Computational design, synthesis and biological evaluation of para-quinone-based inhibitors for redox regulation of the dual-specificity phosphatase Cdc25B

Organic and Biomolecular Chemistry

Volumn 6, Issue 18, 2008, Pages 3256-3263

  Keinan, Shahar ^a   Paquette, William D ^b   Skoko, John J ^b   Beratan, David N ^a   Yang, Weitao ^a   Shinde, Sunita ^b   Johnston, Paul A ^b   Lazo, John S ^b   Wipf, Peter ^a,b  

^a DUKE UNIVERSITY   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONTRAST MEDIA; HYDROGEN; HYDROGEN PEROXIDE; NONMETALS;

ATOMIC POTENTIALS; BIOLOGICAL ACTIVITIES; BIOLOGICAL EVALUATION; COMPUTATIONAL DESIGN; DUAL-SPECIFICITY; HALF-WAVE POTENTIALS; LINEAR COMBINATION; REDOX-REGULATION; REDUCING MEDIA; SYNTHETIC MODELS;

COMPLEXATION;

ENZYME INHIBITOR; HYDROGEN PEROXIDE; PROTEIN TYROSINE PHOSPHATASE; QUINONE DERIVATIVE;

ARTICLE; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; COMBINATORIAL CHEMISTRY; COMPUTER SIMULATION; DRUG ANTAGONISM; DRUG DESIGN; DRUG EFFECT; DRUG SCREENING; ENZYME SPECIFICITY; HUMAN; METABOLISM; OXIDATION REDUCTION REACTION; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

CDC25 PHOSPHATASES; CELL LINE, TUMOR; CELL SURVIVAL; COMBINATORIAL CHEMISTRY TECHNIQUES; COMPUTER SIMULATION; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; HUMANS; HYDROGEN PEROXIDE; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; QUINONES; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 52749098453     PISSN: 14770520     EISSN: None     Source Type: Journal    
DOI: 10.1039/b806712k     Document Type: Article

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