrinol 150 2009 5362 5372 2009
    • (2009) Endocrinol , vol.150 , pp. 5362-5372
    • Thaler, J.P.1    Choi, S.J.2    Sajan, M.P.3
  • 18
    • 0042093781 scopus 로고    scopus 로고
    • Insulin-stimulated protein kinase C λ/ζ activity is reduced in skeletal muscle of humans with obesity and type 2 diabetes: Reversal with weight reduction
    • DOI 10.2337/diabetes.52.8.1935
    • Y.B. Kim, K. Kotani, and T.P. Ciaraldi Insulin-stimulated protein kinase C-λ/ζ activity is reduced in skeletal muscle of humans with obesity and type 2 diabetes; reversal with weight reduction Diabetes 52 2003 1935 1942 (Pubitemid 36919784)
    • (2003) Diabetes , vol.52 , Issue.8 , pp. 1935-1942
    • Kim, Y.-B.1    Kotani, K.2    Ciaraldi, T.P.3    Henry, R.R.4    Kahn, B.B.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.