Drug transport via the intestinal peptide transporter PepT1

Current Opinion in Pharmacology

Volumn 13, Issue 6, 2013, Pages 881-887

  Brandsch, Matthias ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

(3 BETA) 3 HYDROXYOLEAN 12 EN 28 OIC ACID; AMINOLEVULINIC ACID; ANTIVIRUS AGENT; CEFADROXIL; CYCLO 4 HYDROXYPROLYLSERINE; DEXTRO PHENYLGLYCINE LEVODOPA; DIDANOSINE; DIPEPTIDE; GUANIDINE OSELTAMIVIR CARBOXYLATE; JBP 485; LEVODOPA; LYSINE DERIVATIVE; MALTOSINE; METHYLDOPA; NP 647; OLEANOLIC ACID DERIVATIVE; PEPTIDE TRANSPORTER 1; PRODRUG; PROTIRELIN DERIVATIVE; PYROGLUTAMYL(2 PROPYL)HISTIDYLPROLINAMIDE; UNCLASSIFIED DRUG; VALACICLOVIR; ZANAMIVIR;

ARTICLE; BINDING AFFINITY; BINDING SITE; CRYSTAL STRUCTURE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG PENETRATION; DRUG TRANSPORT; GLYCATION; HUMAN; INTESTINE MUCOSA PERMEABILITY; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; STRUCTURE ACTIVITY RELATION; VIRUS INFECTION;

ANIMALS; BIOLOGICAL TRANSPORT; HUMANS; INTESTINES; MEMBRANE TRANSPORT PROTEINS; PHARMACEUTICAL PREPARATIONS; PRODRUGS;

EID: 84888192640     PISSN: 14714892     EISSN: 14714973     Source Type: Journal    
DOI: 10.1016/j.coph.2013.08.004     Document Type: Review

References (35)

