메뉴 건너뛰기




Volumn 5, Issue , 2015, Pages

Amino acid carbamates as prodrugs of resveratrol

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CARBAMIC ACID DERIVATIVE; PRODRUG; RESVERATROL; STILBENE DERIVATIVE;

EID: 84944382558     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep15216     Document Type: Article
Times cited : (39)

References (61)
  • 1
    • 78651502974 scopus 로고    scopus 로고
    • Biosynthesis, metabolism, molecular engineering, and biological functions of stilbene phytoalexins in plants
    • Jeandet, P. et al. Biosynthesis, metabolism, molecular engineering, and biological functions of stilbene phytoalexins in plants. Biofactors 36, 331-341, doi: 10.1002/biof.108 (2010).
    • (2010) Biofactors , vol.36 , pp. 331-341
    • Jeandet, P.1
  • 2
    • 78851470225 scopus 로고    scopus 로고
    • Resveratrol and life extension
    • Agarwal, B. & Baur, J. A. Resveratrol and life extension. Ann N Y Acad Sci 1215, 138-143, doi: 10.1111/j.1749-6632.2010.05850.x (2011).
    • (2011) Ann N y Acad Sci , vol.1215 , pp. 138-143
    • Agarwal, B.1    Baur, J.A.2
  • 3
    • 78851468985 scopus 로고    scopus 로고
    • Anti-inflammatory effects of resveratrol: Possible role in prevention of age-related cardiovascular disease
    • Csiszar, A. Anti-inflammatory effects of resveratrol: possible role in prevention of age-related cardiovascular disease. Ann N Y Acad Sci 1215, 117-122, doi: 10.1111/j.1749-6632.2010.05848.x (2011).
    • (2011) Ann N y Acad Sci , vol.1215 , pp. 117-122
    • Csiszar, A.1
  • 4
    • 77954363244 scopus 로고    scopus 로고
    • The cardiovascular nutrapharmacology of resveratrol: Pharmacokinetics, molecular mechanisms and therapeutic potential
    • Kroon, P. A., Iyer, A., Chunduri, P., Chan, V. & Brown, L. The cardiovascular nutrapharmacology of resveratrol: pharmacokinetics, molecular mechanisms and therapeutic potential. Curr Med Chem 17, 2442-2455, doi: 10.2174/092986710791556032 (2010).
    • (2010) Curr Med Chem , vol.17 , pp. 2442-2455
    • Kroon, P.A.1    Iyer, A.2    Chunduri, P.3    Chan, V.4    Brown, L.5
  • 5
    • 84884680087 scopus 로고    scopus 로고
    • Polyphenols: Benefits to the cardiovascular system in health and in aging
    • Khurana, S., Venkataraman, K., Hollingsworth, A., Piche, M. & Tai, T. C. Polyphenols: benefits to the cardiovascular system in health and in aging. Nutrients 5, 3779-3827, doi: 10.3390/nu5103779 (2013).
    • (2013) Nutrients , vol.5 , pp. 3779-3827
    • Khurana, S.1    Venkataraman, K.2    Hollingsworth, A.3    Piche, M.4    Tai, T.C.5
  • 6
    • 84880385970 scopus 로고    scopus 로고
    • From experimental data to nutritional evidence: The emergence of a new food ingredient
    • Raederstorff, D., Kunz, I. & Schwager, J. Resveratrol, from experimental data to nutritional evidence: the emergence of a new food ingredient. Ann N Y Acad Sci 1290, 136-141, doi: 10.1111/nyas.12147 (2013).
    • (2013) Ann N y Acad Sci , vol.1290 , pp. 136-141
    • Raederstorff, D.1    Kunz, I.2    Resveratrol, S.J.3
  • 7
    • 78851469053 scopus 로고    scopus 로고
    • Anti-diabetic effects of resveratrol
    • Szkudelski, T. & Szkudelska, K. Anti-diabetic effects of resveratrol. Ann N Y Acad Sci 1215, 34-39, doi: 10.1111/j.1749-6632.2010.05844.x (2011).
    • (2011) Ann N y Acad Sci , vol.1215 , pp. 34-39
    • Szkudelski, T.1    Szkudelska, K.2
  • 8
    • 84901659368 scopus 로고    scopus 로고
    • Effect of resveratrol on glucose control and insulin sensitivity: A meta-analysis of 11 randomized controlled trials
    • Liu, K., Zhou, R., Wang, B. & Mi, M. T. Effect of resveratrol on glucose control and insulin sensitivity: a meta-analysis of 11 randomized controlled trials. Am J Clin Nutr 99, 1510-1519, doi: 10.3945/ajcn.113.082024 (2014).
