메뉴 건너뛰기




Volumn 17, Issue 23, 2010, Pages 2442-2455

The cardiovascular nutrapharmacology of resveratrol: Pharmacokinetics, molecular mechanisms and therapeutic potential

Author keywords

cardiovascular remodelling; preconditioning; Resveratrol; sirtuins

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; NITRIC OXIDE; POLYPHENOL; REACTIVE OXYGEN METABOLITE; RESVERATROL; SIRTUIN; THIOREDOXIN;

EID: 77954363244     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986710791556032     Document Type: Article
Times cited : (73)

References (127)
  • 3
    • 33748341697 scopus 로고    scopus 로고
    • Impact of dietary patterns and interventions on cardiovascular health
    • Zarraga, I.G.E.; Schwarz, E.R. Impact of dietary patterns and interventions on cardiovascular health. Circulation, 2006, 114, 961-973.
    • (2006) Circulation , vol.114 , pp. 961-973
    • Zarraga, I.G.E.1    Schwarz, E.R.2
  • 4
    • 0001348344 scopus 로고
    • Coronary heart disease in seven countries
    • Keys, A. Coronary heart disease in seven countries. Circulation, 1970, 44 (Supp 1), 1-211.
    • (1970) Circulation , vol.44 , Issue.SUPP 1 , pp. 1-211
    • Keys, A.1
  • 5
  • 6
    • 0032955055 scopus 로고    scopus 로고
    • Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction. Final report of the Lyon Diet Heart Study
    • De Lorgeril, M.; Salen, P.; Martin, J-L.; Monjaud, I.; Delaye, J.; Mamelle, N. Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction. Final report of the Lyon Diet Heart Study. Circulation, 1999, 99, 779-785.
    • (1999) Circulation , vol.99 , pp. 779-785
    • De Lorgeril, M.1    Salen, P.2    Martin, J.-L.3    Monjaud, I.4    Delaye, J.5    Mamelle, N.6
  • 7
    • 33745243800 scopus 로고    scopus 로고
    • The Mediterranean diet in secondary prevention of coronary heart disease
    • De Lorgeril, M.; Salen, P. The Mediterranean diet in secondary prevention of coronary heart disease. Clin. Invest. Med., 2006, 29, 154-158.
    • (2006) Clin. Invest. Med. , vol.29 , pp. 154-158
    • De Lorgeril, M.1    Salen, P.2
  • 8
    • 74949098826 scopus 로고    scopus 로고
    • Grapes, wines, resveratrol, and heart health
    • Bertelli, A.A.; Das, D.K. Grapes, wines, resveratrol, and heart health. J. Cardiovasc. Pharmacol., 2009, 54, 468-476.
    • (2009) J. Cardiovasc. Pharmacol. , vol.54 , pp. 468-476
    • Bertelli, A.A.1    Das, D.K.2
  • 9
    • 0026651085 scopus 로고
    • Wine, alcohol, platelets, and the French paradox for coronary heart disease
    • Renaud, S.; de Lorgeril, M. Wine, alcohol, platelets, and the French paradox for coronary heart disease. Lancet, 1992, 339, 1523-1526.
    • (1992) Lancet , vol.339 , pp. 1523-1526
    • Renaud, S.1    de Lorgeril, M.2
  • 10
    • 33745962138 scopus 로고    scopus 로고
    • Therapeutic potential of resveratrol: The in vivo evidence
    • Baur, J.A.; Sinclair, D.A. Therapeutic potential of resveratrol: the in vivo evidence. Nat. Rev. Drug. Discov., 2006, 5, 493-506.
    • (2006) Nat. Rev. Drug. Discov. , vol.5 , pp. 493-506
    • Baur, J.A.1    Sinclair, D.A.2
  • 11
    • 33644659068 scopus 로고    scopus 로고
    • Resveratrol in cardioprotection: A therapeutic promise of alternative medicine
    • Das, D.K.; Maulik, N. Resveratrol in cardioprotection: a therapeutic promise of alternative medicine. Mol. Interv., 2006, 6, 36-47.
    • (2006) Mol. Interv. , vol.6 , pp. 36-47
    • Das, D.K.1    Maulik, N.2
  • 12
    • 34250756115 scopus 로고    scopus 로고
    • Resveratrol: A therapeutic promise for cardiovascular disease
    • Das, S.; Das, D.K. Resveratrol: a therapeutic promise for cardiovascular disease. Recent Pat. Cardiovasc. Drug. Discov., 2007, 2, 133-138.
    • (2007) Recent Pat. Cardiovasc. Drug. Discov. , vol.2 , pp. 133-138
    • Das, S.1    Das, D.K.2
  • 13
    • 34547817147 scopus 로고    scopus 로고
    • The red wine hypothesis: From concepts to protective signalling molecules
    • Opie, L.H.; Lecour, S. The red wine hypothesis: from concepts to protective signalling molecules. Eur. Heart J., 2007, 28, 1683-1693.
    • (2007) Eur. Heart J. , vol.28 , pp. 1683-1693
    • Opie, L.H.1    Lecour, S.2
  • 15
    • 38649132291 scopus 로고    scopus 로고
    • Resveratrol and its analogs: Defense against cancer, coronary disease and neurodegenerative maladies or just a fad?
    • Saiko, P.; Szakmary, A.; Jaeger, W.; Szekeres, T. Resveratrol and its analogs: Defense against cancer, coronary disease and neurodegenerative maladies or just a fad? Mutat. Res., 2008, 658, 68-94.
    • (2008) Mutat. Res. , vol.658 , pp. 68-94
    • Saiko, P.1    Szakmary, A.2    Jaeger, W.3    Szekeres, T.4
  • 17
    • 43549088782 scopus 로고    scopus 로고
    • A multitargeted agent for age-associated chronic diseases
    • Harikumar, K.B.; Aggarwal, B.B. Resveratrol. A multitargeted agent for age-associated chronic diseases. Cell Cycle, 2008, 7, 1020-1035.
    • (2008) Cell Cycle , vol.7 , pp. 1020-1035
    • Harikumar, K.B.1    Aggarwal, B.B.2    Resveratrol3
  • 21
    • 20344407841 scopus 로고    scopus 로고
    • Resveratrol as an anti-inflammatory and anti-aging agent: Mechanisms and clinical implications
    • de la Lastra, C.A.; Villegas, I. Resveratrol as an anti-inflammatory and anti-aging agent: mechanisms and clinical implications. Mol. Nutr. Food Res., 2005, 49, 405-430.
    • (2005) Mol. Nutr. Food Res. , vol.49 , pp. 405-430
    • de la Lastra, C.A.1    Villegas, I.2
  • 23
    • 0032997123 scopus 로고    scopus 로고
    • Stimulation of endogenous adenosine release by oral administration of quercetin and resveratrol in man
    • Blardi, P.; De Lalla, A.; Volpi, L.; Di Perri, T. Stimulation of endogenous adenosine release by oral administration of quercetin and resveratrol in man. Drugs. Exp. Clin. Res., 1999, 25, 105-110.
