Increased gluconeogenesis in youth with newly diagnosed type 2 diabetes

Diabetologia

Volumn 58, Issue 3, 2015, Pages 596-603

  Chung, Stephanie T ^a,b   Hsia, Daniel S ^b   Chacko, Shaji K ^b   Rodriguez, Luisa M ^b   Haymond, Morey W ^b  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Fasting hyperglycaemia; Gluconeogenesis; Glucose production; Paediatric type 2 diabetes

Indexed keywords

FATTY ACID; GLUCAGON; GLUCOSE; GLUTAMATE DECARBOXYLASE; GLYCEROL; HEMOGLOBIN A1C; INSULIN; LACTIC ACID;

ADOLESCENT; ARTICLE; BLOOD SAMPLING; BODY WATER; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETIC PATIENT; DIET RESTRICTION; FEMALE; GLUCAGON BLOOD LEVEL; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLYCEROL BLOOD LEVEL; GLYCOGENOLYSIS; HUMAN; HYPERGLYCEMIA; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PATHOPHYSIOLOGY; PATIENT EDUCATION; PRIORITY JOURNAL; RESPIRATORY QUOTIENT; BLOOD; METABOLISM; PHYSIOLOGY;

ADOLESCENT; CHILD; DIABETES MELLITUS, TYPE 2; FEMALE; GLUCONEOGENESIS; GLUCOSE; HUMANS; HYPERGLYCEMIA; INSULIN RESISTANCE; MALE;

EID: 84925513591     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-014-3455-x     Document Type: Article

References (50)