    • (2014) Am J Clin Nutr , vol.99 , pp. 1510-1519
    • Liu, K.1    Zhou, R.2    Wang, B.3    Mi, M.T.4
  • 9
    • 78851469588 scopus 로고    scopus 로고
    • Effect of resveratrol on fat mobilization
    • Baile, C. A. et al. Effect of resveratrol on fat mobilization. Ann N Y Acad Sci 1215, 40-47, doi: 10.1111/j.1749-6632.2010.05845.x (2011).
    • (2011) Ann N y Acad Sci , vol.1215 , pp. 40-47
    • Baile, C.A.1
  • 10
    • 84889564987 scopus 로고    scopus 로고
    • Novel insights of dietary polyphenols and obesity
    • Wang, S. et al. Novel insights of dietary polyphenols and obesity. J Nutr Biochem 25, 1-18, doi: 10.1016/j.jnutbio.2013.09.001 (2014).
    • (2014) J Nutr Biochem , vol.25 , pp. 1-18
    • Wang, S.1
  • 11
    • 84914678932 scopus 로고    scopus 로고
    • Resveratrol increases brown adipose tissue thermogenesis markers by increasing SIRT1 and energy expenditure and decreasing fat accumulation in adipose tissue of mice fed a standard diet
    • Andrade, J. M. et al. Resveratrol increases brown adipose tissue thermogenesis markers by increasing SIRT1 and energy expenditure and decreasing fat accumulation in adipose tissue of mice fed a standard diet. Eur J Nutr, doi: 10.1007/s00394-014- 0655-6 (2014).
    • (2014) Eur J Nutr
    • Andrade, J.M.1
  • 12
    • 84903384321 scopus 로고    scopus 로고
    • Resveratrol attenuates hepatic steatosis in high-fat fed mice by decreasing lipogenesis and inflammation
    • Andrade, J. M. et al. Resveratrol attenuates hepatic steatosis in high-fat fed mice by decreasing lipogenesis and inflammation. Nutrition 30, 915-919, doi: 10.1016/j.nut.2013.11.016 (2014).
    • (2014) Nutrition , vol.30 , pp. 915-919
    • Andrade, J.M.1
  • 13
    • 80155167889 scopus 로고    scopus 로고
    • Mitochondrial effects of plant-made compounds
    • Biasutto, L., Szabo, I. & Zoratti, M. Mitochondrial effects of plant-made compounds. Antioxid Redox Signal 15, 3039-3059, doi: 10.1089/ars.2011.4021 (2011).
    • (2011) Antioxid Redox Signal , vol.15 , pp. 3039-3059
    • Biasutto, L.1    Szabo, I.2    Zoratti, M.3
  • 14
    • 84863011114 scopus 로고    scopus 로고
    • Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases
    • Park, S. J. et al. Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. Cell 148, 421-433, doi: 10.1016/j.cell.2012.01.017 (2012).
    • (2012) Cell , vol.148 , pp. 421-433
    • Park, S.J.1
  • 15
    • 81155123332 scopus 로고    scopus 로고
    • Role of resveratrol and its analogues in the treatment of neurodegenerative diseases: Focus on recent discoveries
    • Foti Cuzzola, V., Ciurleo, R., Giacoppo, S., Marino, S. & Bramanti, P. Role of resveratrol and its analogues in the treatment of neurodegenerative diseases: focus on recent discoveries. CNS Neurol Disord Drug Targets 10, 849-862, doi: 10.2174/187152711798072310 (2011).
    • (2011) CNS Neurol Disord Drug Targets , vol.10 , pp. 849-862
    • Foti Cuzzola, V.1    Ciurleo, R.2    Giacoppo, S.3    Marino, S.4    Bramanti, P.5
  • 16
    • 78851472360 scopus 로고    scopus 로고
    • Resveratrol modulates astroglial functions: Neuroprotective hypothesis
    • Quincozes-Santos, A. & Gottfried, C. Resveratrol modulates astroglial functions: neuroprotective hypothesis. Ann N Y Acad Sci 1215, 72-78, doi: 10.1111/j.1749-6632.2010.05857.x (2011).