    • (1999) Drugs. Exp. Clin. Res. , vol.25 , pp. 105-110
    • Blardi, P.1    De Lalla, A.2    Volpi, L.3    Di Perri, T.4
  • 25
    • 48649106985 scopus 로고    scopus 로고
    • Quantification of free and protein-bound trans-resveratrol metabolites and identification of trans-resveratrol- C/O-conjugated diglucuronides - two novel resveratrol metabolites in human plasma
    • Burkon, A.; Somoza, V. Quantification of free and protein-bound trans-resveratrol metabolites and identification of trans-resveratrol- C/O-conjugated diglucuronides - two novel resveratrol metabolites in human plasma. Mol. Nutr. Food. Res., 2008, 52, 549-557.
    • (2008) Mol. Nutr. Food. Res. , vol.52 , pp. 549-557
    • Burkon, A.1    Somoza, V.2
  • 26
    • 0034981157 scopus 로고    scopus 로고
    • Measurement of transresveratrol, (+)-catechin, and quercetin in rat and human blood and urine by gas chromatography with mass selective detection
    • Soleas, G.J.; Yan, J.; Goldberg, D.M. Measurement of transresveratrol, (+)-catechin, and quercetin in rat and human blood and urine by gas chromatography with mass selective detection. Methods Enzymol., 2001, 335, 130-145.
    • (2001) Methods Enzymol. , vol.335 , pp. 130-145
    • Soleas, G.J.1    Yan, J.2    Goldberg, D.M.3
  • 27
    • 38349165313 scopus 로고    scopus 로고
    • Potential for metabolic engineering of resveratrol biosynthesis
    • Halls, C.; Yu, O. Potential for metabolic engineering of resveratrol biosynthesis. Trends. Biotechnol., 2008, 26, 77-81.
    • (2008) Trends. Biotechnol. , vol.26 , pp. 77-81
    • Halls, C.1    Yu, O.2
  • 28
    • 27644595792 scopus 로고    scopus 로고
    • Antioxidant metabolite profiles in tomato fruit constitutively expressing the grapevine stilbene synthase gene
    • Giovinazzo, G.; D'Amico, L.; Paradiso, A.; Bollini, R.; Sparvoli, F.; DeGara, L. Antioxidant metabolite profiles in tomato fruit constitutively expressing the grapevine stilbene synthase gene. Plant Biotech. J., 2005, 3, 57-69.
    • (2005) Plant Biotech. J. , vol.3 , pp. 57-69
    • Giovinazzo, G.1    D'Amico, L.2    Paradiso, A.3    Bollini, R.4    Sparvoli, F.5    DeGara, L.6
  • 29
    • 23044437589 scopus 로고    scopus 로고
    • Stereoselective Synthesis of (E)-hydroxystilbenoids by rutheniumcatalyzed cross-metathesis
    • Ferré-Filmon, K.; Delaude, L.; Demonceau, A.; Noels, A.F. Stereoselective Synthesis of (E)-hydroxystilbenoids by rutheniumcatalyzed cross-metathesis. Eur. J. Org. Chem., 2005, 15, 3319-3325.
    • (2005) Eur. J. Org. Chem. , vol.15 , pp. 3319-3325
    • Ferré-Filmon, K.1    Delaude, L.2    Demonceau, A.3    Noels, A.F.4
  • 33
    • 0037248470 scopus 로고    scopus 로고
    • Absorption of three winerelated polyphenols in three different matrices by healthy subjects
    • Goldberg, D.M.; Yan, J.; Soleas, G.J. Absorption of three winerelated polyphenols in three different matrices by healthy subjects. Clin. Biochem., 2003, 36, 79-87.
    • (2003) Clin. Biochem. , vol.36 , pp. 79-87
    • Goldberg, D.M.1    Yan, J.2    Soleas, G.J.3
  • 34
    • 9444296057 scopus 로고    scopus 로고
    • High absorption but very low bioavailability of oral resveratrol in humans
    • Walle, T.; Hsieh, F.; DeLegge, M.H.; Oatis, J.E. Jr.; Walle, U.K. High absorption but very low bioavailability of oral resveratrol in humans. Drug Metab. Dispos., 2004, 32, 1377-1382.
    • (2004) Drug Metab. Dispos. , vol.32 , pp. 1377-1382
    • Walle, T.1    Hsieh, F.2    DeLegge, M.H.3    Oatis Jr., J.E.4    Walle, U.K.5
  • 35
    • 0034795649 scopus 로고    scopus 로고
    • Carbon dioxide is the major metabolite of quercetin in humans
    • Walle, T.; Walle, U.K.; Halushka, P.V. Carbon dioxide is the major metabolite of quercetin in humans. J. Nutr., 2001, 131, 264826-264852.
    • (2001) J. Nutr. , vol.131 , pp. 264826-264852
    • Walle, T.1    Walle, U.K.2    Halushka, P.V.3
  • 36
    • 4043130207 scopus 로고    scopus 로고
    • Properties of quercetin conjugates: Modulation of LDL oxidation and binding to human serum albumin
    • Janisch, K.M.; Williamson, G.; Needs, P.; Plumb, G.W. Properties of quercetin conjugates: modulation of LDL oxidation and binding to human serum albumin. Free Radic. Res., 2004, 38, 877-884.
    • (2004) Free Radic. Res. , vol.38 , pp. 877-884
    • Janisch, K.M.1    Williamson, G.2    Needs, P.3    Plumb, G.W.4
  • 37
    • 4143141119 scopus 로고    scopus 로고
    • Transport of resveratrol, a cancer chemopreventive agent, to cellular targets: Plasmatic protein binding and cell uptake
    • Jannin, B.; Menzel, M.; Berlot, J.P.; Delmas, D.; Lançon, A.; Latruffe, N. Transport of resveratrol, a cancer chemopreventive agent, to cellular targets: plasmatic protein binding and cell uptake. Biochem. Pharmacol., 2004, 68, 1113-1118.
    • (2004) Biochem. Pharmacol. , vol.68 , pp. 1113-1118
    • Jannin, B.1    Menzel, M.2    Berlot, J.P.3    Delmas, D.4    Lançon, A.5    Latruffe, N.6
  • 38
    • 18844372768 scopus 로고    scopus 로고
    • Uptake of diet resveratrol into the human low-density lipoprotein. Identification and quantification of resveratrol metabolites by liquid chromatography coupled with tandem mass spectrometry
    • Urpí-Sardà, M.; Jáuregui, O.; Lamuela-Raventós, R.M.; Jaeger, W.; Miksits, M.; Covas, M.I.; Andres-Lacueva, C. Uptake of diet resveratrol into the human low-density lipoprotein. Identification and quantification of resveratrol metabolites by liquid chromatography coupled with tandem mass spectrometry. Anal. Chem., 2005, 77, 3149-3155.
