Lipidomics identifies cardiolipin oxidation as a mitochondrial target for redox therapy of brain injury

Nature Neuroscience

Volumn 15, Issue 10, 2012, Pages 1407-1413

  Ji, Jing ^a,b,c   Kline, Anthony E ^a,b,c   Amoscato, Andrew ^b   Samhan Arias, Alejandro K ^b   Sparvero, Louis J ^b   Tyurin, Vladimir A ^b   Tyurina, Yulia Y ^b   Fink, Bruno ^d   Manole, Mioara D ^c,e   Puccio, Ava M ^a   Okonkwo, David O ^a   Cheng, Jeffrey P ^a,c   Alexander, Henry ^a,c   Clark, Robert S B ^a,c,e   Kochanek, Patrick M ^a,c,e   Wipf, Peter ^b   Kagan, Valerian E ^b   Bayir, Hülya ^a,b,c,e  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c UNIVERSITY OF PITTSBURGH   (United States)

^d Noxygen Science Transfer and Diagnostics GmbH   (Germany)

^e CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARDIOLIPIN; NEUROPROTECTIVE AGENT; NITROXIDE; POLYUNSATURATED FATTY ACID; SCAVENGER; UNCLASSIFIED DRUG; XJB 5 131;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR CHANGE; BRAIN CELL; BRAIN CORTEX LESION; COGNITION; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG MECHANISM; DRUG PENETRATION; DRUG POTENCY; DRUG TARGETING; LIPID OXIDATION; LIPIDOMICS; MITOCHONDRION; NERVE CELL NECROSIS; NERVE DEGENERATION; NEUROPATHOLOGY; NONHUMAN; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; RAT; RNA INTERFERENCE; TRAUMATIC BRAIN INJURY; TREATMENT OUTCOME;

ANIMALS; BEHAVIOR, ANIMAL; BRAIN INJURIES; CARDIOLIPINS; CELL DEATH; CEREBRAL CORTEX; CYCLIC N-OXIDES; FREE RADICAL SCAVENGERS; LIPID PEROXIDATION; MEMBRANE PROTEINS; MITOCHONDRIA; NEURONS; OXIDATION-REDUCTION; PRIMARY CELL CULTURE; RATS; TRANSFERASES (OTHER SUBSTITUTED PHOSPHATE GROUPS);

EID: 84866726957     PISSN: 10976256     EISSN: 15461726     Source Type: Journal    
DOI: 10.1038/nn.3195     Document Type: Article

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