Mitochondrial targeted β-lapachone induces mitochondrial dysfunction and catastrophic vacuolization in cancer cells

Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 21, 2015, Pages 4828-4833

  Ma, Jing ^a,b   Lim, Chaemin ^c   Sacher, Joshua R ^c   Van Houten, Bennett ^a   Qian, Wei ^a   Wipf, Peter ^c  

^a UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Cytotoxicity; Lapachone; Mitochondria; Mitophagy; ROS; Vacuolization; XJB 5 131

Indexed keywords

3 HYDROXY BETA LAPACHONE; ANTINEOPLASTIC AGENT; BETA LAPACHONE; LIPOCORTIN 5; MYC PROTEIN; OLIGOMYCIN; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; BETA-LAPACHONE; NAPHTHOQUINONE;

APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER CELL; CANCER CELL LINE; CELL ASSAY; CELL SURVIVAL; CELL SURVIVAL ASSAY; CELL VACUOLE; CELL VIABILITY; CONTROLLED STUDY; CYTOPLASM; CYTOTOXICITY; DRUG CONJUGATION; DRUG SYNTHESIS; ELECTRON MICROSCOPY; GENE OVEREXPRESSION; GLYCOLYSIS; HUMAN; HUMAN CELL; MEMBRANE PERMEABILITY; MITOCHONDRION; MITOPHAGY; OXIDATIVE PHOSPHORYLATION UNCOUPLING; OXYGEN CONSUMPTION; CELL DEATH; CHEMICAL STRUCTURE; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; NEOPLASM; PATHOLOGY; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE;

APOPTOSIS; CELL DEATH; CELL LINE, TUMOR; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MITOCHONDRIA; MOLECULAR STRUCTURE; NAPHTHOQUINONES; NEOPLASMS; REACTIVE OXYGEN SPECIES; STRUCTURE-ACTIVITY RELATIONSHIP; VACUOLES;

EID: 84944275825     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2015.06.073     Document Type: Article

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