    • (2005) Anal. Chem. , vol.77 , pp. 3149-3155
    • Urpí-Sardà, M.1    Jáuregui, O.2    Lamuela-Raventós, R.M.3    Jaeger, W.4    Miksits, M.5    Covas, M.I.6    Andres-Lacueva, C.7
  • 39
    • 0037418605 scopus 로고    scopus 로고
    • Distribution of [14C]- trans-resveratrol, a cancer chemopreventive polyphenol, in mouse tissues after oral administration
    • Vitrac, X.; Desmoulière, A.; Brouillaud, B.; Krisa, S.; Deffieux, G.; Barthe, N.; Rosenbaum, J.; Mérillon, J.M. Distribution of [14C]- trans-resveratrol, a cancer chemopreventive polyphenol, in mouse tissues after oral administration. Life Sci., 2003, 72, 2219-2233.
    • (2003) Life Sci. , vol.72 , pp. 2219-2233
    • Vitrac, X.1    Desmoulière, A.2    Brouillaud, B.3    Krisa, S.4    Deffieux, G.5    Barthe, N.6    Rosenbaum, J.7    Mérillon, J.M.8
  • 41
    • 0037219688 scopus 로고    scopus 로고
    • Deglycosylation by small intestinal epithelial cell beta-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans
    • Nemeth, K.; Plumb, G.W.; Berrin, J.G.; Juge, N.; Jacob, R.; Naim, H.Y.; Williamson, G.; Swallow, D.M.; Kroon, P.A. Deglycosylation by small intestinal epithelial cell beta-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans. Eur. J. Nutr., 2003, 42, 29-42.
    • (2003) Eur. J. Nutr. , vol.42 , pp. 29-42
    • Nemeth, K.1    Plumb, G.W.2    Berrin, J.G.3    Juge, N.4    Jacob, R.5    Naim, H.Y.6    Williamson, G.7    Swallow, D.M.8    Kroon, P.A.9
  • 42
    • 0036082463 scopus 로고    scopus 로고
    • Metabolism and disposition of resveratrol in rats: Extent of absorption, glucuronidation, and enterohepatic recirculation evidenced by a linked-rat model
    • Marier, J.F.; Vachon, P.; Gritsas, A.; Zhang, J.; Moreau, J.P.; Ducharme, M.P. Metabolism and disposition of resveratrol in rats: extent of absorption, glucuronidation, and enterohepatic recirculation evidenced by a linked-rat model. J. Pharmacol. Exp. Ther., 2002, 302, 369-373.
    • (2002) J. Pharmacol. Exp. Ther. , vol.302 , pp. 369-373
    • Marier, J.F.1    Vachon, P.2    Gritsas, A.3    Zhang, J.4    Moreau, J.P.5    Ducharme, M.P.6
  • 43
    • 0037355909 scopus 로고    scopus 로고
    • Resveratrol transport and metabolism by human intestinal Caco-2 cells
    • Kaldas, M.I.; Walle, U.K.; Walle, T. Resveratrol transport and metabolism by human intestinal Caco-2 cells. J. Pharm. Pharmacol., 2003, 55, 307-312.
    • (2003) J. Pharm. Pharmacol. , vol.55 , pp. 307-312
    • Kaldas, M.I.1    Walle, U.K.2    Walle, T.3
  • 44
    • 33750600920 scopus 로고    scopus 로고
    • Increased transport of resveratrol across monolayers of the human intestinal Caco-2 cells is mediated by inhibition and saturation of metabolites
    • Maier-Salamon, A.; Hagenauer, B.; Wirth, M.; Gabor, F.; Szekeres, T.; Jager, W. Increased transport of resveratrol across monolayers of the human intestinal Caco-2 cells is mediated by inhibition and saturation of metabolites. Pharm. Res., 2006, 23, 2107-2115.
    • (2006) Pharm. Res. , vol.23 , pp. 2107-2115
    • Maier-Salamon, A.1    Hagenauer, B.2    Wirth, M.3    Gabor, F.4    Szekeres, T.5    Jager, W.6
  • 45
    • 0033777342 scopus 로고    scopus 로고
    • Sulphation of resveratrol, a natural compound present in wine, and its inhibition by natural flavonoids
    • De Santi, C.; Pietrabissa, A.; Spisni, R.; Mosca, F.; Pacifici, G.M. Sulphation of resveratrol, a natural compound present in wine, and its inhibition by natural flavonoids. Xenobiotica, 2000, 30, 857-866.
    • (2000) Xenobiotica , vol.30 , pp. 857-866
    • De Santi, C.1    Pietrabissa, A.2    Spisni, R.3    Mosca, F.4    Pacifici, G.M.5
  • 46
    • 0034491047 scopus 로고    scopus 로고
    • Glucuronidation of resveratrol, a natural product present in grape and wine, in the human liver
    • De Santi, C.; Pietrabissa, A.; Mosca, F.; Pacifici, GM. Glucuronidation of resveratrol, a natural product present in grape and wine, in the human liver. Xenobiotica, 2000, 30, 1047-1054.
    • (2000) Xenobiotica , vol.30 , pp. 1047-1054
    • De Santi, C.1    Pietrabissa, A.2    Mosca, F.3    Pacifici, G.M.4
  • 49
    • 39149104669 scopus 로고    scopus 로고
    • Metabolism of resveratrol in breast cancer cell lines: Impact of sulfotransferase 1A1 expression on cell growth inhibition
    • Murias, M.; Miksits, M.; Aust, S.; Spatzenegger, M.; Thalhammer, T.; Szekeres, T.; Jaeger, W. Metabolism of resveratrol in breast cancer cell lines: impact of sulfotransferase 1A1 expression on cell growth inhibition. Cancer Lett., 2008, 26, 172-182.
    • (2008) Cancer Lett. , vol.26 , pp. 172-182
    • Murias, M.1    Miksits, M.2    Aust, S.3    Spatzenegger, M.4    Thalhammer, T.5    Szekeres, T.6    Jaeger, W.7
  • 51
    • 3242676024 scopus 로고    scopus 로고
    • Involvement of cytochrome P450 1A2 in the biotransformation of trans-resveratrol in human liver microsomes
    • Piver, B.; Fer, M.; Vitrac, X.; Merillon, J.M.; Dreano, Y.; Berthou, F.; Lucas, D. Involvement of cytochrome P450 1A2 in the biotransformation of trans-resveratrol in human liver microsomes. Biochem. Pharmacol., 2004, 68, 773-782.
    • (2004) Biochem. Pharmacol. , vol.68 , pp. 773-782
    • Piver, B.1    Fer, M.2    Vitrac, X.3    Merillon, J.M.4    Dreano, Y.5    Berthou, F.6    Lucas, D.7
  • 52
    • 0032535055 scopus 로고    scopus 로고
    • Resveratrol inhibits transcription of CYP1A1 in vitro by preventing activation of the aryl hydrocarbon receptor
    • Ciolino, H.P.; Daschner, P.J.; Yeh, G.C. Resveratrol inhibits transcription of CYP1A1 in vitro by preventing activation of the aryl hydrocarbon receptor. Cancer Res.,1998, 58, 5707-5712.