    • (2011) Ann N y Acad Sci , vol.1215 , pp. 72-78
    • Quincozes-Santos, A.1    Gottfried, C.2
  • 17
    • 6944250259 scopus 로고    scopus 로고
    • Role of resveratrol in prevention and therapy of cancer: Preclinical and clinical studies
    • Aggarwal, B. B. et al. Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. Anticancer Res 24, 2783-2840 (2004).
    • (2004) Anticancer Res , vol.24 , pp. 2783-2840
    • Aggarwal, B.B.1
  • 18
    • 84860275721 scopus 로고    scopus 로고
    • Epigenetic impact of dietary polyphenols in cancer chemoprevention: Lifelong remodeling of our epigenomes
    • Vanden Berghe, W. Epigenetic impact of dietary polyphenols in cancer chemoprevention: lifelong remodeling of our epigenomes. Pharmacol Res 65, 565-576, doi: 10.1016/j.phrs.2012.03.007 (2012).
    • (2012) Pharmacol Res , vol.65 , pp. 565-576
    • Vanden Berghe, W.1
  • 19
    • 84855850686 scopus 로고    scopus 로고
    • Phytochemicals resveratrol and sulforaphane as potential agents for enhancing the anti-tumor activities of conventional cancer therapies
    • Kaminski, B. M., Steinhilber, D., Stein, J. M. & Ulrich, S. Phytochemicals resveratrol and sulforaphane as potential agents for enhancing the anti-tumor activities of conventional cancer therapies. Curr Pharm Biotechnol 13, 137-146, doi: 10.2174/138920112798868746 (2012).
    • (2012) Curr Pharm Biotechnol , vol.13 , pp. 137-146
    • Kaminski, B.M.1    Steinhilber, D.2    Stein, J.M.3    Ulrich, S.4
  • 21
    • 84886015444 scopus 로고    scopus 로고
    • Review of recent data on the metabolism, biological effects, and toxicity of resveratrol in humans
    • Cottart, C. H., Nivet-Antoine, V. & Beaudeux, J. L. Review of recent data on the metabolism, biological effects, and toxicity of resveratrol in humans. Mol Nutr Food Res 58, 7-21, doi: 10.1002/mnfr.201200589 (2014).
    • (2014) Mol Nutr Food Res , vol.58 , pp. 7-21
    • Cottart, C.H.1    Nivet-Antoine, V.2    Beaudeux, J.L.3
  • 22
    • 78650399854 scopus 로고    scopus 로고
    • Resveratrol: Challenges in translation to the clinic-a critical discussion
    • Subramanian, L. et al. Resveratrol: challenges in translation to the clinic-a critical discussion. Clin Cancer Res 16, 5942-5948, doi: 10.1158/1078-0432.ccr-10-1486 (2010).
    • (2010) Clin Cancer Res , vol.16 , pp. 5942-5948
    • Subramanian, L.1
  • 23
    • 78851469101 scopus 로고    scopus 로고
    • Bioavailability of resveratrol
    • Walle, T. Bioavailability of resveratrol. Ann N Y Acad Sci 1215, 9-15, doi: 10.1111/j.1749-6632.2010.05842.x (2011).
    • (2011) Ann N y Acad Sci , vol.1215 , pp. 9-15
    • Walle, T.1
  • 24
    • 12244285648 scopus 로고    scopus 로고
    • Human, rat, and mouse metabolism of resveratrol
    • Yu, C. et al. Human, rat, and mouse metabolism of resveratrol. Pharm Res 19, 1907-1914, doi: 10.1023/A:1021414129280 (2002).
    • (2002) Pharm Res , vol.19 , pp. 1907-1914
    • Yu, C.1
  • 25
    • 84897078117 scopus 로고    scopus 로고
    • Bioaccumulation of resveratrol metabolites in myocardial tissue is dose-time dependent and related to cardiac hemodynamics in diabetic rats
    • Bresciani, L. et al. Bioaccumulation of resveratrol metabolites in myocardial tissue is dose-time dependent and related to cardiac hemodynamics in diabetic rats. Nutr Metab Cardiovasc Dis 24, 408-415, doi: 10.1016/j.numecd.2013.09.008 (2014).
