β-Lapachone induces programmed necrosis through the RIP1-PARP-AIF-dependent pathway in human hepatocellular carcinoma SK-Hep1 cells

Cell Death and Disease

Volumn 5, Issue 5, 2014, Pages

  Park, E J ^a   Min, K J ^a   Lee, T J ^b   Yoo, Y H ^c   Kim, Y S ^d   Kwon, T K ^a  

^a Keimyung University   (South Korea)

^b Yeungnam University College of Medicine   (South Korea)

^c Dong A University College of Medicine   (South Korea)

^d Ajou University School of Medicine   (South Korea)

Author keywords

AIF; NQO1; PARP1; RIP1; ROS; Lapachone

Indexed keywords

BETA LAPACHONE; CASPASE 3; DICOUMAROL; HIGH MOBILITY GROUP B1 PROTEIN; NECROSTATIN 1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PHOSPHOTRANSFERASE INHIBITOR; PROPIDIUM IODIDE; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL VIABILITY; CLONOGENESIS; CONTROLLED STUDY; DRUG INHIBITION; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME SYNTHESIS; EXTRACELLULAR SPACE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; NECROPTOSIS; PRIORITY JOURNAL; PROTEIN SECRETION; TRANSMISSION ELECTRON MICROSCOPY; WILD TYPE;

ANTINEOPLASTIC AGENTS; APOPTOSIS INDUCING FACTOR; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; HMGB1 PROTEIN; HUMANS; LIVER NEOPLASMS; NAD(P)H DEHYDROGENASE (QUINONE); NAPHTHOQUINONES; NECROSIS; NUCLEAR PORE COMPLEX PROTEINS; POLY(ADP-RIBOSE) POLYMERASES; PROTEIN KINASE INHIBITORS; PROTEIN TRANSPORT; REACTIVE OXYGEN SPECIES; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES; RNA INTERFERENCE; RNA-BINDING PROTEINS; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFECTION;

EID: 84901023217     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2014.202     Document Type: Article

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