    • (1998) Cancer Res. , vol.58 , pp. 5707-5712
    • Ciolino, H.P.1    Daschner, P.J.2    Yeh, G.C.3
  • 53
    • 11844306055 scopus 로고    scopus 로고
    • Cell-based high-throughput bioassays to assess induction and inhibition of CYP1A enzymes
    • Yueh, M.F.; Kawahara, M.; Raucy, J. Cell-based high-throughput bioassays to assess induction and inhibition of CYP1A enzymes. Toxicol. In Vitro., 2005, 19, 275-287.
    • (2005) Toxicol. In Vitro. , vol.19 , pp. 275-287
    • Yueh, M.F.1    Kawahara, M.2    Raucy, J.3
  • 54
    • 33749646867 scopus 로고    scopus 로고
    • Significance of wine and resveratrol in cardiovascular disease: French paradox revisited
    • Vidavalur, R.; Otani, H.; Singal, P.K.; Maulik, N. Significance of wine and resveratrol in cardiovascular disease: French paradox revisited. Exp. Clin. Cardiol., 2006, 11, 217-225.
    • (2006) Exp. Clin. Cardiol. , vol.11 , pp. 217-225
    • Vidavalur, R.1    Otani, H.2    Singal, P.K.3    Maulik, N.4
  • 57
    • 67349189553 scopus 로고    scopus 로고
    • Resveratrol, a unique phytoalexin present in red wine, delivers either survival signal or death signal to the ischemic myocardium depending on dose
    • Dudley, J.; Das, S.; Mukherjee, S.; Das, D.K. Resveratrol, a unique phytoalexin present in red wine, delivers either survival signal or death signal to the ischemic myocardium depending on dose. J. Nutr. Biochem., 2009, 20, 443-452.
    • (2009) J. Nutr. Biochem. , vol.20 , pp. 443-452
    • Dudley, J.1    Das, S.2    Mukherjee, S.3    Das, D.K.4
  • 59
    • 67949102053 scopus 로고    scopus 로고
    • Recent progress in the biology and physiology of sirtuins
    • Finkel, T.; Deng, C.X.; Mostoslavsky, R. Recent progress in the biology and physiology of sirtuins. Nature, 2009, 460, 587-591.
    • (2009) Nature , vol.460 , pp. 587-591
    • Finkel, T.1    Deng, C.X.2    Mostoslavsky, R.3
  • 64
    • 40849135481 scopus 로고    scopus 로고
    • The sirtuin family: Therapeutic targets to treat diseases of aging
    • Milne, J.C.; Denu, J.M. The sirtuin family: therapeutic targets to treat diseases of aging. Curr. Opin. Chem. Biol., 2008, 12, 11-17.
    • (2008) Curr. Opin. Chem. Biol. , vol.12 , pp. 11-17
    • Milne, J.C.1    Denu, J.M.2
  • 65
    • 52649144195 scopus 로고    scopus 로고
    • Resveratrol and novel potent activators of SIRT1: Effects on aging and age-related diseases
    • Knutson, M.D.; Leeuwenburgh, C. Resveratrol and novel potent activators of SIRT1: effects on aging and age-related diseases. Nutr. Rev., 2008, 66, 591-596.
    • (2008) Nutr. Rev. , vol.66 , pp. 591-596
    • Knutson, M.D.1    Leeuwenburgh, C.2
  • 66
    • 77953480631 scopus 로고    scopus 로고
    • Biochemical effects of SIRT1 activators
    • doi:10.1016/j.bbapap.2009.10.025
    • Baur, J.A. Biochemical effects of SIRT1 activators. Biochim. Biophys. Acta, 2009, doi:10.1016/j.bbapap.2009.10.025.
    • (2009) Biochim. Biophys. Acta
    • Baur, J.A.1
  • 67
    • 47249108032 scopus 로고    scopus 로고
    • Sirtuins: Novel targets for metabolic disease in drug development
    • Jiang, W-J. Sirtuins: Novel targets for metabolic disease in drug development. Biochem. Biophys. Res. Commun., 2008, 373, 341-344.
    • (2008) Biochem. Biophys. Res. Commun. , vol.373 , pp. 341-344
    • Jiang, W.-J.1
  • 70
    • 44449129847 scopus 로고    scopus 로고
    • EPR studies on the superoxide-scavenging capacity of the nutraceutical resveratrol
    • Jia, Z.; Zhu, H.; Misra, B.R.; Mahaney, J.E.; Li, Y.; Misra, H.P. EPR studies on the superoxide-scavenging capacity of the nutraceutical resveratrol. Mol. Cell Biochem., 2008, 313, 187-194.
    • (2008) Mol. Cell Biochem. , vol.313 , pp. 187-194
    • Jia, Z.1    Zhu, H.2    Misra, B.R.3    Mahaney, J.E.4    Li, Y.5    Misra, H.P.6
  • 71
    • 19444364321 scopus 로고    scopus 로고
    • Coordinated induction of iNOS-VEGF-KDR-eNOS after resveratrol consumption. A potential mechanism for resveratrol preconditioning of the heart
    • Das, S.; Alagappan, V.K.T.; Dagchi, D.; Sharma, H.S.; Maulik, N.; Das, D.K. Coordinated induction of iNOS-VEGF-KDR-eNOS after resveratrol consumption. A potential mechanism for resveratrol preconditioning of the heart. Vasc. Pharmacol., 2005, 42, 281-289.
    • (2005) Vasc. Pharmacol. , vol.42 , pp. 281-289
    • Das, S.1    Alagappan, V.K.T.2    Dagchi, D.3    Sharma, H.S.4    Maulik, N.5    Das, D.K.6
  • 72
    • 51049085099 scopus 로고    scopus 로고
    • Resveratrol, at concentrations attainable with moderate wine consumption, stimulates human platelet nitric oxide production
    • Gresele, P.; Pignatelli, P.; Guglielmini, G.; Carnevale, R.; Mezzasoma, A.M.; Ghiselli, A.; Momi, S.; Violi, F. Resveratrol, at concentrations attainable with moderate wine consumption, stimulates human platelet nitric oxide production. J. Nutr., 2008, 138, 1602-1608.
    • (2008) J. Nutr. , vol.138 , pp. 1602-1608
    • Gresele, P.1    Pignatelli, P.2    Guglielmini, G.3    Carnevale, R.4    Mezzasoma, A.M.5    Ghiselli, A.6    Momi, S.7    Violi, F.8
  • 73
    • 33751165449 scopus 로고    scopus 로고
    • Resveratrol affords protection against peroxynitrite-mediated endothelial cell death: A role for intracellular glutathione
    • Brito, P.M.; Mariano, A.; Almeida, L.M.; Dinis, T.C. Resveratrol affords protection against peroxynitrite-mediated endothelial cell death: A role for intracellular glutathione. Chem. Biol. Interact., 2006, 164, 157-166.