    • (2014) Nutr Metab Cardiovasc Dis , vol.24 , pp. 408-415
    • Bresciani, L.1
  • 26
    • 84890905758 scopus 로고    scopus 로고
    • Resveratrol and its metabolites inhibit pro-inflammatory effects of lipopolysaccharides in U-937 macrophages in plasma-representative concentrations
    • Walker, J. et al. Resveratrol and its metabolites inhibit pro-inflammatory effects of lipopolysaccharides in U-937 macrophages in plasma-representative concentrations. Food Funct 5, 74-84, doi: 10.1039/c3fo60236b (2014).
    • (2014) Food Funct , vol.5 , pp. 74-84
    • Walker, J.1
  • 27
    • 84878061243 scopus 로고    scopus 로고
    • Resveratrol metabolites modify adipokine expression and secretion in 3T3-L1 pre-adipocytes and mature adipocytes
    • Eseberri, I., Lasa, A., Churruca, I. & Portillo, M. P. Resveratrol metabolites modify adipokine expression and secretion in 3T3-L1 pre-adipocytes and mature adipocytes. PLoS One 8, e63918, doi: 10.1371/journal.pone.0063918 (2013).
    • (2013) PLoS One , vol.8 , pp. e63918
    • Eseberri, I.1    Lasa, A.2    Churruca, I.3    Portillo, M.P.4
  • 28
    • 84867063845 scopus 로고    scopus 로고
    • Delipidating effect of resveratrol metabolites in 3T3-L1 adipocytes
    • Lasa, A., Churruca, I., Eseberri, I., Andres-Lacueva, C. & Portillo, M. P. Delipidating effect of resveratrol metabolites in 3T3-L1 adipocytes. Mol Nutr Food Res 56, 1559-1568, doi: 10.1002/mnfr.201100772 (2012).
    • (2012) Mol Nutr Food Res , vol.56 , pp. 1559-1568
    • Lasa, A.1    Churruca, I.2    Eseberri, I.3    Andres-Lacueva, C.4    Portillo, M.P.5
  • 29
    • 79955689719 scopus 로고    scopus 로고
    • Resveratrol metabolites do not elicit early pro-apoptotic mechanisms in neuroblastoma cells
    • Kenealey, J. D. et al. Resveratrol metabolites do not elicit early pro-apoptotic mechanisms in neuroblastoma cells. J Agric Food Chem 59, 4979-4986, doi: 10.1021/jf104901g (2011).
    • (2011) J Agric Food Chem , vol.59 , pp. 4979-4986
    • Kenealey, J.D.1
  • 30
    • 84879080696 scopus 로고    scopus 로고
    • Influence of glucuronidation and reduction modifications of resveratrol on its biological activities
    • Lu, D. L. et al. Influence of glucuronidation and reduction modifications of resveratrol on its biological activities. Chembiochem 14, 1094-1104, doi: 10.1002/cbic.201300080 (2013).
    • (2013) Chembiochem , vol.14 , pp. 1094-1104
    • Lu, D.L.1
  • 31
    • 77954701127 scopus 로고    scopus 로고
    • Pleiotropic mechanisms facilitated by resveratrol and its metabolites
    • Calamini, B. et al. Pleiotropic mechanisms facilitated by resveratrol and its metabolites. Biochem J 429, 273-282, doi: 10.1042/ bj20091857 (2010).
    • (2010) Biochem J , vol.429 , pp. 273-282
    • Calamini, B.1
  • 32
    • 77954331919 scopus 로고    scopus 로고
    • Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites
    • Hoshino, J. et al. Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites. J Med Chem 53, 5033-5043, doi: 10.1021/jm100274c (2010).
    • (2010) J Med Chem , vol.53 , pp. 5033-5043
    • Hoshino, J.1
  • 33
    • 84884258015 scopus 로고    scopus 로고
    • Microbial metabolism. Part 14. Isolation and bioactivity evaluation of microbial metabolites of resveratrol
    • Herath, W., Khan, S. I. & Khan, I. A. Microbial metabolism. Part 14. Isolation and bioactivity evaluation of microbial metabolites of resveratrol. Nat Prod Res 27, 1437-1444, doi: 10.1080/14786419.2012.722089 (2013).
    • (2013) Nat Prod Res , vol.27 , pp. 1437-1444
    • Herath, W.1    Khan, S.I.2    Khan, I.A.3
  • 34
    • 84887615201 scopus 로고    scopus 로고
    • Anti-estrogenic activity of a human resveratrol metabolite
    • Ruotolo, R. et al. Anti-estrogenic activity of a human resveratrol metabolite. Nutr Metab Cardiovasc Dis 23, 1086-1092, doi: 10.1016/j.numecd.2013.01.002 (2013).