1. M. Brandsch, I. Knütter, and E. Bosse-Doenecke Pharmaceutical and pharmacological importance of peptide transporters J Pharm Pharmacol 60 2008 543 585 (Pubitemid 351589044)
2. M. Brandsch Transport of drugs by proton-coupled peptide transporters: pearls and pitfalls Expert Opin Drug Metab Toxicol 5 2009 887 905
3. C.M.H. Anderson, and D.T. Thwaites Hijacking solute carriers for proton-coupled drug transport Physiology 25 2010 364 377
4. F. Cao, Y. Gao, and Q. Ping Advances in research of PepT1-targeted prodrug Asian J Pharm Sci 7 2012 110 122
5. D.E. Smith, B. Clémençon, and M.A. Hediger Proton-coupled oligopeptide transporter family SLC15: physiological, pharmacological and pathological implications Mol Aspects Med 34 2013 323 336
6. T. Terada, and K-I. Inui Recent advances in structural biology of peptide transporters Curr Top Membr 70 2012 257 274
7. S. Newstead, D. Drew, A.D. Cameron, V.L.G. Postis, X. Xia, P.W. Fowler, J.C. Ingram, E.P. Carpenter, M.S.P. Sansom, and M.J. McPherson Crystal structure of a prokaryotic homologue of the mammalian oligopeptide-proton symporters, PepT1 and PepT2 EMBO J 30 2011 417 426
8. N. Solcan, J. Kwok, P.W. Fowler, A.D. Cameron, D. Drew, S. Iwata, and S. Newstead Alternating access mechanism in the POT family of oligopeptide transporters EMBO J 31 2012 3411 3421
9. R. Agu, E. Cowley, D. Shao, C. MacDonald, D. Kirkpatrick, K. Renton, and E. Massoud Proton-coupled oligopeptide transporter (POT) family expression in human nasal epithelium and their drug transport potential Mol Pharm 8 2011 664 672
10. W. Tai, Z. Chen, and K. Cheng Expression profile and functional activity of peptide transporters in prostate cancer cells Mol Pharm 10 2013 477 487
11. M.E. Ganapathy, M. Brandsch, P.D. Prasad, V. Ganapathy, and F.H. Leibach Differential recognition of β-lactam antibiotics by intestinal and renal peptide transporters, PEPT 1 and PEPT 2 J Biol Chem 270 1995 25672 25677
12. M.M. Posada, and D.E. Smith Relevance of PepT1 in the intestinal permeability and oral absorption of cefadroxil Pharm Res 30 2013 1017 1025
13. B. Yang, and D.E. Smith Significance of peptide transporter 1 in the intestinal permeability of valacyclovir in wild-type and PepT1 knockout mice Drug Metab Dispos 41 2013 608 614
14. F. Döring, J. Walter, J. Will, M. Föcking, M. Boll, S. Amasheh, W. Clauss, and H. Daniel Delta-aminolevulinic acid transport by intestinal and renal peptide transporters and its physiological and clinical implications J Clin Invest 101 1998 2761 2767 (Pubitemid 28294585)
15. J. Neumann, and M. Brandsch δ-Aminolevulinic acid transport in cancer cells of the human extrahepatic biliary duct J Pharmacol Exp Ther 305 2003 219 224 (Pubitemid 36373854)
16. C-W. Chung, C.H. Kim, H.M. Lee, D.H. Kim, T-W. Kwak, K-D. Chung, Y-I. Jeong, and D.H. Kang Aminolevulinic acid derivatives-based photodynamic therapy in human intra- and extrahepatic cholangiocarcinoma cells Eur J Pharm Biopharm 2013 10.1016/j.ejpb.2013.01.022
17. Y. Hagiya, Y. Endo, Y. Yonemura, K. Takahashi, M. Ishizuka, F. Abe, T. Tanaka, I. Okura, M. Nakajima, and T. Ishikawa Pivotal roles of peptide transporter PEPT1 and ATP-binding cassette (ABC) transporter ABCG2 in 5-aminolevulinic acid (ALA)-based photocytotoxicity of gastric cancer cells in vitro Photodiagn Photodyn Ther 9 2012 204 214
18. C-L. Wang, Y-B. Fan, H-H. Lu, T-H. Tsai, M-C. Tsai, and H-P. Wang Evidence of d-phenylglycine as delivering tool for improving l-dopa absorption J Biomed Sci 17 2010 71
19. M. Hellwig, S. Geissler, R. Matthes, A. Peto, C. Silow, M. Brandsch, and T. Henle Transport of free and peptide-bound glycated amino acids: synthesis, transepithelial flux at Caco-2 cell monolayers, and interaction with apical membrane transport proteins ChemBioChem 12 2011 1270 1279
20. S. Geissler, M. Hellwig, F. Markwardt, T. Henle, and M. Brandsch Synthesis and intestinal transport of the iron chelator maltosine in free and dipeptide form Eur J Pharm Biopharm 78 2011 75 82
21. Z. Liu, C. Wang, Q. Liu, Q. Meng, J. Cang, L. Mei, T. Kaku, and K. Liu Uptake, transport and regulation of JBP485 by PEPT1 in vitro and in vivo Peptides 32 2011 747 754
22. X. Guo, Q. Meng, Q. Liu, C. Wang, Q. Mao, H. Sun, J. Peng, T. Kaku, and K. Liu Peptide cotransporter 1 in intestine and organic anion transporters in kidney are targets of interaction between JBP485 and lisinopril in rats Drug Metab Pharmacokinet 27 2012 232 241
23. S. Varghese Gupta, D. Gupta, J. Sun, A. Dahan, Y. Tsume, J. Hilfinger, K-D. Lee, and G.L. Amidon Enhancing the intestinal membrane permeability of zanamivir: a carrier mediated prodrug approach Mol Pharm 8 2011 2358 2367
24. D. Gupta, S. Varghese Gupta, A. Dahan, Y. Tsume, J. Hilfinger, K-D. Lee, and G.L. Amidon Increasing oral absorption of polar neuraminidase inhibitors: a prodrug transporter approach applied to oseltamivir analogue Mol Pharm 10 2013 512 522
25. Z. Yan, J. Sun, Y. Chang, Y. Liu, Q. Fu, Y. Xu, Y. Sun, X. Pu, Y. Zhang, and Y. Jing Bifunctional peptidomimetic prodrugs of didanosine for improved intestinal permeability and enhanced acidic stability: synthesis, transepithelial transport, chemical stability and pharmacokinetics Mol Pharm 8 2011 319 329
26. K.S. Khomane, P.P. Nandekar, B. Wahlang, P. Bagul, N. Shaikh, Y.B. Pawar, C.L. Meena, A.T. Sangamwar, R. Jain, and K. Tikoo Mechanistic insights into PEPT1-mediated transport of a novel antiepileptic, NP-647 Mol Pharm 9 2012 2458 2468
27. +-coupled glucose transport Pharm Res 10 1993 667 673 (Pubitemid 23152310)
28. M. Negom Kouodom, L. Ronconi, M. Celegato, C. Nardon, L. Marchiò, Q.P. Dou, D. Aldinucci, F. Formaggio, and D. Fregona Toward the selective delivery of chemotherapeutics into tumor cells by targeting peptide transporters: tailored gold-based anticancer peptidomimetics J Med Chem 55 2012 2212 2226
29. M. Negom Kouodom, G. Boscutti, M. Celegato, M. Crisma, S. Sitran, D. Aldinucci, F. Formaggio, L. Ronconi, and D. Fregona Rational design of gold(III)-dithiocarbamato peptidomimetics for the targeted anticancer chemotherapy J Inorg Biochem 117 2012 248 260
30. F. Cao, J. Jia, Z. Yin, Y. Gao, L. Sha, Y. Lai, Q. Ping, and Y. Zhang Ethylene glycol-linked amino acid diester prodrugs of oleanolic acid for PepT1-mediated transport: synthesis, intestinal permeability and pharmacokinetics Mol Pharm 9 2012 2127 2135
31. F. Cao, Y. Gao, M. Wang, L. Fang, and Q. Ping Propylene glycol-linked amino acid/dipeptide diester prodrugs of oleanolic acid for PepT1-mediated transport: synthesis, intestinal permeability and pharmacokinetics Mol Pharm 10 2013 1378 1387
32. aa-Ser-OH dipeptides: evaluation of H-Phe-Ser-OH as a pro-moiety for ibuprofen and benzoic acid prodrugs Eur J Pharm Biopharm 77 2011 327 331
33. F. Guettou, E.M. Quistgaard, L. Trésaugues, P. Moberg, C. Jegerschöld, L. Zhu, A.J. Jong, P. Nordlund, and C. Löw Structural insights into substrate recognition in proton-dependent oligopeptide transporters EMBO Rep 13 2013 804 810
34. +/peptide cotransporters PEPT1 and PEPT2 in intestinal and renal epithelial cells Eur J Biochem 271 2004 2012 2017 (Pubitemid 38657353)
35. S. Doki, H.E. Kato, N. Solcan, M. Iwaki, M. Koyama, M. Hattori, N. Iwase, T. Tsukazaki, Y. Sugita, and H. Kandori Structural basis for dynamic mechanism of proton-coupled symport by the peptide transporter POT Proc Natl Acad Sci USA 110 2013 11343 11348