    • (2006) Chem. Biol. Interact. , vol.164 , pp. 157-166
    • Brito, P.M.1    Mariano, A.2    Almeida, L.M.3    Dinis, T.C.4
  • 74
    • 1942484416 scopus 로고    scopus 로고
    • Potent induction of cellular antioxidants and phase 2 enzymes by resveratrol in cardiomyocytes: Protection against oxidative and electrophilic injury
    • Cao, Z.; Li, Y. Potent induction of cellular antioxidants and phase 2 enzymes by resveratrol in cardiomyocytes: protection against oxidative and electrophilic injury. Eur. J. Pharmacol., 2004, 489, 39-48.
    • (2004) Eur. J. Pharmacol. , vol.489 , pp. 39-48
    • Cao, Z.1    Li, Y.2
  • 75
    • 0036158062 scopus 로고    scopus 로고
    • The possible implication of trans-resveratrol in the cardioprotective effects of long-term moderate wine consumption
    • Orallo, F.; Alvarez, E.; Camina, M.; Leiro, J.M.; Gomez, E.; Fernandez, P. The possible implication of trans-resveratrol in the cardioprotective effects of long-term moderate wine consumption. Mol. Pharmacol., 2002, 61, 294-302.
    • (2002) Mol. Pharmacol. , vol.61 , pp. 294-302
    • Orallo, F.1    Alvarez, E.2    Camina, M.3    Leiro, J.M.4    Gomez, E.5    Fernandez, P.6
  • 76
    • 49349099323 scopus 로고    scopus 로고
    • Emerging potential of thioredoxin and thioredoxin interacting proteins in various disease conditions
    • Maulik, N.; Das, D.K. Emerging potential of thioredoxin and thioredoxin interacting proteins in various disease conditions. Biochim. Biophys. Acta., 2008, 1780, 1368-1382.
    • (2008) Biochim. Biophys. Acta. , vol.1780 , pp. 1368-1382
    • Maulik, N.1    Das, D.K.2
  • 78
    • 33846244291 scopus 로고    scopus 로고
    • Preconditioning: A paradigm shift in the biology of myocardial ischemia
    • Bolli, R. Preconditioning: a paradigm shift in the biology of myocardial ischemia. Am. J. Physiol. Heart Circ. Physiol., 2007, 292, H19-27.
    • (2007) Am. J. Physiol. Heart Circ. Physiol. , vol.292
    • Bolli, R.1
  • 79
    • 33646768213 scopus 로고    scopus 로고
    • Potentiation of a survival signal in the ischemic heart by resveratrol through p38 mitogen-activated protein kinase/mitogen- and stress-activated protein kinase 1/cAMP response element-binding protein signaling
    • Das, S.; Tosaki, A.; Bagchi, D.; Maulik, N.; Das, D.K. Potentiation of a survival signal in the ischemic heart by resveratrol through p38 mitogen-activated protein kinase/mitogen- and stress-activated protein kinase 1/cAMP response element-binding protein signaling. J. Pharmacol. Exp. Ther., 2006, 317, 980-988.
    • (2006) J. Pharmacol. Exp. Ther. , vol.317 , pp. 980-988
    • Das, S.1    Tosaki, A.2    Bagchi, D.3    Maulik, N.4    Das, D.K.5
  • 81
    • 11144348684 scopus 로고    scopus 로고
    • Pharmacological preconditioning with resveratrol: Role of CREB-dependent Bcl-2 signaling via adenosine A3 receptor activation
    • Das, S.; Cordis, G.A.; Maulik, N.; Das, D.K. Pharmacological preconditioning with resveratrol: role of CREB-dependent Bcl-2 signaling via adenosine A3 receptor activation. Am. J. Physiol. Heart Circ. Physiol., 2005, 288, H328-335.
    • (2005) Am. J. Physiol. Heart Circ. Physiol. , vol.288
    • Das, S.1    Cordis, G.A.2    Maulik, N.3    Das, D.K.4
  • 82
    • 22944481180 scopus 로고    scopus 로고
    • Resveratrolmediated activation of cAMP response element-binding protein through adenosine A3 receptor by Akt-dependent and -independent pathways
    • Das, S.; Tosaki, A.; Bagchi, D.; Maulik, N.; Das, D.K. Resveratrolmediated activation of cAMP response element-binding protein through adenosine A3 receptor by Akt-dependent and -independent pathways. J. Pharmacol. Exp. Ther., 2005, 314, 762-769.
    • (2005) J. Pharmacol. Exp. Ther. , vol.314 , pp. 762-769
    • Das, S.1    Tosaki, A.2    Bagchi, D.3    Maulik, N.4    Das, D.K.5
  • 83
    • 33749265695 scopus 로고    scopus 로고
    • Cardioprotective effect of resveratrol via HO-1 expression involves p38 map kinase and PI-3-kinase signaling, but does not involve NFβB
    • Das, S.; Fraga, C.G.; Das, D.K. Cardioprotective effect of resveratrol via HO-1 expression involves p38 map kinase and PI-3-kinase signaling, but does not involve NFβB. Free Radic. Res., 2006, 40, 1066-1075.
    • (2006) Free Radic. Res. , vol.40 , pp. 1066-1075
    • Das, S.1    Fraga, C.G.2    Das, D.K.3
  • 85
    • 57149123016 scopus 로고    scopus 로고
    • Resveratrol enhances GLUT- 4 translocation to the caveolar lipid raft fractions through AMPK/AKT/eNOS signaling pathway in diabetic myocardium
    • Penumathsa, S.V.; Thirunavukkarasu, M.; Zhan, L.; Maulik, G.; Menon, V.P.; Bagchi, D.; Maulik, N. Resveratrol enhances GLUT- 4 translocation to the caveolar lipid raft fractions through AMPK/AKT/eNOS signaling pathway in diabetic myocardium. J. Cell Mol. Med., 2008, 12, 2350-2361.
    • (2008) J. Cell Mol. Med. , vol.12 , pp. 2350-2361
    • Penumathsa, S.V.1    Thirunavukkarasu, M.2    Zhan, L.3    Maulik, G.4    Menon, V.P.5    Bagchi, D.6    Maulik, N.7
  • 86
    • 19744369830 scopus 로고    scopus 로고
    • Chronic administration of resveratrol prevents biochemical cardiovascular changes in fructose-fed rats
    • Miatello, R.; Vázquez, M.; Renna, N.; Cruzado, M.; Ponce Zumino, A.; Risler, N. Chronic administration of resveratrol prevents biochemical cardiovascular changes in fructose-fed rats. Am. J. Hypertens., 2005, 18, 864-870.
    • (2005) Am. J. Hypertens. , vol.18 , pp. 864-870
    • Miatello, R.1    Vázquez, M.2    Renna, N.3    Cruzado, M.4    Ponce Zumino, A.5    Risler, N.6
  • 89
    • 37349064416 scopus 로고    scopus 로고
    • Resveratrol reverses hydrogen peroxide-induced proliferative effects in human coronary smooth muscle cells: A novel signalling mechanism
    • El-Mowafy, A.M.; Alkhalaf, M.; El-Kashef, H.A. Resveratrol reverses hydrogen peroxide-induced proliferative effects in human coronary smooth muscle cells: a novel signalling mechanism. Arch. Med. Res., 2008, 39, 155-161.