    • (2013) Nutr Metab Cardiovasc Dis , vol.23 , pp. 1086-1092
    • Ruotolo, R.1
  • 35
    • 84885454938 scopus 로고    scopus 로고
    • Sulfate metabolites provide an intracellular pool for resveratrol generation and induce autophagy with senescence
    • 205ra133
    • Patel, K. R. et al. Sulfate metabolites provide an intracellular pool for resveratrol generation and induce autophagy with senescence. Sci Transl Med 5, 205ra133, doi: 10.1126/scitranslmed.3005870 (2013).
    • (2013) Sci Transl Med , vol.5
    • Patel, K.R.1
  • 36
    • 84896925980 scopus 로고    scopus 로고
    • Resveratrol-sulfates provide an intracellular reservoir for generation of parent resveratrol, which induces autophagy in cancer cells
    • Andreadi, C., Britton, R. G., Patel, K. R. & Brown, K. Resveratrol-sulfates provide an intracellular reservoir for generation of parent resveratrol, which induces autophagy in cancer cells. Autophagy 10, 524-525, doi: 10.4161/auto.27593 (2014).
    • (2014) Autophagy , vol.10 , pp. 524-525
    • Andreadi, C.1    Britton, R.G.2    Patel, K.R.3    Brown, K.4
  • 37
    • 84927586797 scopus 로고    scopus 로고
    • Organic carbamates in drug design and medicinal chemistry
    • Ghosh, A. K. & Brindisi, M. Organic Carbamates in Drug Design and Medicinal Chemistry. J Med Chem, doi: 10.1021/jm501371s (2015).
    • (2015) J Med Chem
    • Ghosh, A.K.1    Brindisi, M.2
  • 38
    • 0026569225 scopus 로고
    • Phenyl carbamates of amino acids as prodrug forms for protecting phenols against firstpass metabolism
    • Hansen, J., Mrk, N. & Bundgaard, H. Phenyl carbamates of amino acids as prodrug forms for protecting phenols against firstpass metabolism. Int J Pharm 81, 253-261, doi: 10.1016/0378-5173(92)90017-V (1992).
    • (1992) Int J Pharm , vol.81 , pp. 253-261
    • Hansen, J.1    Mrk, N.2    Bundgaard, H.3
  • 39
    • 84896352537 scopus 로고    scopus 로고
    • Prodrugs of quercetin and resveratrol: A strategy under development
    • Biasutto, L. & Zoratti, M. Prodrugs of quercetin and resveratrol: a strategy under development. Curr Drug Metab 15, 77-95, doi: 10.2174/1389200214666131211160005 (2014).
    • (2014) Curr Drug Metab , vol.15 , pp. 77-95
    • Biasutto, L.1    Zoratti, M.2
  • 40
    • 77953529026 scopus 로고    scopus 로고
    • Prodrug design of phenolic drugs
    • Ferriz, J. M. & Vinsova, J. Prodrug design of phenolic drugs. Curr Pharm Des 16, 2033-2052, doi: 10.2174/138161210791293042 (2010).
    • (2010) Curr Pharm des , vol.16 , pp. 2033-2052
    • Ferriz, J.M.1    Vinsova, J.2
  • 42
    • 0035100834 scopus 로고    scopus 로고
    • Pre-clinical and clinical study of QC12, a water-soluble, pro-drug of quercetin
    • Mulholland, P. J. et al. Pre-clinical and clinical study of QC12, a water-soluble, pro-drug of quercetin. Ann Oncol 12, 245-248, doi: 10.1023/A:1008372017097 (2001).
    • (2001) Ann Oncol , vol.12 , pp. 245-248
    • Mulholland, P.J.1
  • 43
    • 58949103807 scopus 로고    scopus 로고
    • In vitro solubility, stability and permeability of novel quercetin-amino acid conjugates
    • Kim, M. K., Park, K. S., Yeo, W. S., Choo, H. & Chong, Y. In vitro solubility, stability and permeability of novel quercetin-amino acid conjugates. Bioorg Med Chem 17, 1164-1171, doi: 10.1016/j.bmc.2008.12.043 (2009).
