Requirements for pseudosubstrate arginine residues during autoinhibition and phosphatidylinositol 3,4,5-(PO4)3-dependent activation of atypical PKC

Journal of Biological Chemistry

Volumn 289, Issue 36, 2014, Pages 25021-25030

  Ivey, Robert A ^a   Sajan, Mini P ^a,b   Farese, Robert V ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; ARGININE; INSULIN; RESTORATION;

AUTOPHOSPHORYLATION; CONSTITUTIVELY ACTIVES; INHIBITORY EFFECT; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLINOSITOL 3-KINASE; PLECKSTRIN HOMOLOGY DOMAINS; SITE DIRECTED MUTAGENESIS; SUBSTRATE-BINDING SITES;

CHEMICAL ACTIVATION;

ARGININE; ATYPICAL PROTEIN KINASE C; CERAMIDE; GLUTAMIC ACID; INSULIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PROTEIN KINASE C; PROTEIN KINASE C LAMBDA; PROTEIN KINASE C ZETA; UNCLASSIFIED DRUG; ISOENZYME; PEPTIDE; PHOSPHATIDYLINOSITOL 3 PHOSPHATE; PHOSPHATIDYLINOSITOL 3,4,5-TRIPHOSPHATE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PHOSPHATIDYLSERINE; POLYPHOSPHOINOSITIDE;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOPHOSPHORYLATION; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PROTEIN TARGETING; SITE DIRECTED MUTAGENESIS; 129 MOUSE; 3T3 CELL LINE; AMINO ACID SEQUENCE; ANIMAL; C57BL MOUSE; DOSE RESPONSE; DRUG EFFECTS; ENZYME SPECIFICITY; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHOSPHORYLATION; WESTERN BLOTTING;

3T3-L1 CELLS; AMINO ACID SEQUENCE; ANIMALS; ARGININE; BLOTTING, WESTERN; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; HUMANS; ISOENZYMES; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MICE, 129 STRAIN; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PEPTIDES; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; PHOSPHATIDYLINOSITOL PHOSPHATES; PHOSPHATIDYLSERINES; PHOSPHORYLATION; PROTEIN KINASE C; SUBSTRATE SPECIFICITY;

EID: 84906987336     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.565671     Document Type: Article

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