    • (2008) Arch. Med. Res. , vol.39 , pp. 155-161
    • El-Mowafy, A.M.1    Alkhalaf, M.2    El-Kashef, H.A.3
  • 90
    • 0033916480 scopus 로고    scopus 로고
    • Resveratrol inhibits AGEsinduced proliferation and collagen synthesis activity in vascular smooth muscle cells from stroke-prone spontaneously hypertensive rats
    • Mizutani, K.; Ikeda, K.; Yamori, Y. Resveratrol inhibits AGEsinduced proliferation and collagen synthesis activity in vascular smooth muscle cells from stroke-prone spontaneously hypertensive rats. Biochem. Biophys. Res. Commun., 2000, 274, 61-67.
    • (2000) Biochem. Biophys. Res. Commun. , vol.274 , pp. 61-67
    • Mizutani, K.1    Ikeda, K.2    Yamori, Y.3
  • 91
    • 34250857969 scopus 로고    scopus 로고
    • Prevention of concentric hypertrophy and diastolic impairment in aortic-banded rats treated with resveratrol
    • Juric, D.; Wojciechowski, P.; Das, D.K.; Netticandan, T. Prevention of concentric hypertrophy and diastolic impairment in aortic-banded rats treated with resveratrol. Am. J. Physiol. Heart. Circ. Physiol., 2007, 292, H2138-H2143.
    • (2007) Am. J. Physiol. Heart. Circ. Physiol. , vol.292
    • Juric, D.1    Wojciechowski, P.2    Das, D.K.3    Netticandan, T.4
  • 93
    • 13944256603 scopus 로고    scopus 로고
    • Inhibition of cardiac fibroblast proliferation and myofibroblast differentiation by resveratrol
    • Olson, E.R;. Naugle, J.E.; Zhang, X.; Bomser, J.A.; Meszaros, J.G. Inhibition of cardiac fibroblast proliferation and myofibroblast differentiation by resveratrol. Am. J. Physiol., 2005, 288, H1131-H1138.
    • (2005) Am. J. Physiol. , vol.288
    • Olson, E.R.1    Naugle, J.E.2    Zhang, X.3    Bomser, J.A.4    Meszaros, J.G.5
  • 94
    • 34249103889 scopus 로고    scopus 로고
    • Resveratrol inhibits proliferation of cultured rat cardiac fibroblasts: Correlated with NO-cGMP signaling pathway
    • Wang, S.J.; Wang, X.X.; Yan, J.; Xie, X.D.; Fan, F.H.; Zhou, X.; Han, L.; Chen, J.Z. Resveratrol inhibits proliferation of cultured rat cardiac fibroblasts: correlated with NO-cGMP signaling pathway. Eur. J. Pharmacol., 2007, 567, 26-35.
    • (2007) Eur. J. Pharmacol. , vol.567 , pp. 26-35
    • Wang, S.J.1    Wang, X.X.2    Yan, J.3    Xie, X.D.4    Fan, F.H.5    Zhou, X.6    Han, L.7    Chen, J.Z.8
  • 95
    • 44249100660 scopus 로고    scopus 로고
    • Female rats fed a high-fat diet were associated with vascular dysfunction and cardiac fibrosis in the absence of overt obesity and hyperlipidemia: Therapeutic potential of resveratrol
    • Aubin, M-C.; Lajoie, C.; Clément, R.; Gosselin, H.; Calderone, A.; Perrault, L.P. Female rats fed a high-fat diet were associated with vascular dysfunction and cardiac fibrosis in the absence of overt obesity and hyperlipidemia: therapeutic potential of resveratrol. J. Pharmacol. Exp. Ther., 2008, 325, 961-968.
    • (2008) J. Pharmacol. Exp. Ther. , vol.325 , pp. 961-968
    • Aubin, M.-C.1    Lajoie, C.2    Clément, R.3    Gosselin, H.4    Calderone, A.5    Perrault, L.P.6
  • 96
    • 34648830916 scopus 로고    scopus 로고
    • Anti-inflammatory responses of resveratrol
    • Das, S.; Das, D.K. Anti-inflammatory responses of resveratrol. Inflamm. Allergy Drug Targets, 2007, 6, 168-173.
    • (2007) Inflamm. Allergy Drug Targets , vol.6 , pp. 168-173
    • Das, S.1    Das, D.K.2
  • 97
    • 33750981282 scopus 로고    scopus 로고
    • Attenuation of ischemia/reperfusion injury in rats by the anti-inflammatory action of resveratrol
    • Das, S.; Falchi, M.; Bertelli, A.; Maulik, N.; Das, D.K. Attenuation of ischemia/reperfusion injury in rats by the anti-inflammatory action of resveratrol. Arzneimittelforschung, 2006, 56, 700-706.
    • (2006) Arzneimittelforschung , vol.56 , pp. 700-706
    • Das, S.1    Falchi, M.2    Bertelli, A.3    Maulik, N.4    Das, D.K.5
  • 99
    • 46149101224 scopus 로고    scopus 로고
    • Curcumin and resveratrol inhibit nuclear factor-kappaB-mediated cytokine expression in adipocytes
    • Gonzales, A.M.; Orlando, R.A. Curcumin and resveratrol inhibit nuclear factor-kappaB-mediated cytokine expression in adipocytes. Nutr. Metab. (Lond), 2008, 12, 5-17.
    • (2008) Nutr. Metab. (Lond) , vol.12 , pp. 5-17
    • Gonzales, A.M.1    Orlando, R.A.2
  • 100
    • 33845436010 scopus 로고    scopus 로고
    • In vivo electrophysiological mechanisms for antiarrhythmic efficacy of resveratrol, a red wine antioxidant
    • Chen, W-P.; Su, M-J.; Hung, L-M. In vivo electrophysiological mechanisms for antiarrhythmic efficacy of resveratrol, a red wine antioxidant. Eur. J. Pharmacol., 2007, 554, 196-204.
    • (2007) Eur. J. Pharmacol. , vol.554 , pp. 196-204
    • Chen, W.-P.1    Su, M.-J.2    Hung, L.-M.3
  • 101
    • 55949088579 scopus 로고    scopus 로고
    • Resveratrol attenuates ventricular arrhythmias and improves the long-term survival in rats with myocardial infarction
    • Chen, Y.R.; Yi, F.F.; Li, X.Y.; Wang, C.Y.; Chen, L.; Yang, X.C.; Su, P.X.; Cai, J. Resveratrol attenuates ventricular arrhythmias and improves the long-term survival in rats with myocardial infarction. Cardiovasc. Drugs. Ther., 2008, 22, 479-485.