    • (2009) Bioorg Med Chem , vol.17 , pp. 1164-1171
    • Kim, M.K.1    Park, K.S.2    Yeo, W.S.3    Choo, H.4    Chong, Y.5
  • 44
    • 84907484184 scopus 로고    scopus 로고
    • New water-soluble carbamate ester derivatives of resveratrol
    • Mattarei, A. et al. New water-soluble carbamate ester derivatives of resveratrol. Molecules (Basel, Switzerland) 19, 15900-15917, doi: 10.3390/molecules191015900 (2014).
    • (2014) Molecules (Basel, Switzerland) , vol.19 , pp. 15900-15917
    • Mattarei, A.1
  • 45
    • 84885382399 scopus 로고    scopus 로고
    • Amino acids as promoieties in prodrug design and development
    • Vig, B. S., Huttunen, K. M., Laine, K. & Rautio, J. Amino acids as promoieties in prodrug design and development. Adv Drug Deliver Rev 65, 1370-1385, doi:10.1016/j.addr.2012.10.001 (2013).
    • (2013) Adv Drug Deliver Rev , vol.65 , pp. 1370-1385
    • Vig, B.S.1    Huttunen, K.M.2    Laine, K.3    Rautio, J.4
  • 46
    • 38349170961 scopus 로고    scopus 로고
    • Amino acid transport across mammalian intestinal and renal epithelia
    • Broer, S. Amino acid transport across mammalian intestinal and renal epithelia. Physiol Rev 88, 249-286, doi: 10.1152/ physrev.00018.2006 (2008).
    • (2008) Physiol Rev , vol.88 , pp. 249-286
    • Broer, S.1
  • 47
    • 84888192640 scopus 로고    scopus 로고
    • Drug transport via the intestinal peptide transporter PepT1
    • Brandsch, M. Drug transport via the intestinal peptide transporter PepT1. Curr Opin Pharmacol 13, 881-887, doi: 10.1016/j. coph.2013.08.004 (2013).
    • (2013) Curr Opin Pharmacol , vol.13 , pp. 881-887
    • Brandsch, M.1
  • 49
    • 84859712703 scopus 로고    scopus 로고
    • Oral drug delivery utilizing intestinal OATP transporters
    • Tamai, I. Oral drug delivery utilizing intestinal OATP transporters. Adv Drug Deliver Rev 64, 508-514, doi: 10.1016/j. addr.2011.07.007 (2012).
    • (2012) Adv Drug Deliver Rev , vol.64 , pp. 508-514
    • Tamai, I.1
  • 50
    • 50449097993 scopus 로고    scopus 로고
    • Pharmacokinetic role of L-type amino acid transporters LAT1 and LAT2
    • del Amo, E. M., Urtti, A. & Yliperttula, M. Pharmacokinetic role of L-type amino acid transporters LAT1 and LAT2. Eur J Pharm Sci 35, 161-174, doi: 10.1016/j.ejps.2008.06.015 (2008).
    • (2008) Eur J Pharm Sci , vol.35 , pp. 161-174
    • Del Amo, E.M.1    Urtti, A.2    Yliperttula, M.3
  • 51
    • 39749166269 scopus 로고    scopus 로고
    • Large neutral amino acid transporter enables brain drug delivery via prodrugs
    • Gynther, M. et al. Large neutral amino acid transporter enables brain drug delivery via prodrugs. J Med Chem 51, 932-936, doi: 10.1021/jm701175d (2008).
    • (2008) J Med Chem , vol.51 , pp. 932-936
    • Gynther, M.1
  • 52
    • 80053517788 scopus 로고    scopus 로고
    • Large amino acid transporter 1 (LAT1) prodrugs of valproic acid: New prodrug design ideas for central nervous system delivery
    • Peura, L. et al. Large amino acid transporter 1 (LAT1) prodrugs of valproic acid: new prodrug design ideas for central nervous system delivery. Mol Pharm 8, 1857-1866, doi: 10.1021/mp2001878 (2011).
    • (2011) Mol Pharm , vol.8 , pp. 1857-1866
    • Peura, L.1
  • 53
    • 84883865879 scopus 로고    scopus 로고
    • Design, synthesis and brain uptake of LAT1-targeted amino acid prodrugs of dopamine
    • Peura, L. et al. Design, synthesis and brain uptake of LAT1-targeted amino acid prodrugs of dopamine. Pharm Res 30, 2523-2537, doi: 10.1007/s11095-012-0966-3 (2013).