1. Imperatore G, Boyle J, Thompson T et al (2012) Projections of type 1 and type 2 diabetes burden in the U.S. population aged <20 years through 2050: dynamic modeling of incidence, mortality, and population growth. Diabetes Care 35:2515–2520
2. Dart A, Martens P, Rigatto C, Brownell M, Dean H, Sellers E (2014) Earlier onset of complications in youth with type 2 diabetes. Diabetes Care 37:436–443
3. Defronzo R (2009) Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. Diabetes 58:773–795
4. Bock G, Chittilapilly E, Basu R et al (2007) Contribution of hepatic and extrahepatic insulin resistance to the pathogenesis of impaired fasting glucose: role of increased rates of gluconeogenesis. Diabetes 56:1703–1711
5. Basu R, Barosa C, Jones J et al (2013) Pathogenesis of prediabetes: role of the liver in isolated fasting hyperglycemia and combined fasting and postprandial hyperglycemia. J Clin Endocrinol Metab 98:E409–E417
6. Basu R, Chandramouli V, Dicke B, Landau B, Rizza R (2005) Obesity and type 2 diabetes impair insulin-induced suppression of glycogenolysis as well as gluconeogenesis. Diabetes 54:1942–1948
7. Gastaldelli A, Baldi S, Pettiti M et al (2000) Influence of obesity and type 2 diabetes on gluconeogenesis and glucose output in humans: a quantitative study. Diabetes 49:1367–1373
8. Basu R, Basu A, Johnson CM, Schwenk WF, Rizza RA (2004) Insulin dose-response curves for stimulation of splanchnic glucose uptake and suppression of endogenous glucose production differ in nondiabetic humans and are abnormal in people with type 2 diabetes. Diabetes 53:2042–2050
9. Rizza RA (2010) Pathogenesis of fasting and postprandial hyperglycemia in type 2 diabetes: implications for therapy. Diabetes 59:2697–2707
10. Bacha F, Lee S, Gungor N, Arslanian S (2010) From pre-diabetes to type 2 diabetes in obese youth: pathophysiological characteristics along the spectrum of glucose dysregulation. Diabetes Care 33:2225–2231
11. Sunehag AL, Toffolo G, Campioni M, Bier DM, Haymond MW (2005) Effects of dietary macronutrient intake on insulin sensitivity and secretion and glucose and lipid metabolism in healthy, obese adolescents. J Clin Endocrinol Metab 90:4496–4502
12. Pigon J, Giacca A, Ostenson CG, Lam L, Vranic M, Efendic S (1996) Normal hepatic insulin sensitivity in lean, mild noninsulin-dependent diabetic patients. J Clin Endocrinol Metab 81:3702–3708
13. Tayek JA, Katz J (1996) Glucose production, recycling, and gluconeogenesis in normals and diabetics: a mass isotopomer [U-13C]glucose study. Am J Physiol 270:E709–E717
14. ADA (2011) Standards of medical care in diabetes—2011. Diabetes Care 34(Suppl 1):S11–S61
15. ADA (2011) Update of ADA’s major position statement, “Standards of Medical Care in Diabetes” Introduction. Diabetes Care 34(Suppl 1):S1–S2
16. Sunehag AL, Treuth MS, Toffolo G et al (2001) Glucose production, gluconeogenesis, and insulin sensitivity in children and adolescents: an evaluation of their reproducibility. Pediatr Res 50:115–123
17. Chacko S, Sunehag A, Sharma S, Sauer PJJ, Haymond M (2008) Measurement of gluconeogenesis using glucose fragments and mass spectrometry after ingestion of deuterium oxide. J Appl Physiol 104:944–951
18. Ferrannini E (1988) The theoretical bases of indirect calorimetry: a review. Metab Clin Exp 37:287–301
19. Livesey G, Elia M (1988) Estimation of energy expenditure, net carbohydrate utilization, and net fat oxidation and synthesis by indirect calorimetry: evaluation of errors with special reference to the detailed composition of fuels. Am J Clin Nutr 47:608–628
20. Matsuda M, DeFronzo RA (1999) Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 22:1462–1470
21. Kaplan W, Sunehag AL, Dao H, Haymond MW (2008) Short-term effects of recombinant human growth hormone and feeding on gluconeogenesis in humans. Metab Clin Exp 57:725–732
22. Gastaldelli A, Miyazaki Y, Pettiti M et al (2004) Separate contribution of diabetes, total fat mass, and fat topography to glucose production, gluconeogenesis, and glycogenolysis. J Clin Endocrinol Metab 89:3914–3921
23. Wajngot A, Chandramouli V, Schumann WC et al (2001) Quantitative contributions of gluconeogenesis to glucose production during fasting in type 2 diabetes mellitus. Metab Clin Exp 50:47–52
24. Wan M, Leavens K, Hunter R et al (2013) A noncanonical, GSK3-independent pathway controls postprandial hepatic glycogen deposition. Cell Metab 18:99–105
25. Stark R, Guebre Egziabher F, Zhao X et al (2014) A role for mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) in the regulation of hepatic gluconeogenesis. J Biol Chem 289:7257–7263