    • (2008) Cardiovasc. Drugs. Ther. , vol.22 , pp. 479-485
    • Chen, Y.R.1    Yi, F.F.2    Li, X.Y.3    Wang, C.Y.4    Chen, L.5    Yang, X.C.6    Su, P.X.7    Cai, J.8
  • 102
    • 47849088748 scopus 로고    scopus 로고
    • Emerging roles of SIRT1 in vascular endothelial homeostasis
    • Potente, M.; Dimmeler, S. Emerging roles of SIRT1 in vascular endothelial homeostasis. Cell Cycle, 2008, 7, 2117-2122.
    • (2008) Cell Cycle , vol.7 , pp. 2117-2122
    • Potente, M.1    Dimmeler, S.2
  • 104
    • 38749131263 scopus 로고    scopus 로고
    • Effects of dietary polyphenols on gene expression in human vascular endothelial cells
    • Nicholson, S.K.; Tucker, G.A. Effects of dietary polyphenols on gene expression in human vascular endothelial cells. Proc. Nutr. Soc., 2008, 67, 42-47.
    • (2008) Proc. Nutr. Soc. , vol.67 , pp. 42-47
    • Nicholson, S.K.1    Tucker, G.A.2
  • 105
    • 34547674896 scopus 로고    scopus 로고
    • Resveratrol inhibits rat aortic vascular smooth muscle cell proliferation via estrogen receptor dependent nitric oxide production
    • Ekshyyan, V.P.; Hebert, V.Y.; Khandewal, A.; Dugas, T.R. Resveratrol inhibits rat aortic vascular smooth muscle cell proliferation via estrogen receptor dependent nitric oxide production. J. Cardiovasc. Pharmacol., 2007, 50, 83-93.
    • (2007) J. Cardiovasc. Pharmacol. , vol.50 , pp. 83-93
    • Ekshyyan, V.P.1    Hebert, V.Y.2    Khandewal, A.3    Dugas, T.R.4
  • 106
  • 107
    • 33749365317 scopus 로고    scopus 로고
    • Resveratrol attenuates TNF-α-induced activation of coronary arterial endothelial cells: Role of NF-βB inhibition
    • Csiszar, A.; Smith, K.; Labinskyy, N.; Orosz, Z.; Rivera, A.; Ungvari, Z. Resveratrol attenuates TNF-α-induced activation of coronary arterial endothelial cells: role of NF-βB inhibition. Am. J. Physiol. Heart Circ. Physiol., 2006, 291, H1694-H1699.
    • (2006) Am. J. Physiol. Heart Circ. Physiol. , vol.291
    • Csiszar, A.1    Smith, K.2    Labinskyy, N.3    Orosz, Z.4    Rivera, A.5    Ungvari, Z.6
  • 108
    • 34147182364 scopus 로고    scopus 로고
    • Resveratrol attenuates ox-LDL-stimulated NADPH oxidase activity and protects endothelial cells from oxidative functional damages
    • Chow, S.E.; Hshu, Y.C.; Wang, J.S.; Chen, J.K. Resveratrol attenuates ox-LDL-stimulated NADPH oxidase activity and protects endothelial cells from oxidative functional damages. J. Appl. Physiol., 2007, 102, 1520-1527.
    • (2007) J. Appl. Physiol. , vol.102 , pp. 1520-1527
    • Chow, S.E.1    Hshu, Y.C.2    Wang, J.S.3    Chen, J.K.4
  • 110
    • 52949093112 scopus 로고    scopus 로고
    • Resveratrol reduces endothelial progenitor cells senescence through augmentation of telomerase activity by Akt-dependent mechanisms
    • Xia, L.; Wang, X.X.; Hu, X.S.; Guo, X.G.; Shang, Y.P.; Chen, H.J.; Zeng, C.L.; Zhang, F.R.; Chen, J.Z. Resveratrol reduces endothelial progenitor cells senescence through augmentation of telomerase activity by Akt-dependent mechanisms. Br. J. Pharmacol., 2008, 155, 387-394.
    • (2008) Br. J. Pharmacol. , vol.155 , pp. 387-394
    • Xia, L.1    Wang, X.X.2    Hu, X.S.3    Guo, X.G.4    Shang, Y.P.5    Chen, H.J.6    Zeng, C.L.7    Zhang, F.R.8    Chen, J.Z.9
  • 111
    • 33947171433 scopus 로고    scopus 로고
    • Resveratrol attenuates ischemia-reperfusion-induced leukocyte-endothelial cell adhesive interactions and prolongs allograft survival across the MHC barrier
    • Hsieh, Y-H.; Huang, S-S.; Wei, F-C.; Huang, L-M. Resveratrol attenuates ischemia-reperfusion-induced leukocyte-endothelial cell adhesive interactions and prolongs allograft survival across the MHC barrier. Circ. J., 2007, 71, 423-428.
    • (2007) Circ. J. , vol.71 , pp. 423-428
    • Hsieh, Y.-H.1    Huang, S.-S.2    Wei, F.-C.3    Huang, L.-M.4
  • 112
    • 33947679773 scopus 로고    scopus 로고
    • Reactive oxygen species drives myocardial angiogenesis?
    • Maulik, N. Reactive oxygen species drives myocardial angiogenesis? Antioxid. Redox. Signal., 2006, 8, 2161-2168.
    • (2006) Antioxid. Redox. Signal. , vol.8 , pp. 2161-2168
    • Maulik, N.1
  • 113
    • 26844449558 scopus 로고    scopus 로고
    • Resveratrol enhances neovascularization in the infarcted rat myocardium through the induction of thioredoxin-1, heme oxygenase-1 and vascular endothelial growth factor
    • Kaga, S.; Zhan, L.; Matsumoto, M.; Maulik, N. Resveratrol enhances neovascularization in the infarcted rat myocardium through the induction of thioredoxin-1, heme oxygenase-1 and vascular endothelial growth factor. J. Mol. Cell Cardiol., 2005, 39, 813-822.
    • (2005) J. Mol. Cell Cardiol. , vol.39 , pp. 813-822
    • Kaga, S.1    Zhan, L.2    Matsumoto, M.3    Maulik, N.4
  • 114
    • 51549090151 scopus 로고    scopus 로고
    • Strategic targets to induce neovascularization by resveratrol in hypercholesterolemic rat myocardium: Role of caveolin-1, endothelial nitric oxide synthase, hemeoxygenase-1, and vascular endothelial growth factor
    • Penumathsa, S.V.; Koneru, S.; Samuel, S.M.; Maulik, G.; Bagchi, D.; Yet, S-F.; Menon, V.P.; Maulik, N. Strategic targets to induce neovascularization by resveratrol in hypercholesterolemic rat myocardium: Role of caveolin-1, endothelial nitric oxide synthase, hemeoxygenase-1, and vascular endothelial growth factor. Free. Radic. Biol. Med., 2008, 45, 1027-1034.