    • (2013) Pharm Res , vol.30 , pp. 2523-2537
    • Peura, L.1
  • 54
    • 34748824652 scopus 로고    scopus 로고
    • Syntheses of Carbamate Derivatives of Quercetin by Reaction with Amino Acid Ester Isocyanates
    • Wu, X., Cheng, L., Xiang, D. & Wei, Y. Syntheses of Carbamate Derivatives of Quercetin by Reaction with Amino Acid Ester Isocyanates. Lett Org Chem 2, 535-538, doi: 10.2174/1570178054640796 (2005).
    • (2005) Lett Org Chem , vol.2 , pp. 535-538
    • Wu, X.1    Cheng, L.2    Xiang, D.3    Wei, Y.4
  • 55
    • 0142026967 scopus 로고    scopus 로고
    • Investigation of trialkoxysilane hydrolysis kinetics using liquid chromatography with inductively coupled plasma atomic emission spectrometric detection and non-linear regression modeling
    • Kozerski, G. E., Gallavan, R. H. & Ziemelis, M. J. Investigation of trialkoxysilane hydrolysis kinetics using liquid chromatography with inductively coupled plasma atomic emission spectrometric detection and non-linear regression modeling. Anal Chim Acta 489, 103-114, doi: 10.1016/S0003-2670(03)00710-4 (2003).
    • (2003) Anal Chim Acta , vol.489 , pp. 103-114
    • Kozerski, G.E.1    Gallavan, R.H.2    Ziemelis, M.J.3
  • 56
    • 0009354933 scopus 로고
    • Esters of carbamic acid
    • Adams, P. & Baron, F. A. Esters of Carbamic Acid. Chem Rev 65, 567-602, doi: 10.1021/cr60237a002 (1965).
    • (1965) Chem Rev , vol.65 , pp. 567-602
    • Adams, P.1    Baron, F.A.2
  • 57
    • 84907545089 scopus 로고    scopus 로고
    • Pharmacokinetics and tissue distribution of pterostilbene in the rat
    • Azzolini, M. et al. Pharmacokinetics and tissue distribution of pterostilbene in the rat. Mol Nutr Food Res 58, 2122-2132, doi: 10.1002/mnfr.201400244 (2014).
    • (2014) Mol Nutr Food Res , vol.58 , pp. 2122-2132
    • Azzolini, M.1
  • 58
    • 77957315722 scopus 로고    scopus 로고
    • Determination of quercetin and resveratrol in whole blood-implications for bioavailability studies
    • Biasutto, L., Marotta, E., Garbisa, S., Zoratti, M. & Paradisi, C. Determination of quercetin and resveratrol in whole blood-implications for bioavailability studies. Molecules (Basel, Switzerland) 15, 6570-6579, doi: 10.3390/ molecules15096570 (2010).
    • (2010) Molecules (Basel, Switzerland) , vol.15 , pp. 6570-6579
    • Biasutto, L.1    Marotta, E.2    Garbisa, S.3    Zoratti, M.4    Paradisi, C.5
  • 59
    • 71949109410 scopus 로고    scopus 로고
    • Soluble polyphenols: Synthesis and bioavailability of 3,4?,5-tri(alpha-D-glucose-3-O-succinyl) resveratrol
    • Biasutto, L. et al. Soluble polyphenols: synthesis and bioavailability of 3,4?,5-tri(alpha-D-glucose-3-O-succinyl) resveratrol. Bioorg Med Chem Lett 19, 6721-6724, doi: 10.1016/j.bmcl.2009.09.114 (2009).
    • (2009) Bioorg Med Chem Lett , vol.19 , pp. 6721-6724
    • Biasutto, L.1
  • 60
    • 84944396394 scopus 로고    scopus 로고
    • European Patent Application EP2774915. Application Number EP20140157948. Filing date 03/05/2014. Publication Date 09/10/2014
    • Mattarei, A. et al. New derivatives of resveratrol. (2014). European Patent Application EP2774915. Application Number EP20140157948. Filing date 03/05/2014. Publication Date 09/10/2014.
    • (2014) New Derivatives of Resveratrol
    • Mattarei, A.1
  • 61
    • 84879730138 scopus 로고    scopus 로고
    • Acetal derivatives as prodrugs of resveratrol
    • Mattarei, A. et al. Acetal derivatives as prodrugs of resveratrol. Mol Pharm 10, 2781-2792, doi: 10.1021/mp400226p (2013).
    • (2013) Mol Pharm , vol.10 , pp. 2781-2792
    • Mattarei, A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.