26. Saltiel AR, Kahn CR (2001) Insulin signalling and the regulation of glucose and lipid metabolism. Nature 414:799–806
27. Lin H, Accili D (2011) Hormonal regulation of hepatic glucose production in health and disease. Cell Metab 14:9–19
28. Gastaldelli A, Toschi E, Pettiti M et al (2001) Effect of physiological hyperinsulinemia on gluconeogenesis in nondiabetic subjects and in type 2 diabetic patients. Diabetes 50:1807–1812
29. Adkins A, Basu R, Persson M et al (2003) Higher insulin concentrations are required to suppress gluconeogenesis than glycogenolysis in nondiabetic humans. Diabetes 52:2213–2220
30. Tigas S, Sunehag A, Haymond M (2002) Metabolic adaptation to feeding and fasting during lactation in humans. J Clin Endocrinol Metab 87:302–307
31. Boden G, Chen X, Capulong E, Mozzoli M (2001) Effects of free fatty acids on gluconeogenesis and autoregulation of glucose production in type 2 diabetes. Diabetes 50:810–816
32. Hue L, Taegtmeyer H (2009) The Randle cycle revisited: a new head for an old hat. Am J Physiol Endocrinol Metab 297:E578–E591
33. Jahoor F, Klein S, Wolfe R (1992) Mechanism of regulation of glucose production by lipolysis in humans. Am J Physiol 262:E353–E358
34. Nurjhan N, Consoli A, Gerich J (1992) Increased lipolysis and its consequences on gluconeogenesis in non-insulin-dependent diabetes mellitus. J Clin Invest 89:169–175
35. Puhakainen I, Koivisto VA, Yki Järvinen H (1992) Lipolysis and gluconeogenesis from glycerol are increased in patients with noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 75:789–794
36. Jenssen T, Nurjhan N, Consoli A, Gerich JE (1990) Failure of substrate-induced gluconeogenesis to increase overall glucose appearance in normal humans. Demonstration of hepatic autoregulation without a change in plasma glucose concentration. J Clin Invest 86:489–497
37. Consoli A, Nurjhan N, Reilly JJ, Bier DM, Gerich JE (1990) Mechanism of increased gluconeogenesis in noninsulin-dependent diabetes mellitus. Role of alterations in systemic, hepatic, and muscle lactate and alanine metabolism. J Clin Invest 86:2038–2045
38. Gastaldelli A, Cusi K, Pettiti M et al (2007) Relationship between hepatic/visceral fat and hepatic insulin resistance in nondiabetic and type 2 diabetic subjects. Gastroenterology 133:496–506
39. van der Heijden G-J, Wang Z, Chu Z et al (2010) A 12-week aerobic exercise program reduces hepatic fat accumulation and insulin resistance in obese, Hispanic adolescents. Obesity 18:384–390
40. van der Heijden G-J, Toffolo G, Manesso E, Sauer PJJ, Sunehag A (2009) Aerobic exercise increases peripheral and hepatic insulin sensitivity in sedentary adolescents. J Clin Endocrinol Metab 94:4292–4299
41. Sharma R, Sinha S, Danishad KA et al (2009) Investigation of hepatic gluconeogenesis pathway in non-diabetic Asian Indians with non-alcoholic fatty liver disease using in vivo ((31)P) phosphorus magnetic resonance spectroscopy. Atherosclerosis 203:291–297
42. Sunny N, Parks E, Browning J, Burgess S (2011) Excessive hepatic mitochondrial TCA cycle and gluconeogenesis in humans with nonalcoholic fatty liver disease. Cell Metab 14:804–810
43. Landau BR, Wahren J, Chandramouli V, Schumann WC, Ekberg K, Kalhan SC (1996) Contributions of gluconeogenesis to glucose production in the fasted state. J Clin Invest 98:378–385
44. Haymond MW, Sunehag AL (2000) The reciprocal pool model for the measurement of gluconeogenesis by use of [U-(13)C]glucose. Am J Physiol Endocrinol Metab 278:E140–E145
45. Landau BR, Wahren J, Chandramouli V, Schumann WC, Ekberg K, Kalhan SC (1995) Use of 2H2O for estimating rates of gluconeogenesis. Application to the fasted state. J Clin Invest 95:172–178
46. Rose IA (1975) Mechanism of the aldose-ketose isomerase reactions. Adv Enzymol Relat Areas Mol Biol 43:491–517
47. (2004) SEARCH for Diabetes in Youth: a multicenter study of the prevalence, incidence and classification of diabetes mellitus in youth. Control Clin Trials 25: 458-471
48. Clore JN, Glickman PS, Helm ST, Nestler JE, Blackard WG (1989) Accelerated decline in hepatic glucose production during fasting in normal women compared with men. Metab Clin Exp 38:1103–1107
49. Robertson MD, Livesey G, Mathers JC (2002) Quantitative kinetics of glucose appearance and disposal following a 13C-labelled starch-rich meal: comparison of male and female subjects. Br J Nutr 87:569–577
50. Anderwald C, Gastaldelli A, Tura A et al (2011) Mechanism and effects of glucose absorption during an oral glucose tolerance test among females and males. J Clin Endocrinol Metab 96:515–524