    • (2008) Free. Radic. Biol. Med. , vol.45 , pp. 1027-1034
    • Penumathsa, S.V.1    Koneru, S.2    Samuel, S.M.3    Maulik, G.4    Bagchi, D.5    Yet, S.-F.6    Menon, V.P.7    Maulik, N.8
  • 115
    • 36348932703 scopus 로고    scopus 로고
    • New insights into mechanism for the effect of resveratrol preconditioning against cerebral ischemic stroke: Possible role of matrix metalloprotease-9
    • Dong, W.; Gao, D.; Lin, H.; Zhang, X.; Li, N.; Li, F. New insights into mechanism for the effect of resveratrol preconditioning against cerebral ischemic stroke: Possible role of matrix metalloprotease-9. Med. Hypoth., 2008, 70, 52-55.
    • (2008) Med. Hypoth. , vol.70 , pp. 52-55
    • Dong, W.1    Gao, D.2    Lin, H.3    Zhang, X.4    Li, N.5    Li, F.6
  • 116
    • 33846235472 scopus 로고    scopus 로고
    • Resveratrol, a polyphenolic phytostilbene, inhibits endothelial monocyte chemotactic protein-1 synthesis and secretion
    • Cullen, J.P.; Morrow, D.; Jin, Y.; Curley, B.; Robinson, A.; Sitzmann, J.V.; Cahill, P.A.; Redmond, E.M. Resveratrol, a polyphenolic phytostilbene, inhibits endothelial monocyte chemotactic protein-1 synthesis and secretion. J. Vasc. Res., 2007, 44, 75-84.
    • (2007) J. Vasc. Res. , vol.44 , pp. 75-84
    • Cullen, J.P.1    Morrow, D.2    Jin, Y.3    Curley, B.4    Robinson, A.5    Sitzmann, J.V.6    Cahill, P.A.7    Redmond, E.M.8
  • 117
    • 20344378481 scopus 로고    scopus 로고
    • Resveratrol: Preventing properties against vascular alterations and ageing
    • Delmas, D.; Jannin, B.; Latruffe, N. Resveratrol: preventing properties against vascular alterations and ageing. Mol. Nutr. Food Res., 2005, 49, 377-395.
    • (2005) Mol. Nutr. Food Res. , vol.49 , pp. 377-395
    • Delmas, D.1    Jannin, B.2    Latruffe, N.3
  • 118
    • 47749085845 scopus 로고    scopus 로고
    • Long-term effects of resveratrol supplementation on suppression of atherogenic lesion formation and cholesterol synthesis in apo E-deficient mice
    • Do, G-M.; Kwon, E-Y.; Kim, H-J.; Jeon, S-M.; Ha, T-Y.; Park, T.; Choi, M-S. Long-term effects of resveratrol supplementation on suppression of atherogenic lesion formation and cholesterol synthesis in apo E-deficient mice. Biochem. Biophys. Res. Commun., 2008, 374, 55-59.
    • (2008) Biochem. Biophys. Res. Commun. , vol.374 , pp. 55-59
    • Do, G.-M.1    Kwon, E.-Y.2    Kim, H.-J.3    Jeon, S.-M.4    Ha, T.-Y.5    Park, T.6    Choi, M.-S.7
  • 119
    • 34848900430 scopus 로고    scopus 로고
    • Inhibitory mechanisms of resveratrol in platelet activation: Pivotal roles of p38 MAPK and NO/cyclic GMP
    • Shen, M.Y.; Hsiao, G.; Liu, C.L.; Fong, T.H.; Lin, K.H.; Chou, D.S.; Sheu, J.R. Inhibitory mechanisms of resveratrol in platelet activation: pivotal roles of p38 MAPK and NO/cyclic GMP. Br. J. Haematol., 2007, 139, 475-485.
    • (2007) Br. J. Haematol. , vol.139 , pp. 475-485
    • Shen, M.Y.1    Hsiao, G.2    Liu, C.L.3    Fong, T.H.4    Lin, K.H.5    Chou, D.S.6    Sheu, J.R.7
  • 120
    • 33748509090 scopus 로고    scopus 로고
    • Resveratrol inhibits aggregation of platelets from high-risk cardiac patients with aspirin resistance
    • Stef, G.; Csiszar, A.; Lerea, K.; Ungvari, Z.; Veress, G. Resveratrol inhibits aggregation of platelets from high-risk cardiac patients with aspirin resistance. J. Cardiovasc. Pharmacol., 2006, 48, 1-5.
    • (2006) J. Cardiovasc. Pharmacol. , vol.48 , pp. 1-5
    • Stef, G.1    Csiszar, A.2    Lerea, K.3    Ungvari, Z.4    Veress, G.5
  • 122
    • 33847619327 scopus 로고    scopus 로고
    • Functional contribution of the endothelial component to the vasorelaxing effect of resveratrol and NS 1619, activators of the large-conductance calcium-activated potassium channels
    • Calderone, V.; Martelli, A.; Testai, L.; Martinotti, E.; Breschi, M.C. Functional contribution of the endothelial component to the vasorelaxing effect of resveratrol and NS 1619, activators of the large-conductance calcium-activated potassium channels. Naunyn. Schmiedebergs. Arch. Pharmacol., 2007, 375, 73-80.
    • (2007) Naunyn. Schmiedebergs. Arch. Pharmacol. , vol.375 , pp. 73-80
    • Calderone, V.1    Martelli, A.2    Testai, L.3    Martinotti, E.4    Breschi, M.C.5
  • 123
    • 52949145570 scopus 로고    scopus 로고
    • A role of ion channels in the endothelium-independent relaxation of rat mesenteric artery induced by resveratrol
    • Gojkovic-Bukarica, L.; Novakovic, A.; Kanjuh, V.; Mumbasirevic, M.; Lesic, A.; Neinle, H. A role of ion channels in the endothelium-independent relaxation of rat mesenteric artery induced by resveratrol. J. Pharmacol. Sci., 2008, 108, 124-130.
    • (2008) J. Pharmacol. Sci. , vol.108 , pp. 124-130
    • Gojkovic-Bukarica, L.1    Novakovic, A.2    Kanjuh, V.3    Mumbasirevic, M.4    Lesic, A.5    Neinle, H.6
  • 125
    • 33644814524 scopus 로고    scopus 로고
    • Resveratrol decreases calcium sensitivity of vascular smooth muscle and enhances cytosolic calcium increase in endothelium
    • Buluc, M.; Demirel-Yilmaz, E. Resveratrol decreases calcium sensitivity of vascular smooth muscle and enhances cytosolic calcium increase in endothelium. Vasc. Pharmacol., 2006, 44, 231-237.
    • (2006) Vasc. Pharmacol. , vol.44 , pp. 231-237
    • Buluc, M.1    Demirel-Yilmaz, E.2
  • 127
    • 44349141200 scopus 로고    scopus 로고
    • The effects of chronic resveratrol treatment on vascular responsiveness of streptozotocin-induced diabetic rats
    • Silan, C. The effects of chronic resveratrol treatment on vascular responsiveness of streptozotocin-induced diabetic rats. Biol. Pharm. Bull., 2008, 31, 879-902.
    • (2008) Biol. Pharm. Bull. , vol.31 , pp. 879-902
    • Silan, C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.